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    Identification of m6A methyltransferase-related WTAP and ZC3H13 predicts immune infiltrates in glioblastoma by Liyun Gao, Jiaxin Gao, Jiayin He, Wenyan Fan, Xiangxin Che, Xin Wang, Tao Wang, Chunhua Han

    Published 2025-02-01
    “…WGCNA identified 15 genes closely associated with WTAP/ZC3H13 expression and immune scores, notably CTLA4, CD27, ICOS, and LAG3. Our results suggested that WTAP and ZC3H13 influence on immune contexture of GBM, providing new insights into tumor immunity in GBM.…”
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    Immunizing adult female mice with a TcpA-A2-CTB chimera provides a high level of protection for their pups in the infant mouse model of cholera. by Gregory A Price, Randall K Holmes

    Published 2014-12-01
    “…We developed a TcpA holotoxin-like chimera (TcpA-A2-CTB) to elicit both anti-TcpA and anti-CTB antibodies and evaluated its immunogenicity and protective efficacy in the infant mouse model of cholera. Adult female CD-1 mice were immunized intraperitoneally three times with the TcpA-A2-CTB chimera and compared with similar groups immunized with a TcpA+CTB mixture, TcpA alone, TcpA with Salmonella typhimurium flagellin subunit FliC as adjuvant, or CTB alone. …”
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    Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis by Hongbin Luo, Qunya Zheng, Youzheng Zhou, Weipeng Lai, Nanwen Zhang, Peng Chen

    Published 2025-01-01
    “…The RA group displayed stronger cell type interactions compared to the OA group with enhanced signaling pathways, such as fibronectin 1-cluster of differentiation 44 (FN1-CD44) and C-X-C motif chemokine ligand 12-C-X-C motif chemokine receptor 4 (CXCL12-CXCR4). …”
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    Comparative transcriptome analysis reveals a serotype-specific immune response in Nile tilapia (Oreochromis niloticus) infected with Streptococcus agalactiae by Renan José Casarotto Appel, Renan José Casarotto Appel, Karine Nicole Siqueira, Ioannis Konstantinidis, Maria Isabel Mello Martins, Rajesh Joshi, Lucienne Garcia Pretto-Giordano, Laurival Antônio Vilas-Boas, Jorge Manuel de Oliveira Fernandes, Jorge Manuel de Oliveira Fernandes

    Published 2025-01-01
    “…Our findings revealed significant variation in the expression of genes involved in immune (e.g., CD209 antigen, granulin, C-X-C motif chemokine 10, prostacyclin synthase, and interleukins) and neuroendocrine (e.g., mmp13a, mmp9, brain aromatase, and pmch) pathways. …”
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