Induced Inflammatory and Oxidative Markers in Cerebral Microvasculature by Mentally Depressive Stress by Yuequan Zhu, Yazeed Haddad, Ho Jun Yun, Xiaokun Geng, Yuchuan Ding

“…A total of forty 6-week-old male C57BL/6J mice were randomly divided into the CRS and control groups. …”
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PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer by Jiacheng Li, Jia Liu, Shifeng Yang, Yu Xia, Qingzhe Meng, Biying Sun, Yansong Liu, Bin Zhao, Jiaqi Jin, Hui Xu, Lihong Wang, Pengxia Zhang, Zhuoxin Cheng

“…In vivo, CD274 knockout (KO), CD8a KO, platelet-specific KO (PF4-Cre-Hsp90b1flox/flox) mouse models and a subcutaneous tumour model treated with aspirin and PD-L1 mAb were established in C57BL/6 N mice. Results We found that PD-L1 positive platelets are correlated with a poor prognosis, CD8 + T cell exhaustion and serve as a novel noninvasive biomarker for predicting immunotherapy efficacy in patients with CRC. …”
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小鼠脑实质注射水通道蛋白4抗体所致的病理损伤 by 康新梅, 孙晓渤, 周一凡, 彭立胜

“…【目的】探讨小鼠脑实质注射视神经脊髓炎谱系疾病（NMOSD）患者来源水通道蛋白4（AQP4）抗体 （AQP4-IgG）造成的病理损伤，以及全身免疫状态对局部病灶的影响。【方法】于C57BL/6小鼠诱导实验性自身免 疫性脑脊髓炎（EAE），在发病高峰期脑实质局部注射 AQP4-IgG 阳性患者血清来源的 IgG 和健康人补体（hC） （EAE+AQP4-IgG+hC组，n=5），以单纯脑实质注射IgG和hC（AQP4-IgG+hC组，n=5）与EAE小鼠脑实质注射生理 盐水（NS；EAE+NS组，n=5）为对照组。…”
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TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis by Lin Wang, Diqing Ouyang, Lin Li, Yunchuan Cao, Yingwen Wang, Nina Gu, Zhaosi Zhang, Zhao Li, Shuang Tang, Hui Tang, Yuan Zhang, Xiaochuan Sun, Jin Yan

“…Methods In this study, a controlled cortical impact model was used to induce TBI in adult male wild-type (WT) C57BL/6 mice and adult male TREM2 knockout mice. Various techniques were used to assess the role of DAM-like cells in TBI and the effects of glycolysis on DAM-like cells, including RT‒qPCR, immunofluorescence assays, behavioural tests, extracellular acidification rate (ECAR) tests, Western blot analysis, cell magnetic sorting and culture, glucose and lactate assays, and flow cytometry. …”
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Plasma prolactin axis shift from placental to pituitary origin in late prepartum mice by Taku James Sairenji, Shinnosuke Masuda, Yuya Higuchi, Mitsue Miyazaki, Hiroyuki Yajima, Oh Kwan Ee, Yuki Fujiwara, Takuya Araki, Noriaki Shimokawa, Noriyuki Koibuchi

“…By measuring maternal plasma PRL3B1 and PRL every 4 hrs from gestational day 17 (G17), we newly discovered that maternal plasma PRL3B1 levels decrease rapidly in prepartum C57BL/6 mice. Interestingly, the onset of this decline coincided with the PRL surge at G18, demonstrating a plasma prolactin axis shift from placental to pituitary origin. …”
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Nerve Growth Factor Regulation by TNF-α and IL-1β in Synovial Macrophages and Fibroblasts in Osteoarthritic Mice by Shotaro Takano, Kentaro Uchida, Masayuki Miyagi, Gen Inoue, Hisako Fujimaki, Jun Aikawa, Dai Iwase, Atsushi Minatani, Kazuya Iwabuchi, Masashi Takaso

“…The expression of TNF-α, IL-1β, IL-6, and NGF in the ST of STR/Ort was higher than that in C57/BL6J mice. Compared to the CD11b– cell fraction, higher expression levels of TNF-α, IL-1β, and IL-6 were detected in the CD11b+ cell fraction, whereas no differences in the expression of NGF were detected between the two cell fractions. …”
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Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction by Jingrun Lin, Xiaoqiu Zhu, Xuan Li, Yu Hong, Yaohui Liang, Siqi Chen, Chenzhuo Feng, Lin Cao

“…This study aimed to investigate the potential biological mechanisms underlying POCD. Methods Male C57BL/6 mice (2 and 17 months old) were randomly assigned to surgery or control groups. …”
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环状RNA circ_0036176结合miR-218-5p发挥抑制心肌纤维化的作用 by 黄智琪, 严钰敏, 郭晶, 郭继深, 朱杰宁, 方咸宏, 徐金东, 单志新

“…利用双萤光素酶报告基因实验和RNA反义纯化技术（RAP）筛选可与circ_0036176有效结合的miRNA。利用C57BL/6乳小鼠心肌成纤维细胞（mCFs）研究miR-218-5p是否介导circ_0036176对心肌纤维化表型的调节作用。…”
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Comparative Analysis of Immunoactivation by Nanosecond Pulsed Electric Fields and PD-1 Blockade in Murine Hepatocellular Carcinoma by Maiweilidan Yimingjiang, Talaiti Tuergan, Xinhua Chen, Hao Wen, Yingmei Shao, RuiQing Zhang, Kasimu Aihaiti, Jing Xue, Tuerganaili Aji, Wei Zhang

“…In this study, we evaluated the immunoactivating effects and mechanisms of action of nsPEF ablation and PD-1 blockade on an HCC orthotopic xenograft mouse model. Briefly, 24 C57BL-6J tumor-bearing mice were randomly assigned to three groups: nsPEF ablation group, anti-PD-1 administration group, and untreated control group. …”
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Therapeutic efficacy and mechanism of artesunate for mouse model of polycystic ovary syndrome by WANG Xueling, WANG Xueling, ZHONG Peiling, ZHONG Peiling, ZHAO Zhipeng

“…Methods‍　‍Twenty-five female C57BL/6J mice were randomly divided into Control group, model group (PCOS group), low- and high-dose AS groups (AS15 and AS30 groups) and metformin group (Met group). …”
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Functional Characteristics and Lipid Lowering Activity of Auricularia heimuer Soluble Dietary Fiber by Xueyu SHANG, Heriban MEI, Ling SU, Qi WANG

“…The obese animal model was constructed by high fat diet (HFD) C57BL/6J mice, and treated with A. heimuer soluble dietary fiber. …”
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活体情况下评价载脂蛋白A1对小鼠视网膜血管生成的影响 by 苏焜仪, 胡安娣娜, 陈珠婷, 连玉, 吕林, 胡洁

“…方法在正常生理条件（常氧）下，通过<italic>apoA1^+/+</italic>鼠、<italic>apoA1 ^-/-</italic>鼠与C57/BL6J小鼠对比，分别在第17天末（幼年期）、8 周龄（成年期）、20周龄（中老年期），进行体内实验：①小鼠眼底照相（观察血管形态）及②荧光造影（FFA）（观察血管渗漏情况，分析视网膜平均血管密度、孔隙率及连接点个数）；并分别制备它们缺氧条件下的氧诱导的视网膜病变（OIR）模型进行实验：①眼底照相；②荧光眼底血管造影。…”
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Effects of Walnut Protein Peptides on Promotion of White Adipose Tissue Browning and Prevention of Obesity by Yankun FU, Yuzheng CAI, Zhiqiang FENG, Siru CHEN, Tianlin WANG, Lianjun SONG, Tiange LI

“…Lipid accumulation, mitochondrial quantity, and the protein expression of key factors involved in WAT browning were detected in 3T3-L1 preadipocytes after differentiation. Furthermore, male C57BL/6 mice fed with high-fat diet (HFD) were treated with WPP (400 mg/kg BW) for 8 weeks. …”
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Identification of Potential Diagnostic Biomarkers of Carotid Atherosclerosis in Obese Populations by Wu X, Pan J, Pan X, Kang J, Ren J, Huang Y, Gong L, Li Y

“…Finally, high-fat diet-fed C57BL/6J ApoE−/− mice were used for in vivo validation.Results: MMP9, PLA2G7, and SPP1 as regulators of the immune infiltration microenvironment in OB patients with CAS, and stratified CAS samples into subtypes with differences in metabolic pathways based on OB classification. …”
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Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice by Carmine Carbone, Roberto De Luca, Emanuele Puca, Antonio Agostini, Alessia Caggiano, Lorenzo Priori, Annachiara Esposito, Serena Ascrizzi, Geny Piro, Lisa Salvatore, Francesco De Sanctis, Stefano Ugel, Vincenzo Corbo, Dario Neri, Giampaolo Tortora

“…Methods We tested the effectiveness of different immunocytokines through in vivo characterization in syngeneic C57BL/6J orthotopic mouse models of PDAC. Based on these results, we decided to focus on L19-IL2. …”
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岭南火针通过调控Hippo-YAP信号通路抑制白癜风模型小鼠黑素细胞凋亡 by 李晶晶, 曾婧纯, 梁雪松, 张瑜, 阎路达, 林诗雨, 林国华, 周鹏

“…目的基于Hippo-YAP信号通路探讨岭南火针对氢醌诱导的氧化应激后白癜风模型的影响。方法将C57BL/6 小鼠随机分为空白对照组（Control）、模型对照组（HQ）、HQ+卤米松组 （Halometasone）、HQ+岭南火针组（FA），每组8只。…”
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Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation by Chrissa Petersen, Adhini Kuppuswamy Satheesh Babu, Ceres Mattos Della Lucia, Henry A. Paz, Lisard Iglesias-Carres, Ying Zhong, Thunder Jalili, J David Symons, Kartik Shankar, Andrew P. Neilson, Umesh D. Wankhade, Pon Velayutham Anandh Babu

“…We addressed this knowledge gap using strawberry phytochemicals as a model. C57BL/6J mice were fed a standard diet [C]; strawberry-supplemented diet (~2 human servings) [CS]; strawberry-supplemented diet and treated with antibiotics (to deplete gut microbes) [CSA]; high-fat diet (HFD) [HF]; strawberry-supplemented HFD [HS]; and strawberry-supplemented HFD and treated with antibiotics [HSA] for 12 weeks. …”
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Cinnamic acid alleviates endothelial dysfunction and oxidative stress by targeting PPARδ in obesity and diabetes by Yizhen Bai, Dechao Tan, Qiaowen Deng, Lingchao Miao, Yuehan Wang, Yan Zhou, Yifan Yang, Shengpeng Wang, Chi Teng Vong, Wai San Cheang

“…Methods High-fat diet (HFD) with 60 kcal% fat was used to induce obesity/diabetes in C57BL/6 mice for 12 weeks. These diet-induced obese (DIO) mice were orally administered with CA at 20 or 40 mg/kg/day, pioglitazone (PIO) at 20 mg/kg/day or same volume of vehicle during the last 4 weeks. …”
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Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil by Eliana Lucchinetti, Phing-How Lou, Alessandro Quaranta, Craig E. Wheelock, Akash Chakravarty, Martin Hersberger, Stefanie D. Krämer, Michael Zaugg

“…Methods: Instrumented male C57BL/6NCrl mice (N=5) were subjected to a 7-day TPN with Vegaven (VEGA) or SMOFlipid (SMOF). …”
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Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity by Krishma Tailor, Krishma Tailor, Janine van Ree, Timothy Stowe, Brit Ventura, Connor Sisk, Joanna Courtis, Anna Camp, Fatima Elzamzami, Jan van Deursen, Robert O’Brien, Jeffrey Baron, Julian C. Lui

“…Here, we studied CV1574-1 in a second mouse model, C57BL/6 wild-type mice treated with pegvisomant to induce GH resistance. …”
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