A rare case of adult-onset vanishing white matter leukoencephalopathy with movement disorder, expressing homozygous EIF2B3 and PRKN pathogenic variants by Bashar Kamal Ali Douden, Yazan Mohammad Abdullah Abufara, Mahmood Fayez Ali Aldrabeeh, Naela Ramadan Mohammad Tell, Ismail Abudaya

“…It is typified by a gradual loss of white matter in the brain and spinal cord, which results in impairments in vision and hearing, cerebellar ataxia, muscular weakness, stiffness, seizures, and dysarthria cogitative decline. …”
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Predictive modeling of consecutive intravenous immunoglobulin treatment resistance in Kawasaki disease: A nationwide study by Eun Jung Cheon, Gi Beom Kim, Seung Park

“…Clinical and laboratory findings included white blood cell count, absolute neutrophil count (ANC), platelet count, erythrocyte sedimentation rate, serum protein, aspartate aminotransferase, alanine aminotransferase, total bilirubin, N-terminal pro-brain natriuretic peptide, and presence of pyuria. …”
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Multitask Learning-Based Pipeline-Parallel Computation Offloading Architecture for Deep Face Analysis by Faris S. Alghareb, Balqees Talal Hasan

“…Deep Neural Networks (DNNs) have been widely adopted in several advanced artificial intelligence applications due to their competitive accuracy to the human brain. Nevertheless, the superior accuracy of a DNN is achieved at the expense of intensive computations and storage complexity, requiring custom expandable hardware, i.e., graphics processing units (GPUs). …”
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Nonfluent/Agrammatic PPA with In-Vivo Cortical Amyloidosis and Pick’s Disease Pathology by Francesca Caso, Benno Gesierich, Maya Henry, Manu Sidhu, Amanda LaMarre, Miranda Babiak, Bruce L. Miller, Gil D. Rabinovici, Eric J. Huang, Giuseppe Magnani, Massimo Filippi, Giancarlo Comi, William W. Seeley, Maria Luisa Gorno-Tempini

“…This patient demonstrates that biomarkers indicating brain amyloidosis should not be considered conclusive evidence that AD pathology accounts for a typical FTD clinical/anatomical syndrome.…”
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Association between the dietary index for gut microbiota and diabetes: the mediating role of phenotypic age and body mass index by Yingxuan Huang, Xiaobo Liu, Chanchan Lin, Xinqi Chen, Yingyi Li, Yisen Huang, Yubin Wang, Xiaoqiang Liu

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Development and in vitro evaluation of biomimetic injectable hydrogels from decellularized human nerves for central nervous system regeneration by Gopal Agarwal, Kennedy Moes, Christine E. Schmidt

“…Human SH-SY5Y neuroblastoma cells exhibited higher viability and improved neuronal differentiation in iHPN compared to TCP. Human brain neurons had higher neuronal differentiation within iHPN compared to TCP or collagen hydrogels. …”
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Developing non-invasive molecular markers for early risk assessment of Alzheimer's disease by Tapas K. Sur, Tanmoy Mondal, Zarish Noreen, Jheannelle Johnson, Gail Nunlee-Bland, Christopher A. Loffredo, Brent E. Korba, Vijay Chandra, Siddhartha S. Jana, Bernard Kwabi-Addo, Sumit Sarkar, Somiranjan Ghosh

“…Current improvements have unveiled the disease's pathophysiology and clinical diagnostic tests, targeting the neurological changes (neurodegeneration, amyloid precursor protein metabolism and tangle pathology) with precise PET/MRI imaging and xMAP/SIMOA (Multiplex simultaneous detection/single molecule array) to identify and quantify β-amyloids (Aβ40, Aβ42), total tau (T-tau) and phosphorylated tau (P-tau) proteins in the brain and cerebrospinal fluid (CSF) of patients. …”
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Mutation Analysis of Synthetic DNA Barcodes in a Fission Yeast Gene Deletion Library by Sanger Sequencing by Minho Lee, Shin-Jung Choi, Sangjo Han, Miyoung Nam, Dongsup Kim, Dong-Uk Kim, Kwang-Lae Hoe

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Policy Versus Practice: Facilitators and Barriers of Chronic Care Integration in Dutch General Practice – a Survey Study by Toine E. P. Remers, Simone A. van Dulmen, Erik W. M. A. Bischoff, Florien M. Kruse, Marcel G. M. Olde Rikkert, Patrick P. T. Jeurissen

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Erratum to ‘Efficacy and safety of local fibrinolytic therapy in intracranial hemorrhages: A systematic review and meta-analysis of randomised controlled trials’ [World Neurosurger... by Arun Babu Rajeswaran, Arshad Ali, Saleh Safi, Ahmed Eid Abdulghani Saleh

“…In pooled analysis for ICH, with fibrinolysis vs standard craniotomy, there was a reduced mortality [RR-0.65 (0.20, 2.51)] with decreased risk for new hemorrhages in the fibrinolysis arm [RR-0.48 (0.30, 0.78)] while in fibrinolysis vs standard medical treatment, the trend was also a reduced mortality [RR-0.83 (0.65, 1.05)] with favourable outcome [RR-1.20 (1.00, 1.44)] and higher risk of new bleeds (RR-2.27 [1.23, 4.19]) but no significant difference in brain infections (RR-1.34 [0.24, 7.49]). Conclusion: Local fibrinolytic therapy in ICH and IVH decreases mortality and improves the clot resolution but shows no substantial gain in the good functional outcome and has increased risk of new hemorrhages. …”
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Disability of military personnel in Ukraine for 2014-2022 by I.Y. Khanyukova, N.O. Hondulenko, N.A. Sanina

“…More than half of those first recognized as disabled were identified as such not due to traumatic injuries but for other reasons, mainly due to cardiovascular diseases (32.4%). Brain traumas and traumatic injuries of the limbs prevailed among the injuries. …”
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18F-Fluorothymidine-Pet Imaging of Glioblastoma Multiforme: Effects of Radiation Therapy on Radiotracer Uptake and Molecular Biomarker Patterns by Sanjay Chandrasekaran, Andrew Hollander, Xiangsheng Xu, Joseph L. Benci, James J. Davis, Jay F. Dorsey, Gary Kao

“…Conventional 18F-FDG-PET imaging is of limited usefulness for imaging Glioblastoma Multiforme (GBM) due to high levels of glucose uptake by normal brain and the resultant signal-to-noise intensity. 18F-Fluorothymidine (FLT) in contrast has shown promise for imaging GBM, as thymidine is taken up preferentially by proliferating cells. …”
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Screening and Functional Pathway Analysis of Pulmonary Genes Associated with Suppression of Allergic Airway Inflammation by Adipose Stem Cell-Derived Extracellular Vesicles by Sung-Dong Kim, Shin Ae Kang, Yong-Wan Kim, Hak Sun Yu, Kyu-Sup Cho, Hwan-Jung Roh

“…Expression of paraoxonase 1 (PON1), brain-expressed X-linked 2 (Bex2), insulin-like growth factor binding protein 6 (Igfbp6), formyl peptide receptor 1 (Fpr1), and secretoglobin family 1C member 1 (Scgb1c1) was significantly increased in asthmatic mice following treatment with ASC-derived EVs. …”
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Metagenomic analysis of DNA viruses from posttransplant lymphoproliferative disorders by Vikas R. Dharnidharka, Marianna B. Ruzinova, Chun‐Cheng Chen, Priyanka Parameswaran, Harry O'Gorman, Charles W. Goss, Hongjie Gu, Gregory A. Storch, Kristine Wylie

“…In univariable analysis, death within 5 years of PTLD diagnosis was associated with anellovirus (P = 0.037) and gammapapillomavirus (P = 0.036) detection by MSS, higher tissue qPCR levels of the predominant human anellovirus species torque teno virus (TTV; P = 0.016), T cell type PTLD, liver, brain or bone marrow location. In multivariable analyses, T cell PTLD (P = 0.006) and TTV PCR level (P = 0.012) remained significant. …”
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Association of Glioblastoma Multiforme Stem Cell Characteristics, Differentiation, and Microglia Marker Genes with Patient Survival by Sandra Bien-Möller, Ellen Balz, Susann Herzog, Laura Plantera, Silke Vogelgesang, Kerstin Weitmann, Carolin Seifert, Matthias A. Fink, Sascha Marx, Angela Bialke, Chitra Venugopal, Sheila K. Singh, Wolfgang Hoffmann, Bernhard H. Rauch, Henry W. S. Schroeder

“…Here, we performed expression analyses of stem cell (ABCG2, CD44, CD95, CD133, ELF4, Nanog, and Nestin) as well as differentiation and microglia markers (GFAP, Iba1, and Sparc) in GBM compared to nonmalignant brain. Furthermore, the role of these proteins for patient survival and their expression in LN18 stem-like neurospheres was analyzed. …”
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Reversal gene expression assessment for drug repurposing, a case study of glioblastoma by Shixue Sun, Zeenat Shyr, Kathleen McDaniel, Yuhong Fang, Dingyin Tao, Catherine Z. Chen, Wei Zheng, Qian Zhu

“…Abstract Background Glioblastoma (GBM) is a rare brain cancer with an exceptionally high mortality rate, which illustrates the pressing demand for more effective therapeutic options. …”
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Drosulfakinin signaling encodes early-life memory for adaptive social plasticity by Jiwon Jeong, Kujin Kwon, Terezia Klaudia Geisseova, Jongbin Lee, Taejoon Kwon, Chunghun Lim

“…In particular, social deprivation suppressed the expression of the neuropeptide Drosulfakinin (Dsk) in three pairs of adult brain neurons. Male-specific DSK signaling to cholecystokinin-like receptor 17D1 mediated the SNB plasticity. …”
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Correlation between Cortical Excitability and Hand Function in Patients with Subacute Cerebral Infarction by Ling CHEN, Junling WANG, Dongfeng HUANG

“…Objective:To observe the cortical activation characteristics of cerebral motor prediction in patients with subacute cerebral infarction in the palm grasping task, and to explore the correlation between cortical excitability and hand function in patients with cerebral infarction.Methods:A total of twenty-five patients with subacute cerebral infarction who were hospitalized in the first affiliated hospital of Sun Yat-sen University from January 2017 to March 2018 were selected as the experimental group, and twenty-five healthy individuals matched with the gender and age of the experimental group were selected as the control group.Event related potentials were used to collect the electroencephalogram signals of the two groups in the palm grasping task, and then analyzed the latencies and amplitudes of the contingent negative variation(CNV)in the cerebral cortex before motor activation.Action Research Arm Test(ARAT)was used to assess the function of hand, and the correlation between CNV amplitude and ARAT score was analyzed.Results:Compared with the control group, the CNV latencies in the midline region of the experimental group were significantly shorter during the left hand grasp and right hand grasp, and the CNV amplitude were statistically significantly increased in the midline, bilateral frontal lobe and primary motor area(M1)(<italic>P</italic>&lt;0.05).There was no significant difference in CNV latency between left hand grasp and right hand grasp in the experimental group(<italic>P</italic>&gt;0.05), with the CNV amplitude of Cz electrode in midline statistically significantly greater than that of C4 electrode in contralateral M1(<italic>P</italic>&lt;0.05).There was moderate correlation between the CNV amplitude and ARAT in the non-lesioned frontal lobe, M1 and midline during right hand grasp in the experimental group(F4: <italic>r</italic>=0.510; C4: <italic>r</italic>=0.442; Fz: <italic>r</italic>=0.428).There was moderate correlation between the CNV amplitude and ARAT in the non-lesioned frontal lobe, M1 and midline during left hand grasp in the experimental group(F4: <italic>r</italic>=0.422; C4: <italic>r</italic>=0.496; Fz: <italic>r</italic>=0.446).Conclusion:The neural mechanism of motor anticipation in patients with subacute cerebral infarction is abnormal, the time of brain motor preparation is prolonged, and the non-lesioned frontal lobe and M1 are hyperactivity compensatory during motor anticipation.There was moderate correlation between the cortical excitability and hand dysfunction.Therefore, CNV may be a neural indicator of the severity of hand dysfunction in patients with cerebral infarction.…”
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Intracranial otogenic complications in adults: new factors that influenced its onset, frequency and nature by Małgorzata Wierzbicka, Michalina Staśkiewicz, Oskar Rosiak, Katarzyna Karmelita-Katulska, Witold Szyfter, Wojciech Gawęcki

“…In COVID period, CVST was more prevalent, with 2 cases (22.2%) presenting solitary CVST, and 3 cases (33.3%) CVST and a simultaneous brain abscess or meningitis. CVST was much more frequent in the COVID period (p < 0.01). …”
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Single‐Nucleus RNA Sequencing Reveals That Gabra6+ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave‐Induced TBI by Xiaowei Fei, Zehan Zhang, Ya‐nan Dou, Weihao Lv, Hongqing Chen, Li Wang, Xin He, Wangshu Chao, Peng Luo, Zhou Fei

“…Abstract Shockwave‐induced traumatic brain injury (TBI) results in the onset of post‐traumatic stress disorder (PTSD), triggered either by the TBI itself or other stressors. …”
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