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A SOFTWARE SOLUTION FOR REAL-TIME COLLECTION AND PROCESSING OF MEDICAL DATA FOR EPILEPSY PATIENTS
Published 2024-12-01Get full text
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Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROS
Published 2025-01-01“…POM@Coa markedly reduced HCC invasiveness, reversed macrophage polarization from M2 to M1, and promoted the infiltration and activation of CD8+ T cells, ultimately inhibiting HCC metastasis. …”
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2024 Polish recommendations for the management of familial hypercholesterolemia in children and adolescents
Published 2024-11-01Get full text
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The Result of Timely Therapy for Whipple's Disease: a Clinical Case
Published 2024-01-01“…The identified changes were represented by thickening of the villi and accumulations in the stroma of large macrophages (CD68+) with wide light cytoplasm containing abundant accumulations of PAS-positive, negative when stained with carbol fuchsin according to Ziehl — Nielsen and auramine-rhodamine (under microscopy in luminescence mode) short rods, as well as numerous optically empty small and larger cavities. …”
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Transcript Profiles of Stria Vascularis in Models of Waardenburg Syndrome
Published 2020-01-01“…The expression of Col2a1, Col3a1, Col11a1, and Col11a2 genes were higher, and the expression of Col8a2, Cd34, and Ncam genes were lower in the porcine models compared to mouse models. …”
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Features of Crohn's Disease Depending on the Age of Disease Onset
Published 2023-12-01“…At the end of the follow-up, the worsening of endoscopic SES-CD level was observed more frequently in the patients with the onset before 30 years old in group A2 (p = 0.01).Conclusions. …”
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Progression of Luminal Breast Tumors Is Promoted by Ménage à Trois between the Inflammatory Cytokine TNFα and the Hormonal and Growth-Supporting Arms of the Tumor Microenvironment...
Published 2013-01-01“…Jointly, TNFα + Estrogen + EGF had a stronger effect on breast cancer cells than each element alone, leading to the following: (1) extensive cell spreading and formation of FAK/paxillin-enriched cellular protrusions; (2) elevated proportion of tumor cells coexpressing high levels of CD44 and β1 and VLA6; (3) EMT and cell migration; (4) resistance to chemotherapy; (5) release of protumoral factors (CXCL8, CCL2, MMPs). …”
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PEDF Overexpression Ameliorates Cardiac Lipotoxicity in Diabetic Cardiomyopathy via Regulation of Energy Metabolism
Published 2025-01-01“…In both db/db mice and HG+PA-treated H9c2 cells, PEDF overexpression modulated cardiac energy metabolism, mitigated lipotoxicity, and promoted the expression of adipose triglyceride lipase(ATGL) and glucose transporter type 4(Glut4) while inhibiting the expression of peroxisome proliferator-activated receptor alpha (PPARα), carnitine palmitoyltransferase 1 alpha (CPT1α), and scavenger receptor B2 (CD36). Additionally, PEDF overexpression reduced ROS generation and apoptosis in db/db mice myocardium and HG+PA-treated h9c2 cells.Conclusion: PEDF can effectively prevent cardiac hypertrophy, fibrosis remodeling, and the deterioration of diastolic dysfunction in DCM by modulating cardiac energy metabolism and mitigating ROS production and apoptosis induced by lipotoxicity.Keywords: PEDF, diabetic cardiomyopathy, metabolic disorders, lipotoxicity, reactive oxygen species, apoptosis…”
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