Effect of Electroacupuncture at Auricular Vagus Nerve on Depression and Anxiety-Like Behaviours of Mice with Preweaning Maternal Separation by WU Nan, WANG Qiang, LI Yongfeng, WU Yuwei, QIAO Haifa, LI Guohui, YUAN Wei

“…ObjectiveTo observe the effect of electroacupuncture at auricular vagus nerve on depression and anxiety-like behaviours of mice with preweaning maternal separation (PMS), and to explore its possible neural mechanism.MethodsA total of three male and nine female adult C57BL/6 mice were paired randomly by one male and three females for breeding. …”
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ＦＧＦ２１在小鼠非酒精性脂肪肝病程中的变化及与 ＳＲＥＢＰ的相关性 by 郭云蔚

“…摘 要： 【目的】 探讨成纤维细胞生长因子（ＦＧＦ２１）在小鼠非酒精性脂肪肝病程中肝组织和血清中的变化及其与胆固醇调节元件结合蛋白（ＳＲＥＢＰ）的相关性，探讨其中的可能机制。【方法】 分别给予Ｃ５７ＢＬ／６小鼠素食和高脂饮食喂养１、９、１８周，Ｗｅｓｔｅｒｎ ｂｌｏｔ和实时荧光定量ＲＴ－ＰＣＲ检测肝脏组织ＦＧＦ２１和ＳＲＥＢＰ的表达，并分析二者的相关性；ＥＬＩＳＡ法检测小鼠血清的ＦＧＦ２１水平，分析血清ＦＧＦ２１水平与肝组织ＦＧＦ２１的蛋白和ｍＲＮＡ水平的相关性。…”
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Exosomes secreted by ATF3/Nrf2-mediated ferroptotic renal tubular epithelial cells promote M1/M2 ratio imbalance inducing renal interstitial fibrosis following ischemia and reperfu... by Qiao Tang, Jiatao Xie, Yifei Wang, Chong Dong, Chong Dong, Qian Sun

“…Therefore, we aimed to explore the mechanisms by which ferrotosis occurs in renal tubular epithelial cells (RTECs) and ferroptotic cell-derived exosomes induce macrophage polarization in IRI-related RIF model.MethodsIn vivo, C57BL/6J mice were randomly divided into four groups: sham group, ischemia and reperfusion (IR) group, IR + Ferrostatin-1 (Fer-1) group, and IR +ATF3 knockdown (ATFKD) group. …”
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Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism by Naika Prince, Lucia N. Peralta Marzal, Léa Roussin, Magali Monnoye, Catherine Philippe, Elise Maximin, Sabbir Ahmed, Karoliina Salenius, Jake Lin, Reija Autio, Youri Adolfs, R. Jeroen Pasterkamp, Johan Garssen, Laurent Naudon, Sylvie Rabot, Aletta D. Kraneveld, Paula Perez-Pardo

“…Briefly, we depleted the microbiota of conventional male BALB/cAnNCrl (Balb/c) and C57BL/6J (BL/6) mice prior to human fecal microbiota transplantation (hFMT) with samples from children with ASD or their neurotypical siblings. …”
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Effects of exercise intensity and diet on cardiac tissue structure and FGF21/β-Klotho signaling in type 2 diabetic mice: a comparative study of HFD and HFD + STZ induced type 2 dia... by Sevda Moharamzadeh, Majid Kashef, Mojtaba Salehpour, Meysam Torabi, Samira Vesali, Zakieh Samsonchi, Ensiyeh Hajizadeh-Saffar

“…Methods Thirty-six male C57BL/6J mice were divided into high-fat diet (HFD) and normal chow diet (ND) groups. …”
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感染后肠易激综合征小鼠肠黏膜和血中细胞因子的表达变化

“…摘 要： 【目的】 观察感染后肠易激综合征小鼠不同肠段和外周血中ＩＦＮ－γ、ＩＬ－１７、ＩＬ－１０的表达及以上细胞因子的改变对肠道动力和内脏敏感性的影响。【方法】 ４０只雌性Ｃ５７ＢＬ\６小鼠随机分为ＰＩ－ＩＢＳ组和对照组，每组２０只。ＰＩ－ＩＢＳ组小鼠用０．２ ｍＬ含３５０条旋毛虫幼虫的生理盐水悬液灌胃，对照组给予等体积的生理盐水。…”
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AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation by Serena Sagliocchi, Elisabetta Schiano, Lucia Acampora, Fortuna Iannuzzo, Annunziata Gaetana Cicatiello, Caterina Miro, Annarita Nappi, Federica Restolfer, Mariano Stornaiuolo, Stefano Zarrilli, Fabrizia Guerra, Gian Carlo Tenore, Monica Dentice, Ettore Novellino

“…In this study, we investigated the effects of chronic supplementation with an infusion based on lyophilized, thin nectarines rich in abscisic acid (ABA), named AbaComplex, on promoting browning of WAT and activating BAT in mice. Over 30 days, C57BL/6 mice were treated with the ABA-rich infusion, and various metabolic and molecular parameters were assessed. …”
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Modulation of Caecal Microbiome in Obese Mice Associated with Administration of Amaranth or Soybean Protein Isolates by Diana Olguín-Calderón, Jorge L. González-Escobar, Rosalva Ríos-Villa, Elena Dibildox-Alvarado, Antonio De León-Rodríguez, Ana P. Barba de la Rosa

“…The aim of this study was to analyse the changes of gut microbiota in diet-induced obese mice due to amaranth protein consumption and to compare them with the changes due to soybean protein intake. Male C57BL/6 mice were fed for 8 weeks with regular (RD) or high-fat (HF) diet, without or with complementation with amaranth or soybean protein isolates. …”
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Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension by Justin H. Berger, Yuji Shi, Timothy R. Matsuura, Kirill Batmanov, Xian Chen, Kelly Tam, Mackenzie Marshall, Richard Kue, Jiten Patel, Renee Taing, Russell Callaway, Joanna Griffin, Attila Kovacs, Dinesh Hirenallur-Shanthappa, Russell Miller, Bei B. Zhang, Rachel J. Roth Flach, Daniel P. Kelly

“…We developed a novel “two-hit” model, which combines obesity and insulin resistance with chronic pressure overload to recapitulate clinical features of HFpEF. C57Bl6/NJ mice fed a high-fat diet (HFD) for > 10 weeks were administered an AAV8-driven vector resulting in constitutive overexpression of mouse Renin1d. …”
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Correlation Analysis of the Entorhinal Cortex-Hippocampus Nerve Fiber Changes and Memory Dysfunction in P301L-Tau Mouse Model and Molecular Mechanism by CHEN Xiaocheng, LIANG Shengxiang, LIN Bingbing, LIU Weilin, HUANG Jia

“…ObjectiveTo observe the correlation between the changes of entorhinal cortex-hippocampus nerve fibers and learning and memory function in the P301L-Tau mouse model of Alzheimer's disease (AD) and related molecular mechanism, so as to provide the evidence for Tau-targeted treatment in AD patients.MethodsA total of 16 3-month-old male C57BL/6 mice were randomly divided into non-vector virus control group (control group) and P301L-Tau model group (model group), with eight mice in each group. …”
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Bisphenol Analogs Downregulate the Self-Renewal Potential of Spermatogonial Stem Cells by Seo-Hee Kim, Seung Hee Shin, Seok-Man Kim, Sang-Eun Jung, Beom-Jin Shin, Jin Seop Ahn, Kyoung Taek Lim, Dong-Hwan Kim, Kichoon Lee, Buom-Yong Ryu

“…Materials and Methods: SSCs enriched from 6- to 8-day-old C57BL/6-eGFP+ male mice testes were treated with varying concentrations of bisphenols for 7 days to examine bisphenol-derived cytotoxicity and changes in SSC characteristics. …”

Identification and Characterization of Genes Associated with Intestinal Ischemia-Reperfusion Injury and Oxidative Stress: A Bioinformatics and Experimental Approach Integrating Hig... by Xie Y, Yang M, Huang J, Jiang Z

“…Concurrently, in vivo experimental results of IIRI in C57BL/6 mice, and the establishment of ROC curves, reflected the accuracy and specificity of HIOSRGs. …”
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Mucosal-adapted bacteriophages as a preventive strategy for a lethal Pseudomonas aeruginosa challenge in mice by Luiz Felipe Leomil Coelho, Mateus de Souza Terceti, Sergio Pereira Lima Neto, Raíne Piva Amaral, Ana Luisa Cauvila dos Santos, William Permagnani Gozzi, Bianca Andrade de Carvalho, Gustavo Aparecido da Cunha, Maria Fernanda Romboli Durante, Lais Sanchietta, Giovana Soares Marangoni, Matheus Luca Carotta Gabriel, Luiz Cosme Cotta Malaquias, Eliana Leonor Hurtado Celis, Giovanna de Souza Apolinário, João Pessoa Araujo Junior, Carine Ervolino de Oliveira, Victoria Fulgencio Queiroz, Gabriel Magno de Freitas Almeida

“…However, phage VAC3 is more efficient in replicating in mucin-exposed P. aeruginosa in vitro and is preferentially held in the respiratory tract of C57BL/6 mice. Pre-treatment with VAC3 phage protects mice from a lethal dose of P. aeruginosa while VAC1 does not. …”
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Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice by Alexandra O. Strohm, Sadie Oldfield, Eric Hernady, Carl J. Johnston, Brian Marples, M. Kerry O'Banion, Ania K. Majewska

“…We performed a comprehensive analysis of the cortical proteomes from irradiated and control C57BL/6J, P2Y12−/−, and CX3CR1−/− mice of both sexes using multiple bioinformatics methods. …”
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同种异基因小鼠骨髓腔内脐血移植模型的建立及其对造血干细胞植入的影响 by 蔡耘, 黄绍良, 陈凤英, 黄文革, 魏著, 车丽洪

“…【目的】建立同种异基因小鼠骨髓腔内脐血移植模型，研究该技术对造血干细胞（HSC）归巢、植入率、移植后免疫造血重建、移植物抗宿主病（GVHD）等方面的影响。【方法】用C57BL／6胎鼠及新生鼠外周血（FNPB）作供体，以单侧胫骨骨髓腔内注射（IBMI）和尾静脉注射（IV）两种途径移植经亚致死量60Coγ射线辐照预处理的BALB／c鼠。…”
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Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice by Thomas Guerbette, Vincent Ciesielski, Manon Brien, Daniel Catheline, Roselyne Viel, Mégane Bostoën, Jean-Baptiste Perrin, Agnès Burel, Régis Janvier, Vincent Rioux, Annaïg Lan, Gaëlle Boudry

“…The aim of the project was to determine whether DIO alters the mitochondrial function of IEC, and what are the consequences on intestinal homeostasis. Methods: C57Bl/6J mice were fed a control diet for 22 weeks or a high fat diet (58 kcal% fat). …”
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Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent by Jan Mersmann, Franziska Iskandar, Kathrina Latsch, Katharina Habeck, Vera Sprunck, René Zimmermann, Ralf R. Schumann, Kai Zacharowski, Alexander Koch

“…The objective of this study was to identify HMGB1 as an activator of TLR2 signalling during MI/R. C57BL/6 wild-type (WT) or TLR2−/−-mice were injected with vehicle, HMGB1, or HMGB1 BoxA one hour before myocardial ischemia (30 min) and reperfusion (24 hrs). …”
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β-glucan attenuates intestinal ischemia-reperfusion injury in mice by promoting glucagon-like peptide-1 secretion by WANG Wei, HAN Ben, SUN Lihua

“…Objective‍　‍To investigate the protective effect of β-glucan (BG) against intestinal ischemia reperfusion (II/R) injury by regulating the secretion of glucagon-like peptide-1 (GLP-1). Methods‍　‍Male C57BL/6 mice (6~8 weeks old) were subjected, and finally, the experiments had sham group, II/R group, II/R+BG group (0.1 mg/mL BG in drinking water for 2 weeks before modeling), II/R+liraglutide (LLT, GLP-1 analogue) group (0.2 μg/g LLT injected every 12 hours for 3 consecutive days before modeling), and II/R+BG+Ex9-39 (GLP-1R antagonist) group (intraperitoneal injection of 2 μg/g Ex9-39 1 h before modeling). …”
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Impact of Edible Insect Polysaccharides on Mouse Gut Microbiota: A Study on White-Spotted Flower Chafer Larva (<i>Protaetia brevitarsis seulensis</i>) and Silkworm Pupa (<i>Bombyx... by Joon-Ha Lee, Hyojung Son, Sathiyamoorthy Subramaniyam, Hyun-Jung Lim, Sohyun Park, Ra-Yeong Choi, In-Woo Kim, Minchul Seo, Hae-Yong Kweon, Yongsoon Kim, Seong-Wan Kim, Jong-Soon Choi, Younhee Shin

“…Seven-week-old female C57BL/6J mice were administered the edible insects, along with fracto-oligosaccharide (FOS) as a positive control and sham (phosphate buffer saline (PBS)) as a negative control, to assess the relative abundance of insect-diet-associated gut microbes. …”
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Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway by Yunpeng Lou, Hongguang Shi, Ning Sha, Feifei Li, Xiaofeng Gu, Huiyan Lin

“…This study aimed to evaluate the protective effects of UDCA against sepsis-induced acute kidney injury (AKI) and to elucidate the underlying mechanisms. Methods Sixty male C57BL/6 N mice were utilized to establish a sepsis-induced AKI model through intravenous injection of lipopolysaccharides (LPS, 10 mg/kg). …”
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