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7101
Maternal exposure to dim light at night induces behavioral alterations in the adolescent and adult offspring Wistar rat
Published 2025-01-01“…Throughout development, microglia are responsible for the remodeling of diverse brain regions via synaptic pruning. During adolescence, this process occurs within the NAc, where immune-mediated remodeling directly impacts social play behavior.MethodsThis study investigated the effects of maternal exposure to DLAN or a light-dark cycle (LD) before (5 weeks) and during the gestational period (21–23 days) on the metabolism and behavior of offspring in adolescence and adulthood. …”
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7102
Oxygenation targets for endovascular therapy in acute ischemic stroke patients (Oxy-TARGET): protocol for a single-centre, open-label randomised controlled trial
Published 2025-01-01“…Introduction Preclinical studies have shown that oxygen therapy can improve ischaemic brain tissue oxygen tension, reduce reperfusion injury after revascularisation, promote neuroregeneration and inhibit inflammatory responses potentially exerting a beneficial effect after endovascular treatment (EVT) in patients with acute ischaemic stroke (AIS). …”
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7103
The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradati...
Published 2025-01-01“…Melatonin has been indicated to confer neuroprotection against brain diseases via its potent anti-ferroptotic effects. …”
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7104
Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis
Published 2025-01-01“…Methods We quantitatively measured amino acids, biogenic amines, hexoses, acylcarnitines (AC), cholesteryl esters (CE), glycerides, phosphatidylcholines (PC), lysophosphatidylcholines (LPC), sphingomyelins (SM), and ceramides (Cer) in 117 CSF samples from various groups of healthy controls (HC, n = 10), patients with LM (LM, n = 47), parenchymal brain tumor (PBT, n = 45), and inflammatory disease (ID, n = 13) with internal standards using the Absolute IDQ- p400® targeted mass spectrometry kit. …”
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7105
Gambaran Faktor Risiko dan Tipe Stroke pada Pasien Rawat Inap di Bagian Penyakit Dalam RSUD Kabupaten Solok Selatan Periode 1 Januari 2010 - 31 Juni 2012
Published 2013-05-01“…<br />Kata kunci: stroke ischemic, stroke hemorrhagic, faktor risiko stroke<br />Abstract<br />Stroke is a disease caused by disorder of brain blood circulation with many risk factors that contribute in this disease, consist of non modifiable risk factor including age and sex and modifiable risk factors example hypertension, high glucose level, dyslipidemia, and jobs. …”
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7108
Multi-channel microelectrode arrays for detection of single-cell level neural information in the hippocampus CA1 under general anesthesia induced by low-dose isoflurane
Published 2025-01-01“…Currently, a high spatiotemporal resolution microdevice technology for the accurate detection of deep brain nuclei is lacking. In this research, four-shank 32-channel implantable microelectrode arrays (MEAs) were developed for the real-time recording of single-cell level neural information in rat hippocampal CA1. …”
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7109
Investigation of metabolic features of glioblastoma tissue and the peritumoral environment using targeted metabolomics screening by LC-MS/MS and gene network analysis
Published 2025-01-01“…The metabolomic profiles of glioblastoma and surrounding brain tissue, comprising 17 glioblastoma samples and 15 peritumoral tissue samples, were thoroughly analyzed in this investigation. …”
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7110
Early intervention in psychosis programs in Africa, Asia and Latin America; challenges and recommendations
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7111
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7112
Associations Between Complement C4, Habitual Constipation, and Sleep Disturbance in Oldest-Old and Centenarian Chinese Adults
Published 2025-01-01“…Zhigao Sun,1,* Yan Nie,2,* Jianqiu Pei,3,* Ming Gao,4,* Zhe Luan,5,* Yali Zhao,6 Zhaoxing Li,7 Shihui Fu8,9 1Traditional Chinese Medicine Department, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, People’s Republic of China; 2Department of Gastroenterology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, People’s Republic of China; 3Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of China; 4School of Engineering Medicine, Beihang University, Beijing, People’s Republic of China; 5Department of Gastroenterology and Hepatology, The First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of China; 6Central Laboratory, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, People’s Republic of China; 7Department of General Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 8Department of Cardiology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, People’s Republic of China; 9Department of Geriatric Cardiology, Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhaoxing Li, Department of General Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China, Email lizhaoxing1984@hebmu.edu.cn Shihui Fu, Department of Cardiology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, People’s Republic of China, Email xiaoxiao0915@126.comBackground: Sleep disturbance is an immune-related disease, and the gut–brain axis is an important regulatory pathway. This cross-sectional study was designed to address these associations between complement C4, habitual constipation, and sleep disturbance and presents a reference for prevention and treatment of sleep disturbance.Methods: Based on the China Hainan Centenarian Cohort Study, Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep disturbance following standard procedure. …”
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7113
Prenatal exposure to a mixture of organophosphate ester and organophosphorus pesticides in relation to child neurodevelopment in the Shanghai Birth Cohort
Published 2025-01-01“…Neurotoxicity of organophosphate esters (OPEs) and organophosphorus pesticides (OPPs) has been documented in toxicological studies, though epidemiological evidence remains inconsistent. The developing fetal brain is susceptible to environmental exposures. …”
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7114
Clinical novel exploration of intractable fever in stroke rehabilitation: a single-center cross-sectional retrospective study
Published 2025-01-01“…In clinical settings, intractable fever is as common as acute fever, particularly in patients with brain injuries. Beyond infectious causes, stroke survivors often experience recurrent intractable fever due to central or neurogenic mechanisms. …”
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7116
Technological dental sealants: in vitro evaluation of material properties and antibiofilm potential
Published 2025-02-01“…For the HI test, specimens were exposed to S. mutans for 24 h in brain–heart infusion (BHI) agar under microaerophilic conditions, with the diameter of the HI (mm) measured by digital caliper. …”
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7117
International perspective on social cognition in schizophrenia: current stage and the next steps
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7118
Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration
Published 2025-02-01“…Western blot was used to detect the expression of apoptosis and autophagy related proteins in the brain tissue of mice in each group. Results The results of molecular docking showed that the selected active compounds had good binding activity with the target. …”
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7119
Multiomics unravels the complexity of male obesity: a prospective observational study
Published 2025-01-01“…Deep phenotyping, including targeted metabolomics, transcriptomics, and brain magnetic resonance imaging (MRI), was performed. …”
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7120
Oncolytic influenza virus enhances killing effect of gemcitabine against pancreatic cancer cells
Published 2025-01-01“…HE staining was performed to observe the pathological changes in major organs (heart, liver, lungs, kidneys and brain), and the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured to evaluate the safety of the recombinant oncolytic virus. …”
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