Modelling the immunopathogenesis of HIV-1 infection and the effect of multidrug therapy: The role of fusion inhibitors in HAART by Gesham Magombedze, Winston Garira, Eddie Mwenje

“…We firstdevelop a basic mathematical model of the immuno-pathogenesis of HIV-1infection that incorporates three distinct stages in the infection cycle of HIV-1:entry of HIV-1 into the cytoplasm of CD4+ T cells, transcription of HIV-1RNA to DNA within CD4+ T cells, and production of HIV-1 viral particleswithin CD4+ T cells. …”
Get full text

Fas/FasL 在复发性自然流产患者中的表达 by 刘玉昆

“…【结论】不明原因RSA患者的绒毛滋养细胞FasL表达弱于正常者,并且其表达Fas的CD8+T淋巴细胞和NK细胞均较正常妇女增多,表明RSA患者存在CD8+T淋巴细胞和NK细胞的异常激活。…”
Get full text

Notch1 Signaling Regulates the Th17/Treg Immune Imbalance in Patients with Psoriasis Vulgaris by Lei Ma, HaiBo Xue, Tianqin Gao, MeiLan Gao, YuJie Zhang

“…Additionally, CD4+ T cells from 12 PV patients were treated with γ-secretase inhibitor DAPT, and the above indexes were measured. …”
Get full text

Parameter fitting-based traveling wave fault location method for multi-terminal DC grids by Le Liu, Fan Xie, Xiaoning Kang, Zhiguo Hao, Aleksandra Lekić, Marjan Popov

Get full text

Early mucosal sensing of SIV infection by paneth cells induces IL-1β production and initiates gut epithelial disruption. by Lauren A Hirao, Irina Grishina, Olivier Bourry, William K Hu, Monsicha Somrit, Sumathi Sankaran-Walters, Chris A Gaulke, Anne N Fenton, Jay A Li, Robert W Crawford, Frank Chuang, Ross Tarara, Maria L Marco, Andreas J Bäumler, Holland Cheng, Satya Dandekar

“…HIV causes rapid CD4+ T cell depletion in the gut mucosa, resulting in immune deficiency and defects in the intestinal epithelial barrier. …”
Get full text

Pyridoxal-5′-Phosphate Promotes Immunomodulatory Function of Adipose-Derived Mesenchymal Stem Cells through Indoleamine 2,3-Dioxygenase-1 and TLR4/NF-κB Pathway by Cong Li, Jinxian Huang, Huasu Zhu, Qing Shi, Dong Li, Xiuli Ju

“…In addition, coculture was used to detect A-MSCs-mediated apoptosis of CD3+CD8+ T lymphocytes. These results showed that A-MSCs stimulated with PLP were highly proliferative, consistent with their pluripotent capacity. …”
Get full text

Efficacy and safety of an Albuvirtide-based regimen for preventing mother-to-child transmission of multidrug-resistant HIV: a case report by Na Li, Shifei Wen, Fangfang Zhu, Guirong Liu, Daqing Zhu

“…The tests revealed an HIV- RNA concentration of 1730 copies/mL, a CD4 T lymphocyte (CD4 cell) concentration of 145 cells/µL and genotypic resistance to NRTI and NNRTI. …”
Get full text

Synergistic therapeutic approach for hemorrhoids: integrating mesenchymal stem cells with diosmin-hesperidin to target tissue edema and inflammation by M. Hidayat Budi Kusumo, Adi Prayitno, Soetrisno ., Abdurahman Laqif

“…Results Characterization confirmed the MSCs’ plastic adherence, osteogenic differentiation potential, and immunophenotype (positive for CD90 and CD29, negative for CD45 and CD31). Treatment with MSCs alone or in combination with MPFF significantly reduced tissue edema, inflammation, TNF-α expression, and MMP-9 activity. …”
Get full text

胸腺肽类药物对体外诱导ES细胞分化为T细胞的作用 by 彭延文, 徐霖, 张秀明, 张嘉晴, 李树浓, 项鹏

“…【结果】在加入胸腺肽和胸腺素α1诱导的实验组，均有细胞表达CD3分子，CD3^＋细胞的百分比随诱导时间的增加而增多；而加入胸腺五肽的实验组无CD3^＋细胞出现。…”
Get full text

Long-Term Trends and Ecological Risks of Heavy Metal Accumulation in Cultivated Land of Songnen Plain, China by Zonglai Liu, Jinying Li, Yanan Chen, Fengjun Zhang, Wei Feng

“…Source analysis indicated that toxic Pb originates from vehicle exhaust emission, while Cd, Cu, and Ni are attributed to industrial activities. …”
Get full text

Identification of KIFC1 as an independent prognostic marker in renal clear cell carcinoma correlates with tumor proliferation and immune infiltration by Bin Du, Jia Wang, Jinping Zheng, Jing Huo, Pu Wang

“…Further, intratumoral immune cell analysis revealed that high expression of KIFC1 predicted more infiltration of CD8 + T and CD4 + T cells (p < 0.001). However, there was a significant positive relationship between CD8 + T cells and numerous immune checkpoint genes. …”
Get full text

Ca–Mg-Doped Surface-Modified Nano-Sized Ferrihydrite Powder Synthesized by Surfactant Mediation–Precipitation Technique: A Novel Super Adsorbent for Cations by M. Mohapatra, T. Padhi, S. Anand, B.K. Mishra

“…Desorption studies confirmed that Pb(II)- or Cd(II)-loaded adsorbent can be regenerated/reused. …”
Get full text

万山汞矿区弹琴蛙重金属富集与组织关联分析 by 张晓东, 王婷, 卢志宏, 钟莉传, 陈芬

“…结果表明：重金属元素在万山汞矿区弹琴蛙体内富集程度不同，平均质量分数由大到小依次为Zn、Cu、Mn、Pb、Se、Cr、Hg、Cd、Ni、As；Cu、Se、Cr、Ni、Cd和Hg主要富集在肝脏组织中，Mn、Zn和Pb主要富集在股骨和趾骨组织中，As主要富集在肌肉组织中。…”
Get full text

A Rare Collision Tumor Composed of Follicular Lymphoma and Adenocarcinoma in the Ampulla of Vater: A Case Report by Shioto Suzuki, Fumihiko Tanioka, Keisuke Inaba, Shingo Takatori, Hideto Ochiai, Shohachi Suzuki

“…The atypical lymphoid cells were immunohistochemically positive for CD10, CD20, and CD79a but negative for CD5 and cyclin D1. …”
Get full text

Induction of Interleukin-8 from Nasal Epithelial Cells during Bacterial Infection: The Role of IL-8 for Neutrophil Recruitment in Chronic Rhinosinusitis by Bit-Na Yoon, Nan-Geum Choi, Hyun-Sun Lee, Kyu-Sup Cho, Hwan-Jung Roh

“…IL-8 concentration and IL-8 mRNA expression continued to increase from 3 hours after incubation in SP number-dependent manner. The expression of CD11b/CD18 on neutrophils and E-selectin/ICAM-1 on HUVECs, and the adherence between neutrophils and HUVECs were significantly increased in 10 SP/MEC-CM, and the increments were significantly blocked by anti-IL-8 antibody. …”
Get full text

Molecular Networks Involved in the Immune Control of BK Polyomavirus by Eva Girmanova, Irena Brabcova, Jiri Klema, Petra Hribova, Mariana Wohlfartova, Jelena Skibova, Ondrej Viklicky

“…Analysis of biopsies from asymptomatic viruria patients resulted in the identification of 5 differentially expressed genes (CD3E, CD68, CCR2, ICAM-1, and SKI) (P<0.05), and functional analysis showed a significantly heightened presence of costimulatory signals (e.g., CD40/CD40L; P<0.05). …”
Get full text

Enhancement of the Stabilities and Intracellular Antioxidant Activities of Lavender Essential Oil by Metal-Organic Frameworks Based on β-Cyclodextrin and Potassium Cation by Ying Wang, Liang Wang, Jin Tan, Rong Li, Zi-Tao Jiang, Shu-Hua Tang

“…In addition, the intracellular antioxidant activities of LEO were also enhanced by the K-βCD-MOFs inclusion. These results suggested the potential of K-βCD-MOFs as carriers for essential oils in food industry applications.…”
Get full text

Importance of NAB2-STAT6 Fusion in the Diagnosis of Pancreatic Solitary Fibrous Tumor with Hamartoma-Like Features: A Case Report and Review of the Literature by Kei Tanaka, Takashi Kishimoto, Masayuki Ohtsuka, Yukio Nakatani, Masaru Miyazaki

“…The fibroblastic cells in the stroma were immune-positive for CD34, CD99, and bcl-2. But these expressions were not decisive in the differentiation between solitary fibrous tumor and pancreatic hamartoma, because CD34 was positive for both tumors, and CD99 and bcl-2 expressions were not elucidated in the previous cases of pancreatic hamartomas. …”
Get full text

Hepatitis B Vaccination Induced TNF-α- and IL-2-Producing T Cell Responses in HIV− Healthy Individuals Higher than in HIV+ Individuals Who Received the Same Vaccination Regimen by Kriangkrai Chawansuntati, Kanokporn Chaiklang, Romanee Chaiwarith, Jutarat Praparattanapan, Khuanchai Supparatpinyo, Jiraprapa Wipasa

“…An increase in the IL-2-producing memory CD4+ T cells in the healthy control group was also observed at 7 months after vaccination. …”
Get full text

Environmental safety of soils in conditions of intensive agricultural land use by A. N. Nekos, O. I. Khripko, O. O. Bolotova

“…When the crop rotation is saturated with winter rapeseed, Cd and Cu accumulate more in the soil, and when sunflower predominates, Pb and Zn. …”
Get full text