Suggested Topics within your search.
Suggested Topics within your search.
- Anatomy 5
- Abdomen 4
- Chest 4
- Dissection 4
- Extremities (Anatomy) 4
- Human anatomy 4
- methods 4
- Brain 2
- Brain Diseases 1
- Complications 1
- Diabetes 1
- Diabetes Mellitus, Type 2 1
- Emotions 1
- Etiology 1
- Intraoperative Complications 1
- Motivation 1
- Motivation (Psychology) 1
- Nervous System 1
- Neuroanatomy 1
- Pathogenesis 1
- Personality and motivation 1
- Postoperative Complications 1
- Surgery 1
- anatomy & histology 1
- etiology 1
- prevention & control 1
- surgery 1
- therapy 1
-
7141
CLN6‐related continuum phenotype caused by aberrant splicing
Published 2025-02-01“…A skin biopsy revealed a mixed storage of curvilinear and fingerprint profiles. A brain MRI showed severe cortical atrophy. Performing genetic analyses, two biallelic variants were identified in the CLN6 gene, each inherited from one of the healthy parents, one c.722T>C, p.…”
Get full text
Article -
7142
-
7143
Characterisation of the effects of the chemotherapeutic agent paclitaxel on neuropathic pain-related behaviour, anxiodepressive behaviour, cognition, and the endocannabinoid system...
Published 2025-01-01“…Post-mortem measurement of endocannabinoid and related N-acylethanolamine levels in spinal cord and discrete brain regions revealed a PTX-induced increase of 2-Arachidonoyl Glycerol (2-AG), N-Palmitoylethanolamine (PEA) and N-Oleoylethanolamine (OEA) levels in the amygdala of male and female animals, but not in the other areas. …”
Get full text
Article -
7144
Small Extracellular Vesicles from Young Healthy Human Plasma Inhibit Cardiac Fibrosis After Myocardial Infarction via miR-664a-3p Targeting SMAD4
Published 2025-01-01“…Weiwei Wang,1,* Ying Li,1,* Cheng Zhang,2,* Haoyang Zhou,1 Chunyu Li,3 Rong Cheng,1 Xufeng Chen,1 Yanan Pu,4 Yan Chen1,5,6 1Department of Emergency and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 2Long Jiang Central Laboratory, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China; 3Long Jiang Intensive Care Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 4Department of Clinical Laboratory, Nanjing Chest Hospital, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 5Department of Emergency and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215000, People’s Republic of China; 6Department of Emergency Management, School of Health Policy & Management, Nanjing Medical University, Nanjing, 211166, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Chen; Yanan Pu, Email chenyandoc@njmu.edu.cn; pyn342626@njmu.edu.cnPurpose: Cardiac fibrosis, a key contributor to ventricular pathologic remodeling and heart failure, currently lacks effective therapeutic approaches.Patients and Methods: Small extracellular vesicles from young healthy human plasma (Young-sEVs) were characterized via protein marker, transmission electron microscopy, and nanoparticle tracking analysis, then applied in cellular models and mouse models of cardiac fibrosis. …”
Get full text
Article -
7145
Post-traumatic pituitary stalk transection syndrome (PSTS) expeditiously manifested after a fall from a height combined with acute traumatic spinal cord injury: a rare case report...
Published 2024-08-01“…Post-traumatic pituitary stalk transection syndrome (PSTS) is an extremely rare cause of combined pituitary hormone deficiency (CPHD), affecting approximately 9 per 100,000 cases of traumatic brain injury. In contrast, pituitary stalk interruption syndrome (PSIS) is also a rare cause of CPHD. …”
Get full text
Article -
7146
Analysis of early effects of human APOE isoforms on Alzheimer’s disease and type III hyperlipoproteinemia pathways using knock-in rat models with humanized APP and APOE
Published 2024-09-01“…We found that APOE2 hAβ rats had the highest levels of APOE in serum and brain, with no significant transcriptional differences among isoforms, suggesting variations in protein translation or stability. …”
Get full text
Article -
7147
-
7148
Effect of Electroacupuncture Prestimulation with Mental Tri-Needles on the Inflammatory Response of Hippocampus in Aged Rats with Perioperative Neurocognitive Disorders
Published 2023-08-01“…Compared with the control group and the anesthesia group, the percentages of apoptotic cells in the hippocampus of the operation group and the acupuncture group significantly increased (<italic>P</italic><0.05); and compared with the operation group, the percentage of apoptotic cells in the hippocampus of the acupuncture group significantly decreased (<italic>P</italic><0.05). (4) Protein contents and mRNA levels of IL-1β, IL-6 and TNF-α in hippocampus: compared with the control group and the anesthesia group, the protein contents and mRNA levels of IL-1β, IL-6 and TNF-α in the operation group significantly increased (<italic>P</italic><0.05); compared with the operation group, the protein expression of IL-1β, IL-6 and TNF-α and their mRNA levels in the acupuncture group significantly decreased (<italic>P</italic><0.05).ConclusionEA prestimulation with mental trineedles can reduce the injury and apoptosis of hippocampal cells in aged rats with PND, and improve cognitive function, which may be related to the inhibition of the overexpression of IL-1β, IL-6 and TNF-α in the hippocampus of aged rats and reducing the inflammatory reaction in brain tissue.…”
Get full text
Article -
7149
The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19
Published 2025-02-01“…Sixty-seven healthy controls (COV−) completed the same recruitment protocol. Results: Whole-brain voxel-wise analysis showed that gray matter volume (GMV) during the acute phase did not differ between the COV+ and COV− groups. …”
Get full text
Article -
7150
Evaluation of Simulated Weightlessness Model of Hindlimb Unloading Miniature Pigs and Their Tissue Damage
Published 2024-10-01“…Additionally, western blotting was employed to detect the expression levels of skeletal muscle atrophy-related proteins, including muscle-specific RING finger protein 1 (MuRf-1) and muscle atrophy F-box (MAFbx, as known as Atrogin-1), while immunohistochemistry was used to detect the expression of glial fibrillary acidic protein (GFAP), an indicator of astrocyte activation in the brain, reflecting the pathophysiological functional changes across systems. …”
Get full text
Article -
7151
A New Smartphone-Based Cognitive Screening Battery for Multiple Sclerosis (icognition): Validation Study
Published 2025-01-01“…It is planned to be included in a digital health platform that includes volumetric brain analysis and patient-reported outcome measures. …”
Get full text
Article -
7152
Identification of the optimal candidates to benefit from surgery and chemotherapy among elderly female breast cancer patients with bone metastases
Published 2025-02-01“…Both univariate and multivariate Cox regression analyses validated those variables such as age, race, marital status, histological type, tumor grade, ER status, PR status, breast subtype, distant metastases (lung, liver, and brain), and treatment methods (surgery and chemotherapy) independently predicted OS in elderly female breast cancer patients with bone metastases (p < 0.05). …”
Get full text
Article -
7153
A Turbo‐Charging System‐Like Contrast Agent for MRI‐Guided STING Pathway‐Activated Cancer Immunotherapy
Published 2025-01-01“…Abstract To overcome the problems of Gd‐based contrast agents (GBCAs) (nephrotoxicity and brain deposition) and stimulator of interferon genes (STING) agonists (poor stability, low delivery efficiency, and potential toxicity), in this study, a Turbo‐charging system‐like GBCA is designed and constructed for magnetic resonance imaging (MRI) guided STING pathway‐activated cancer immunotherapy. …”
Get full text
Article -
7154
Active ingredients and mechanisms of peony seed blended oil in diabetes treatment using Kunming mice: Insights from GC–MS, network pharmacology, and experimental verification
Published 2025-02-01“…The lecithin content in soybeans is also essential for the development and growth of the nervous system, blood vessels, and brain. Canola oil, with a higher level of Omega-3 polyunsaturated fatty acids, helps soften blood vessels and can prevent atherosclerosis, offering benefits for both cardiovascular and cerebrovascular health. …”
Get full text
Article -
7155
Strength Training Session Induces Important Changes on Physiological, Immunological, and Inflammatory Biomarkers
Published 2018-01-01“…The strength training session elevated the levels of apelin and fatty acid-binding proteins-3 (FABP3) in both groups and brain-derived neurotrophic factor (BDNF) in TG. The single exercise session was capable of inducing elevated HR, RPE, lactate level, and CK levels. …”
Get full text
Article -
7156
An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene
Published 2025-01-01“…DNA methylation profiling (Illumina EPIC BeadArrays, brain tumour classifier (MNP v12.5 R package)) classified the tumour as ‘DMG, H3 K27-altered’ (calibrated score = 0.99). …”
Get full text
Article -
7157
Feasibility and potential diagnostic value of [18F]PI-2620 PET in patients with down syndrome and Alzheimer’s disease: a case series
Published 2025-01-01“…Visual read of tau PET scans was performed by three blinded raters, assessing increased tracer uptake in brain areas corresponding to the six Braak stage regions and basal ganglia.ResultsVisual read of tau burden revealed three tau-positive individuals which corresponded to their clinical decline while two cognitively stable individuals were rated as negative. …”
Get full text
Article -
7158
Serious Bacterial Infections and Hepatitis C Virus Among People Who Inject Drugs: A Syndemic or Intertwined Epidemics?
Published 2025-01-01“…., endocarditis), bone, spine, brain, or joints (e.g., osteomylelitis) and hepatitis C virus (HCV) infections. …”
Get full text
Article -
7159
-
7160
Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD
Published 2025-02-01“…And the mean dFC values between right IFG and bilateral IC (right, β = −1.563, p-FDR = 0.021; left, β = −1.868, p-FDR = 0.012) at baseline could predict antidepressant treatment response.ConclusionThese findings demonstrate that dFC patterns between some brain areas could be a prospective factor for predicting antidepressant treatment response.…”
Get full text
Article