Multi-locus CRISPRi targeting with a single truncated guide RNA by Molly M. Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J. Cruz, Yanjing V. Liu, Nauman Javed, Salvador Casaní-Galdón, Jason D. Buenrostro, Charles B. Epstein, Eugenio Mattei, John G. Doench, Bradley E. Bernstein, Noam Shoresh, Fadi J. Najm

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Unsupervised deep learning of electrocardiograms enables scalable human disease profiling by Sam F. Friedman, Shaan Khurshid, Rachael A. Venn, Xin Wang, Nate Diamant, Paolo Di Achille, Lu-Chen Weng, Seung Hoan Choi, Christopher Reeder, James P. Pirruccello, Pulkit Singh, Emily S. Lau, Anthony Philippakis, Christopher D. Anderson, Mahnaz Maddah, Puneet Batra, Patrick T. Ellinor, Jennifer E. Ho, Steven A. Lubitz

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Rational engineering of minimally immunogenic nucleases for gene therapy by Rumya Raghavan, Mirco J. Friedrich, Indigo King, Samuel Chau-Duy-Tam Vo, Daniel Strebinger, Blake Lash, Michael Kilian, Michael Platten, Rhiannon K. Macrae, Yifan Song, Lucas Nivon, Feng Zhang

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Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution by Brianna R. Watson, Biplab Paul, Raza Ur Rahman, Liat Amir-Zilberstein, Åsa Segerstolpe, Eliana T. Epstein, Shane Murphy, Ludwig Geistlinger, Tyrone Lee, Angela Shih, Jacques Deguine, Ramnik J. Xavier, Jeffrey R. Moffitt, Alan C. Mullen

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High-throughput Identification of Phage-derived Imaging Agents by Kimberly A. Kelly, Paul A. Clemons, Amy M. Yu, Ralph Weissleder

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Response of the gut microbiome and metabolome to dietary fiber in healthy dogs by Amrisha Bhosle, Matthew I. Jackson, Aaron M. Walsh, Eric A. Franzosa, Dayakar V. Badri, Curtis Huttenhower

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A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer by Veronica Rendo, Michael Schubert, Nicholas Khuu, Maria F. Suarez Peredo Rodriguez, Declan Whyte, Xiao Ling, Anouk van den Brink, Kaimeng Huang, Michelle Swift, Yizhou He, Johanna Zerbib, Ross Smith, Jonne Raaijmakers, Pratiti Bandopadhayay, Lillian M. Guenther, Justin H. Hwang, Amanda Iniguez, Susan Moody, Ji-Heui Seo, Elizabeth H. Stover, Levi Garraway, William C. Hahn, Kimberly Stegmaier, René H. Medema, Dipanjan Chowdhury, Maria Colomé-Tatché, Uri Ben-David, Rameen Beroukhim, Floris Foijer

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A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment by Bokai Zhu, Yunhao Bai, Yao Yu Yeo, Xiaowei Lu, Xavier Rovira-Clavé, Han Chen, Jason Yeung, Dingani Nkosi, Jonathan Glickman, Antonio Delgado-Gonzalez, Georg K. Gerber, Mike Angelo, Alex K. Shalek, Garry P. Nolan, Sizun Jiang

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Evaluation of imputation performance of multiple reference panels in a Pakistani population by Jiayi Xu, Dongjing Liu, Arsalan Hassan, Giulio Genovese, Alanna C. Cote, Brian Fennessy, Esther Cheng, Alexander W. Charney, James A. Knowles, Muhammad Ayub, Roseann E. Peterson, Tim B. Bigdeli, Laura M. Huckins

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Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life by Sebastiano Montante, Rym Ben-Othman, Nelly Amenyogbe, Asimenia Angelidou, Anita van den Biggelaar, Bing Cai, Yixuan Chen, Alansana Darboe, Joann Diray-Arce, Rebecca Ford, Olubukola Idoko, Amy Lee, Mandy Lo, Kerry McEnaney, Mehrnoush Malek, David Martino, Geraldine Masiria, Oludare A. Odumade, William Pomat, Casey Shannon, Kinga Smolen, The EPIC Consortium, Al Ozonoff, Peter Richmond, Scott Tebbutt, Ofer Levy, Beate Kampmann, Ryan Brinkman, Tobias Kollmann

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Editorial: Current insights in Epigenetics and Epigenomics by Steven Henikoff, Steven Henikoff, Sharon Y. R. Dent, Sharon Y. R. Dent, Raul Mostoslavsky, Raul Mostoslavsky, Ting Wang, Luca Comai

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scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria by Collins M. Morang’a, Riley S. Drake, Riley S. Drake, Riley S. Drake, Riley S. Drake, Vincent N. Miao, Vincent N. Miao, Vincent N. Miao, Vincent N. Miao, Nancy K. Nyakoe, Dominic S. Y. Amuzu, Vincent Appiah, Yaw Aniweh, Yaw Bediako, Saikou Y. Bah, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Gordon A. Awandare, Thomas D. Otto, Lucas Amenga-Etego

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Acetaminophen Use in Pregnancy: A Comparison of Self-Reported Intake with Maternal and Newborn Biomarker Measures by Guo P, Johnson CH, Yan H, Xiao J, Dennis C, Pierce KA, DeWan AT, Liew Z

“…Pengfei Guo,1,2 Caroline H Johnson,1,2 Hong Yan,1– 3 Jingyuan Xiao,1,2 Courtney Dennis,4 Kerry A Pierce,4 Andrew T DeWan,2,5 Zeyan Liew1,2 1Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA; 2Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, New Haven, CT, USA; 3State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong, People’s Republic of China; 4Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA; 5Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USACorrespondence: Zeyan Liew, Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven, CT, 06510, USA, Tel +1 203-764-9727, Email zeyan.liew@yale.edu…”
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Relationships between the menstrual cycle and neuropsychiatric and physical symptoms in females with Tourette syndrome by Daisy T. Noriega-Makarskyy, Evan Realbuto, Ariadne Kaylor, Lisa Osiecki, Angela Essa, Dongmei Yu, Dongmei Yu, Cornelia Illmann, Carol A. Mathews, Carol A. Mathews, Carol A. Mathews, Jeremiah M. Scharf, Jeremiah M. Scharf, Jeremiah M. Scharf, Jeremiah M. Scharf, Jeremiah M. Scharf

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Genome-wide association analysis of composite sleep health scores in 413,904 individuals by Matthew O. Goodman, Tariq Faquih, Valentina Paz, Pavithra Nagarajan, Jacqueline M. Lane, Brian Spitzer, Matthew Maher, Joon Chung, Brian E. Cade, Shaun M. Purcell, Xiaofeng Zhu, Raymond Noordam, Andrew J. K. Phillips, Simon D. Kyle, Kai Spiegelhalder, Michael N. Weedon, Deborah A. Lawlor, Jerome I. Rotter, Kent D. Taylor, Carmen R. Isasi, Tamar Sofer, Hassan S. Dashti, Martin K. Rutter, Susan Redline, Richa Saxena, Heming Wang

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Deeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial by Omar Nadeem, Michelle P. Aranha, Robert Redd, Michael Timonian, Sophie Magidson, Elizabeth D. Lightbody, Jean-Baptiste Alberge, Luca Bertamini, Ankit K. Dutta, Habib El-Khoury, Mark Bustoros, Jacob P. Laubach, Giada Bianchi, Elizabeth O’Donnell, Ting Wu, Junko Tsuji, Kenneth C. Anderson, Gad Getz, Lorenzo Trippa, Paul G. Richardson, Romanos Sklavenitis-Pistofidis, Irene M. Ghobrial

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Deep learning to decode sites of RNA translation in normal and cancerous tissues by Jim Clauwaert, Zahra McVey, Ramneek Gupta, Ian Yannuzzi, Venkatesha Basrur, Alexey I. Nesvizhskii, Gerben Menschaert, John R. Prensner

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Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans by Hugues Allard-Chamard, Kirsty Hillier, Michelle L. Ramseier, Alice Bertocchi, Naoki Kaneko, Katherine Premo, Grace Yuen, Marshall Karpel, Vinay S. Mahajan, Christina Tsekeri, Joseph S. Hong, Jean Vencic, Rory Crotty, Anish V. Sharda, Sara Barmettler, Emma Westermann-Clark, Jolan E. Walter, Musie Ghebremichael, Alex K. Shalek, Jocelyn R. Farmer, Shiv Pillai

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Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan by Chi-Neu Tsai, Yu-Chung Chang, Hsun-Ching Chao, Yi-Hsiang Hsu, Yuan-Hung Wang, Shih-Yen Chen

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Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues by Robel Alemu, Nigussie T. Sharew, Yodit Y. Arsano, Muktar Ahmed, Fasil Tekola-Ayele, Tesfaye B. Mersha, Azmeraw T. Amare

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