Effects of central administration of the human Tau proteinon the <i>Bdnf, Trkb, p75, Mapt, Bax</i> and <i>Bcl-2</i> genes expression in the mouse brain by A. S. Oreshko, A. Ya. Rodnyy, D. V. Bazovkina, V. S. Naumenko

“…Thus, central administration of aggregating human Tau protein decreases the expression of the Bdnf gene in the frontal cortex and the Mapt gene encoding endogenous mouse Tau protein in the cerebellum of C57Bl/6J mice.…”
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Extracts of Coreopsis tinctoria Nutt. Flower Exhibit Antidiabetic Effects via the Inhibition of α-Glucosidase Activity by Wujie Cai, Lijing Yu, Yu Zhang, Li Feng, Siyuan Kong, Hongsheng Tan, Hongxi Xu, Cheng Huang

“…For the animal experiments, C57BL/6 mice were fed with a chow diet, high-fat diet, or high-fat diet mixed with 0.4% (w/w) water and ethanol extracts of Coreopsis tinctoria flower for 8 weeks. …”
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Evaluation of the Digital Ventilated Cage® system for circadian phenotyping by Selma Tir, Russell G. Foster, Stuart N. Peirson

“…C57BL/6J mice exhibited a 24 h period under light/dark conditions, with a free-running period of 23.5 h under constant dark, and period lengthening under constant light. …”
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Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice by Luciana Lontro Alves, Priscila Gomes Pereira, Bianca Torres Ciambarella, Miguel Porto Campos, Kíssila Rabelo, Ana Lúcia Rosa Nascimento, Raíssa Leal de Carvalho dos Santos Cunha, Cherley Borba Vieira Andrade, Alan Cesar Nunes Moraes, Andressa Bernardi, Fernanda Verdini Guimarães, Jemima Fuentes Ribeiro da Silva, Jorge José de Carvalho

“…Eighteen 3-month-old male C57Bl/6 mice received a control or high-fat diet for 18 weeks. …”
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Fmoc固相直接法合成Aβ1-15肽疫苗及其免疫活性 by 杨学森, 汪华侨, 袁群芳, 谢瑶, 姚志彬, 叶小舟, 吴继明, 邹爱国

“…但还有其它不同分子质量的离子峰存在。以合成的MAP Aβ1-15免疫C57BL／6小鼠后。可产生高滴度的特异性抗Aβ越抗体，第3次接种后抗体平均滴度为1：467±196，第5次免疫接种后。…”
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Effects of growth factors during in vitro culture of mouse and rat embryos by E. Yu. Brusentsev, T. N. Igonina, I. N. Rozhkova, D. S. Ragaeva, S. Ya. Amstislavsky

“…In vitro culture of preimplantation embryos of ICR, HT1AN/Icgn, HT1AC/Icgn and C57BL/6J-Ay mouse strains as well as in OXYS/Icgn rat strain in media containing granulocyte-macrophage colony stimulating factor (GM-CSF) or epidermal growth factor (EGF) has been studied. …”
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Olfaction-based learned preference assessment without the use of motivational fear or motivational weight loss by Sara E. Moss, Ekaterina S. McCurdy, Natalya N. Thomas, Danielle Gulick, Angela M. Poff, Dominic P. D'Agostino

“…However, many inbred strains of mice present background pathologies that interfere with traditional learning tests. The C57BL/6 J mouse, a widely used laboratory strain, sporadically develops auditory and visual impairments that complicate interpretation. …”
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Apolipoprotein C-II Mimetic Peptide Promotes the Plasma Clearance of Triglyceride-Rich Lipid Emulsion and the Incorporation of Fatty Acids into Peripheral Tissues of Mice by Tomohiro Komatsu, Toshihiro Sakurai, Anna Wolska, Marcelo J. Amar, Akiko Sakurai, Boris L. Vaisman, Denis Sviridov, Stephen Demosky, Milton Pryor, Katsunori Ikewaki, Alan T. Remaley

“…After intravenous injection into C57BL/6N mice, the plasma half-life of the 3H-triolein for control and C-II-a treated emulsions was 18.3 ± 2.2 min and 14.8 ± 0.1 min, respectively. …”
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FDFT1 inhibits macrophage M1 polarization and promotes colorectal cancer progression by GAO Yuan, HUANG Yulan, ZHAO Kun

“…After peritoneal macrophages were extracted from male C57BL/6 mice (6 weeks old, weighing 13~18 g), the macrophages were then treated with the conditioned media of MC38 cells transfected with different siRNAs for 48 h. …”
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高脂饮食诱导<italic>APP_swe/PS1_ΔE9</italic>小鼠脑内炎症反应及细胞焦亡损伤神经功能 by 李泽, 宋祯彦, 李富周, 贺春香, 杨苗, 于文静, 成绍武

“…目的探讨高脂饮食引起的慢性炎症反应与阿尔兹海默病神经功能障碍之间的关系。方法12月龄C57BL/6J小鼠和<italic>APP_swe/PS1_ΔE9</italic>（<italic>APP/PS1</italic>）雄性小鼠，按体质量随机分为4组，正常组（C57BL/6J小鼠<italic>n</italic>=6）、普通高脂组（C57BL/6J小鼠+高脂饲料<italic>n</italic>=6）、痴呆组（<italic>APP/PS1</italic>小鼠<italic>n</italic>=6）、痴呆高脂组（<italic>APP/PS1</italic>小鼠+高脂饲料<italic>n</italic>=6）4组；普通饲料/高脂饲料喂养6周。…”
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Regulation of Murine Ovarian Epithelial Carcinoma by Vaccination against the Cytoplasmic Domain of Anti-Müllerian Hormone Receptor II by Cagri Sakalar, Suparna Mazumder, Justin M. Johnson, Cengiz Z. Altuntas, Ritika Jaini, Robert Aguilar, Sathyamangla V. Naga Prasad, Denise C. Connolly, Vincent K. Tuohy

“…We found that AMHR2-CD immunization of C57BL/6 females induced a prominent antigen-specific proinflammatory CD4+ T cell response that resulted in a mild transient autoimmune oophoritis that resolved rapidly with no detectable lingering adverse effects on ovarian function. …”
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小鼠软脑膜淋巴管内皮细胞的发育特点及其对行为功能的影响 by 谭立人, 肖颂华, 雷鸣

“…方法免疫荧光检测1周，2周，4周，10周，15周，15月龄野生型C57BL/6小鼠背侧，颞侧，腹侧，侧脑室旁软脑膜中Lyve-1⁺和CD68⁺细胞数量，并将15周龄野生型C57BL/6小鼠和APP/PS1转基因小鼠不同软脑膜区域中Lyve-1⁺和CD68⁺细胞数量进行比较。…”
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Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans by Mariano A. Aufiero, Li-Yin Hung, De'Broski R. Herbert, Tobias M. Hohl

“…We found that Mpeg1−/− mice generated on a mixed C57BL/6J-DBA/2 background exhibited enhanced survival, reduced lung fungal burden, and greater neutrophil fungal killing activity compared to wild-type C57BL/6J (B6) mice, suggesting that Perforin-2 may impair antifungal immune responses. …”
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tVNS alters inflammatory response in adult VPA‐induced mouse model of autism: evidence for sexual dimorphism by Hale Gök Dağıdır, Neslihan Bukan, Meltem Bahcelioglu, Ayşen Çalıkuşu, Ece Alim, Saadet Özen Dizakar, Elif Topa, Hayrunnisa Bolay

“…Therefore, we aimed to examine the effect of bilateral transcutaneous auricular vagus nerve stimulation (tVNS) on the inflammatory response in an adult valproic acid (VPA) induced mouse (C57BL6) model of autism for the first time. The autism model was induced by oral VPA administration (600 mg·kg−1) to C57BL/6 pregnant mice on E12.5 days. …”
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Disruption of the CRF1 receptor eliminates morphine-induced sociability deficits and firing of oxytocinergic neurons in male mice by Alessandro Piccin, Anne-Emilie Allain, Jérôme M Baufreton, Sandrine S Bertrand, Angelo Contarino

“…Antalarmin completely abolished sociability deficits induced by morphine in male, but not in female, C57BL/6J mice. Accordingly, genetic CRF1 receptor-deficiency eliminated morphine-induced sociability deficits in male mice. …”
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Alterations in the social-conditioned place preference and density of dopaminergic neurons in the ventral tegmental area in Clsnt2-KO mice by I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev, K. E. Uldanova, E. A. Chuyko, V. A. Naprimerov, T. V. Lipina, T. G. Amstislavskaya, S. Ya. Amstislavsky

“…By contrast, the control males of the C57BL/6J strain spent more time in socializing-associated compartment and less time in the compartment that was associated with loneness. …”
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Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition by Anne-Sophie Pepin, Patrycja A Jazwiec, Vanessa Dumeaux, Deborah M Sloboda, Sarah Kimmins

“…Males were timed-mated with control-fed C57BL6/J females to generate pregnancies, followed by collection of sperm, and placentas at embryonic day (E)14.5. …”
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Single-nucleotide polymorphism analysis accurately predicts multiple impairments in hippocampal activity and memory performance in a murine model of idiopathic autism by Isabel Barón-Mendoza, Luis A. Márquez, Aliesha González Arenas, Jessica Guzmán-Condado, Vladimir A. Martínez-Rojas, Johaly Anguiano-Buenfil, Montserrat Mejía-Hernández, Jorge Luis Almazán, Leonor Pérez-Martínez, Gustavo Pedraza-Alva, Emilio J. Galván, Angélica Zepeda

“…Through in silico analysis, we found that the C58/J strain carries single nucleotide polymorphisms (SNPs) compared to the C57BL/6J control strain related to synaptic structure and LTP induction. …”
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三种不同型别小鼠骨髓来源间质干细胞的生物学特性分析

“…为此,本研究拟进一步探讨小鼠MSC的体外分离方法，并对MSC克隆形成单位进行生物学特性分析【方法】 取C57BL/6小鼠，冲洗股骨骨髓腔获得骨髓单个核细胞悬液，低密度接种培养,并通过有限稀释克隆挑选获得三种形态生长特点不同的克隆形成单位(CFU)采用流式分析技术对三种类型的CFU进行表型分析，并用油红O和茜素红分别进行成脂和成骨分化诱导鉴定【结果】 低密度培养并结合克隆化培养分离技术成功获得C57BL/6小鼠骨髓间充质干细胞,并观察到偏圆形(MSC1)长梭形(MSC2)以及纺锤形多边形(MSC3)三种贴壁形态细胞类型；免疫表型分析显示，三种细胞均强表达Sca-1，不表达CD11bCD45，部分表达CD90.2；体外诱导分化实验证实，MSC1仅具有向脂肪细胞分化的潜能，MSC2仅具有向成骨细胞分化的潜能;MSC3则具有成骨成脂双向分化能力【结论】 低密度培养并结合克隆化培养分离技术可成功分离小鼠骨髓间充质干细胞;小鼠MSCs是一种高度异质性的细胞群，其中可能含有多能MSC或单一分化方向的前体细胞等处于不同分化阶段的细胞类型…”
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Neuronal density in the brain cortex and hippocampus in Clsnt2-KO mouse strain modeling autistic spectrum disorder by I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev, E. E. Uldanova, E. А. Chuyko, T. V. Lipina, T. G. Amstislavskaya, S. Ya. Amstislavsky

“…This mouse strain was obtained by a knockout of the calsinthenin-2 gene (Clsnt2) in C57BL/6J mice; the latter (wild type) was used as controls. …”
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