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262001
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262002
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262003
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262004
Efeitos da adoção do IFRS 9 sobre a auditoria dos instrumentos financeiros em empresas não financeiras
Published 2025-01-01Get full text
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262005
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262006
鼻咽癌中EB病毒启动子Qp的突变及其功能学研究
Published 2010-01-01“…【目的】 探讨鼻咽癌细胞中启动EB病毒核抗原1(EBNA1蛋白)表达的EB病毒Q启动子(Qp)的变异特征,比较有第62 225位点(g→a)和第62 422位点(g→c)两个点突变的Qp与原型Qp(B95.8型)的功能学差异及其生物学意义65377;【方法】 采用PCR的方法扩增29例鼻咽癌组织石蜡标本和14例健康成人外周血标本(总共43例)中的Qp序列,PCR产物测序后分析其突变情况,统计学分析Qp中的点突变与鼻咽癌的相关性65377;把突变型和原型Qp分别克隆到荧光素酶报告基因载体上,检测相对光强度(RLU),比较突变型与原型Qp启动转录的活性65377;使用染色质免疫共沉淀(ChIP)实验来比较突变型和原型Qp与Sp1蛋白的亲和力65377; 【结果】 通过PCR扩增和测序实验,证实Qp的突变与鼻咽癌有密切的相关性(P = 0.0395,< 0.05)65377;突变型Qp启动转录的活性明显高于原型(RLU之比约为2.5:1,P < 0.05),并且突变型Qp与Sp1的亲和力较原型Qp增强约1.52倍65377;【结论】 在鼻咽癌组织中,突变型Qp可能通过增强与Sp1亲和力的机制,使其启动转录的活性明显增强65377;Qp特定位点的突变在EB病毒对鼻咽上皮细胞的感染和转化过程中可能起了重要的作用65377;…”
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262007
ATIVIDADES FÍSICAS PRATICADAS NO LAZER POR UNIVERSITÁRIOS DE UMA INSTITUIÇÃO PÚBLICA DO NORDESTE DO BRASIL
Published 2012-09-01Get full text
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262008
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262009
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262010
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262011
Role of percutaneous testis biopsy in management of patients with azoospermia
Published 2020-09-01Get full text
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262012
Factores biomecánicos en la rehabilitación por prótesis parcial fija sobre implantes Microdent
Published 2011-04-01Get full text
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262013
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262014
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262015
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262016
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262017
Nitrogen and phosphorus absorption capability in environmental culture by Taiwan gravestone Anadonta woodiana Lea
Published 2013-11-01“…Results of water quality analysis showed that the DO values decreased from baseline to end of treatment (from 5.08 to 4.86 mg/L), the average water temperature from 26.5 to 27.4 °C, pH values 7‒8, and highest turbidity values was obtained in the density of five gravestone. …”
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262018
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262019
Localization of Liv2 as an Immature Hepatocyte Marker in EB Outgrowth
Published 2009-01-01Get full text
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262020