Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based study by Qin Lu, Yongyan Wu, Yonglin Xie, Shuxu Yang, Hongchuan Jin

“…BackgroundWHO grade II oligodendroglioma (OG/II) is a rare primary brain tumor with various outcomes. Our study aims to investigate prognostic factors for postoperative OG/II patients and then evaluate the instructional value of tumor size.MethodsWe retrospectively studied the cases from the Surveillance, Epidemiology, and End Results (SEER) database. …”
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White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study by K. P. Wadden, S. Peters, M. R. Borich, J. L. Neva, K. S. Hayward, C. S. Mang, N. J. Snow, K. E. Brown, T. S. Woodward, S. K. Meehan, L. A. Boyd

“…Continuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the contralesional hemisphere, can influence the excitability of the ipsilesional hemisphere in individuals with stroke. cTBS applied prior to skilled motor practice interventions may augment motor learning; however, there is a high degree of variability in individual response to this intervention. …”
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Enhancement of Cognitive Benefits and Anti-Anxiety Effects of <i>Phytolacca americana</i> Fruits in a Zebrafish (<i>Danio rerio</i>) Model of Scopolamine-Induced Memory Impairment by Lucia-Florina Popovici, Ion Brinza, Florentina Gatea, Georgiana Ileana Badea, Emanuel Vamanu, Simona Oancea, Lucian Hritcu

“…Subsequently, the activity of acetylcholinesterase (AChE) and the extent of oxidative stress in the zebrafish brain were investigated. Our findings suggest that both PEC and PEU possess anxiolytic effects, alleviating SCO-induced anxiety and enhancing cognitive performance in amnesic zebrafish. …”
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Effect of PCSK9 inhibitor on early neurological deterioration in acute ischemic stroke patients with a history of coronary heart disease: a study protocol for a randomized controll... by Xing Gong, Xinting Yu, Lanlan Pu, Yang Jiao, Lin Liu, Hua Cao, Xiaofei Ji

“…Shared risk factors between CHD and AIS, especially elevated low-density lipoprotein cholesterol (LDL-C), contribute to atherosclerosis and inflammation, which worsen brain tissue damage. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors offer a promising treatment option. …”
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Leveraging survival analysis and machine learning for accurate prediction of breast cancer recurrence and metastasis by Shahd M. Noman, Youssef M. Fadel, Mayar T. Henedak, Nada A. Attia, Malak Essam, Sarah Elmaasarawii, Fayrouz A. Fouad, Esraa G. Eltasawi, Walid Al-Atabany

“…The LightGBM model reached an AUC of 92% in predicting recurrences, while XGBoost and Random Forest models distinguished recurrence types with up to 86% accuracy, and they effectively differentiated between bone metastasis and all other locations combined (brain, liver, and lungs). This study highlights the significant potential of machine learning in advancing breast cancer management and sets a new benchmark for predictive analytics. …”
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Valerenic acid ameliorates amphetamine-related neurotoxicity by improving hypothalamus tyrosine hydroxylase and histamine-N-methyl transferase enzymes by Khaled M.M. Koriem, Ammar H.A. Naiem

“…Results: METH decreased superoxide dismutase, glutathione peroxidase, catalase, NADPH oxidase, interleukin-10, sucrose preference test, distance traveled test, and center square entries test, ATPase activity and the enzymes tyrosine hydroxylase and histamine-N-methyl transferase but increased malondialdehyde, conjugated dienes, oxidative index, serotonin, dopamine, norepinephrine, γ-aminobutyric acid, tumor necrosis factor-α, interleukin-1β, interleukin-6, nuclear factor kappa B levels, the center square duration test, tail suspension test, and forced swimming test. in the METH-treated animals' brain in contrast to the control group. After four weeks of oral administration of VA to METH-treated rats, all of these parameters returned to levels that were nearly control, indicating that a higher dose was more effective than a lower one. …”
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Case report: Adult case of A20 haploinsufficiency suspected as neuro-Behçet disease by Harumi Shirai, Naoko Saito-Sato, Naoko Saito-Sato, Emiko Horiuchi, Hirotoshi Kikuchi, Saori Kadowaki, Hidenori Ohnishi, Takeshi Suzuki

“…He experienced transient episodes of diplopia over a short period, and brain magnetic resonance imaging T2 fluid-attenuated inversion recovery images revealed nonspecific hyperintensities in the cerebral white matter. …”
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Parkinson’s Disease Prediction: An Attention-Based Multimodal Fusion Framework Using Handwriting and Clinical Data by Sabrina Benredjem, Tahar Mekhaznia, Abdulghafor Rawad, Sherzod Turaev, Akram Bennour, Bourmatte Sofiane, Abdulaziz Aborujilah, Mohamed Al Sarem

“…Our focus in this investigation is on PD, a neurodegenerative disorder characterized by the loss of dopamine-producing neurons in the brain, leading to motor disturbances. Early detection of PD is paramount for enhancing quality of life through timely intervention and tailored treatment. …”
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Development of clinical decision support for patients older than 65 years with fall-related TBI using artificial intelligence modeling. by Biche Osong, Eric Sribnick, Jonathan Groner, Rachel Stanley, Lauren Schulz, Bo Lu, Lawrence Cook, Henry Xiang

“…<h4>Background</h4>Older persons comprise most traumatic brain injury (TBI)-related hospitalizations and deaths and are particularly susceptible to fall-induced TBIs. …”
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Auditory attention decoding based on neural-network for binaural beamforming applications by Roy Gueta, Elana Zion-Golumbic, Jacob Goldberger, Sharon Gannot

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Impaired arbitration between reward-related decision-making strategies in Alcohol Users compared to Alcohol Non-Users: a computational modeling study by Srinivasan A. Ramakrishnan, Riaz B. Shaik, Tamizharasan Kanagamani, Gopi Neppala, Jeffrey Chen, Vincenzo G. Fiore, Christopher J. Hammond, Shankar Srinivasan, Iliyan Ivanov, V. Srinivasa Chakravarthy, Wouter Kool, Muhammad A. Parvaz

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Optimal treatment approach for intracranial germinoma: a systematic review and meta-analysis by Zhirui Zhou, Jiabing Liu, Qi Yue, Lingxiao Chen, Xiwei Zhang, Xin Lin, Lin Zheng, Enmin Wang, Yang Wang, Ying Mao

“…Meta-analyses demonstrated focal field RT were with higher recurrence rate compared with craniospinal irradiation (CSI) [RR = 7.128, 95% CI (5.083, 9.995)], whole-brain RT (WBRT) [RR = 4.094, 95% CI (2.923, 5.735)] or whole-ventricle RT (WVRT) [RR = 3.361, 95% CI (2.126, 5.312)]; both WBRT and WVRT were also with higher recurrence compared with CSI; but no significant difference in recurrence and mortality between WVRT and WBRT. …”
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Effect of nursing process-based nursing decision implementation on emergency patients with acute ST-segment elevation myocardial infarction by Tiantian Wan, Caixia Wang, Jingli Shi, Shujian Wu

“…Data on time management indicators, major cardiac adverse events, QoL scores, left ventricular ejection fraction (LVEF), brain natriuretic peptide (BNP), and cardiac troponin I (cTnI) levels were collected. …”
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Degradation of amyloid β-peptides catalyzed by nattokinase in vivo and in vitro by Aixin Ni, He Li, Ruya Wang, Rentong Sun, Yingjiu Zhang

“…Peripheral clearance of Aβ42 largely affects its level in the brain and affects AD progression. Although nattokinase (NK) degrades Aβ40, the details of NK’s capture of various Aβ species and reduction of plasma Aβ42/Aβ40 are uncharacterized. …”
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Advancements in the Treatment of Mucopolysaccharidoses: From Established Therapies to Gene Therapy by Joanna Wanat, Wojciech Homa, Aleksandra Warunek, Gabriela Gronowicz, Izabela Dzikowska, Agata Siejka, Daria Stefaniak, Weronika Zielińska, Michał Chról

“…Among the promising new treatments are: blood-brain barrier (BBB)-penetrable enzyme replacement therapy (ERT), substrate reduction therapy, nonsense suppression therapy, and mRNA engineering. …”
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When to stop social learning from a predecessor in an information-foraging task by Hidezo Suganuma, Aoi Naito, Kentaro Katahira, Tatsuya Kameda

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Environmental maternal exposures and the risk of premature birth and intrauterine growth restriction: The Generation Gemelli study protocol of newborn exposome. by Leonardo Villani, Angelo Maria Pezzullo, Roberta Pastorino, Alessandra Maio, Francesca Stollagli, Chiara Tirone, Marta Barba, Angela Maria Cozzolino, Denise Pires Marafon, Martina Porcelli, Annamaria Sbordone, Maria Letizia Patti, Anthea Bottoni, Angela Paladini, Simona Fattore, Domenico Marco Romeo, Ornella Parolini, Wanda Lattanzi, Guido Rindi, Luca Tamagnone, Marco Marazza, Maurizio Genuardi, Elisabetta Tabolacci, Eugenio Maria Mercuri, Antonio Chiaretti, Tina Pasciuto, Maurizio Sanguinetti, Vincenzo Valentini, Giovanni Scambia, Walter Ricciardi, Giovanni Vento, Antonio Lanzone, Stefania Boccia

“…We will perform laboratory examinations including dosage of heavy metals and essential elements, investigation of placental distress and fetal brain damage of biomarkers, analysis of microbiota and of DNA methylation profile. …”
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Effects of Manual Acupuncture Versus Sham Acupuncture in patients with Post-Stroke Depression: A Randomized Clinical Trial by Conghui Wei, Jinling Chen, Qu Yang, Jingjing Xu, Qingsong Li, Fulin Li, Yu Liu, Jun Luo

“…Meanwhile, the mechanism of acupuncture in treating PSD patients may be through decreasing the slow wave power spectrum and increasing the fast wave power spectrum, and enhancing brain functional connectivity. Trial registration Chinese Clinical Trial Registry (ChiCTR2200065112/2022-10-28).…”
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Evaluation of plasma cell sorting methods in multiple myeloma patients: flow cytometry versus magnetic beads by Yu Jeong Choi, Jaeguk Choi, Yehyun Kang, Saeam Shin, Seung-Tae Lee, Jong Rak Choi

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Development, in vitro and ex vivo characterization of lamotrigine-loaded bovine serum albumin nanoparticles using QbD approach by Maryana Salamah, Bence Sipos, Zsuzsanna Schelz, István Zupkó, Ágnes Kiricsi, Ágnes Szalenkó-Tőkés, László Rovó, Gábor Katona, György Tibor Balogh, Ildikó Csóka

“…The results of the blood-brain barrier parallel artificial membrane permeability assay (BBB-PAMPA) showed an increase in the permeability of LAM through the BBB with NP-GLUC-9 and an increase in flux with all selected formulations. …”
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