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    Transurethral Water Vapor Ablation: Potential for a Novel Prostate Cancer Management Strategy by Warlick CA, Spilseth BD, Dixon CM

    Published 2025-02-01
    “…Using cystoscopy and transrectal ultrasound (TRUS) guidance, water vapor (~103°C) was delivered to prostate zones for hemigland ablation inclusive of cancers identified by multiparamertric MRI (mpMRI) and biopsy. …”
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    Identification of common and specific fibrosis-related genes in three common chronic kidney diseases by Zhangning Fu, Xiaodong Geng, Chao Liu, Wanjun Shen, Zheyi Dong, Guannan Sun, Guangyan Cai, Xiangmei Chen, Quan Hong

    Published 2024-12-01
    “…Quantitative real-time PCR (qRT-PCR) was performed to validate the expression of the selected genes.Results Protein tyrosine phosphatase receptor type C (PTPRC), intercellular cell adhesion molecule-1 (ICAM1), vascular cell adhesion molecule-1 (VCAM1), interleukin 10 receptor alpha (IL10RA) and CC chemokine receptor 2 (CCR2) were identified as the potential common genes for kidney fibrosis in different types of CKD, while peroxisome proliferator-activated receptor alpha (PPARA), lactate oxidase (LOX), secreted phosphoprotein 1 (SPP1) were identified as the specific fibrosis-associated genes for DN, IgAN and MN respectively. qRT-PCR demonstrated that the expression levels of these selected genes were consistent with the NanoString analysis.Conclusions There were both commonalities and differences in the mechanisms of fibrosis in different types of CKD, the commonalities might be used as the common therapeutic targets for kidney fibrosis in CKD, while the differences might be used as the diagnostic markers for DN, IgAN and MN respectively. …”
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    熊果酸通过靶向STAT3信号通路对葡聚糖硫酸钠诱导的小鼠溃疡性结肠炎的保护作用 by 庄群川, 沈阿灵, 刘丽雅, SANKARARAMAN Senthilkumar, SFERRA Thomas Joseph, 陈骐, 陈友琴

    Published 2021-02-01
    “…目的:研究熊果酸 (UA) 对葡聚糖硫酸钠 (DSS) 诱导的实验性小鼠结肠炎模型的抗炎作用, 旨在阐明其对肠上皮细胞 (IEC) 作用的可能分子机制.方法:在体内研究中, 将体质量为20~22 g的雄性BALB/c小鼠15只采用随机数字表法分为正常对照组、DSS模型组、DSS+熊果酸治疗组. 通过3%DSS诱导8 d, 制备小鼠结肠炎模型;其中一组DSS诱导的小鼠结肠炎模型采用UA预处理. …”
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