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    «Green-Ligand» in Metallodrugs Design—Cu(II) Complex with Phytic Acid: Synthetic Approach, EPR-Spectroscopy, and Antimycobacterial Activity by Kseniya A. Koshenskova, Natalia V. Makarenko, Fedor M. Dolgushin, Dmitriy S. Yambulatov, Olga B. Bekker, Matvey V. Fedin, Sergei A. Dementev, Olesya A. Krumkacheva, Igor L. Eremenko, Irina A. Lutsenko

    Published 2025-01-01
    “…The interaction of sodium phytate hydrate C<sub>6</sub>H<sub>18</sub>O<sub>24</sub>P<sub>6</sub>·xNa·yH<sub>2</sub>O (phytNa) with Cu(OAc)<sub>2</sub>·H<sub>2</sub>O and 1,10-phenanthroline (phen) led to the anionic tetranuclear complex [Cu<sub>4</sub>(H<sub>2</sub>O)<sub>4</sub>(phen)<sub>4</sub>(phyt)]·2Na<sup>+</sup>·2NH<sub>4</sub><sup>+</sup>·32H<sub>2</sub>O (<b>1</b>), the structure of the latter was determined by X-ray diffraction analysis. …”
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    Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling by Katherine A. Kentistou, Brandon E. M. Lim, Lena R. Kaisinger, Valgerdur Steinthorsdottir, Luke N. Sharp, Kashyap A. Patel, Vinicius Tragante, Gareth Hawkes, Eugene J. Gardner, Thorhildur Olafsdottir, Andrew R. Wood, Yajie Zhao, Gudmar Thorleifsson, Felix R. Day, Susan E. Ozanne, Andrew T. Hattersley, Stephen O’Rahilly, Kari Stefansson, Ken K. Ong, Robin N. Beaumont, John R. B. Perry, Rachel M. Freathy

    Published 2025-01-01
    “…IGF1R and PAPPA2 (fetal and maternal-acting) have known roles in insulin-like growth factor bioavailability and signalling. PPARG, INHBE and ACVR1C (fetal-acting) are involved in adipose tissue regulation, and the latter two also show associations with favourable adiposity patterns in adults. …”
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