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    Mannogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in T1DM mice by Ting Liu, Si Chen, Yunhe Qu, Lujuan Zheng, Xiaoxuan Yang, Shuhan Men, Yuanning Wang, Hanrui Ma, Yifa Zhou, Yuying Fan

    Published 2024-05-01
    “…Besides that, AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors, increased Ca2+ signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase II (CamkII) and cAMP/PKA signals, and enhanced insulin secretory vesicle fusion with the plasma membrane via vesicle-associated membrane protein 2 (VAMP2). …”
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