Antibiotic-induced changes in the human gut microbiota for the most commonly prescribed antibiotics in primary care in the UK: a systematic review by Alastair D Hay, Alyson L Huntley, Karen T Elvers, Esther T van der Werf, Victoria J Wilson, Ashley Hammond, Lorna Duncan

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Developing a core outcome set for assessing interventions and care for parents after neonatal death in high-income countries (iCHOOSE Neonatal study): protocol for a mixed-methods... by James Webbe, Mehali Patel, Danya Bakhbakhi, Christy Burden, Mary Lynch, Laura Timlin, Lisa Hinton, Abigail Fraser, Anna Davies, Maggie Redshaw, David Odd, Charlotte Williams, Dimitris Siasakos, Abi Merriel, Sadie Mullin, Lucy Moy, Leanne Watts

“…A parent involvement group and stakeholder steering committee have been established and have informed each planned phase: (1) systematic review of quantitative studies evaluating care and interventions provided after neonatal death, to describe interventions, outcomes and outcome measurement tools used to assess intervention effectiveness; (2) qualitative interviews with parents who have experienced neonatal death to identify outcomes important and relevant to them; (3) think-aloud interviews with stakeholders (bereaved parents, healthcare professionals and other stakeholders) to develop and refine an online survey; (4) real-time online international Delphi survey with bereaved parents, healthcare professionals and other stakeholders to shortlist outcomes for consideration in the COS; (5) adapted nominal group online consensus meetings with parents, healthcare professionals and other stakeholders to agree final COS and (6) identification of a preliminary set of measurement tools.Ethics and dissemination Ethical approval has been granted for all activities to be undertaken by the University of Bristol Health Sciences Faculty Research Ethics Committee (reference: 15121). …”
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Corrigendum to “HDR Brachytherapy in the Management of High-Risk Prostate Cancer” by Susan Masson, Raj Persad, Amit Bahl

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Micro silica bead scintillators for the relative dosimetry of a stereotactic radiosurgery unit by Chris J. Stepanek, Jack D. Aylward, Ronald Hartley-Davies, Lucy Winch

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Exploring how PRIME-Parkinson care is implemented and whether, how and why it produces change, for who and under what conditions: a protocol for an embedded process evaluation with... by Yoav Ben-Shlomo, Sabi Redwood, Judi Kidger, Emma Tenison, Heather Brant, Emily J Henderson, Fiona Lithander, Katherine Lloyd, Safi Smith

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Impact of glucocorticoids on patients’ quality of life: a qualitative study assessing face validity and feasibility of the Steroid PRO in patients with inflammatory gastroenterolog... by Shaney L Barratt, Emma Dures, Mwidimi Ndosi, Michelle Sharp, Sebastian E Sattui, Jill Dawson, Susan M Goodman, Sarah L Mackie, Tom Creed, Catherine L Hill, Joanna C Robson, Pamela Richards, Susan Bridgewater, Christine A Silverthorne, Jen Orme, Anne-Marie T Sweeney, Elizabeth Arthurs, Genevieve Osborne, Giles Dunhill, Richard P Ramonell, Timothy Patton

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Strategies adopted by men to deal with uncertainty and anxiety when following an active surveillance/monitoring protocol for localised prostate cancer and implications for care: a... by Chris Metcalfe, Jenny Donovan, Julia Wade, Vincent J Gnanapragasam, Michael Davis, David Neal, Richard Martin, Athene Lane, Edward Rowe, Freddie Hamdy, James Catto, Emma Turner, David Gillatt, Eleanor Walsh, Derek Rosario, Tim Peters, Roger Kockelbergh, Alan Paul, Peter Holding, Howard Kynaston, Owen Hughes, Prasad Bollina, Alan Doherty, Edgar Paez

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Associations between autistic traits and early ear and upper respiratory signs: a prospective observational study of the Avon Longitudinal Study of Parents and Children (ALSPAC) ge... by Amanda Hall, Dheeraj Rai, Jean Golding, Yasmin Iles-Caven, Steven Gregory, Richard Maw

“…Objective To determine whether early ear and upper respiratory signs are associated with the development of high levels of autistic traits or diagnosed autism.Design Longitudinal birth cohort: Avon Longitudinal Study of Parents and Children (ALSPAC).Setting Area centred on the city of Bristol in Southwest England. Eligible pregnant women resident in the area with expected date of delivery between April 1991 and December 1992 inclusive.Participants 10 000+ young children followed throughout their first 4 years. …”
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Improved Delay-and-Sum Beamforming Algorithm for Breast Cancer Detection by M. Klemm, I. J. Craddock, J. A. Leendertz, A. Preece, R. Benjamin

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In silico modelling of organ-on-a-chip devices: an overview by Yue Wang, Lucia Marucci, Lucia Marucci, Lucia Marucci, Martin E. Homer

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Development and validation of the Multimorbidity Treatment Burden Questionnaire (MTBQ) by Daisy Gaunt, Chris Salisbury, Mei-See Man, Katherine Chaplin, Polly Duncan, Mairead Murphy

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The impact of routines on emotional and behavioural difficulties in children and on parental anxiety during COVID-19 by Vera Lees, Rosie Hay, Helen Bould, Helen Bould, Helen Bould, Alex S. F. Kwong, Daniel Major-Smith, Daniel Major-Smith, Daphne Kounali, Rebecca M. Pearson, Rebecca M. Pearson

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Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decorticati... by Liz Darlison, John Edwards, Apostolos Nakas, Nick A Maskell, Wendy Underwood, Chris Rogers, Matthew Callister, David Waller, Richard Milton, Victoria Ashford-Turner, Paul Taylor, Claire Matthews, Victoria Hughes, Kelvin Lau, Alan Kirk, Robert C Rintoul, Elizabeth A Stokes, Kate Ashton, Daisy Elliott, Rosie Harris, Marie Kirwan, Juliette Novasio, Sara Waplington, Eric Lim, Holly Mckeon, Charlotte Jacobs, Laura White, Mary O’Brien, Judith Moore, Louise Li, Nicola Mills, Sanjay Popat, Suzanne Miller, Nadia Yousaf, D A Fennell, Clinton Ali, Andrea Bille, Liz Fuller, Andreea Ionescu, Manjusha Keni, Pek Koh, Talal Mansy, Dakshinamoorthy Muthukumar, Tony Pope, Amy Roy, Riyaz Shah, Jonathan Shamash, Zacharias Tasigiannopoulos, Sarah Treece, Katherine Joyce, Barbara Warnes, Athanasia Gravani, Rachel Brophy, Nicola Farrar, Jane Elliott, Philip Noyes, Louise Nelson, Sara Tenconi, Laura Socci, Hilary Wood, Helena Hanratty, Helena Stanley, Robert Rintoul, Amy Gladwell, Jenny Castedo, Amanda Stone, Charlotte Ingle, Hayley Hewer, Eleanor Aynsley, Andrea Watson, Alison Hassall, Masuma Begum, Christopher Worth, Ellie Piggott, Elizabeth Nadin, Yvonne Summers, Raffaele Califano, Laura Cove-Smith, Matt Evison, Maria Blinston, Amal Ismail, Rachel Chant, Asmita Desai, Ian Morgan, Victoria Lake, Nichola Harris, Simon Hodge, Nadza Tokaca, Adam Januszewski, Avani Athauda, Anisha Ramessur, Emily Grist, Niamh Colman, Michael Flynn, Joan Joyce, Sarah Vaughan, Maria Piga, Derya Sahin, Agnieszka Yongue, Emma Turay, Jaishree Bhosle, Rajiv Kumar, Charlotte Milner-Watts, Jessica Brown, David Walder, Alexandros Georgiou, Xiaorong Wu, Naila Kaudeer, Kroopa Joshi, Michael Davidson, Shelize Khakoo, Bee Ayite, Kathryn Priest, James Dobbyn, Vasanthi Prathapan, Deborah McCrimmon, Natalie Ash, Alison Norton, Bianca Peet, Libby Hennessy, Rosemary Johnson

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Operationalizing goal setting as an outcome measure in trials involving patients with frailty, multimorbidity or complexity by Emma Tenison, Katherine Lloyd, Yoav Ben-Shlomo, Emily J. Henderson

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Brief intervention to reduce fatigue impact in patients with inflammatory arthritis: design and outcomes of a single-arm feasibility study by Paul Ewings, Emma Dures, Sarah Hewlett, Joanna Thorn, Mwidimi Ndosi, Siobhan Creanor, Jo Adams, Lance M McCracken, Joe Lomax, Susan Bridgewater, Bryan Abbott, Alice Berry, Marie Urban

“…The Fatigue - Reducing its Effects through individualised support Episodes in Inflammatory Arthritis (FREE-IA) study tested the feasibility of RHP training, intervention delivery and outcome collection ahead of a potential trial of clinical and cost-effectiveness.Methods In this single-arm feasibility study, eligible patients were ≥18 years, had a clinician-confirmed diagnosis of an inflammatory arthritis and scored ≥6/10 on the Bristol Rheumatoid Arthritis Fatigue (BRAF) Numerical Rating Scale (NRS) Fatigue Effect. …”
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Feasibility of engaging parents attending an adult weight management programme with child weight management support: a mixed methods study by Russell Jago, Julian PH Shield, Aidan Searle, Ruth Mears, Deborah Sharp

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Maternal and paternal depressive symptoms and parental vocalisation behaviours in infancy: findings from UK-based birth cohort by Amy Campbell, Amy Campbell, Amy Campbell, Amy Campbell, Gemma Lewis, Ilaria Costantini, Miguel Cordero, Andy Skinner, Esther Dermott, Tina Miller, Mari-Rose Kennedy, Iryna Culpin, Iryna Culpin

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Piloting creative engagement strategies to explore themes of parenthood with fathers by Iryna Culpin, Iryna Culpin, Catherine Lamont-Robinson, Mark Billington, Matthew James, James Prewett, Gareth Ward, Mireia Bes Garcia, Giovanni Biglino, Giovanni Biglino

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FathomDEM: an improved global terrain map using a hybrid vision transformer model by Peter Uhe, Chris Lucas, Laurence Hawker, Malcolm Brine, Hamish Wilkinson, Anthony Cooper, Alex A Saoulis, James Savage, Christopher Sampson

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Autotuning of Isotropic Hardening Constitutive Models on Real Steel Buckling Data with Finite Element Based Multistart Global Optimisation on Parallel Computers by Anton Shterenlikht, Mohammad M. Kashani, Nicholas A. Alexander, Gethin Williams, Adam J. Crewe

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