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6541
Bariatric Endocrinology: Principles of Medical Practice
Published 2014-01-01“…Therapy for adiposopathy hinges on effectively lowering the ratio of orexigenic to anorexigenic signals reaching the the hypothalamus and other relevant brain regions, favoring a lower caloric intake. Adiposopathy, overweight and obesity should be treated indefinitely with the specific aims to reduce fat mass for the adiposity complications, and to normalize adipose tissue function for the adiposopathic complications. …”
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6542
Glymphatic system clearance and Alzheimer’s disease risk: a CSF proteome-wide study
Published 2025-01-01“…In Stage 1 (evaluated in the Cohort 1 of aMCI participants (n = 11)), we correlated the levels of 7K cerebrospinal fluid (CSF) proteins (estimated by SOMAscan) with GS health in 78 Freesurfer-segmented brain regions of interest (ROIs). Results A total of seven different proteins were significantly associated with GS health (p-value < 6.4 × 10–4). …”
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6543
Clinical study of colorViz fusion image vascular grading based on multi-phase CTA reconstruction in acute ischemic stroke
Published 2025-01-01“…Results The mCTA ColorViz fusion images revealed ischemic changes in brain tissue, demonstrating a sensitivity of 88.7% for superficial infarctions and 48.5% for deep infarctions. …”
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6544
The Association of Depression and Anxiety Disorders With Gastrointestinal Symptoms Among Nurses
Published 2025-01-01“…Background: The significant overlap of psychological disorders in both functional and organic gastrointestinal (GI) diseases highlights the complex and interconnected relationship between the brain and the gut. Objectives: This study investigated the association between depression and anxiety with GI symptoms among nurses. …”
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6545
Iconography of abnormal non-neuronal cells in pediatric focal cortical dysplasia type IIb and tuberous sclerosis complex
Published 2025-01-01“…These abnormal cells emerge during early brain development as a result of a hyperactive mTOR pathway and may express both neuronal and glial markers. …”
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6546
Spectral and coupling characteristics of somatosensory cortex and centromedian thalamus differentiate between pre- and inter-ictal 5–9 Hz oscillations in a genetic rat model of abs...
Published 2025-02-01“…Time-frequency analysis was used to assess spectral power and non-linear-association analysis was used to determine coupling strength and directionality between brain areas. Phase-specific electrical stimulation was used to compare cortical excitability and to assess the risk for epileptic afterdischarges.Coupling strength and spectral power were higher for the inter-ictal compared to the pre-ictal 5–9 Hz oscillations. …”
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6547
Effectiveness and utilization of a cognitive screening program for primary geriatric care
Published 2025-01-01“…Medical records documented discussion of screening results with the patient in 69% of cases (80% if MCI or dementia was detected) and often referral to a specialist (62%), new brain imaging (54%), or change in medication (58%) when screening indicated potential cognitive impairment. …”
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6548
Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis
Published 2015-01-01“…Despite an efficient B cell transmigration across brain derived endothelial cells, total and anti-MOG B cells transmigration was similar between MS and HI. …”
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6549
GEPREP: A comprehensive data atlas of RNA-seq-based gene expression profiles of exercise responses
Published 2025-12-01“…There were also samples across 9 mice tissues with skeletal muscle (359, 35.7 %) and brain (280, 27.8 %) accounting for the main fractions. …”
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6550
A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD
Published 2025-01-01“…When delivered to the brain of a transgenic rodent model, this Cas13-based platform curbed the expression of the G4C2 repeat-containing RNA without affecting normal C9ORF72 levels, which in turn decreased the formation of RNA foci, reduced the production of a dipeptide repeat protein, and reversed transcriptional deficits. …”
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6551
Visual Imagery in Modern Mind-Body Practices: Biophotonic Information Transfer through Water-Mediated Neural Resonance
Published 2025-01-01“…Evidence suggests that KKK practice induces measurable changes in practitioners' biophotonic emissions, particularly from brain regions and fingertips. These changes correlate with specific EEG patterns and entropy measures. …”
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6553
Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects
Published 2025-01-01“…Notably, LDRT demonstrates remarkable efficacy even in challenging metastatic sites such as the liver (uveal) and brain (cutaneous), particularly in advanced melanoma stages. …”
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6554
Association between deep gray matter iron deposition and clinical symptoms in Parkinson’s disease: a quantitative susceptibility mapping study
Published 2025-01-01“…PurposeThis study aimed to assess the association between motor and non-motor symptoms of Parkinson’s disease (PD) and iron accumulation within the deep gray matter of the brain by Quantitative Susceptibility Mapping (QSM).MethodsFifty-six PD patients and twenty-nine healthy controls were recruited in this study. …”
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6555
Efficacy and safety of Xiongzhitongluo granules in the treatment of acute ischemic stroke: study protocol for a randomized controlled trial
Published 2025-01-01“…Intravenous thrombolysis and mechanical thrombectomy are essential treatments for AIS, offering substantial benefits for neurological recovery and brain protection. However, their efficacy is often limited by stringent time constraints and contraindications, restricting accessibility for certain patient populations. …”
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6556
Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults
Published 2025-01-01“…Plasma biomarkers provide an accessible way to assess evolving brain changes; non-specific neurodegeneration (NfL, GFAP) or evolving Alzheimer’s disease (Aβ 42/40 ratio, P-Tau181). …”
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6557
Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma
Published 2024-12-01“…<b>Background/Objectives:</b> The two obstacles for treating glioma are the skull and the blood brain–barrier (BBB), the first of which forms a physical shield that increases the difficulties of traditional surgery or radiotherapy, while the latter prevents antitumor drugs reaching tumor sites. …”
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6558
Unveiling risk factors: a prognostic model of frequent peritonitis in peritoneal dialysis patients
Published 2025-01-01“…In the training set, we found several independent risk factors significantly associated with frequent episodes in PDAP patients, including diabetes mellitus (DM), hemoglobin (HB), serum albumin (ALB), lactatic dehydrogenase (LDH), serum potassium (K), N-terminal pro-brain natriuretic peptide (NT-proBNP) and peritoneal dialysate white cell counts on day 1. …”
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6559
An Atypical Case of Taravana Syndrome in a Breath-Hold Underwater Fishing Champion: A Case Report
Published 2013-01-01“…A magnetic resonance imaging of the brain disclofsed a cortical T1-weighted hypointense area in the temporal region corresponding to infarction with partial hemorrhage. …”
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6560
Proximity‐dependent biotinylation reveals an interaction between ubiquitin‐specific peptidase 46 and centrosome‐related proteins
Published 2025-01-01“…Ubiquitin‐specific peptidase 46 (USP46), a deubiquitinase, is highly expressed in the brain and regulates neural functions. Deleting lysine 92 (ΔK92) in USP46 reduces murine depression‐like behavior in the tail suspension test. …”
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