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7161
Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study
Published 2024-04-01“…Among the adjusted covariates, CD4 cell count<50 cells/mm3 (adjusted CSH (aCSH) 8.61, 95% CI: 4.75 to 15.60), uncontrolled viremia (aCSH 1.95, 95% CI: 1.20 to 3.17), 10-year increase in age (aCSH 2.41, 95% CI: 1.89 to 3.07), schizophrenia (aCSH 2.85, 95% CI: 1.69 to 4.80), traumatic brain injury (aCSH 2.43, 95% CI: 1.59 to 3.71), delirium (aCSH 2.27, 95% CI: 1.45 to 3.55), substance use disorder (SUD) (aCSH 1.94, 95% CI: 1.18 to 3.21) and mood/anxiety disorders (aCSH 1.80, 95% CI: 1.13 to 2.86) were associated with an increased hazard for dementia. …”
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7162
The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice
Published 2025-01-01“…ABCA7 transports lipids from/across cell membranes, regulates Aβ peptide processing and clearance, and modulates microglial and T-cell functions to maintain immune homeostasis in the brain. During AD pathogenesis, neuroinflammation is one of the key mechanisms involved. …”
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7163
Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma
Published 2025-01-01“…To enhance the effectiveness of NKG2D CAR-T therapy, we investigated the potential of combining NKG2D CAR-T with approved drugs that cross the blood-brain barrier and augment NKG2D ligands expression in glioma cells. …”
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7164
Synergy of rehabilitation for stress-related disorders and ARIs in school-age children under the war condition in Ukraine
Published 2024-11-01“…The study was carried out as part of the program of outpatient observation of children with various acute manifestations of ARIs against the background of stress damage to the nervous system due to the war in Ukraine, and taking naturopathic drugs with immunocorrective properties (scheme (1)): 1) affinity-purified antibodies to human interferon gamma (6 mg), histamine (6 mg) and CD4 (6 mg) — a mixture of homeopathic dilutions C12, C30 and C50; or in combination with a drug with a sedative effect (scheme (1+2)): 1) affinity-purified antibodies to human gamma interferon (6 mg), histamine (6 mg) and CD4 (6 mg) — a mixture of homeopathic dilutions C12, C30 and C50; 2) affinity-purified antibodies to brain-specific protein S100 (3 mg) — a mixture of homeopathic dilutions C12, C30 and C50. …”
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7165
Delta radiomics modeling based on CTP for predicting hemorrhagic transformation after intravenous thrombolysis in acute cerebral infarction: an 8-year retrospective pilot study
Published 2025-02-01“…Similar results were validated in the test set, and a novel nomogram was constructed to simplify the prediction process for HT-ACI.ConclusionThe combined model established based on delta radiomics from CTP may provide early insights into the hemodynamic status of acutely ischemic brain tissue, holding significant clinical importance for predicting HT-ACI. …”
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7166
Botulinum Toxin Injection with Conjunctival Microincision for the Treatment of Acute Acquired Comitant Esotropia and Its Effectiveness
Published 2020-01-01“…Neurological evaluation and brain magnetic resonance imaging (MRI) were unremarkable in all patients. …”
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7167
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7168
Association between red blood cell distribution width-to-albumin ratio and prognosis in post-cardiac arrest patients: data from the MIMIC-IV database
Published 2025-01-01“…BackgroundCardiac arrest (CA) triggers a systemic inflammatory response, resulting in brain and cardiovascular dysfunction. The red blood cell distribution width (RDW)-to-albumin ratio (RAR) has been widely explored in various inflammation-related diseases. …”
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7169
The role of mNGS in the diagnosis of talaromycosis and case series
Published 2025-02-01“…Another case was positive in blood and bone marrow cultures, brain tissue culture and mNGS. They were both treated with voriconazole and improved. …”
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7170
The comparative analysis of the influence of bisoprolol and carvedilol on the course of heart failure of ischemic origin in patients with concomitant atrial fibrillation and diabet...
Published 2024-11-01“…The levels of thyroid-stimulating hormone, free triiodothyronine and free thyroxine, glucose, glycated hemoglobin, galectin-3, suppression of tumorigenicity 2 peptide, B-type natriuretic peptide, N-terminal prohormone of brain natriuretic peptide were determined. Genotyping was carried out for 4 polymorphisms (rs1801253 and rs1801252 of the β1-АР, rs1042714 of the β2-AP gene, and rs2274273 of the LGALS-3 gene). …”
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7171
Case report: Atypical young case of MV1 Creutzfeldt-Jakob disease with unusually long survival
Published 2025-01-01“…EEG was negative for periodic sharp wave complexes; however, brain MRI was suggestive of prion disease. The cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) assay was indeterminate. …”
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7172
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7173
Differential Signature of the Centrosomal MARK4 Isoforms in Glioma
Published 2011-01-01“…Accordingly, only MARK4L is expressed in brain neurogenic regions. Moreover, while both MARK4 isoforms are localised to the centrosome and midbody in glioma and normal cells, the L isoform exhibits an additional nucleolar localisation in tumour cells. …”
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7174
Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke
Published 2025-01-01“…Results Electroacupuncture improved neurological deficits in rats model of MCAO/R, decreased the brain infarct volume, alleviated neuronal damage, inhibited the Fe2+, ROS, and MDA accumulation, increased SOD levels, increased the expression of GPX4, SLC7A11 and FTH1, and rescued injured mitochondria. …”
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7175
Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage
Published 2025-01-01“…Treatment of mice with propranolol and phenoxybenzamine prevented endothelial and microvascular dysfunction, which was supported by a decrease in markers of inflammation and oxidative stress in heart tissue and the brain. Amelioration of noise-induced hypertension (systolic blood pressure) was not observed, whereas pulse pressure was lowered by trend. …”
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7176
Proteogenomic annotation of T6SS components identified in Bacteroides fragilis secretome
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7177
The HFA‐PEFF score identifies ‘early‐HFpEF’ phenogroups associated with distinct biomarker profiles
Published 2022-06-01“…The top eight biomarkers—N‐terminal prohormone brain natriuretic peptide, growth differentiation factor‐15, matrix metalloproteinase‐2, osteoprotegerin, tissue inhibitor of metalloproteinase‐4, chitinase‐3‐like protein 1, insulin‐like growth factor‐binding protein 2, and insulin‐like growth factor‐binding protein 7—are mainly involved in inflammation and extracellular matrix remodelling, which are currently proposed key processes in HFpEF pathophysiology. …”
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7179
APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
Published 2025-01-01“…We used immunohistochemical and biochemical analysis along with single-cell spatial omics and bulk proteomics to explore the impact of the ApoeCh variant on AD pathological development and the brain’s response to plaques and tau. Results In 5xFAD mice, ApoeCh enhances a Disease-Associated Microglia (DAM) phenotype in microglia surrounding plaques, and reduces plaque load, dystrophic neurites, and plasma neurofilament light chain. …”
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7180