Fluorescent, Plasmonic, and Radiotherapeutic Properties of the Lu–Dendrimer-AuNP–Folate–Bombesin Nanoprobe Located Inside Cancer Cells by Héctor Mendoza-Nava PhD, Guillermina Ferro-Flores PhD, Flor de María Ramírez PhD, Blanca Ocampo-García PhD, Clara Santos-Cuevas PhD, Erika Azorín-Vega PhD, Nallely Jiménez-Mancilla PhD, Myrna Luna-Gutiérrez PhD, Keila Isaac-Olivé PhD

“…The aim of this research was to evaluate the fluorescent properties and the plasmonic–photothermal, therapeutic, and radiotherapeutic potential of 177 Lu–dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity ( 177 Lu–DenAuNP–folate–bombesin) when it is internalized in T47D breast cancer cells. The intense near-Infrared (NIR) fluorescence emitted at 825 nm from the conjugate inside cells corroborated the usefulness of DenAuNP–folate–bombesin for optical imaging. …”
Get full text

Skin and Soft Tissue Infections in Patients with Solid Tumours by Diamantis P. Kofteridis, Antonios Valachis, Eirini Koutsounaki, Sofia Maraki, Eleni Mavrogeni, Foteini N. Economidou, Dimitra Dimopoulou, Kostas Kalbakis, Vassilis Georgoulias, George Samonis

“…The most common underlying malignancy was breast cancer in 17 patients (24%). Most episodes (89%) occurred in nonneutropenics. …”
Get full text

New parameterized quantum gates design and efficient gradient solving based on variational quantum classification algorithm by Xiaodong Ding, FuDong Liu, Weilong Wang, Yu Zhu, Yifan Hou, Yizhen Huang, Jinchen Xu, Zheng Shan

“…Experimental validation on benchmark datasets such as breast cancer and iris shows that the method proposed in this paper exhibits excellent performance on quantum classification tasks. …”
Get full text

Lung Cancer with Skin and Breast Metastasis: A Case Report and Literature Review by Bikash Bhattarai, Marie Frances Schmidt, Meenakshi Ghosh, Abhisekh Sinha Ray, Saveena Manhas, Vikram Oke, Chidozie Charles Agu, Md. Rawshan Basunia, Danilo Enriquez, Joseph Quist, Catherine Bianchi, Ravi Hans, Saroj Kandel

“…A 48-year-old African American male with a past medical history of poorly differentiated left breast cancer status after modified radical mastectomy (MRM), chronic obstructive pulmonary disease, and smoking (20 pack-years) presents to the ER with progressive shortness of breath on exertion, upper back pain, and weight loss for 2 months in duration. …”
Get full text

Identifying Complex Scheduling Patterns Among Patients With Cancer With Transportation and Housing Needs: Feasibility Pilot Study by Allan Fong, Christian Boxley, Laura Schubel, Christopher Gallagher, Katarina AuBuchon, Hannah Arem

“…We apply the scheduling complexity algorithm to scheduling data from 38 patients with breast cancer enrolled in a 6-month comorbidity management intervention at an urban hospital in the Washington, DC area that serves low-income patients. …”
Get full text

The p85 Regulatory Subunit of PI3K Mediates cAMP-PKA and Insulin Biological Effects on MCF-7 Cell Growth and Motility by E. Di Zazzo, A. Feola, C. Zuchegna, A. Romano, C. F. Donini, S. Bartollino, C. Costagliola, R. Frunzio, P. Laccetti, M. Di Domenico, A. Porcellini

“…This study highlights the p85αPI3KS83 role as a key regulator of cell proliferation and motility induced by insulin in MCF-7 cells breast cancer model.…”
Get full text

Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1 by Naeme Javid, Shahriyar Abdoli, Majid Shahbazi, Majid Shahbazi

“…Subsequently, the expression of hub genes was verified by real-time polymerase chain reaction (qRT-PCR) in MDA-MB-231 (a breast cancer cell line) infected with oHSV-1 and non-infected cells.ResultsThe results of our data analysis indicated notable disparities in the genes associated with the proteasome pathway between infected and non-infected cells. …”
Get full text

DCUN1D5 is a prognostic biomarker and correlated immune infiltrates and glycolysis in lung adenocarcinoma by Song Zhao, Xiaoli Han, Jingtao Huang, Jingxiong Zheng, Baoshan Zhao, Zongying Liang

“…Abstract DCUN1D5 is up-regulated and promotes tumor progression in many cancers such as laryngeal squamous cell carcinoma and breast cancer, but the expression of DCUN1D5 in lung adenocarcinoma and its molecular mechanism are not clear. …”
Get full text

Effect of Propolis on PPP2R1A and Apoptosis in Cancer Cells by Burak Durmaz, Latife Merve Oktay Çelebi, Ayşe Çekin, Ayshan Ahadova, Nur Selvi Günel, Hatice Kalkan Yıldırım, Ali Mert Özgönül, Eser Yıldırım Sözmen

“…In this study, we investigated the effect of propolis on PPP2R1A expression and its relationship with apoptosis in the SW-620 (colorectal cancer), DU-145 and PC-3 (prostate cancer), and MCF-7 (breast cancer) cell lines, with WI-38 (healthy fibroblast) cells serving as the control. …”
Get full text

Patients’ and plastic surgeons’ experiences with an online patient decision aid for breast reconstruction: considerations for nationwide implementation by Jacqueline A. ter Stege, Ellen G. Engelhardt, Leonie A.E. Woerdeman, Hester S.A. Oldenburg, Jacobien M. Kieffer, Daniela E.E. Hahn, Frederieke H. van Duijnhoven, Martine A. van Huizum, Regina The, Klemens Karssen, Marianne Kuenen, Miranda A. Gerritsma, Quinten (PQ) Ruhe, Irene S. Krabbe-Timmerman, Martijne van’t Riet, Nikola (AN) Kimmings, Eveline M.L. Corten, Kerry A. Sherman, Arjen J. Witkamp, Eveline M.A. Bleiker

“…Abstract Background Women diagnosed with breast cancer undergoing a mastectomy often have the option to undergo breast reconstruction (BR). …”
Get full text

Factors Associated With the Recovery of Left Ventricular Ejection Fraction in Patients With Anthracycline-Induced Left Ventricular Dysfunction by Tyler Shugg PharmD, PhD, Tk Nguyen PharmD, Xuesi Hua BS, Blair Richards MPH, James Rae PhD, Robert Dess MD, Daniel Perry MD, Bradley Kay MD, Salim S. Hayek MD, Monika Leja MD, Jasmine A. Luzum PharmD, PhD

“…Results Out of 104 patients, 83% were female, 86% self-reported white race, 53% had breast cancer, median (IQR) age was 52 (22) years, and LVEF recovery was 14% (16%). …”
Get full text

Targeting murine metastatic cancers with cholera toxin A1-adjuvanted peptide vaccines by Sanchari Paul, Mustafa Kaya, Olivia Johnsson, Hanna Grauers Wiktorin, Andreas Törnell, Mohammad Arabpour, Kristoffer Hellstrand, Anna Martner

“…We report that an adjuvant where CTA1 was fused to a dimer from Staphylococcus aureus protein A (DD) enhanced immune responses against the tumor-associated antigens TRP2 and Twist1 in mice, providing protection against B16F1 melanoma and 4T1 breast cancer metastasis, respectively. Both mucosal (intranasal) and systemic (intraperitoneal) vaccine administration provided effective protection against intravenously injected tumor cells, with intranasal administration leading to superior induction of CD4+ T cells at metastatic sites. …”
Get full text

Syntheses, structures and anticancer activities of CuII and ZnII complexes containing 1,1′-[(3-fluorophenyl)methylene]bis[3-(3-fluorophenyl)imidazo[1,5-a]pyridine] by Hai Le Thi Hong, Hau Nguyen Van, Duong Hoang Tuan, Hung Tran Quang, Tuan Dang Thanh, Luc Van Meervelt

“…Notably, the CuII complex displays excellent inhibitory activity against the MCF7 breast cancer cell line (IC50 = 27.99 µM), approximately twice as effective as cisplatin. …”
Get full text

An intraoperative nomogram for predicting secondary margin positivity in breast conserving surgery utilizing frozen section analysis by Cheng Li, Yan Jiang, Xumiao Wu, Yong Luo, Qi Li

“…BackgroundBreast conserving surgery (BCS) is a standard treatment for breast cancer. Intraoperative frozen section analysis (FSA) is widely used for margin assessment in BCS. …”
Get full text

MammaPrint Feasibility in a Large Tertiary Urban Medical Center: An Initial Experience by C. Francisco Espinel, Shaughn Keating, Hanina Hibshoosh, Bret Taback, Kathie-Ann Joseph, Mahmoud El-Tamer, Sheldon Feldman

“…The MammaPrint (MP) diagnostic assay stratifies breast cancer patients into high- and low-risk groups using mRNA analysis of a 70-gene profile. …”
Get full text

Primary epidemiological evaluation of the effectiveness of the All-National Dispensarization as a cancer screening by the data of the Arkhangelsk Regional Cancer Registry by L. E. Valkova, M. L. Levit, V. M. Merabishvili, A. Yu. Pankrateva, D. M. Dubovichenko, A. V. Agaeva, A. Yu. Ryzhov, E. F. Potekhina, M. Yu. Valkov

“…An increasing change of the trend of annual Stage I proportion was found in colorectal cancer since 2010, breast cancer since 2011, cervical cancer since 2013, prostate cancer since 2014, kidneys since 2006 with APC by 7.5%, 9, 6%, 9.6%, 40.3%, 13.4%, respectively.Conclusion. …”
Get full text

Cyclooxygenase-2/prostaglandin E2 inhibition remodulated photodynamic therapy-associated immunosuppression for enhanced cancer immunotherapy by Tao Xu, Kehan Liu, Shuqi Mi, Yao Yao, Mengyao Zhang, Shujuan Xue, Feng Zhi, Sally-Ann Cryan, Dawei Ding

“…To this end, biocompatible albumin nanoassemblies co-delivering IR780 and diclofenac are herein developed for enhanced therapy against triple-negative breast cancer. PDT-exacerbated PGE2 overexpression is effectively abolished by diclofenac-mediated COX-2 inhibition, which reprograms immunosuppressive TME via downregulating the infiltration of various immunosuppressive cells and their cytokine secretion to enhance effector T cell infiltration. …”
Get full text

Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10 by Ya-Hui Wang, Rong-Kun Li, Ying Fu, Jun Li, Xiao-Mei Yang, Yan-Li Zhang, Lei Zhu, Qin Yang, Jian-Ren Gu, Xin Xing, Zhi-Gang Zhang

“…Exemestane (EXE) is an irreversible steroidal aromatase inhibitor mainly used as an adjuvant endocrine therapy for postmenopausal women suffering from breast cancer. Besides inhibiting aromatase activity, EXE has multiple biological functions, such as antiproliferation, anti-inflammatory, and antioxidant activities which are all involved in hepatic fibrosis. …”
Get full text

Adenoid cystic carcinoma of the breast, from diagnosis to management: a case report by Mendoza-Urbano Diana Marcela, Cañon Diana, Palazuelos Gloria Ines, Torres Fabio, Wills Beatriz, Rodriguez-Urrego Paula Andrea

“…Despite being categorized as a type of triple-negative breast cancer, it generally has a favorable prognosis. …”
Get full text

Desmoid-type fibromatosis of the breast: a case report and literature review by Zijun Zhao, Qingyao Shang, Chenxuan Yang, Jiaxiang Liu, Shanqing Liu, Xiaoqian Li, Xiyu Kang, Jiaxian Yue, Xin Wang, Xiang Wang

“…It has a high recurrence rate, although distal metastasis is uncommon. It resembles breast cancer clinically, and histological pathology is the only approach to a confirmed diagnosis. …”
Get full text