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    内质网应激通过抑制PI3K/AKT/mTOR信号通路诱导多形性胶质母细胞瘤干细胞凋亡的机制

    Published 2016-01-01
    “…A2B5的表达;caspase3/7细胞凋亡检测试剂盒检测衣霉素(Tun)和毒胡萝卜素(Thap)对GSC的凋亡作用及MTS法检测细胞增殖活性;同时Western blot分析凋亡蛋白caspase3,ER stress标志蛋白C/EBP 同源性蛋白(CHOP)及PI3K/AKT/mTOR信号通路标志蛋白AKT?mTOR表达水平;使用siRNA沉默CHOP基因后,检测上述蛋白表达水平变化?…”
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    What are the training and support needs for homelessness hostel staff supporting older residents with memory and cognitive problems? A qualitative study by Luna Zalc, Sophie N. Gaber, Penny Rapaport

    Published 2025-01-01
    “…Results We identified three main themes: (a) Emotional and psychoeducational support needs within hostel staff teams, including training on memory and cognitive problems, responsive behaviours, communication strategies, and reflective spaces for hostel staff to manage their emotional responses (b) Training and support needs to deliver a person-centred approach, including tools and support packages to enhance hostel residents’ independence, multidisciplinary meetings to evaluate hostel residents’ needs, and communication strategies tailored to hostel residents’ understanding and (c) Support to facilitate collaboration with external agencies, including training on professional language, capacity assessment, dementia case studies, improved communication skills to bring external services into hostels, and reflective practices to advocate for hostel residents with dual diagnoses. …”
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