An integrative analysis reveals cancer risk associated with artificial sweeteners by Jumin Xie, Ying Zhu, Zixuan Yang, Zhang Yu, Mingzhi Yang, Qingzhi Wang

“…Conclusion This study integrated data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample analysis to demonstrate that AS increases the risk of kidney cancer, low-grade glioma, breast cancer, and prostate cancer through multiple targets and signaling pathways. …”
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A study of relationship between cardiac exposure dose-volume and cardiovascular autonomic dysfunction in radiotherapy by CHEN Hongyu, SU Pengyu, LUO Wenzi, PANG Dequan, WANG Feiran

“…Inclusion criteria: ① Patients who were pathologically confirmed to have malignant tumors (lung cancer breast cancer or esophageal cancer); ② patients with radiation therapy indications as recommended by the guidelines; ③ patients with an ECOG score of 0-1; ④ patients with no significant abnormalities in electrocardiogram and echocardiography results. …”
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A co-registration method to validate in vivo optical coherence tomography in the breast surgical cavity by Rowan W. Sanderson, Renate Zilkens, Peijun Gong, Imogen Boman, Ken Y. Foo, Skandha Shanthakumar, James Stephenson, Wei Ling Ooi, José Cid Fernandez, Synn Lynn Chin, Lee Jackson, Mireille Hardie, Benjamin F. Dessauvagie, Anmol Rijhumal, Saud Hamza, Christobel M. Saunders, Brendan F. Kennedy

“…Breast-conserving surgery accompanied by adjuvant radiotherapy is the standard of care for patients with early-stage breast cancer. However, re-excision is reported in 20–30 % of cases, largely because of close or involved tumor margins in the specimen. …”
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Dietary inflammatory index and its associations with cardiovascular diseases and cancer: Evidence form NHANES 2017–2018 and Mendelian randomization analysis by Xuehua Wang, Qian Xu, Wenhu Liu, Jingjie Xiong, Han Li, Ni Xiong, Yan Wang, Zhaohui Wang

“…The logistic regression analysis revealed a correlation between DII and CHF (OR = 1.197, p = 0.002), stroke (OR = 1.205, p < 0.001), as well as breast cancer (OR = 1.306, p = 0.004). The pro-inflammatory diet also resulted in lower hemoglobin levels (p < 0.001). …”
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Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment by Ananda Kishore Mukherjee, Subhajit Dutta, Ankita Singh, Shalu Sharma, Shuvra Shekhar Roy, Antara Sengupta, Megha Chatterjee, Soujanya Vinayagamurthy, Sulochana Bagri, Divya Khanna, Meenakshi Verma, Dristhi Soni, Anshul Budharaja, Sagar Kailasrao Bhisade, Vivek Anand, Ahmad Perwez, Nija George, Mohammed Faruq, Ishaan Gupta, Radhakrishnan Sabarinathan, Shantanu Chowdhury

“…Further, IL1R1 expression was telomere-sensitive in triple-negative breast cancer (TNBC) clinical samples. Infiltration of tumour-associated macrophages (TAM) was also sensitive to the length of tumour cell telomeres and highly correlated with IL1R1 expression. …”
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Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions by Yuanyuan Liu, Zerong Zhang, Xiaoyan Li, Qinghong Hu, Zhangyu Jiang, Jia Lv, Jiayi Xue, Dongyu Wang, Jianxiong Cao, Lingyu Li, Xiaowen Ou, Lijun Zhu, Zhongqiu Liu, Tao Su

“…The efflux transporters, breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 2 (MRP2) are critical regulatory molecules within the enterohepatic triple recycling pathways. …”
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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer by Peter Jung, Stefan P. Glaser, Jing Han, Alexandra Popa, Laura Pisarsky, Ningping Feng, Antonia Geyer, Franziska Haderk, Donat Alpar, Christopher Bristow, Susanne Schmittner, Paula-Elena Traexler, Mikhila Mahendra, Birgit Poehn, Poojabahen Gandhi, Roberto Fiorelli, Sanket Awate, Nicole Budano, Florian Martin, Christoph Albrecht, Barbara Drobits-Handl, Sathanandam S. Anand, Srinath Kasturirangan, Francesca Trapani, Norbert Schweifer, Joseph R. Marszalek, Ulrike Tontsch-Grunt, Mark Pearson, Timothy P. Heffernan, Norbert Kraut, Christopher P. Vellano, Juan Manuel García-Martínez

“…By utilizing the cell line screening platform PRISM, we found selective TR2/CDH3 BAB efficacy in various cancer types, such as pancreatic, gastric, colorectal, and triple negative breast cancer. The efficacy of TR2/CDH3 BAB correlated with caspase activation in cancer cell lines and in xenograft tumor tissues. …”
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Bilateral Paget’s Disease of the Breast—Case Report of Long-Time Misdiagnosed Tumors with Underlying Ductal Carcinomas and Review of the Literature by Dietrich Barth

“…We report on a 72-year old patient with a history of 2.5 years without any malignant findings, followed by the identification of a bilateral Paget’s disease with bilateral breast cancers. This case underlines how important histological examinations even in unusual clinical pictures are.…”
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Primary Stromal Breast Sarcoma with Concomitant Contralateral Carcinoma: A Rare Case from Syria by Rawan Al khudari, Mohannad Homsi, Hasan Al zohaily, Maher S. Saifo

“…Bilateral breast cancers are rare cases encountered and are usually the same type in both sides. …”
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Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion by Mehmet Erdem Çakmak, Nida Oztop, Osman Ozan Yeğit

“…5-Fluorouracil (5-FU) is a chemotherapeutic agent widely used in the treatment of gastrointestinal tract, skin and breast cancers. Hypersensitivity reactions may occur due to the use of chemotherapeutic drugs. …”
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Contrast-Enhanced Mammography in the Diagnosis of Breast Angiosarcoma by Maya Grisaru Kacen, Nikhil Sangle, Anat Kornecki

“…Breast angiosarcoma is a rare entity that represents less than 1% of all breast cancers. To our knowledge, this is the first case describing the imaging findings of breast angiosarcoma on contrast-enhanced mammography.…”
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A Bayesian Hierarchical Model for Relating Multiple SNPs within Multiple Genes to Disease Risk by Lewei Duan, Duncan C. Thomas

“…The method is applied to data on 504 SNPs in 38 candidate genes involved in DNA damage response in the WECARE study of second breast cancers in relation to radiotherapy exposure.…”
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The micro(nano)plastics perspective: exploring cancer development and therapy by Xiangying Deng, Yajun Gui, Lin Zhao

“…., lung, liver, and breast cancers), the long-term effects and specific mechanisms still need to be studied. …”
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Near-Infrared Fluorescence Imaging of EGFR-Overexpressing Tumors in the Mouse Xenograft Model Using scFv-IRDye800CW and Cetuximab-IRDye800CW by Abolfazl Amini, Yaghoub Safdari, Fatemeh Tash Shamsabadi

“…EGFR (epidermal growth factor receptor) is overexpressed in a variety of human cancers (including squamous cell carcinoma of head and neck, colon cancer, and some breast cancers) and therefore is regarded as an ideal target for cancer therapy or imaging purposes. …”
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Targeting heparan sulfate proteoglycans as an effective strategy for inhibiting cancer cell migration and invasiveness compared to heparin by Lorenzo Depau, Jlenia Brunetti, Chiara Falciani, Elisabetta Mandarini, Marta Zanchi, Maria Francesca Paolocci, Marta Garfì, Alessandro Pini, Luisa Bracci

“…We exploited our anti-heparan sulfate branched peptide NT4 to test the opposite approach, namely, targeting HSPGs to interfere with their functions, instead of using heparin as a soluble competitor in human cell lines from pancreas adenocarcinoma, colon adenocarcinoma, rhabdomyosarcoma and two different breast cancers. We found that the anti-heparan sulfate peptide NT4 is more effective than heparin for inhibiting cancer cell adhesion, directional migration, colony formation and even cell growth, suggesting that targeting cell membrane HSPGs may be a more effective anti-metastatic strategy than using soluble heparin. …”
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Effect of Different Parameter Values for Pre-processing of Using Mammography Images by Hanife Avcı, Jale Karakaya

“…Breast cancer is one of the most common types of cancer in women. …”
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Breast Diffuse Large B-cell Lymphoma, Activated B-cell like Subtype: A Case Report by Sneha Samir Babaria, Jinalben Shaileshbhai Patel

“…Primary Breast Lymphoma (PBL) is an uncommon form of Non Hodgkin Lymphoma (NHL) that arises within the breast tissue, representing less than 1-2% of all cases of NHL and under 0.5% of all breast cancers. Most PBL cases are of the B-cell type, accounting for up to 50% of all PBL. …”
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Tingkat Kesadaran terhadap Resiko Kanker Payudara pada Mahasiswa by Devia Putri Lenggogeni, Hema Malini, Hacidira Vichalova, Bobby Febri Krisdianto

“…Tingkat kesadaran terhadap faktor resiko kanker payudara diukur menggunakan kuesioner Breast Cancers Awareness Scale (BCAS-1). Hasil penelitian menunjukkan sebagian besar responden berusia 19 tahun (51,4%) dan sebagian besar responden (69,2%) memiliki tingkat kesadaran sedang. …”
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HER2 Negative Mammary Paget’s Disease or In Situ Melanoma? A Case Report and Review of the Literature by Luana-Andreea Boșoteanu, Mariana Așchie, Cristian Ionuţ Orǎșanu, Mădălina Boșoteanu

“…Mammary Paget’s disease (MPD) is a rare histological condition, accounting for 1-4% of female breast cancers, which may appear either independently (1.4-13% of the cases), or in association with an in situ or invasive ductal carcinoma (approximately 90% of the cases). …”
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