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Transdermal delivery of PeptiCRAd cancer vaccine using microneedle patches
Published 2025-03-01“…The findings indicated that MN-delivered PeptiCRAd was effective in peptide presentation in vivo, leading to complete tumor rejection when mice were pre-vaccinated. A rise in the cDC1 population in the lymph nodes of the MN treated mice led to an increase in the effector memory T cells in the body. …”
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Predicting Urinary Function Outcomes Following Low-dose-rate Brachytherapy for Prostate Cancer
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Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea
Published 2016-01-01“…Dividing subjects into four groups as TSH < 1.0 μIU/mL, 1.0 ≤ THS ≤ 1.9 μIU/mL, 1.91 ≤ TSH < 4.5 μIU/mL, and TSH ≥ 4.5 μIU/mL, only 26.3% of OSA subjects exhibited TSH between 1.0 and 1.9 μIU/mL, significantly less than non-OSA subjects (26.3% versus 38.2%, P=0.01). DBP and serum LDL-c elevated with TSH increasing and were only significantly higher in TSH ≥ 4.5 μIU/mL group than in 1.0 ≤ TSH ≤ 1.9 μIU/mL group (96.32±14.19 versus 92.31±12.86 mmHg; P=0.040; 0.99±0.60 versus 0.87±0.34 mmol/L, P=0.023). …”
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Quinazolinone Derivative MR2938 Protects DSS-Induced Barrier Dysfunction in Mice Through Regulating Gut Microbiota
Published 2025-01-01“…MR2938, a quinazolin-4(3H)-one derivative derived from the marine natural product penipanoid C, alleviated DSS-induced colitis in a dose-dependent manner. …”
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Th1/Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure
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Review and Prospect of Research on Urban Walking Safety and Environmental Influencing Factors Thereof
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激活TGR5缓解肾缺血再灌注后肾脏纤维化损伤
Published 2023-07-01“…目的探讨激活胆汁酸受体TGR5在单肾缺血再灌注损伤合并对侧肾摘除(uIRIx)模型诱导的肾脏纤维化中的作用。方法体内实验:将C57BL/6J小鼠随机分成假手术(Sham)组、uIRIx组及uIRIx+石胆酸(LCA)组,每组6只,使用uIRIx模型诱导肾脏纤维化,通过血和尿生化指标评估肾脏功能,利用HE染色评估肾脏损伤程度,使用Masson染色及免疫组化对肾脏纤维化程度进行评估,并用Western Blotting检测肾脏皮质纤维化相关指标蛋白表达;分别在<italic>TGR5</italic><sup>+/+</sup>小鼠及<italic>TGR5</italic><sup>-/-</sup>小鼠中设置Sham组及uIRIx组,每组6只,利用Western Blotting检测各组肾脏纤维化程度。…”
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Impact of PM2.5, relative humidity, and temperature on sleep quality: a cross-sectional study in Taipei
Published 2025-12-01“…Mediation analysis was used to explore PM2.5, RH, and temperature roles in these relationships.Results A 1% increase in RH over 1 and 7 days was associated with changes in non-rapid eye movement (NREM) sleep stages and increases in the arousal index across all seasons. A 1°C increase in temperature over similar periods led to increases in rapid eye movement (REM) sleep. …”
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What all physicians should know about women’s health: a Delphi study
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MP-LLAVRec: an agricultural product recommendation algorithm based on LLAVA and user modal preference
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