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    慢性乙肝患者拉米夫定耐药后出现肝功能衰竭的危险因素 by 邓洪, 顾琳, 赵志新, 张晓红, 彭晓谋, 高志良

    Published 2007-01-01
    “…【方法】拉米夫定耐药后导致病情加重的慢性乙型肝炎患者56例纳入研究.记录拉米夫定治疗前病程、诊断、拉米夫定疗程,检测并记录临床耐药时的肝功能、乙肝两对半、HBVDNA定量、YMDD变异及前C区变异。按病情加重后的诊断分为肝功能衰竭组和慢性乙型肝炎组进行比较。【结果】肝功能衰竭组患者年龄(45±13)岁,大于慢性乙型肝炎组(37±131岁(P〈0.05);肝功能衰竭组临床耐药时HBV DNA载量高于慢性乙型肝炎组[(2.8×10^8+4.9×10^8)拷贝/mL vs(3.1×10^6±2.9×10^6)拷贝/mL;P〈0.05];肝功能衰竭组出现HBeAg/Anti—HBe血清学转换(54.6%)高于慢性乙型肝炎组(18.4%,P〈0.05)。…”
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  11. 262291

    Evaluation of targeting accuracy of cone beam CT guided histotripsy in an in vivo porcine model by Martin G. Wagner, Grace M. Minesinger, Katrina L. Falk, Ayca Z. Kutlu, Meridith A. Kisting, Michael A. Speidel, Timothy J. Ziemlewicz, J. Louis Hinshaw, John F. Swietlik, Fred T. Lee, Paul F. Laeseke

    Published 2025-12-01
    “…This study evaluates the feasibility and accuracy of cone beam computed tomography (CBCT) guidance for histotripsy treatments in an in vivo porcine model.Materials and methods Histotripsy treatments were performed in the liver of seven healthy swine under the guidance of a C-arm CBCT system that was calibrated to the robotic arm of the histotripsy system. …”
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