Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences by Pål Møller, Aysel Ahadova, Matthias Kloor, Toni T. Seppälä, John Burn, Saskia Haupt, Finlay Macrae, Mev Dominguez-Valentin, Gabriela Möslein, Annika Lindblom, Lone sunde, Ingrid Winship, Gabriel Capella, Kevin Monahan, Daniel D. Buchanan, D. Gareth Evans, Eivind Hovig, Julian R. Sampson

“…In path_MLH1 and path_MSH2 carriers, a direct consequence of stochastic mutations may be the occurrence of invasive growth before tumour expansion, challenging the paradigm that an invasive cancer must always have an non-invasive precursor. In contrast to other path_ MMR carriers, path_PMS2 carriers who receive colonoscopic surveillance exhibit minimal increase in CRC incidence. …”
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Chemical structure–property relationships of photocurable monomers/macromers: Potential binder candidates for ceramic/metal vat photopolymerization by Setareh Zakeri, Antonia Ressler, Piie Konnunaho, Teemu Sandblom, Joshua Cunningham, Milla Rinne, Matti Järveläinen, Anastasia Elias, Erkka J. Frankberg, Erkki Levänen

“…Although resins with higher functionality (fave) generally showed higher Ec, this trend was not always consistent. Photo-DSC results showed that ethoxylated TMPTA slows down crosslinking polymerization in methacrylate-containing resins but accelerates it in acrylate formulations. …”
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Function mechanism of turbulent eddy and process intensification of particle-bubble collision in fine mineral flotation by Xiaoheng LI, Hainan WANG, Kaixin ZHENG, Lijun WANG, Xiaokang YAN, Haijun ZHANG, Jiongtian LIU

“…The separation of fine minerals has always been a difficult problem in the mineral industry, and flotation is the main method for separating fine-grained minerals. …”
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Method for assessing the theoretical characteristics of small axial hydraulic turbines by D. V. Mylkin, A. V. Volkov, B. M. Orakhelashvili, A. A. Druzhinin, V. Yu. Lyapin

“…Construction of transmission lines to provide electricity to such areas is expensive and not always possible. One of the promising areas in this area is local energy generation based on local resources, in particular small watercourses, using small hydroelectric power plants. …”
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Texture evolution and anisotropy of TA18 titanium alloy strip under rolling and heat treatment conditions by Bobo Li, Jiangkun Fan, Wenyuan Zhang, Jiaxing Zhao, Ding Zhao, Huifa Tao, Xiaobo Hao, Fei Wang, Peng Jiang, Hongchao Kou, Jinshan Li

“…Texture and anisotropy control of rolled strip have always been a technical problem in titanium alloy industry, especially for near-alpha titanium alloys. …”
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Duration of External Neck Stabilisation (DENS) following odontoid fracture in older or frail adults: protocol for a randomised controlled trial of collar versus no collar by John Norrie, Julie Woodfield, David J Lowe, Paul M Brennan, Catriona Keerie, Julia Lawton, Matthew J Reed, Andrew Stoddart, Julia Boyd, Helen Eborall, Gina Cranswick, James Tomlinson, Polly L Black, Sadaquate Khan, Patrick Statham, Ellie Edlmann, Phillip Correia Copley, Angela Niven, Susan Deborah Shenkin

“…However, bony healing does not always occur in older adults, and bony healing is not associated with quality of life, functional, or pain outcomes. …”
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Evaluasi Tata Kelola Sumber Daya Teknologi Informasi Menggunakan Kerangka Kerja COBIT 5 Subdomain EDM04, APO07 dan DSS03 pada Perusahaan Jasa Pelabuhan PT. XYZ by Audi Kresna Fathurino, Yusi Tyroni Mursityo, Aditya Rachmadi

“…Aiding its operational activities, the Information Technology Department of PT XYZ faces several disturbances, including frequent reports of complaints related to IT services problems which require the teams to always be fast and responsive in fixing and anticipating problems. …”
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High-performance laser speckle contrast image vascular segmentation without delicate pseudo-label reliance by Shenglan Yao, Huiling Wu, Suzhong Fu, Shuting Ling, Kun Wang, Hongqin Yang, Yaqin He, Xiaolan Ma, Xiaofeng Ye, Xiaofei Wen, Qingliang Zhao

“…However, achieving high-quality vessel segmentation has always been a challenge due to the cost and complexity of label data acquisition and the irregular vascular morphology. …”
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Comparison of the mid-infrared spectra and prediction equations developed from morning and evening milk samples from twice-a-day milked dairy cows by M. Frizzarin, E. Hayes, A. Casa, D.P. Berry

“…The average (SD) difference between the morning and the evening spectrum absorbance values produced by the same cow within 24 h was 0.00097 (0.008), and it was always larger than 0.055 for the wavelengths between 2,920 cm−1 and 2,947 cm−1. …”
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Regulatory signatures involved in the cell cycle pathway contribute to egg production heterosis in chicken by Jingwei Yuan, Yuanmei Wang, Yanyan Sun, Yunlei Li, Aixin Ni, Qin Li, Hanhan Yang, Xinying Xu, Yunhe Zong, Hui Ma, Jilan Chen

“…The molecular mechanism underlying heterosis for egg production is always intriguing in chicken. The transcriptional dynamic changes play a crucial role in the formation of heterosis, but little is known for the egg production traits. …”
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Deltopectoral approach without subscapularis detachment for reverse shoulder arthroplasty. Technique and results of a safe and reproducible subscapularis-sparing approach by Adrien Jacquot, MD, MSc, Thomas Cuinet, MD, Lisa Peduzzi, MD, Patrice Wong, MD, Marc-Olivier Gauci, MD, PhD, Julien Uhring, MD

“…In a deltopectoral approach, a detachment of the subscapularis is performed (tenotomy, tuberosity peeling, or osteotomy), but the tendon is not always repairable at the end. When it is repaired, healing is obtained in only 40%-76% of the cases, with potential consequences for the outcomes. …”
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Gravitational wave luminosity distance for Starobinsky gravity in viscous cosmological models by Jia-nan Chi, Ya-Bo Wu, Yu Sang, Xue Zhang, Yi-liang Hu, Wen-zhong Liu, Bo-hai Chen

“…We observe that, in the range of $$0< z\le 8.2$$ 0 < z ≤ 8.2 , the evolutionary curves of $$\delta (z)$$ δ ( z ) and $$d_L^{GW}(z)/d_L^{EM}(z)$$ d L GW ( z ) / d L EM ( z ) exhibit that $$\delta (z)$$ δ ( z ) ( $$d_L^{GW}(z)/d_L^{EM}(z)$$ d L GW ( z ) / d L EM ( z ) ) monotonically decrease (increase) as redshift rises, moreover there are always $$\delta (z)<0$$ δ ( z ) < 0 and $$d_L^{GW}(z)\ge d_L^{EM}(z)$$ d L GW ( z ) ≥ d L EM ( z ) , specially $$d_L^{GW}(0)=d_L^{EM}(0)$$ d L GW ( 0 ) = d L EM ( 0 ) in the limit of $$z\rightarrow 0$$ z → 0 , which means that detecting GW signals might represent a more efficient tool than detecting EM signals to test modified gravity model on the given scale of cosmic distances. …”
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The Metempiricism of Margins: Professor Anthony Aṣiwaju and the Circumference of Knowledge by Toyin Falola

“…His Excellency, Ambassador Yai, made the remark that the Yoruba had always been diasporic, moving like a river, connecting multiple points, passing through valleys and plateaus, between mountains, across vegetation. …”
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Mechanical response characteristics and damage mechanism of water-containing mudstone under low strain rate dynamic loading by Guichen LI, Sen YANG, Yuantian SUN, Jinghua LI, Haoran HAO, Zeyu SHAO

“…Higher dynamic loading rates and strength tests show a high correlation between loading strain and plastic strain during disturbance, and the plastic strain is always greater than the elastic strain. ④ The percentage of shear damage in the whole loading process of mudstone increases with the increase of water content, in which the dynamic loading stage increases significantly from 6.94% in dry to 33.95% in saturated, and the macroscopic shear damage characteristics are gradually obvious. ⑤ Dissolution and subduction of water in saturated mudstone, fracture of cementation under higher-rate dynamic loading, and wide-scale displacement of particle cementation under higher-intensity dynamic loading are the fundamental causes of the deterioration of mudstone mechanical properties. ⑥ A mudstone damage model considering lateral stress and cyclic dynamic loading was constructed and verified using the stress-strain relationship between loading and unloading during the cyclic dynamic loading stage of specimens with different water contents, and the model parameter F0 has a more significant effect on the strength of mudstone specimens compared with the parameter m. …”
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Principles, barriers and enablers to agroecological animal production systems: a qualitative approach based on five case studies by B. Dumont, C. Barlagne, P. Cassart, J.E. Duval, A. Fanchone, J-L. Gourdine, O. Huguenin-Elie, Y. Kazakova, J. Klötzli, A. Lüscher, E. Oteros-Rozas, D. Pomies, M.G. Rivera Ferre, W.A.H. Rossing, V. Stefanova, A. Swartebroeckx, C. Zagaria

“…All case studies were very advanced in the social dimensions of agroecology, and cooperation networks were always reported among the enablers for scaling out. …”
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Additifs alimentaires : Inventaire des substances ajoutées aux denrées alimentaires de large consommation dans l’Ouest algérien by Zakaria Lotfi Guaouar, Fatima Zahra Besseguir, Mira Gharbi, Imane Kecir

“…Some additives such as caramel dye or SIN150d are found in 3 local cookie brands and 4 local beverage brands (17.5%); sodium benzoate or SIN211 in 12 beverage brands and 2 jam brands (16.09%); butylhydroxyanisol (BHA) or SIN320 in a brand of chocolate, margarine and chips (1.67%).Overall, the labels of the products comply with the Algerian regulations with the exception of some shortcomings such as the nature of the aroma that was not always specified. Conclusion- The study found significant use of food additives. …”
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PENERAPAN PROJECT BASED LEARNING MODEL UNTUK MENINGKATKAN SIKAP ILMIAH MAHASISWA DALAM RANGKA MENGHADAPI ERA MERDEKA BELAJAR by Andik Purwanto, Desy Hanisa Putri, Dedy Hamdani

“…The scientific attitude is always influenced by many factors, one of the factors that influence is the selection of a learning model. …”
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Additifs alimentaires : Inventaire des substances ajoutées aux denrées alimentaires de large consommation dans l’Ouest algérien by Zakaria Lotfi Guaouar, Fatima Zahra Besseguir, Mira Gharbi, Imane Kecir

“…Some additives such as caramel dye or SIN150d are found in 3 local cookie brands and 4 local beverage brands (17.5%); sodium benzoate or SIN211 in 12 beverage brands and 2 jam brands (16.09%); butylhydroxyanisol (BHA) or SIN320 in a brand of chocolate, margarine and chips (1.67%).Overall, the labels of the products comply with the Algerian regulations with the exception of some shortcomings such as the nature of the aroma that was not always specified. Conclusion- The study found significant use of food additives. …”
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Assessment of public literacy in TB prevention and control in the National 13th Five-Year plan for Tuberculosis Prevention and Control (2016–2020) in China by Shuaihu Ni, Gang Chen, Jia Wang, Yuhong Li, Hui Zhang, Yan Qu, Yanlin Zhao, Xiaofeng Luo

“…Abstract Background China has always been a country with a high burden of tuberculosis. …”
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Review of gridded climate products and their use in hydrological analyses reveals overlaps, gaps, and the need for a more objective approach to selecting model forcing datasets by K. R. Mankin, S. Mehan, T. R. Green, D. M. Barnard, D. M. Barnard

“…</p></li><li> <p id="d2e168">G datasets were generally more accurate in representing precipitation and temperature data than S or R datasets, although this did not always translate into better streamflow modeling.</p></li></ol><p> We conclude that hydrologic analyses would benefit from guided dataset selection by investigators, including justification for selecting a specific dataset, and improved gridded datasets that retain dependencies among climate variables and better represent small-scale spatial variability in climate variables in complex topography. …”
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