Save a trip: Clinical outcomes of cardiac allografts recovered by local surgeons compared to recipient center surgeons. by Awab Ahmad, MD, Timothy R. Harris, MD, Aaron Williams, MD, Alexandra DeBose-Scarlett, MD, Rubayet Kamal, BS, Enock Atta Adjei, MD, Hasan K. Siddiqi, MD, Chen Chia Wang, Mark Petrovic, Clifton D. Keck, Shelley R. Scholl, RN, Ashish S. Shah, MD, Swaroop Bommareddi, MD, Brian Lima, MD MBA, John M. Trahanas, MD

“…Methods: A retrospective review of all recoveries of adult cardiac allografts from brain dead donors for a single academic transplant center between 1/2020 and 12/2021 was performed. …”
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β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques by Taisuke Okano, Kengo Sato, Remina Shirai, Tomomi Seki, Koichiro Shibata, Tomoyuki Yamashita, Ayaka Koide, Hitomi Tezuka, Yusaku Mori, Tsutomu Hirano, Takuya Watanabe

“…β-Endorphin, an endogenous opioid peptide, and its μ-opioid receptor are expressed in brain, liver, and peripheral tissues. β-Endorphin induces endothelial dysfunction and is related to insulin resistance. …”
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Predictive value of the systemic immune–inflammation index for outcomes in large artery occlusion treated with mechanical thrombectomy—a single-center study by Ao Qian, Longyi Zheng, Hui He, Jia Duan, Shuang Tang, Wenli Xing

“…The investigating outcomes included hemorrhagic transformation (HT), malignant brain edema (MBE), 90-day functional outcome, and mortality. …”
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Apolipoprotein A-V Is a Novel Diagnostic and Prognostic Predictor in Pediatric Patients with Sepsis: A Prospective Pilot Study in PICU by Chunxia Wang, Yun Cui, Huijie Miao, Xi Xiong, Jiaying Dou, Lujing Shao, Xiaomeng Tang, Yucai Zhang

“…In subgroup analysis, serum levels of ApoA5 were significantly correlated with sepsis-associated multiple organ dysfunction syndrome (MODS) (P<0.001), shock (P=0.002), acute kidney injury (AKI) (P<0.001), acute liver injury (ALI) (P=0.002), and gastrointestinal (GI) dysfunction (P=0.012), but not respiratory failure, brain injury, and pathogenic species (all P>0.05). …”
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Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status? by Tissa Wijeratne, Melanie J. Murphy, Chanith Wijeratne, Paolo Martelletti, Leila Karimi, Vasso Apostolopoulos, Carmela Sales, Nina Riddell, Sheila G. Crewther

“…Main body A retrospective analysis was conducted of medical records using baseline demographics and brain imaging findings from 186 migraine hospitalized in-patients who had at least two sets of white blood cell counts drawn within 24 h following their admission to the emergency department of Western Health a tertiary care center in Melbourne, Australia, over an 18-month period. …”
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Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study by Cuiping Bao, Xuehuan Liu, Yiming Li, Jun Yang, Feng Wei, Yi Gong, Zhihui Ma, Jun Liu

“…All participants underwent brain MRI examination on a 3T MRI scanner. FreeSurfer was performed to segment hippocampus automatically based on T1 MPRAGE images. …”
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Distinct Circle of Willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study by Julien Greggio, Christina Malamateniou, Kelly Pegoretti Baruteau, Constantino Carlos Reyes-Aldasoro, Odaro J. Huckstep, Jane M. Francis, Wilby Williamson, Paul Leeson, Adam J. Lewandowski, Winok Lapidaire

“…This study aims to explore potential differences in the Circle of Willis (CoW), a key arterial ring that perfuses the brain, of healthy adults born preterm. Methods A total of 255 participants (108 preterm, 147 full-term) were included in the analysis. …”
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On the substrate turnover rate of NBCe1 and AE1 SLC4 transporters: structure-function considerations by Alexander Pushkin, Liyo Kao, Hristina R. Zhekova, Rustam Azimov, Natalia Abuladze, Xuesi M. Shao, D. Peter Tieleman, Ira Kurtz, Ira Kurtz

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Sex differences in the association between metabolic disorder and inflammatory cytokines in Han Chinese patients with chronic schizophrenia by Yinghan Tian, Yinghan Tian, Zhenkuo Li, Yun Zhang, Pei Tang, Yu Zhuang, Lewei Liu, Lewei Liu, Haojie Fan, Haojie Fan, Haojie Fan, Xianhu Yao, Wenzheng Li, Lei Xia, Lei Xia, Lei Xia, Huanzhong Liu, Huanzhong Liu, Huanzhong Liu

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Hyperbaric oxygen potentiates platelet-rich plasma composition and accelerates bone healing by Wen-Shuo Chang, Chien-Cheng Huang, Tzu-Hao Chen, Ssu-Han Chao, Cheng-Hsien Lin, Ching-Ping Chang, Chi-Sheng Chien

“…Results: hPRP showed significantly higher concentrations of growth factors such as activin-A, brain-derived neurotrophic factor, nerve growth factor, Flt-3 Ligand, granulocyte-macrophage colony-stimulating factor, hepatocyte growth factor, and platelet-derived growth factor, compared to nPRP. …”
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Impaired Sphenoparietal Venous Drainage Is Associated With Increased Risk of Vasospasm in Aneurysmal Subarachnoid Hemorrhage by Kyle A. Lyman, Gautam Adusumilli, Hera A. Kamdar, Joanna Yang, Guy A. Rordorf, Daniel B. Rubin, Robert W. Regenhardt, Christopher J. Stapleton, Aman B. Patel, Joseph J. Locascio, William Taylor Kimberly, Brian L. Edlow, Jeremy J. Heit, David Y. Chung

“…Background Adequate venous drainage of brain parenchyma is essential to maintain cerebral perfusion and clearance of cerebrospinal fluid. …”
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Comparative analysis of deep learning and radiomic signatures for overall survival prediction in recurrent high-grade glioma treated with immunotherapy by Qi Wan, Clifford Lindsay, Chenxi Zhang, Jisoo Kim, Xin Chen, Jing Li, Raymond Y. Huang, David A. Reardon, Geoffrey S. Young, Lei Qin

“…Abstract Background Radiomic analysis of quantitative features extracted from segmented medical images can be used for predictive modeling of prognosis in brain tumor patients. Manual segmentation of the tumor components is time-consuming and poses significant reproducibility issues. …”
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Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents by Chongshan Dai, Erjie Tian, Hui Li, Subhajit Das Gupta, Zhihui Hao, Zhanhui Wang, Tony Velkov, Jianzhong Shen

“…AFB1 exposure has also been shown to induce DNA damage, apoptosis, pyroptosis, and mitochondrial dysfunction in the brain tissue. Several signaling pathways, including gasdermin D, toll like receptor 2 (TLR2), TLR4, Akt, NF-κB, ERK/MAPK, protein kinase C (PKC), and mitochondrial apoptotic pathways have been shown to participate in AFB1-induced neuronal or astrocyte cell death. …”
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Perspektywiczne kierunki rozwoju biologii człowieka w Polsce, ze szczególnym uwzględnieniem auksologii by Napoleon Wolański, Anna Siniarska

“…Most likely generalizations of tools behaviors and social contacts have caused brain development and favored abstraction, future vision and articular speech. …”
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A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome by Kathleen Campbell, Jeffrey L. Neul, David N. Lieberman, Elizabeth Berry-Kravis, Tim A. Benke, Cary Fu, Alan Percy, Bernhard Suter, David Morris, Randall L. Carpenter, Eric D. Marsh, Jana von Hehn

“…Exploratory efficacy endpoints included change in clinician- and caregiver-rated measures of RTT features, brain activity on electroencephalography, and wearable biosensors to measure respiration, heart rate, sleep, and activity. …”
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Construct validity and responsiveness of clinical upper limb measures and sensor-based arm use within the first year after stroke: a longitudinal cohort study by Johannes Pohl, Geert Verheyden, Jeremia Philipp Oskar Held, Andreas Ruediger Luft, Chris Easthope Awai, Janne Marieke Veerbeek

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Shift work schedules alter immune cell regulation and accelerate cognitive impairment during aging by Karienn A. de Souza, Morgan Jackson, Justin Chen, Jocelin Reyes, Judy Muayad, Emma Tran, William Jackson, M. Karen Newell-Rogers, David J. Earnest

“…These results indicate that disordered circadian timekeeping associated with early exposure to shift work-like schedules alone accelerates cognitive decline during aging in conjunction with altered regulation of immune cells and microglia in the brain.…”
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Role of calcium overload-mediated disruption of mitochondrial dynamics in offspring neurotoxicity due to methylmercury exposure during pregnancy and lactation by Lingxu Kong, Huajie Yang, Jing Yang, Liujiangshan Jiang, Bin Xu, Tianyao Yang, Wei Liu

“…MeHg crosses the placental barrier and accumulates in the brain of the fetus, affecting the growth and development of the central nervous system. …”
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Clinical trial to compare safety and tolerability between intravenous infusion and bolus intravenous injection of ApTOLL in healthy volunteers by Macarena Hernández-Jiménez, Samuel Martín-Vílchez, Gina Mejía-Abril, Manuel Roman, Sergio Luquero-Bueno, David Piñeiro, Marc Ribó, Francisco Abad-Santos, Dolores Ochoa

“…ApTOLL, a new modulator of Toll-like receptor 4, has demonstrated safety and efficacy in healthy subjects and in stroke patients; however, the route of administration used so far (30 min infusion) can potentially be an issue in the acute stroke units where “time is brain.” To safely reduce the time of administration in future clinical trials, a dose-ascending, open-label, phase I clinical trial was conducted in healthy subjects. …”
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Improving the diagnostic accuracy of referrals for papilloedema (DIPP) study: protocol for a mixed-methods study by Luke Bennetto, Beth Stuart, Jonathan Benger, Matthew J Ridd, Helen Bolton, William Hollingworth, Michael Bowen, Amar Shah, Samuel William David Merriel, Alyson Huntley, Victoria Wilson, Maria Theresa Redaniel, Paul Roy, Denize Atan, Frank Moore, Olivia Skrobot, Mary-Ann Sherratt, Marcia Lucraft, Christina Stokes

“…Introduction Papilloedema can be the first sign of life-threatening disease, for example, brain tumours. Due to the potential seriousness of this clinical sign, the detection of papilloedema would normally prompt urgent hospital referral for further investigation. …”
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