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    Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability by Liu Deng, Chen Peixing, Yang Xu, Wang Jianhua

    Published 2020-12-01
    “…Chlortetracycline bisulfate and chlortetracycline mesylate were successfully synthesized and characterized with several techniques, including spectroscopy, chromatography and mass spectrometry, which demonstrated that the C4-dimethylamino group of chlortetracycline can accept a proton from sulfuric acid and methanesulfonic acid to form the corresponding salts. …”
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