Effect of Electroacupuncture on Hippocampal Functional Activity and Molecular Expression Profile in Rats with Vascular Cognitive Impairment by WANG Zeyu, DING Yanyi, DAI Yaling, YANG Minguang, HUANG Jia, ZHANG Shenghang

“…Barnes maze test was used to evaluate the spatial learning and memory ability of rats; Y maze test was used to evaluate the spatial working memory ability of rats; small animal 7.0 T magnetic resonance resting brain functional imaging was used to analyze the changes of regional homogeneity (ReHo) of hippocampal functional activity; Agilent mRNA expression microarray was used to analyze the differential gene expression of the whole hippocampus genome.Results① Behavioral analysis results: compared with the sham operation group, the Barnes maze escape latency of the model group increased significantly (<italic>P</italic>&lt;0.05), the target quadrant duration percentage decreased significantly (<italic>P</italic>&lt;0.05), and the Y maze alternation rate decreased significantly (<italic>P</italic>&lt;0.05); compared with the model group, the Barnes maze escape latency of the electroacupuncture group decreased significantly (<italic>P</italic>&lt;0.05), the target quadrant duration percentage and the Y maze alternation rate increased significantly (<italic>P</italic>&lt;0.05). ② ReHo changes results: compared with the sham operation group, the ReHo of functional activitives of the bilateral prefrontal lobes, hippocampus and other brain regions in the model group decreased significantly (<italic>P</italic>&lt;0.005); compared with the model group, the ReHo of functional activities of the bilateral hippocampus, prefrontal lobes and piriform cortex in the model group increased significantly (<italic>P</italic>&lt;0.005). ③ Genomics results: a total of 705 genes with 2-fold differential expression of hippocampal mRNA between the model group and the sham operation group (<italic>P</italic>&lt;0.05), of which 195 genes (such as Sytl1, Trpv6, Klhl14, Npsr1, Myh3, Galnt3, Nr4a1, Bmp3, Egr2, etc.) were down-regulated, of which 510 genes (such as Insl6, Efcab1, Akr1b1, Tagln, Glrb, Akr1c13, Kcne1L, Ubap1, etc.) were up-regulated. A total of 399 genes with 2-fold differential expression of hippocampal mRNA between the electroacupuncture group and the model group (<italic>P</italic>&lt;0.05), of which 166 genes (such as Klhl14, Bmp3, Npsr1, Cacna1e, etc.) were up-regulated, of which 233 genes (such as Insl6, Ube2k, Cdkn1c, Camp, Upk1b,etc.) were down-regulated.ConclusionThe "Tongdu Tiaoshen" electroacupuncture at Baihui and Shenting acupoints can improve the cognitive function of rats with vascular cognitive impairment, and its mechanism may be related to enhance the function of hippocampus, prefrontal lobes and other brain regions, regulate the expression of calcium ions and energy metabolism-related molecules by regulating nerve activity activity.…”
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JWST Discovery of a Very Fast Biconical Outflow of Warm Molecular Gas in the Nearby Ultraluminous Infrared Galaxy F08572+3915 NW by Kylie Yui Dan, Jerome Seebeck, Sylvain Veilleux, David Rupke, Eduardo Gonzalez-Alfonso, Ismael Garcia-Bernete, Weizhe Liu, Dieter Lutz, Marcio Melendez, Miguel Pereira Santaella, Eckhard Sturm, Francesco Tombesi

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Prevalencia, características y factores asociados con el consumo de alcohol en universitarios peruanos durante la primera etapa de la pandemia de la COVID-19 by William Cabanillas Rojas, Yordanis Enriquez Canto, Luis Menacho Alvirio, Ricardo Murillo Ponte, Giovani Díaz Gervasi

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KATALIKŲ BAŽNYČIOS KAITA LIETUVOJE TRANSFORMACIJŲ LAIKOTARPIU by Valdas Pruskus

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ALTRE PAROLE DEL «DISSESTO FINANZIARIO»: BANCAROTTA, DECOZIONE, INSOLVENZA by Francesca Fusco

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Seroprevalence of Malaria and Hepatitis B Coinfection among Pregnant Women in Tamale Metropolis of Ghana: A Cross-Sectional Study by Gideon Kofi Helegbe, Paul Armah Aryee, Baba Sulemana Mohammed, Anthony Wemakor, David Kolbila, Abdul-Wahid Abubakari, Salam Askanda, Rashid Alhassan, Collins Barnie, Afua Aboagyewaa Donkoh, Ernest Ofosu

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An artificial intelligence application to predict prolonged dependence on mechanical ventilation among patients with critical orthopaedic trauma: an establishment and validation st... by Weigang Jiang, Tao Liu, Baisheng Sun, Lixia Zhong, Zhencan Han, Minhua Lu, Mingxing Lei

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Chemical Composition and Larvicidal Activity of Flower Extracts from Clitoria ternatea against Aedes (Diptera: Culicidae) by Darvin R. Ravindran, Madhuri Bharathithasan, Patmani Ramaiah, Mohd Sukhairi Mat Rasat, Dinesh Rajendran, Shakila Srikumar, Intan H. Ishak, Abd Rahman Said, Rajiv Ravi, Mohamad Faiz Mohd Amin

“…Hence, the major focus of this study is to identify the larvicidal mechanisms, metabolite, antioxidants, and chemical compounds and elucidate their structures from C. ternatea flower and to test their efficacies against early 4th instar larvae of Aedes aegypti and Aedes albopictus. …”
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Cuidado de pessoas com sobrepeso e obesidade na Atenção Primária by Sheila Rubia Lindner, Elza Berger Salema Coelho, Claudia Flemming Colussi, Deise Warmling, Carolina Abreu Henn de Araújo, Sabrina Blasius Faust, Virgínia de Menezes Portes, Dalvan Antonio De Campos

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KiKli Fit: Insights into the Development and Practice of a Physical Activity Program in Pediatric Cancer by Lisa Hillebrech, Lars Rehbein, Ann Christin Schneider, Sara Müller, Christina Schindera, Katharina Eva, Valentin Benzing

“…., Grotzer, M., Roebers, C. M., Steinlin, M., Leibundgut, K., Everts, R., & Schmidt, M. (2021). …”
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The role of artificial intelligence and machine learning in predicting and combating antimicrobial resistance by Hazrat Bilal, Muhammad Nadeem Khan, Sabir Khan, Muhammad Shafiq, Wenjie Fang, Rahat Ullah Khan, Mujeeb Ur Rahman, Xiaohui Li, Qiao-Li Lv, Bin Xu

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Effects of excessive body fat on colostrum lipid patterns: overweight/obese vs. normal weight mothers by Qian Liu, Yan Liu, Di Yang, Yanpin Liu, Yan Liu, Weicang Qiao, Juncai Hou, Yaling Wang, Minghui Zhang, Kai Yang, Xiaofei Fan, Ziqi Li, Junying Zhao, Lijun Chen

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Correlación entre desarrollo del pimpollo floral y el estadío de uninucleado a binucleado en Capsicum chinense "ají mochero" by Martín Giovanni Saavedra-Saldaña, Segundo Eloy López-Medina, José Mostacero-León, Juan Carlos Rodríguez-Soto, Armando Efraín Gil-Rivero, Anthony J. De La Cruz-Castillo, Roger Veneros-Terrones

“…Se concluye que existe una correlación positiva entre el desarrollo del pimpollo floral y el estadío a binucleado de C. chinense "ají mochero", por tanto, los pimpollos que poseen corola ligeramente más pequeña que el cáliz, son ideales para iniciar un proceso de androgénesis, el cual contribuiría con el mejoramiento genético de C. chinense al obtenerse líneas puras. …”
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智能髋关节超声技术在婴儿发育性髋关节发育不良筛查中的应用 by 徐英, 于红奎, 林小影, 赵扬, 杨星怡, 黄子殷, 许晓

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The Effects of Artificial vs. Natural Rearing on Growth Performance, Thyroid Hormone Levels, Locomotor Activity, Carcass Traits and Meat Quality Characteristics in Chios Lambs by Panagiotis Simitzis, Georgia Alexopoulou, Eftychis Karampekos, Konstantina Linardopoulou, Anargyros Rigakis, Niki Stamelou, Michael Goliomytis, Iosif Bizelis, Ioannis Bossis

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Effective semi-fed-batch saccharification with high lignocellulose loading using co-culture of Clostridium thermocellum and Thermobrachium celere strain A9 by Sreyneang Nhim, Sirilak Baramee, Chakrit Tachaapaikoon, Chakrit Tachaapaikoon, Patthra Pason, Patthra Pason, Khanok Ratanakhanokchai, Khanok Ratanakhanokchai, Ayaka Uke, Ruben Michael Ceballos, Akihiko Kosugi, Rattiya Waeonukul, Rattiya Waeonukul, Rattiya Waeonukul

“…These results suggest that the semi-fed-batch saccharification method using co-cultivation of C. thermocellum and T. celere strain A9, supplemented with Tween 20 is an efficient microbial method for saccharifying high-concentration biomass. …”
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Multi-observatory Study of Young Stellar Energetic Flares (MORYSEF): No Evidence for Abnormally Strong Stellar Magnetic Fields after Powerful X-Ray Flares by Konstantin V. Getman, Oleg Kochukhov, Joe P. Ninan, Eric D. Feigelson, Vladimir S. Airapetian, Abygail R. Waggoner, L. Ilsedore Cleeves, Jan Forbrich, Sergio A. Dzib, Charles J. Law, Christian Rab, Daniel M. Krolikowski

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Respuesta del tabaco al riego deficitario para dos fechas de trasplante by J. DIEZ, M. M. ACRECHE

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Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study by Sumihisa Orita, Masaomi Yamashita, Yawara Eguchi, Miyako Suzuki, Gen Inoue, Masayuki Miyagi, Tomoko Watanabe, Tomoyuki Ozawa, Hiroto Kamoda, Tetsuhiro Ishikawa, Yasuchika Aoki, Toshinori Ito, Go Kubota, Munetaka Suzuki, Kazuyo Yamauchi, Eiji Hanaoka, Yoshihiro Sakuma, Jun Shimbo, Yasuhiro Oikawa, Takane Suzuki, Kazuhisa Takahashi, Seiji Ohtori

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Scleral Buckling for Primary Retinal Detachment: Outcomes of Scleral Tunnels versus Scleral Sutures by Matthew R. Starr, Edwin H. Ryan, Anthony Obeid, Claire Ryan, Xinxiao Gao, Malika L. Madhava, Sean M. Maloney, Adam Z. Adika, Krishi V. Peddada, Kareem Sioufi, Luv G. Patel, Michael J. Ammar, Nora J. Forbes, Antonio Capone Jr., Geoffrey G. Emerson, Daniel P. Joseph, Dean Eliott, Carl D. Regillo, Jason Hsu, Omesh P. Gupta, Yoshihiro Yonekawa, for the Primary Retinal Detachment Outcomes (PRO) Study Group

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