Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains by Jong Whi Kim, Sung Min Nam, Dae Young Yoo, Hyo Young Jung, Il Yong Kim, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoon

“…In this study, we investigated the basal level of hippocampal neurogenesis, as well as the effects of treadmill exercise on adult hippocampal neurogenesis in 9 mouse strains: 8 very commonly used laboratory inbred mouse strains (C57BL/6, BALB/c, A/J, C3H/HeJ, DBA/1, DBA/2, 129/SvJ, and FVB) and 1 outbred mouse strain (ICR). …”
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Single-Cell RNA Sequencing Analysis of Steroidogenesis and Spermatogenesis Impairment in the Testis of db/db Mice by Yun Hu, Ting-Ting Cai, Reng-Na Yan, Bing-Li Liu, Bo Ding, Jian-Hua Ma

“…We performed single-cell RNA sequencing analysis in the testis of db/db and C57BL/6J mice. The differentially expressed genes were then confirmed by real-time PCR. …”
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Adipocytes from New Zealand Obese Mice Exhibit Aberrant Proinflammatory Reactivity to the Stress Signal Heat Shock Protein 60 by Tina Märker, Jennifer Kriebel, Ulrike Wohlrab, Volker Burkart, Christiane Habich

“…Hsp60 showed specific binding to (pre-)adipocytes of NOD, NZO, and C57BL/6J mice. Hsp60 binding involved conserved binding structure(s) and Hsp60 epitopes and was strongest to NZO mouse-derived mature adipocytes. …”
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The XIAP inhibitor AZD5582 improves the treatment effect of microwave ablation on hepatocellular carcinoma by Wenhui Wang, Fuyuan Wu, Zhe Wu, Mengfan Zhang, Qiang Lu

“…We established an in vitro IMWA model by heating HCC cell lines and, at the same time, applied the XIAP inhibitor AZD5582 and verified the proliferation, migration, and pro-apoptotic ability of the XIAP inhibitor on tumor cells using CCK8, colony formation assay, cell scratch assay, and flow cytometry flow. The IMWA model of C57BL/6 and NTG mice were established, and AZD5582 was used in combination to evaluate the inhibitory and pro-apoptotic effects of different treatment regimens on tumor growth and to detect the local immune infiltration of C57BL/6 tumors. …”
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不同抗原和不同动物的多发性硬化模型比较 by 陆正齐, 朱灿胜, 郑雪平, 王敦敬, 胡学强

“…[结论]不同抗原和不同动物的EAE模型无论从病程、神经功能评分和病理改变方面均有自己的特点。用MOG 35-55乳化液制作C57BL/6小鼠EAE模型是MS的优秀模型。…”
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间充质干细胞联合NK细胞输注抑制DC减轻aGVHD

“…【目的】 观察骨髓MSC联合NK细胞输注对小鼠异基因骨髓移植后aGVHD的影响,初步探讨其作用机制?【方法】 分离C57BL/6小鼠骨髓细胞,体外培养MSC;取C57BL/6小鼠脾脏细胞,磁珠分选NK细胞;建立C57BL/6→BALB/c小鼠异基因骨髓移植模型,接受移植小鼠随机分为4组,每组10只小鼠,MSC和NK细胞移植组,MSC移植组,NK细胞移植组和培养基对照组?…”
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Calpain Activity and Toll-Like Receptor 4 Expression in Platelet Regulate Haemostatic Situation in Patients Undergoing Cardiac Surgery and Coagulation in Mice by Jui-Chi Tsai, Yi-Wen Lin, Chun-Yao Huang, Feng-Yen Lin, Chien-Sung Tsai

“…Therefore, in this study, we evaluated the platelet TLR4 expression in patients who underwent CABG surgery; we explored the correlation between platelet TLR4 expression and the early outcomes in hospital of patients. Additionally, C57BL/6 and C57BL/6-TlrLPS−/− mice were used to explore the roles of platelet TLR4 in coagulation by platelet aggregometry and rotation thromboelastometry. …”
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Application of deep learning models on single-cell RNA sequencing analysis uncovers novel markers of double negative T cells by Tian Xu, Qin Xu, Ran Lu, David N. Oakland, Song Li, Liwu Li, Christopher M. Reilly, Xin M. Luo

“…In this study, employing the deep learning methodology, we have revealed novel markers for splenic DNT cells in C57BL/6 mice which were validated with flow cytometry analysis. …”
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Immortalized Schwann cell lines as useful tools for pathogenesis-based therapeutic approaches to diabetic peripheral neuropathy by Kazunori Sango, Hideji Yako, Hideji Yako, Naoko Niimi, Shizuka Takaku

“…Several immortalized Schwann cell lines have been established in our laboratory and utilized for the study of DPN; IMS32 from normal ICR mice, 1970C3 from normal C57BL/6 mice, IWARS1 and IKARS1 from wild-type and aldose reductase-deficient C57BL/6 mice, and IFRS1 from normal Fischer 344 rats. …”
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Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma by Zoltán Kellermayer, Sabrin Tahri, Madelon M. E. deJong, Natalie Papazian, Cathelijne Fokkema, Elodie C. G. Stoetman, Remco Hoogenboezem, Gregory vanBeek, Mathijs A. Sanders, Louis Boon, Chelsea Den Hollander, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo

“…Transfer of 5TGM1 cells in C57Bl/6 mice led to stable disease with low tumor burden in a subset of animals. …”
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Cardiac Function Remains Impaired Despite Reversible Cardiac Remodeling after Acute Experimental Viral Myocarditis by Peter Moritz Becher, Frauke Gotzhein, Karin Klingel, Felicitas Escher, Stefan Blankenberg, Dirk Westermann, Diana Lindner

“…Material and Methods. We infected C57BL/6J mice with Coxsackievirus B3 and determined the hemodynamic function 7 as well as 28 days after infection. …”
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Behavioral phenotyping of Kaiso-deficient mice by V. S. Korostina, A. V. Kulikov

“…A Kaiso-deficient mouse strain (KO) with the C57BL/6 strain background has been bred. Here we compare the behavior of KO mice and wild-type control C57BL/6 mice (WT) in the classic battery of behavioral tests, including the open field, elevated plus maze, and forced swim tests. …”
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Effect of VPAC1 Blockade on Adipose Tissue Formation and Composition in Mouse Models of Nutritionally Induced Obesity by H. Roger Lijnen, Kathleen Freson, Marc F. Hoylaerts

“…Administration of MAb 23A11 (25 mg/kg body weight i.p. twice weekly) to 5-week old male C57Bl/6 mice kept on a high-fat diet for 15 weeks had no significant effect on weight gain, nor on subcutaneous (SC) or gonadal (GON) adipose tissue mass, as compared to the control MAb 1C8. …”
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EEPD1 attenuates radiation-induced cardiac hypertrophy and apoptosis by degrading FOXO3A in cardiomyocytes by Yu Kaiwen, Su Xi, Zhou Tongfang, Cai Xuwei, Zhang Min

“…In this study, EEPD1 global knockout mice, C57BL/6J mice, and C57BL/6J mice overexpressing EEPD1 are treated with radiation at a total dose of <sc>20 Gy</sc> or <sc>0 Gy.…”
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Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss by Ning Zhao, Ana’am Alkharabsheh, Fei Xu, Wei Sun

“…Increased acoustic startle responses (ASR), which represent reduced uncomfortable loudness level in humans, have been reported in middle-aged C57BL/6J mice with sensorineural hearing loss. Although neural plasticity changes in the central auditory system after the peripheral lesions were suggested to underlie this phenomenon, the neurological cause of exaggerated ASR is still not clear. …”
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Mast Cell Deficiency Protects Mice from Surgery-Induced Neuroinflammation by Xiang Zhang, Hongquan Dong, Fei Wang, Jun Zhang

“…This study is aimed at ascertaining the exactly role of mast cells on neuroinflammation with the mast cell-deficient mice. Adult male C57BL6/J wild-type (WT) and mast cell-deficient (C57BL6/J KitWsh/Wsh (Wsh)) mice underwent tibial fracture surgery. …”
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The Molecular Effects of SGLT2i Empagliflozin on the Autophagy Pathway in Diabetes Mellitus Type 2 and Its Complications by Ranin Saad, Hagar Tadmor, Offir Ertracht, Nakhoul Nakhoul, Farid Nakhoul, Farber Evgeny, Shaul Atar

“…We used eight weeks old male mice: twenty C57BL/6 wild type (C57BL/6), twenty BTBR ob/ob (DM), and twenty BTBR ob/ob that were treated with empagliflozin (DM+EMPA), FDA approved SGLT2i. …”
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老年小鼠心脏左室重塑和存活相关蛋白的表达变化

“…【目的】 探讨老年小鼠心脏左室重塑以及左室心肌蛋白激酶B(Akt)磷酸化AktB细胞淋巴瘤-2蛋白(Bcl-2)和存活素(Survivin)的蛋白表达变化【方法】 8只成年(5 ~ 5.5 月龄)雄性 C57bl/6小鼠作为对照组,8只老年(21.5 ~ 24 月龄)雄性 C57bl/6小鼠作为老年组(n = 8),计算心脏质量指数和左室质量指数,并利用Western-blot方法检测小鼠左室心肌β-肌动蛋白(β-actin)Akt磷酸化Akt (Ser473)Bcl-2和Survivin的蛋白表达【结果】 与成年对照组小鼠相比,老年组小鼠心脏质量指数左室质量指数左室心肌β-actin表达显著增加(P = 0.003, P = 0.001,P < 0.001),左室心肌Akt磷酸化Akt (Ser473)Survivin表达显著下降(P < 0.001, P = 0.028, P = 0.002),而Bcl-2表达却显著增加(P < 0.001)【结论】这些研究结果表明,小鼠老年化过程中心脏发生左室重塑,同时左室心肌Akt磷酸化Akt (Ser473)和Survivin表达下降,而Bcl-2表达增加,这些改变可能与老年心脏耐受缺血损伤能力下降有关…”
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表达幽门螺杆菌UreB 减毒鼠伤寒沙门氏菌对小鼠的免疫保护作用 by 朱森林, 陈湖, 廖文俊, 陈　洁, 胡品津

“…【结论】构建了表达H .pylori UreB 的重组减毒鼠伤寒沙门氏疫苗菌, 该菌株对C57BL/ 6 有免疫 保护作用。…”
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Effects of age and diet on triglyceride metabolism in mice by Kathryn M. Spitler, Shwetha K. Shetty, Brandon S.J. Davies

“…We fed male and female C57Bl/6 mice a low-fat diet, a western diet (WD), or a diet high in polyunsaturated and omega-3 fatty acids (n3D) for up to 2 years. …”
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