ANGPTL4 Attenuates Ang II-Induced Atrial Fibrillation and Fibrosis in Mice via PPAR Pathway by Xi Zhu, Xiaogang Zhang, Xinpeng Cong, Luoning Zhu, Zhongping Ning

“…This study aimed to investigate angiopoietin-like 4 (ANGPTL4) effects on angiotensin II- (Ang II-) induced AF and its related pathophysiological mechanisms. C57BL/6J mice were randomized and divided into three groups: the control group, the Ang II group, and the ANGPTL4 group (Ang II with ANGPTL4 treatment). …”
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Large Gliadin Peptides Detected in the Pancreas of NOD and Healthy Mice following Oral Administration by Susanne W. Bruun, Knud Josefsen, Julia T. Tanassi, Aleš Marek, Martin H. F. Pedersen, Ulrik Sidenius, Martin Haupt-Jorgensen, Julie C. Antvorskov, Jesper Larsen, Niels H. Heegaard, Karsten Buschard

“…We orally and intravenously administered 33-mer and 19-mer gliadin peptide to NOD, BALB/c, and C57BL/6 mice and found that the peptides readily crossed the intestinal barrier in all strains. …”
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L-theanine promotes angiogenesis in limb ischemic mice by modulating NRP1/VEGFR2 signaling by Jingyi Wang, Yinghui Xu, Yating Ruan, Xinyang Hu

“…To evaluate L-theanine's pro-angiogenic effects, human umbilical vein endothelial cells (HUVECs) were subjected to tube formation, migration, sprouting, and proliferation assays. In vivo, C57BL/6 mice with induced HLI were treated with L-theanine. …”
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Radish Seed Exerts Anti-Diabetic and Obesity-Reducing Effects in Mice by Promoting the Activation of Uncoupling Protein 1 and Peroxisome Proliferator-Activated Receptor-γ Coactivat... by Yao-Chien Wang MD, Yu-An Hsu PhD, Sheng-Chun Lin MD, Li-Shan Chien MS, Jamie Jiin Yi Chen MD, Ming Yen Wu MD, Hui-Ju Lin MD, PhD, Chih-Sheng Chen MD, PhD, Yi-Qi Huang MS, Yu-Chi Tsai PhD, Lei Wan PhD

“…In 3T3-L1 adipocyte differentiation experiments, RSE and SE increased the expression of beige adipocyte markers uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α). In C57BL/6 mice, RSE and SE mitigated weight increase, averted fatty liver, and diminished fat accumulation. …”
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Studying the Oncolytic Activity of <i>Streptococcus pyogenes</i> Strains Against Hepatoma, Glioma, and Pancreatic Cancer <i>In Vitro</i> and <i>In Vivo</i> by Anna N. Tsapieva, Alexander N. Chernov, Nadezhda V. Duplik, Anastasiya O. Morozova, Tatiana A. Filatenkova, Mariia A. Suvorova, Elena Egidarova, Elvira S. Galimova, Kseniya Bogatireva, Alexander N. Suvorov

“…We demonstrated that tumor treatment with <i>S. pyogenes</i> GURSA1 significantly increased the lifespan of C57BL/6 mice with hepatoma (34 days, <i>p =</i> 0.040) and pancreatic cancer (32 days, <i>p =</i> 0.039) relative to the control groups (24 and 28 days, respectively). …”
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补体系统C1q/C3介导的胶质细胞激活在小鼠抑郁样行为中的作用 by 王睿, 王清波, 谢婷, 郭开华

“…方法本实验分3部分：① 采用慢性束缚压力方法建立小鼠抑郁模型，将12只8周龄雄性C57BL/6小鼠随机分为对照（WT）组和抑郁模型（CRS）组，各6只，抑郁模型组造模2周。行为学测试系统悬尾实验（TST）、强迫游泳实验（FST）测试小鼠抑郁状态，采用免疫荧光染色法检测小鼠杏仁核中突触素（Syn）和突触后致密物（PSD95）变化情况，小胶质细胞（Iba-1）和星形胶质细胞（GFAP）细胞荧光强度，C1q、C3含量。…”
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A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice by Peng Ma, Rongrong Huang, Yu Ou

“…To determine the effect of SGP8 on non-alcoholic fatty liver disease (NAFLD), steatosis HepG2 cells were induced by 1 mmol/L free fatty acid (FFA) and C57BL/6J mice were fed with methionine-choline deficient (MCD) diet for 3 weeks to establish NAFLD model. …”
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Early Reciprocal Effects in a Murine Model of Traumatic Brain Injury and Femoral Fracture by Katharina Ritter, Kirsten Jung, Christopher Dolderer, Dominik Appel, Christine C. Oswald, Ulrike Ritz, Michael K. E. Schäfer

“…To address this issue, C57BL/6N mice were subjected to either the controlled cortical impact (CCI) model of TBI, fracture of the left femur (FF), combined injury (CCI+FF), or sham procedure. …”
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TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA by Elizabeth S. Fernandes, Carolina X. L. Brito, Simone A. Teixeira, Renato Barboza, Aramys S. dos Reis, Ana Paula S. Azevedo-Santos, Marcelo Muscará, Soraia K. P. Costa, Claudio R. F. Marinho, Susan D. Brain, Marcos A. G. Grisotto

“…We investigated the effects of capsazepine, a TRPV1 antagonist, in malaria. C57BL/6 mice received 105 red blood cells infected with Plasmodium berghei ANKA intraperitoneally. …”
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Vascular Contractility Relies on Integrity of Progranulin Pathway: Insights Into Mitochondrial Function by Shubhnita Singh, Ariane Bruder, Rafael M. Costa, Juliano V. Alves, Sivakama Bharathi, Eric S. Goetzman, Thiago Bruder‐Nascimento

“…Methods and Results We used aortae from male and female C57BL6/J wild‐type (PGRN+/+) and B6(Cg)‐Grntm1.1Aidi/J (PGRN−/−) mice. …”
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Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics by Ilias Doulamis, Despina N. Perrea, Panagiotis E. Chatzistergos, Athanasios S. Mitousoudis, Stavros K. Kourkoulis

“…A total of 26 adult male C57bl/6J mice were randomly assigned into three groups: (A) Control group (n=6), (B) High-fat diet group (n=10), (C) High-fat diet and exercise group (n=10). …”
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Augmented immunogenicity of the HPV16 DNA vaccine via dual adjuvant approach: integration of CpG ODN into plasmid backbone and co-administration with IL-28B gene adjuvant by Yan Zhou, Ting Zhang, Zhirong Wang, Xuemei Xu

“…Furthermore, vaccination with CpG-modified mE7/HSP70 and mE6/HSP70 plasmids, alongside the Interleukin-28B (IL-28B) gene adjuvant, generated substantial preventive and therapeutic antitumor effects against HPV E6- and E7-expressing tumors in C57BL/6 mice. These results suggested that integrating these multiple strategies into an HPV DNA vaccine holds promise for effectively controlling HPV infection and related diseases.…”
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矢车菊素－３－葡萄糖苷通过降低ＳＴＡＴ３活化抑制ＴＮＦ－α诱导的小鼠血管平滑肌细胞增殖

“…【目的】 探讨矢车菊素－３－葡萄糖苷（Ｃ３Ｇ）对ＴＮＦ－α诱导的血管平滑肌增殖的影响及可能的机制。【方法】 Ｃ５７ＢＬ／６Ｊ小鼠主动脉平滑肌细胞（ＶＳＭＣ） 购于ＡＴＣＣ，体外培养后以Ｃ３Ｇ对细胞进行预处理后观察ＴＮＦ－α的促细胞增殖作用；Ｄｉｈｙｄｒｏｅｔｈｉｄｉｕｍ （ＤＨＥ）荧光染色检测ＶＳＭＣ在ＴＮＦ－α作用下的活性氧（ＲＯＳ）生成情况；实时定量ＰＣＲ检测细胞内ＮＡＤＰＨ氧化酶活化蛋白１（ＮｏｘＡ１）的ｍＲＮＡ水平；蛋白质印迹法检测细胞内ＮｏｘＡ１、信号转导与转录激活因子３ （ＳＴＡＴ３）、磷酸化ＳＴＡＴ３及β－ａｃｔｉｎ的表达水平。…”
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吗啡对小鼠黑色素瘤的生长及免疫治疗效果的影响 by 梁沛彰, 朱浩乾, 张小敏, 陈浩, 汪灵芝

“…方法体外激活CD8⁺ T细胞，并给予不同浓度的吗啡刺激，流式细胞术分析CD8⁺ T细胞激活和分泌IFN⁺的情况；雌性C57小鼠接种小鼠黑色素瘤肿瘤细胞，接种第7天开始腹腔注射中等剂量的吗啡，检测肿瘤体积的变化，观察小鼠黑色素瘤生长曲线和小鼠生存曲线；雌性C57/BL6小鼠接种小鼠黑色素瘤肿瘤细胞，连续腹腔注射给予PD-1抗体3次，同时腹腔注射中等剂量的吗啡，检测肿瘤体积的变化和小鼠生存曲线。…”
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The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes by Avia Paz, Kareem Midlej, Osayd Zohud, Iqbal M. Lone, Fuad A. Iraqi

“…Results Our findings demonstrated significant variations in the recorded phenotypes across different CC lines compared to the reference mouse line, C57BL/6J. CC037 line exhibited a substantial increase in body weight on HFD, whereas line CC005 exhibited differing responses based on sex. …”
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PTPIP51: A New Interaction Partner of the Insulin Receptor and PKA in Adipose Tissue by M. A. Bobrich, S. A. Schwabe, A. Brobeil, M. Viard, M. Kamm, F. C. Mooren, K. Krüger, C. Tag, M. Wimmer

“…Methods. Four groups of ten C57Bl/6 mice each were used. Two groups were fed a standard diet; two groups were fed a high-fat diet. …”
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环磷酰胺预处理脐血移植小鼠模型的建立及其对骨髓龛位的影响 by 徐宏贵, 黄文革

“…【方法】分别以100 , 200 , 380 mg/ kg 3 种剂量CTX 腹腔注射BALB/ c 小鼠, 检测注射后1 周内外周血象、骨髓及外周血CD34 + 细胞含量、骨髓细胞凋亡及病理学改变。用C57BL/6 鼠脐血(FNPB)作供体移植经“ 致死量”CTX 预处理的BALB/ c 鼠, 动态 观察移植后受鼠存活状况、植入水平、造血与免疫功能恢复及移植物抗宿主病(GVHD)情况。…”
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Honokiol Provides Cardioprotection from Myocardial Ischemia/Reperfusion Injury (MI/RI) by Inhibiting Mitochondrial Apoptosis via the PI3K/AKT Signaling Pathway by Linhua Lv, Qiuhuan Kong, Zhiying Li, Ying Zhang, Bijiao Chen, Lihua Lv, Yubi Zhang

“…Methods. Seventy-eight male C57BL/6 mice were categorized randomly into three cohorts including the Sham operation (Sham) cohort, the MI/RI cohort (Con), and the Honokiol cohort (n=26 for each cohort). …”
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The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns by Minting Chen, Abdirahman Abdinasir Gureeye, Yacouba Cissé, Lang Bai

“…After the model was performed, C57BL/6J mice received topical treatment with saline eye drops or pranoprofen eye drops and were, respectively, categorized as saline group and pranoprofen group, whereas the remaining normal mice that were not subjected to alkali burns served as control, each group containing 15 mice (n = 45). …”
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Radio-protective effects of ultra-fine bubble hydrogen water and serum protein responses in whole-body radiation-exposed mice by Masaru Yamaguchi, Khin Thandar Htun, Youta Tatara, Yoshiaki Sato, Masato Hosoda, Suchart Kothan, Chikashi Kamimura, Osamu Inanami, Ikuo Kashiwakura

“…In this study, female C57BL/6J mice given ad libitum access to ultra-fine bubble hydrogen water (UBHW) were subjected to whole-body irradiation (WBI) with X-rays, and the radio-protective effect of UBHW was evaluated. …”
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