Sleep quality among sample of Egyptian patients with Alzheimer’s disease: risk factors and role of genetic profiling for ACE, ACE 2 and APO E genotypes by Khaled Ahmed Elbeh, Mohamed Abdala Abbas, Mohammed H. Hassan, Mohamed Moslem Hefny, Shimaa Fathy Sakr, Reham Bakry Mohamed, Mahmoud Ahmed Bekiet, Tarek Desoky

“…Abstract Background Most individuals having Alzheimer’s disease generally experience increased frequency of awakenings as well as prolonged wakefulness periods at night. Brain wave research indicate reductions in both REM (dreaming stage) along with NREM (non-dreaming stage). …”
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Chlorotoxin-functionalized mesoporous silica nanoparticles for pH-responsive paclitaxel delivery to Glioblastoma multiforme by Mirjana Mundžić, Amelia Ultimo, Minja Mladenović, Aleksandra Pavlović, Oliviero L. Gobbo, Eduardo Ruiz-Hernandez, Maria Jose Santos-Martinez, Nikola Ž. Knežević

“…Glioblastoma multiforme (GBM) is a highly aggressive brain cancer associated with poor survival rates. …”
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Clinical Observation of Different Acupuncture Measures on Restoration of Ischemic Stroke Patients'Hand Function by Zheng JIANG, Liping ZHUO, Shaoqin LIAO, Sai'e HUANG

“…Objective:To assess the differences in brain functional connectivity among transcutaneous nerve stimulation (TS), electroacupuncture (EA), manual acupuncture (MA) and sham acupuncture (SA) in ischemic stroke (IS) patients with upper limb dysfunction using resting-state functional magnetic resonance imaging (rsfMRI).Methods:148 IS patients with upper limb dysfunction were randomly assigned to TS group (<italic>n</italic>=37), EA group (<italic>n</italic>=36), MA group (<italic>n</italic>=38) and SA group (<italic>n</italic>=37). …”
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Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature by Sandra Maria Barbalho, Beatriz Leme Boaro, Jéssica da Silva Camarinha Oliveira, Jiří Patočka, Caroline Barbalho Lamas, Masaru Tanaka, Lucas Fornari Laurindo

“…Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by the dysregulation of molecular pathways and activation of the brain’s immune system, resulting in the release of pro-inflammatory and oxidative molecules. …”
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Adenosine A2A receptor activation is necessary to gate the TrkB-dependent intramuscular nerve sprouting during muscle reinnervation after a nerve crush by Michael Di Palma, Davide Lattanzi, Patrizia Ambrogini, Stefano Sartini

“…Compelling evidence has demonstrated that rehabilitation through physical exercise, a non-invasive and non-surgical intervention, enhances muscle reinnervation and motor recovery after peripheral nerve injury (PNI) by increasing muscle-derived brain-derived neurotrophic factor (BDNF) expression and triggering TrkB-dependent axonal plasticity. …”
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Analysis of risk factors for acute cerebral infarction in patients with intracranial tuberculosis by Xiao-Shan Huang, Xiao-Wei Qiu, An-Long Wang, Fei He, Yi-Jing Wang

“…ObjectiveAcute cerebral infarction is a common complication of intracranial tuberculosis (TB), causing irreversible damage to brain tissue and significantly affecting patient prognosis. …”
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Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study by Jincheol Seo, Kyung Seob Lim, Chang-Yeop Jeon, SeungHo Baek, Hyeon-Gu Yeo, Won Seok Choi, Sung-Hyun Park, Kang Jin Jeong, Jinyoung Won, Keonwoo Kim, Junghyung Park, Jiyeon Cho, Jung Bae Seong, Minji Kim, Yu Gyeong Kim, Jae-Won Huh, Samhwan Kim, Yong Hoon Lim, Hyung Woo Park, Hye Min Tak, Man Seong Heo, Ji-Woong Choi, Sun Ha Paek, Youngjeon Lee

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Optimization of a microarray for fission yeast by Dong-Uk Kim, Minho Lee, Sangjo Han, Miyoung Nam, Sol Lee, Jaewoong Lee, Jihye Woo, Dongsup Kim, Kwang-Lae Hoe

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Temporal Trends in Serum Homer1 Levels and Their Prognostic Implications in Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study by Dai J, Lin Q, Ye L, Chen X, Li Z, Lu C, Chen M, Ba H, Sun J, Cai J

“…Junxia Dai, Qun Lin, Liangzhi Ye, Xiaoxiang Chen, Zhiwei Li, Chuan Lu, Maohua Chen, Huajun Ba, Jun Sun, Jianyong Cai Department of Neurosurgery, Laboratory of Pan-Vascular Disease Management Center, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, Wenzhou, 325000, People’s Republic of ChinaCorrespondence: Jianyong Cai, Email wzlqcjy@163.comBackground: Homer scaffold protein 1 (homer1) may harbor neuroprotective effects against acute brain injury. This study aimed to investigate the prognostic role of serum homer1 in human aneurysmal subarachnoid hemorrhage (aSAH).Methods: A total of 209 patients with aSAH and 100 controls were encompassed in this prospective cohort study. …”
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Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging by Anqin Wang, Hongli Wu, Chunsheng Xu, Lanfeng Tang, Jaeyoun Lee, Min Wang, Man Jiang, Chuanfu Li, Qi Lu, Chunyun Zhang

“…Wilson’s disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain and any other tissues. This article aimed to assess lesions in cerebello-thalamo-cortical network with an advanced technique of diffusion tensor imaging (DTI) in WD. 35 WD patients and 30 age- and sex-matched healthy volunteers were recruited to accept diffusion-weighted images with 15 gradient vectors and conventional magnetic resonance imaging (MRI). …”
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Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection by Ilya A Rybak, Natalia A Shevtsova, Johannie Audet, Sirine Yassine, Sergey N Markin, Boris I Prilutsky, Alain Frigon

“…The thoracic lateral hemisection represents an experimental model of an incomplete spinal cord injury, where connections between the brain and spinal cord are abolished on one side of the cord. …”
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Analgesia and sedation strategies in neonates undergoing whole-body therapeutic hypothermia: A scoping review. by Mahima Joshi, Javed Muneer, Lawrence Mbuagbaw, Ipsita Goswami

“…There is insufficient data on the long-term neurological outcomes of exposure to these medications, adjusted for underlying brain injury and severity of encephalopathy. Future studies will need to develop framework tools to enable precise control of sedation/analgesia drug exposure customized to individual patient needs.…”
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Study on the Regulation Effect of Optogenetic Technology on LFP of the Basal Ganglia Nucleus in Rotenone-Treated Rats by Zongya Zhao, Yanxiang Niu, Peiqi Chen, Yu Zhu, Liangliang Shi, Xuewei Zhao, Chang Wang, Yehong Zhang, Zhixian Gao, Wenshuai Jiang, Wu Ren, Renjun Gu, Yi Yu

“…After observing the behavior and brain morphology, 16 models were finally determined to be successful. …”
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Neurophysiological Effects of Chronic Indoor Environmental Toxic Mold Exposure on Children by Ebere C. Anyanwu, Andrew W. Campbell, Aristo Vojdani

“…Also, there was highly marked 1 to 3 Hz delta activity that was asymmetrical in the right hemisphere of the brain in three out of ten patients. The waveforms of BAEP showed abnormalities in 90% of the patients with both 15’ and 31’ check sizes compared to none in the controls. …”
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Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection by Timo Hautala, Terhi Partanen, Tarja Sironen, Saara-Mari Rajaniemi, Nina Hautala, Olli Vainio, Olli Vapalahti, Heikki Kauma, Antti Vaheri

“…These results reinforce the view that PUUV-HFRS is a general infection that affects the central nervous system and the blood-brain barrier.…”
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Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO by Vidya Narayanaswami PhD, Kenneth Dahl PhD, Vadim Bernard-Gauthier PhD, Lee Josephson PhD, Paul Cumming PhD, Neil Vasdev PhD

“…The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain’s resident macrophages, microglia. Although initiation of an inflammatory response may be beneficial in response to injury of the nervous system, chronic or maladaptive neuroinflammation can have harmful outcomes in many neurological diseases. …”
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Acute Neurotoxicity in Children Treated for Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma: A 10-Year Single-Centre Experience by Izabela Kranjčec, Nada Rajačić, Tamara Janjić, Monika Kukuruzović, Filip Jadrijević-Cvrlje, Maja Pavlović, Jelena Roganović

“…We detected electroencephalogram (EEG) irregularities in almost all patients and various morphological changes in the brain magnetic resonance imaging (MRI), most often consistent with posterior reversible encephalopathy syndrome and leukoencephalopathy. …”
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Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke by Weilin Xu, Weilin Xu, Jun Yan, Zachary D. Travis, Cameron Lenahan, Liansheng Gao, Liansheng Gao, Haijian Wu, Haijian Wu, Jingwei Zheng, Jingwei Zheng, Jianmin Zhang, Jianmin Zhang, Anwen Shao, Anwen Shao, Jun Yu, Jun Yu

“…However, the distribution of the apelin/APJ system varies across different regions and subcellular organelles of the brain. Additionally, the neuroprotective effects of the apelin/APJ system have been reported to inhibit oxidative and nitrative stresses via various signaling pathways. …”
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Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls by Alex P. Lange, Reza Sadjadi, Jameelah Saeedi, Janette Lindley, Fiona Costello, Anthony L. Traboulsee

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Exploratory Investigation of Intestinal Structure and Function after Stroke in Mice by Diya Ye, Yuting Hu, Ning Zhu, Weizhong Gu, Gao Long, Enfu Tao, Marong Fang, Mizu Jiang

“…Ischemic stroke was made as a disease model in mice, in which brain and ileal tissues were collected for experiments on the 1st and 7th day after stroke. …”
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