The carbon footprint and energy consumption of liver transplantation by Paolo De Simone, Paolo De Simone, Quirino Lai, Juri Ducci, Daniela Campani, Daniela Campani, Giandomenico Biancofiore, Giandomenico Biancofiore

“…This study aims to quantify the total greenhouse gas emissions, or carbon footprint, associated with adult whole-size liver transplantation from donors after brain death, including the relevant back-table graft preparation.MethodsThe carbon footprint was calculated retrospectively using a bottom-up approach. …”
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Functional Remediation Improves Serum BDNF and TrkB Levels in Euthymic Patients with Bipolar Disorder: A Randomized Trial Study by Li R, Li J, Ji SS, Li D, Chu L, Zhang J, Sun X, Luo X, Zhang Y

“…Ru Li,1,* Jiaxin Li,1,* Shiyi Suzy Ji,2 Dazhi Li,1 Lijun Chu,1 Jian Zhang,1 Xia Sun,1 Xingguang Luo,3 Yong Zhang1 1Unit of Bipolar Disorder, Tianjin Anding Hospital, Tianjin, People’s Republic of China; 2Department of Counseling and Clinical Psychology, Teachers College, Columbia University, NY, New York, USA; 3Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA*These authors contributed equally to this workCorrespondence: Yong Zhang, Unit of Bipolar Disorder, Tianjin Anding Hospital, 13 Liulin Road, Hexi District, Tianjin, 300222, People’s Republic of China, Tel/Fax +86 22 8818 8258, Email zhangyong@tjmhc.comPurpose: We aimed to verify the impact of functional remediation (FR) on serum brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) levels, to explore the biomechanism of FR intervention in patients with euthymic bipolar disorder (BD).Patients and Methods: This is a randomized controlled, 12-week intervention study with participants randomized into the FR group (n=39) and the treatment as usual group (TAU, n=42) at the 1∶1 ratio. 17-Hamilton Depression Rating Scale-17 (HDRS-17), Young Mania Rating Scale (YMRS), and Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) were used to assess affective symptoms and cognitive functioning both at baseline and week 12, respectively. …”
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Cardiometabolic Risk in Hyperlipidemic Men and Women by Michael Leutner, Christian Göbl, Alice Wielandner, Eleonora Howorka, Marlies Prünner, Latife Bozkurt, Jürgen Harreiter, Helmut Prosch, Oliver Schlager, Silvia Charwat-Resl, Alexandra Kautzky-Willer

“…HL-men were characterized as having higher levels of liver-specific parameters and body weight as well as being more physically active compared to HL-women. Brain natriuretic peptide (pro-BNP) was higher in HL-women than HL-men, while no differences in metabolic syndrome and glycemic parameters were shown. …”
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Glaucoma progression during the COVID-19 pandemics by V.E. Korelina, I.R. Gazizova, A.V. Kuroyedov, M.D. Didur

“…Bekhtereva Institute of the Human Brain, St. Petersburg, Russian Federation</b> </p> <p> <b>³P.V. …”
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Advancing cancer therapy with custom-built alternating electric field devices by Isobel Jobson, Nguyen T. N. Vo, Edward Kujawinski, Chris Denning, Snow Stolnik, Veeren M. Chauhan, Frankie Rawson

“…To better understand how the position and morphology of cells can affect cell therapy responsiveness to alternating electric fields or currents, GBM results were compared to those from the semi-adherent brain tumour cell line, D425. Results Contrary to previous findings, there was no significant difference between the GIN 31 and GCE 31 cells exposed to alternating electric fields or currents treated with or without NP compared to cells untreated and unstimulated. …”
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evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomat... by Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

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Twelve-month follow-up of a controlled trial of a brief behavioural intervention to reduce psychological distress in young adolescent Syrian refugees by Richard A. Bryant, Rand Habashneh, Maha Ghatasheh, Aiysha Malik, Ibrahim Said Aqel, Katie S. Dawson, Sarah Watts, Mark J. D. Jordans, Felicity L. Brown, Mark van Ommeren, Aemal Akhtar

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Evaluation of the Early Development of 6-Month-Old Babies in the Case of Maternal Postpartum Depression with or Without Bipolar Disorder by Jokthan Guivarch, Mélanie-Lou Persia, Laure Le Treut, Pauline Grandgeorge, Federico Solla, Hugo Pergeline, Michel Dugnat, Florence Askenazy, François Poinso, Arthur Varoquaux, Arnaud Fernandez

“…Background: The first year of life is the period of greatest brain plasticity. Postpartum depression can adversely affect the first interactions with the child and, consequently, their emotional, social, and cognitive development. …”
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Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain? by Yanyuan Du, Yaoyuan Li, Jieqing Hu, Ruiying Fang, Yuming Liu, Liu Cai, Ying Song, Susu Ma, Jin Gao, Hanyue Zhang, Baihui Li, Hongtai Xiong, Huibo Yu, Shenglei Yang, Shuduo Zhu, Honggang Zheng

“…The analgesic mechanisms of rTMS include inhibiting nociceptive signal transmission in the spinal cord, modulating hemodynamic changes in brain regions, and promoting endogenous opioid release. …”
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Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression by Nicole R. Silva, Shokouh Arjmand, Luana B. Domingos, Adriano M. Chaves-Filho, Melina Mottin, Caroline C. Real, Anna L. Waszkiewicz, Pedro H. Gobira, Alessio Nicola Ferraro, Anne M. Landau, Carolina H. Andrade, Heidi K. Müller, Gregers Wegener, Sâmia R.L. Joca

“…S-KET (15 mg/kg) effects were assessed in rats exposed to the open field and forced swimming test (FST), followed by analysis of the eCB signaling in the rat prefrontal cortex (PFC), a brain region involved in depression neurobiology. …”
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Correlation Analysis of the Entorhinal Cortex-Hippocampus Nerve Fiber Changes and Memory Dysfunction in P301L-Tau Mouse Model and Molecular Mechanism by CHEN Xiaocheng, LIANG Shengxiang, LIN Bingbing, LIU Weilin, HUANG Jia

“…Pearson correlation analysis was used to analyze the correlation between fractional anisotropy (FA) values in different brain regions of the entorhinal cortex-hippocampus and their corresponding learning and memory functions.Results(1) Learning and memory function test: compared with the control group, the learning and memory function of the model group significantly decreased, the escape latency significantly increased, the number of platform crossings and time ratio of target quadrant significantly decreased (<italic>P</italic>&lt;0.05). (2) Structure of nerve fibers in the entorhinal cortex and hippocampus: compared with the control group, FA values of the entorhinal cortex and hippocampus in the model group decreased more significantly, MD values of the entorhinal cortex in the model group increased more significantly, while there was no significant difference in the MD values of the hippocampus in the model group (<italic>P</italic>&gt;0.05). (3) Correlation analysis between FA values in the entorhinal cortex-hippocampus and learning and memory function: FA values in the entorhinal cortex and hippocampus were positively correlated with the number of platform crossings (<italic>r</italic>=0.76, <italic>P</italic>&lt;0.05; <italic>r</italic>=0.62, <italic>P</italic>&lt;0.05). (4) Expression of t-Tau, Ser262 and GSK3β protein in the entorhinal cortex-hippocampus: compared with the control group, the expression of t-Tau, p-Tau (Ser262) and GSK3β protein of entorhinal cortex and hippocamp increased more significantly in the model group (<italic>P</italic>&lt;0.05).ConclusionThe Tau protein in the entorhinal cortex-hippocampus of the P301LTau mouse model was hyperphosphorylated, which leads to destruction of the nerve fiber structures in the entorhinal cortex-hippocampus and learning and memory dysfunctions. …”
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Lower Plasma β-Amyloid 1-42 Levels in Amnestic Mild Cognitive Impairment Compared to Healthy Individuals by Cynthia Cynthia, Jusak Nugraha, Muhammad Hamdan, Hari Basuki Notobroto, Silvia Francina Lumempouw, Rahajuningsih Dharma

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Decreased prefrontal activation during verbal fluency task after repetitive transcranial magnetic stimulation treatment for depression in Alzheimer’s disease: a functional near-inf... by Yuanzhi Zhao, Yuanzhi Zhao, Conglong Qiu, Conglong Qiu, Ping Lin, Ping Lin, Mei Yang, Mei Yang, Ling Huang, Ling Huang, Zheng Zhao, Zheng Zhao, Xiangping Wu, Dongsheng Zhou, Dongsheng Zhou

“…However, the underlying mechanisms remain poorly understood. The measurement of brain activation links neurobiological and functional aspects but is challenging in patients with dementia. …”
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Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway by Li Q, Zheng JW, Wang ZY, Liao SP, Zhu L, Wang X, Wan LH

“…This study was conducted to explore the protective effects and mechanism of rosmarinic acid (RA) against ERS in endotoxin-induced cognitive dysfunction in mice and neuronal injury in cells.Methods: The efficacy of RA was evaluated using an endotoxin-induced cognitive dysfunction mice model and an in vitro neuronal injury model. Brain injury was assessed using behavioral tests and hematoxylin and eosin (HE) staining. …”
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Potential Risk Factors for In-Hospital Mortality in Patients with Moderate-to-Severe Blunt Multiple Trauma Who Survive Initial Resuscitation by Neslihan Yucel, Tuba Ozturk Demir, Serdar Derya, Hakan Oguzturk, Murat Bicakcioglu, Funda Yetkin

“…Multivariate analysis identified low blood pH (odds ratio [OR] 6.580, 95% confidence interval [CI] 1.12-38.51), high serum lactate level (OR 1.041, 95% CI 1.01-1.07), high ISS (OR 1.109, 95% CI 1.06-1.16), high APACHE II score (OR 1.189, 95% CI 1.07-1.33), traumatic brain injury (TBI) (OR 4.358, 95% CI 0.76-24.86), severe hemorrhage (OR 5.314, 95% CI 1.07-26.49), and coagulopathy (OR 5.916, 95% CI 1.17-29.90) as useful predictors of acute in-hospital mortality. …”
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Chronic Inhibition of FAAH Reduces Depressive-Like Behavior and Improves Dentate Gyrus Proliferation after Chronic Unpredictable Stress Exposure by A. R. Tejeda-Martínez, J. M. Viveros-Paredes, G. V. Hidalgo-Franco, E. Pardo-González, V. Chaparro-Huerta, R. E. González-Castañeda, M. E. Flores-Soto

“…Alterations at the HPA axis level were analyzed using the relative weight of adrenal glands and serum corticosterone levels. Oxidative stress and brain-derived neurotrophic factor (BDNF) were also evaluated. …”
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Mechanism of sodium nitroprusside regulating ginseng quality by Wei Zhang, Pengcheng Yu, Wenfei Liu, Liyang Wang, Xiaowen Song, Yao Yao, Xiubo Liu, Xiangcai Meng

“…The Morris water maze (MWM), histopathological analysis and oxidative stress indexes in brain tissues were used to evaluate the anti-aging effect, indicating that the SNP-treated ginseng further ameliorated D-gal-induced the impaired memory function and oxidative stress in mice, implying the efficacy of SNP-treated ginseng was better than untreated ginseng’s. …”
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Prognostic Value of CXCL13, CCL11, and CCL20 Chemokines in Multiple Sclerosis by Işıl Peker, Hacer Eroğlu İçli, Belgin Mutluay, Burcu Yüksel, Zeynep Özdemir, Mesrure Köseoğlu, Aysu Şen, Dilek Ataklı, Aysun Soysal, Musa Öztürk

“…A PATH analysis showed CSF CXCL13 was significantly associated with new T2 hyperintense lesions on brain magnetic resonance imaging (<i>p</i> < 0.001), and baseline serum CCL11 levels were associated with EDSS (<i>p</i> = 0.030), implying its potential role in indicating neurodegenerative processes and possible progression risk. …”
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Finding the Intersection of Neuroplasticity, Stroke Recovery, and Learning: Scope and Contributions to Stroke Rehabilitation by Leeanne Carey, Alistair Walsh, Achini Adikari, Peter Goodin, Damminda Alahakoon, Daswin De Silva, Kok-Leong Ong, Michael Nilsson, Lara Boyd

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Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease by Hiam Naiditch, Michael R. Betts, H. Benjamin Larman, Moshe Levi, Avi Z. Rosenberg

“…In this context, endovascular neutrophil extracellular trap (NET) formation and microthrombi development can be seen in the lungs and other critical organs throughout the body, such as the heart, gut, and brain. The kidney may be among the most impacted extrapulmonary organ by SARS-CoV-2 infection owing to a high concentration of ACE2 and exposure to systemic SARS-CoV-2. …”
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