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    Biomarkers reflecting disturbed gut barrier under treatment with TNF inhibitors in radiographic axial spondyloarthritis by Denis Poddubnyy, Hildrun Haibel, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Judith Rademacher, Laura Spiller, Christine Maria Hempel

    Published 2024-12-01
    “…LBP showed a positive association in longitudinal analyses with Axial Spondyloarthritis Disease Activity Score (ASDAS) (ß=0.08, 95% CI 0.06 to 0.10), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (ß=0.08, 95% CI 0.04 to 0.12) and C reactive protein (CRP) (ß=1.69, 95% CI 1.04 to 2.34). …”
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  11. 276251

    Immune-checkpoint-inhibitor therapy directed against PD-L1 is tolerated in the heart without manifestation of cardiac inflammation in a preclinical reversible melanoma mouse model by Caroline Schoenherr, Caroline Schoenherr, Stefan Pietzsch, Stefan Pietzsch, Cristina Barca, Franziska E. Müller, Frauke S. Bahr, Martina Kasten, Andre Zeug, Sergej Erschow, Christine S. Falk, Evgeni Ponimaskin, James T. Thackeray, Denise Hilfiker-Kleiner, Denise Hilfiker-Kleiner, Melanie Ricke-Hoch

    Published 2025-01-01
    “…The reversible melanoma cancer mouse model (B16F10 cells stably expressing a ganciclovir (GCV)-inducible suicide gene in C57BL/6N mice: B16F10-GCV) allows chemotherapy-free tumor elimination in advanced disease stage and demonstrates almost complete recovery of the mouse heart from cancer-induced atrophy, molecular impairment and heart failure. …”
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    L-Cysteine Treatment Delays Leaf Senescence in Chinese Flowering Cabbage by Regulating ROS Metabolism and Stimulating Endogenous H<sub>2</sub>S Production by Linzhi Gan, Zhenliang Mou, Jianye Chen, Wei Shan, Jianfei Kuang, Wangjin Lu, Yating Zhao, Wei Wei

    Published 2024-12-01
    “…This study aimed to investigate the effect of L-cysteine (L-cys) on postharvest Chinese flowering cabbage stored at 20 °C. The results showed that 0.5 g L<sup>−1</sup> L-cys treatment effectively slowed leaf senescence by downregulating chlorophyll degradation genes <i>(BrNYC1, BrNOL</i>, <i>BrPPH</i>, <i>BrPAO</i>, <i>BrNYE</i>, and <i>BrSAGs</i>) and senescence marker gene <i>BrSAG12</i>. …”
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