碱性成纤维生长因子对脂肪干细胞分化为心肌细胞的影响

“…【结果】 成功分离ADSC,流式细胞分析显示大多数ADSC表达CD29和CD90,不表达CD34和CD45?ADSC能被诱导分化成成脂?成骨细胞?bFGF+ADSC组及ADSC组的EF高于PBS组和bFGF组(P < 0.01),bFGF+ADSC组的EF高于ADSC组(P < 0.01),PBS组和bFGF组的EF差别无统计学意义(P = 0.33)?…”
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Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study by Tesfay Mehari Atey, Helen Bitew, Solomon Weldegebreal Asgedom, Asrat Endrias, Derbew Fikadu Berhe

“…The study aimed to determine the effect of IPT on the TB incidence, follow-up CD4+ T cells, and all-cause mortality rate. Participants. …”
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Comparison of the extraction efficiencies of four different solvents used in trace metal digestion of selected soils within Abakaliki, Nigeria by NO Omaka, IF Offor, ER Chukwu, U Ewuzie

“…Concentrations of 7 selected trace metals (Pb, Zn, Mn, Ni, Cd, Cu and Fe) were determined in the digested soil samples using atomic absorption  spectrophotometer. …”
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Associations among immunophenotype, plasma metabolites, and benign prostatic hyperplasia: a mediation Mendelian randomization study by FAN Jiuming, ZHAO Yiqiao, JIA Haichang, WANG Tiankun, HAN Yutong, QIN Zihao, CHEN Ping, ZENG Xiantao

“…The second pathway involves CD19 on IgD(-)CD24(- ) affecting BPH via deoxycholic acid glucuronide levels [mediation proportion=-11.230%, 95%CI(-21.873%, -0.588%)]. …”
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Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2 by Yuchen Li, Jiayi Zhou, Tianxin Zhang, Xiaocong Li, Cheng Wu, Ziyi Zhao, Jianyuan Tang, Xiaoyu Tan, Qiongying Hu, Wenhao Liao

“…In addition, AS-IV inhibited Rat weight loss and also alleviated the symptoms of CdCl2-induced nephrotoxicity in a rat model of CdCl2-induced kidney injury. …”
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Chordoma Spontaneous Regression After COVID-19 by Luis Fernando Moura da Silva Junior, Gyl Eanes Barros Silva, Marcos Adriano Garcia Campos, Antonio Augusto Lima Teixeira Júnior, Ramon Moura Santos, Orlando José dos Santos, Natalino Salgado Filho

“…CD20 and CD56 were negative, suggesting the absence of B-lymphocytes and NK-cells. …”
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5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity by Thomas Stübig, Anita Badbaran, Tim Luetkens, York Hildebrandt, Djordje Atanackovic, Thomas M. C. Binder, Boris Fehse, Nicolaus Kröger

“…Additionally, CD8+ T-cells exhibited limited killing capacity against leukemic target cells. …”
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The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease by Yi-Han Chen, Li Wang, Shu-Yi Feng, Wei-Min Cai, Xiao-Fu Chen, Zhi-Ming Huang

“…The receiver operating characteristic analysis showed that the optimum cut-off values of the CRP/ALB ratio for active UC and CD were 0.18 and 0.43, with sensitivities of 67.8% and 75.8% and specificities of 86.7% and 92.0%, respectively. …”
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The Continental Divide: Anti-TNF Use in Pediatric IBD Is Different in North America Compared to Other Parts of the World by Peter C. Church, Jeffrey Hyams, Frank Ruemmele, Lissy de Ridder, Dan Turner, Anne M. Griffiths

“…Respondents treated a median 40 IBD patients. CD was more commonly treated with anti-TNF than UC (40% vs. 10%, p<0.001). …”
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Daclatasvir and Sofosbuvir Therapy Enhance Monocyte Phenotypic Changes in Naive Chronic Hepatitis C Patients: A Prospective Cohort Study by Hanan M. Fayed, Ali A. Ghweil, Mona M. AbdelMeguid

“…A longitudinal study involving 100 treatment-naïve patients and 30 healthy controls, tested for liver function, fibrosis scores (AST to platelet ratio index, FIB-4), and blood monocyte subsets based on CD14/CD16 expression by flow cytometer. Results. …”
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Short-Chain Fatty Acids Promote Immunotherapy by Modulating Immune Regulatory Property in B Cells by Cai-Jie Zhou, Bai-Ling Xie, Hai-Yang Han, Yin Wang, Yong-Hua Wang, Jing-Yi Hong, Yi-Xia Wei, Zhi-Gang Liu, Yan Feng, Gui Yang, Ping-Chang Yang

“…Serum PA levels were positively associated with peripheral CD5+ B cell frequency in AR patients; the CD5+ B cells were also IL-10+. …”
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Cost-effectiveness of Chloride-liberal versus Chloriderestrictive Intravenous Fluids among Patients Hospitalized in the United States by Louise Perrault, Dilip Makhija, Idal Beer, Suzanne Laplante, Sergio Iannazzo, Karthik Raghunathan

“…Outcomes modeled in the decision tree were AKI development, recovery from AKI, progression to acute RRT, progression to CD, and death. Health states included in the Markov model were dialysis free without prior AKI, dialysis-free following AKI, CD, and death. …”
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Frequent Recurrences of Genital Herpes Are Associated with Enhanced Systemic HSV-Specific T Cell Response by Michal Holub, Alžběta Stráníková, Pavel Chalupa, Simona Arientová, Kateřina Roubalová, Ondřej Beran

“…Additionally, no differences in CD38 and HLA-DR expression on circulating CD8+ T cells were found among the study groups. …”
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Association between urinary metallothionein concentration and causes of death among cadmium-exposed residents in Japan: a 35-year follow-up study by Lianen Li, Rie Okamoto, Xian Liang Sun, Teruhiko Kido, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa, Masaru Sakurai

“…Background: As research progresses, there is a growing body of evidence indicating that urinary metallothionein (MT) levels may be elevated in individuals exposed to cadmium (Cd). This study aimed to investigate the potential association between urinary MT levels and causes of mortality among residents of the Kakehashi River Basin who have been exposed to Cd. …”
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Efficacy of caerulomycin A in modulating macrophage polarization and cytokine response in a murine model of lipopolysaccharide-induced sepsis by Jun Zhang, Shiyue Tang

“…For in-vitro assays using the RAW264.7 macrophage cell line, the concentration of caeA that was non-toxic to cell survival was screened using the MTT assay, followed by the analyses by qRT-PCR, ELISA, Western blot and flow cytometry for M1/M2 type macrophage markers (CD86, NOS2, CD206, ARG1) and inflammatory factors (IL-1β, IL-6, TNF-α, IL-4, and IL-10) expression. …”
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Customization of an efficient and cost-effective optical biosensor for trace cadmium detection in milk samples by Varsha S. Pawar, Shivaji D. Pawar, Harish Mudila, Arif D. Sheikh, Ajeet Kaushik, Anil Kumar

“…Conventional techniques for detecting Cd, such as [e.g., atomic absorption spectrometry (AAS), inductively coupled plasma-mass spectrometry (ICP-MS)], often require expensive equipment, extensive sample preparation or specialized expertise. …”
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Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous Chorioretinopathy by Esra Kızıldağ Özbay, Şenol Sabancı, Mehmet Fatih Küçük, Muhammet Kazım Erol

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最优化细胞因子诱导杀伤细胞/自然杀伤细胞 少因子培养体系的探索

“…【目的】 尝试使用IL-2、IL-7和IL-12的单因子双因子和三因子组合进行杀伤细胞/自然杀伤细胞(CIK/NK)细胞扩增培养,探讨最优化CIK/NK细胞少因子培养体系的建立方法】 采用Ficoll-Hypaque法分离脐血单个核细胞并分成6组,每组分别加入IL-2(80 ng/mL) IL-7(40 ng/mL)及IL-12(40 ng/mL)的单因子双因子和三因子组合(IL-7组;IL-12 组;IL-7+IL-12组;IL-2 + IL-7组;IL-2 + IL-12组;IL-2 + IL-7 + IL-12组),每组6个重复孔,共培养21 d收获细胞在细胞培养开始和第21天,实验各组取细胞悬液进行流式细胞仪检测CD3+ CD56 + CIK细胞及CD3- CD56+ NK细胞比例【结果】 单因子培养体系的IL-12组在CIK细胞扩增比例上是各组中最高的(22.96 ± 1.41)%,双因子体系的IL-2 + IL-12组的CIK细胞扩增比例也达到(18.58 ± 0.68)%;上述两组的CIK细胞扩增比例已经达到或基本达到使用传统多因子扩增方法所获得的比例65377;IL-12组的NK细胞扩增比例为(30.23 ± 1.18)%,IL-2 + IL-7组的NK细胞扩增比例也达(29.52 ± 0.89)% 【结论】 使用IL-12IL-2 + IL-12或IL-2 + IL-7组合的少因子培养体系进行CIK/NK细胞的培养扩增是可行的…”
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LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy by Zhishui Chen, Gang Chen, Li Chen, Xiangli Zhao, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Peixiang Lan

“…However, the mechanism has not been clarified.Methods We investigated the proliferation of splenic lymphocytes or CD8+ T cells induced by CD3/CD28 stimulation in vitro. …”
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اثر تاریخ کاشت و تراکم بر سرعت تولید و زوال برگ گلرنگ by بنیامین ترابی, ناصر دست فالی نژاد, افشین سلطانی, اصغر رحیمی

“…تولید برگ در گیاه پس از گذشت 1349 تا 1395 °Cd-1 و 1300 تا 1384 °Cd-1 به‌ترتیب برای تاریخ کاشت‌های اول و دوم پایان یافت. …”
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