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A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease
Published 2025-01-01“…We then prioritized 175 PD likely risk genes (pdRGs), such as SNCA, CTSB, LRRK2, DGKQ, and CD44, which are enriched in druggable targets and differentially expressed genes across multiple human brain-specific cell types. …”
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Conceptual framework of coaches’ decision-making in conventional sports
Published 2025-01-01Get full text
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Oral ATP treatment in alternating hemiplegia of childhood: a case report and review
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Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments
Published 2015-01-01“…Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal tract associated with an imbalance of the intestinal microbiota. Crohn’s disease (CD) and ulcerative colitis (UC) are the most widely known types of IBD and have been the focus of attention due to their increasing incidence. …”
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Deranged Bioenergetics and Defective Redox Capacity in T Lymphocytes and Neutrophils Are Related to Cellular Dysfunction and Increased Oxidative Stress in Patients with Active Syst...
Published 2012-01-01“…Compared to normal cells, SLE-PMN showed decreased intracellular GSH levels, and GGT enzyme activity was found in SLE-PMN and enhanced expression of CD53, a coprecipitating molecule for GGT. We conclude that deranged cellular bioenergetics and defective redox capacity in T and PMN are responsible for cellular immune dysfunction and are related to increased oxidative stress in active SLE patients.…”
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Neuropeptides SP and CGRP Diminish the Moraxella catarrhalis Outer Membrane Vesicle- (OMV-) Triggered Inflammatory Response of Human A549 Epithelial Cells and Neutrophils
Published 2018-01-01“…Finally, CGRP caused an impairment of specific but not azurophilic granule exocytosis from neutrophils as shown by evaluation of gelatinase-associated lipocalin (NGAL) or CD66b expression and elastase release, respectively. …”
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Depositional record of metal(loid)s since late quaternary in the Laizhou Bay, China
Published 2025-01-01“…The objective of this study was to investigate the concentration profiles of metal(loid)s (Cu, Pb, Zn, Cr, Cd, As, and Hg) along a sediment core in order to obtain background values and assess the depositional processes and contamination levels in Laizhou Bay. …”
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Hepatic and immune modulatory effectiveness of lactoferrin loaded Selenium nanoparticles on bleomycin induced hepatic injury
Published 2024-09-01“…The results revealed that BLM caused a significant increase in hepatic lipid peroxidation and nitric oxide, as well as serum markers of liver functions (AST, ALT and GGT activities), and levels of GM-CSF, CD4, TNF-α, IL-1β, TGF-β1, fibronectin, triglycerides, cholesterol and LDL-C. …”
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A Fast Parallel Processing Algorithm for Triangle Collision Detection Based on AABB and Octree Space Slicing in Unity3D
Published 2025-01-01“…This research develops an effective and precise collision detection (CD) algorithm for real-time simulation in virtual environments such as computer graphics, realistic and immersive virtual reality (VR), augmented reality (AR) and physical-based simulation within an enhanced algorithm for object collision detection in 3D geometry. …”
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«ظرفیتسنجی نظریه ادراکات اعتباری برای ساماندهی نظریه بومی فلسفه فضای مجازی »
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Multiscale Feature-Enhanced Water Body Detector of Truncated Gaussian Clutter in SAR Imagery
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