Alan B. Cohen, David C. Colby, Keith A. Wailoo, and Julian A. Zelizer, eds., Medicare and Medicaid at 50: America’s Entitlement Programs in the Age of Affordable Care by Éveline Thévenard

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L’ordre de l’Église. Autour du Contra haereticos sive de Ecclesia d’Hugues d’Amiens, archevêque de Rouen (c. 1085-1164) by Dominique Iogna-Prat

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Response to Article “Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis” [Letter] by Zeng X

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The expression of apoptosis-regulating proteins Bcl-2 and Bad in liver cells of C57Bl/6 mice under light-induced functional pinealectomy and after correction with melatonin by S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, A. Yu. Letyagin, M. A. Korolev, E. L. Zavjalov

“…The presence of humans and animals under long-term continuous lighting leads to a suppression of melatonin synthesis, that is, to light-induced functional pinealectomy (LIFP), and the development of desynchronosis. To create LIFP, C57Bl/6 mice were kept under 24-hour lighting (24hL) for 14 days. …”
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CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors by Chiara Giordano, Simona Carlomagno, Simona Carlomagno, Michela Falco, Claudia Cantoni, Claudia Cantoni, Massimo Vitale, Ignazio Caruana, Johannes Dirks, Alberto Serio, Letizia Muccio, Giulia Bartalucci, Alessandra Bo, Franco Locatelli, Franco Locatelli, Cristina Bottino, Cristina Bottino, Simona Sivori, Simona Sivori, Mariella Della Chiesa, Mariella Della Chiesa

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1H and 13C NMR Assignments of Cytotoxic 3S-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic Acid from the Leaves of Cichorium endivia by Fu-Xin Wang, An-Jun Deng, Jin-Feng Wei, Hai-Lin Qin, Ai-Ping Wang

“…The complete assignment of its 1H and 13C NMR spectroscopic data was carried out also for the first time based on extensive 1D and 2D NMR experiments. …”
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Wedge‐Like Microstructure of Al2O3/i‐Ti3C2Tx Electrode with “Nano‐Pumping” Effect for Boosting Ion Diffusion and Electrochemical Defluoridation by Junce Wang, Jinfeng Chen, Ningning Liu, Jingjing Lei, Hong‐Wen Gao, Fei Yu, Fanghui Pan, Jie Ma

“…The wedge‐like microstructure of aluminum oxide/incomplete‐Ti3C2Tx MXene (Al2O3/i‐Ti3C2 Tx) is constructed by incomplete etching MAX and in situ derivation of A‐layer element, in which the sub‐nanoscale interlayer space is conducive to the small size ions intercalation, and the formation of “nanopump‐like” effect boosted the ions diffusion. …”
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Crystal structure of 1-(4-hydroxybenzyl)-4-methoxy-9,10-dihydrophenanthrene-2,7-diol from Arundina graminifolia, C22H20O4 by Liu Mei-Feng, Zhang Xing-Yu, Du Yi-Mei, Chen Yan

“…C22H20O4, orthorhombic, P212121 (no. 19), a = 11.355(5) Å, b = 15.084(7) Å, c = 20.078(9) Å, V = 3439(3) Å3, Z = 4, Rgt(F) = 0.0382, wRref(F2) = 0.0994, T = 296(2) K.…”
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A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitrile in Aqueous Medium by Manisha Bihani, Pranjal P. Bora, Ghanashyam Bez

“…A completely green and improved method for the synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitriles by a four-component reaction of a mixture of ethyl acetoacetate, hydrazine hydrate, aldehyde, and malononitrile in boiling water is reported. …”
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Crystal structure of 3,5-bis((E)-4-methoxy-2-(trifluoromethyl)benzylidene)-1-methylpiperidin-4-one, C24H21F6NO3 by Zhou Xia, Sun Zhong-Hao, Shan Guang-Zhi, Meng Qing-Guo

“…C24H21F6NO3, monoclinic, P21/c (no. 14), a = 16.0076(10) Å, b = 7.7424(4) Å, c = 17.3259(11) Å, β = 96.161(5)°, V = 2134.9(2) Å3, Z = 4, R gt(F) = 0.0563, wR ref(F 2) = 0.1517, T = 100.0(1) K.…”
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C.G. Bartholomew – H.A. Thomas, "The Minor Prophets.... by Mariusz Szmajdziński

“… Book review: C.G. Bartholomew – H.A. Thomas, "The Minor Prophets. …”
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The crystal structure of N′1,N′3-bis((E)-thiophen-2-ylmethylene)isophthalohydrazide monohydrate, C18H16N4O3S2 by Yin Zi-Yi, Zou Fei, Chen Jue-Yuan, Yuan Lin, Li Zhong-Yan

“…C18H16N4O3S2, monoclinic, C2/c (no. 15), a = 19.694(4) Å, b = 11.450(2) Å, c = 8.3382(16) Å, β = 91.820(2)∘ $91.820{(2)}^{\circ }$ , V = 1879.3(6) Å3, Z = 4, Rgt ${R}_{gt}$ (F) = 0.0408, wRref $w{R}_{ref}$ (F 2) = 0.1206, T = 296(2) K.…”
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Long-term survival with pemetrexed-based chemotherapy in a patient with metastatic lung adenocarcinoma of unclear primary origin harboring MTHFR C677T(T/T) mutation: a case report by Yuan Yu, Yuan Yu, Yuan Yu, Nan-Jing Li, Nan-Jing Li, Nan-Jing Li, Nan-Jing Li, Jin Wang, Jin Wang, Jin Wang, Jin Wang

“…To further investigate the correlation between pemetrexed efficacy and genetic polymorphisms, genotyping tests on folate-metabolism-related genes [methylenetetrahydrofolate reductase (MTHFR) (C677T) and MTHFR (A1298C)] were performed, revealing that the patient exhibited the T/T genotype for MTHFR (C677T) and the A/A genotype for MTHFR (A1298C). …”
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Is C-reactive protein sufficient to guide antimicrobial therapy for lower respiratory tract infections among children?... by Chris A Rees, Prashant Mahajan, Quique Bassat

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The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice by Yange Liu, Ronglong Chen, Lanzhou Li, Ruitao Dong, Hui Yin, Yawen Wang, Anhui Yang, Jianbin Wang, Changtian Li, Di Wang

“…This study aims to investigate the hepatoprotective role of triterpenoids-enriched extracts from Antrodia cinnamomea mycelia (ACT) in chronic alcohol-induced liver injury mice, establishing in C57BL/6 mice through gradient alcohol feeding for 24 weeks. …”
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Synthesis and crystal structure (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one, C11H12BrNO2 by Dong Zhang-Chao, Zheng Liang-Liang, Pan Bo-Wen, Shi Yang, Zhou Ying

“…C11H12BrNO2, monoclinic, P21/n (no. 14), a = 7.5143(12) Å, b = 11.8968(15) Å, c = 12.9852(13) Å, β = 105.575(14)°, V = 1118.2(3) Å3, Z = 4, R gt(F) = 0.0607, wR ref(F 2) = 0.1615, T = 293.00(10) K.…”
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TẠO DÒNG VÀ BIỂU HIỆN GEN nahC MÃ HÓA 1,2-dihydroxynaphthalene dioxygenase CỦA VI KHUẨN Paenibacillus naphthalenovorans 4B1 by Le Thi Ha Thanh, Thị Ái Thoa Nguyễn, Thị Xuân Nguyễn, Vũ Ngọc Thi Trần

“…Kết quả điện di SDS-PAGE cho thấy gen nahC đã được biểu hiện thành công trong E. coli BL21 ở điều kiện cảm ứng 0,5 mM IPTG. …”
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Crystal structure of 2,2-dichloro-1-(4-chloro-1H-indol-1-yl)ethan-1-one, C10H6Cl3NO by Ma Zhao-Yu, Lu Wan, Guo Yu-Chao, Li Ying-Jiao

“…C10H6Cl3NO, monoclinic, P21/n (no. 14), a = 9.7097(10) Å, b = 10.6037(11) Å, c = 10.1735(10) Å, β = 96.580(4)°, V = 1040.55(18) Å3, Z = 4, Rgt(F) = 0.0214, wRref(F2) = 0.0574, T = 101 K.…”
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Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes by Chun-Yin Huang, Hsiu-Jung Lin, Hsin-Shui Chen, Shi-Yann Cheng, Horng-Chaung Hsu, Chih-Hsin Tang

“…Treatment with specific inhibitors for PKCδ, c-Src, EGFR, PI3K, Akt, or AP-1 or with the corresponding siRNAs against these signaling proteins also abolished the thrombin-mediated increase in MMP-13 production in chondrocytes. …”
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Modelling the potential clinical and economic impact of universal antenatal hepatitis C (HCV) screening and providing treatment for pregnant women with HCV and their infants in Egypt: a cost-effectiveness study by Giuseppe Indolfi, Diana M Gibb, Aya Mostafa, Sarah Pett, Yazdan Yazdanpanah, Sylvie Deuffic-Burban, Anthony E Ades, Karen Scott, Ali Judd, Nadia Hachicha-Maalej, Clotilde Lepers, Intira Jeannie Collins, Manal H El Sayed

“…Backgrounds and aims Pregnant women and children are not included in Egypt’s hepatitis C virus (HCV) elimination programmes. This study assesses the cost-effectiveness of several screening and treatment strategies for pregnant women and infants in Egypt.Design A Markov model was developed to simulate the cascade of care and HCV disease progression among pregnant women and their infants according to different screening and treatment strategies, which included: targeted versus universal antenatal screening; treatment of women in pregnancy or deferred till after breast feeding; treatment of infected children at 3 years vs 12 years. …”
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