Reverse Genetic Strategies in Caenorhabditis elegans: Towards Controlled Manipulation of the Genome by Howard A. Baylis, Rafael P. Vázquez-Manrique

“…Thus, one dream of C. elegans researchers is to establish a toolkit for the controlled manipulation of any loci within the genome. …”
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Sulfurous Gases As Biological Messengers and Toxins: Comparative Genetics of Their Metabolism in Model Organisms by Neal D. Mathew, David I. Schlipalius, Paul R. Ebert

“…The genes for H2S synthesis have actually increased in number in C. elegans. Interestingly, D. melanogaster and Arthropoda in general, lack a gene for 3-mercaptopyruvate sulfurtransferase, an enzym for H2S synthesis under reducing conditions.…”
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Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. by Amanda L Kauffman, Jasmine M Ashraf, M Ryan Corces-Zimmerman, Jessica N Landis, Coleen T Murphy

“…We find that crh-1, the C. elegans homolog of the CREB transcription factor, is required for long-term associative memory, but not for learning or short-term memory. …”
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Automated cell annotation in multi-cell images using an improved CRF_ID algorithm by Hyun Jee Lee, Jingting Liang, Shivesh Chaudhary, Sihoon Moon, Zikai Yu, Taihong Wu, He Liu, Myung-Kyu Choi, Yun Zhang, Hang Lu

“…To illustrate the application of the advance, we show the characterization of CRF_ID 2.0 in multi-cell imaging and cell-specific gene expression analysis in C. elegans. This work demonstrates that high-accuracy automated cell annotation in multi-cell imaging can expedite cell identification and reduce its subjectivity in C. elegans and potentially other biological images of various origins.…”
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VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans. by Sung Min Han, Hajer El Oussini, Jelena Scekic-Zahirovic, Jack Vibbert, Pauline Cottee, Jeevan K Prasain, Hugo J Bellen, Luc Dupuis, Michael A Miller

“…We have shown that C. elegans and Drosophila neurons secrete a cleavage product of VAPB, the N-terminal major sperm protein domain (vMSP). …”
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Sleep drive is coupled to tissue damage via shedding of Caenorhabditis elegans EGFR ligand SISS-1 by Andrew J. Hill, Bryan Robinson, Jesse G. Jones, Paul W. Sternberg, Cheryl Van Buskirk

“…Sleep in the nematode C. elegans is independent of circadian cues and can be triggered rapidly by damaging conditions. …”
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A versatile site-directed gene trap strategy to manipulate gene activity and control gene expression in Caenorhabditis elegans. by Haania Khan, Xinyu Huang, Vishnu Raj, Han Wang

“…Thus, our cGAL-based gene trap is versatile and represents a powerful genetic tool for gene function analysis in C. elegans, which will ultimately provide new insights into how genes in the genome control the biology of an organism.…”
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The use of the model organism Caenorhabditis elegans in the investigation of the adverse effects of electronic cigarettes by Kamila Melnikov, Alžbeta Kaiglová, Soňa Kucharíková

“…Due to its short lifespan and easy use, C. elegans is an ideal model organism for studying chronic exposure to drugs and environmental toxicology. …”
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Structure, Immune and Anti-aging Activities of Capsular Polysaccharide Produced by Lactobacillus plantarum W1 by Yongjiao GAO, Kun WANG, Jing ZHAO, Feng ZUO

“…Concurrently, CPS significantly enhanced the antioxidant system of C. elegans (P<0.05), prolonged their lifespan, and improved their stress tolerance. …”
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Chlorogenic Acid and Biohanin A from Trifolium pratense L. Callus Culture Extract: Functional Activity In Vivo by Irina S. Milentyeva, Anna D. Vesnina, Anastasiya M. Fedorova, Elena V. Ostapova, Timothy A. Larichev

“…The biologically active substances exhibited relative neuroprotective activity and affected the expression of antioxidant defense gene in C. elegans.…”
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Complex and severe infection in a 67-year-old liver transplant recipient due to Cunninghamella elegans, Bordetella bronchiseptica, and Pneumocystis jirovecii by Muyun Wei, Kangyi Gu, Juanxiu Qin, Xinhua Lu, Junqi Feng, Shaowei Mao, Min Li, Zhilan Li, Changsheng Wang

“…Subsequent mNGS testing further revealed the presence of C. elegans, indicating that different pathogens played dominant roles at various stages of the disease progression. …”
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Coelomocytes: Biology and Possible Immune Functions in Invertebrates with Special Remarks on Nematodes by Qudsia Tahseen

“…The model nematode, C. elegans lacks an adaptive immune system and the coelomocytes are capable of endocytosis, but their involvement in phagocytosis of bacteria seems unlikely. …”
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Integrating representation learning, permutation, and optimization to detect lineage-related gene expression patterns by Hannah M. Schlüter, Caroline Uhler

“…We validate our method using synthetic data and apply it to recent paired lineage and scRNA-seq data of lung cancer in a mouse model and embryogenesis of mouse and C. elegans. Our method pinpoints subtrees giving rise to metastases or new cell states, and genes identified as most informative about lineage overlap with known pathways involved in lung cancer progression. …”
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Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning by Sonu Peedikayil-Kurien, Rizwanul Haque, Asaf Gat, Meital Oren-Suissa

“…Here, we reveal sexual dimorphism in learning: C. elegans males do not learn to avoid the pathogenic bacteria PA14 as efficiently and rapidly as hermaphrodites. …”
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At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis by J. Layne Myhre, David B. Pilgrim

“…Unc45b has been proposed to act exclusively as an adaptor molecule, stabilizing interactions between Hsp90 and myosin; however, recent discoveries in zebrafish and C. elegans suggest the possibility of an earlier role for Unc45b during myofibrillogenesis. …”
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Transcriptomic Approaches to Investigate the Anti-Aging Effects of Blueberry Anthocyanins in a Caenorhabditis Elegans Aging Model by Jie Ding, Jiahui Liu, Qingqi Guo, Na Zhang

“…Transcriptomic analysis was conducted to explore the regulatory effects of BA on anti-aging molecular pathways and key genes in <i>C. elegans</i>. Results showed a significant, dose-dependent extension of lifespan, improvement in locomotion and pharyngeal pumping rate, and reduction in lipofuscin and ROS accumulation. …”
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Kank Is an EB1 interacting protein that localises to muscle-tendon attachment sites in Drosophila. by Sara M R Clohisey, Nikola S Dzhindzhev, Hiroyuki Ohkura

“…This is in sharp contrast to C. elegans in which the Kank orthologue VAB-19 is required for development by stabilising attachment structures between muscle and epidermal cells.…”
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Comprehensive toxicity assessment of silver nanoparticles on Bacteria, human vein endothelial cells, and Caenorhabditis Elegans by Bircan Dinç

“…Our results revealed a significant inhibition of bacterial growth (52 % at 50 μg/mL), a 25 % reduction in C. elegans reproduction at just 10 μg/mL, and a decrease in body bending frequency from 42 to 19 beats per minute. …”
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The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response. by Tania Veuthey, Jeremy T Florman, Sebastián Giunti, Stefano Romussi, María José De Rosa, Mark J Alkema, Diego Rayes

“…Here, we show that the ILP, insulin-3 (INS-3), plays a crucial role in modulating the response to various environmental stressors in C. elegans. ins-3 mutants display increased resistance to heat, oxidative stress, and starvation; however, this advantage is countered by slower reproductive development under favorable conditions. …”
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GPX modulation promotes regenerative axonal fusion and functional recovery after injury through PSR-1 condensation by Su-Hyuk Ko, Kyung-Ah Cho, Xin Li, Qitao Ran, Zhijie Liu, Lizhen Chen

“…We discover that ferroptosis signaling can promote axonal fusion and functional recovery in C. elegans in a dose-sensitive manner. Ferroptosis-induced lipid peroxidation enhances injury-triggered phosphatidylserine exposure (PS) to promote axonal fusion through PS receptor (PSR-1) and EFF-1 fusogen. …”
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