Patient stratification by genetic risk in Alzheimer's disease is only effective in the presence of phenotypic heterogeneity. by Jack Euesden, Muhammad Ali, Chloe Robins, Praveen Surendran, Padhraig Gormley, Alzheimer’s Disease Neuroimaging Initiative (ADNI), David Pulford, Carlos Cruchaga

“…Genome-wide association studies identified no loci associated with progression at genome-wide significance (α = 5×10-8); MR analyses provided no significant evidence of an association between cognitive decline in AD patients and protein levels in brain, cerebrospinal fluid (CSF), and plasma. Polygenic risk scores for AD risk did not reliably stratify fast from slow progressors; however, a deeper investigation found that APOE ε4 status predicts amyloid-β and tau positive versus negative patients (odds ratio for an additional APOE ε4 allele = 5.78 [95% confidence interval: 3.76-8.89], P<0.001) when restricting to a subset of patients with available CSF biomarker data. …”
Get full text

Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording by Gota Shinohara, Tasuku Kayama, Ayumu Okui, Wataru Oda, Atsushi Nishikawa, Alexander Loesing, Nahoko Kuga, Takuya Sasaki, Hiroto Sekiguchi

“…The thin MicroLED probes minimize invasiveness while maintaining optical performance. Validated in mouse brain models, the system achieves selective neural activation and recording with minimal thermal effects. …”
Get full text

Haemophilus parasuis Subunit Vaccines Based on Native Proteins with Affinity to Porcine Transferrin Prevent the Expression of Proinflammatory Chemokines and Cytokines in Pigs by R. Frandoloso, S. Martínez-Martínez, E. F. Rodríguez-Ferri, S. Yubero, D. Rodríguez-Lázaro, M. Hernández, C. B. Gutiérrez-Martín

“…However, overexpression of all proinflammatory molecules was observed in CHG group, mainly in the target infection tissues (brain, lungs, and spleen). High expression of CCL-2, CXCL-8, IL-1α, IL-1β, and IL-6 can be considered one of the characteristics of H. parasuis infection by serovar 5.…”
Get full text

Mtazamo Wa Walimu Wa Kiswahili Ka Tika Shule Za Upili Kuhusu UbadilishaJi Wa Mtaala Wa Elimu Wilay Ani Kabale Nchini Uganda. by Akakikunda, Brenda

“…Marys'College Rushoroza, Kigezi High School na BrainStorm High. Wahojiwa kumi ndio waliolengwa katika Utafiti huu kutoka katika Kila shule lililohusishwa yaani walimu watano na wanafunzi watano. …”
Get full text

Effect of High Alcohol Consumption Among the Youth in Kitumba Sub County-Kabale District. by Twijukye, Junior

“…The effects of alcohol consumption on the youths according to the study findings were; school dropout, increased thefts, loss of jobs, committing suicide, wastage of money, increased stress, poor coordination, slurred speech, destruction of the reproductive system, damage of; the brain, liver, kidney, and breast, contraction of HIV, and death. …”
Get full text

Association of inflammation cytokines with cognitive function in first-episode major depressive disorder by Yan Qing Xi, Yan Qing Xi, Yan Qing Xi, Zong Qi Wang, Zong Qi Wang, Zong Qi Wang, Guo Juan Li, Guo Juan Li, Guo Juan Li, Zhuo Qun Hao, Zhuo Qun Hao, Zhuo Qun Hao, Jia Hui Nie, Jin Xiang Li, Yu Ting Tan, Xiao Dong Hu, Xiao Dong Hu, Gen Wei Wang, Sha Liu, Sha Liu, Yan Fang Wang, Yan Fang Wang, Yan Fang Wang

“…Current studies suggest that the occurrence of MDD may be related to oxidative stress-induced inflammation, hypothalamic-pituitary-adrenal axis disorders, diminished monoamine function and microbe-brain-gut axis, among other pathways. In recent years, the relationship between the immune-inflammatory response and MDD has been a hot topic of research, but how the relationship between immunoinflammation and cognitive function is manifested in MDD is still unclear. …”
Get full text

Neuroprotective Effect of Crocin on Rats with Focal Cerebral Ischemia-Reperfusion Injury Based on TLR4/NF-κB Pathway by LI Xiaolei, ZHU Haisheng, MA Ruijuan, HU Ke, FENG Lina, WANG Xudong

“…After reperfution for 24 h, modified neurological severity score (mNSS) was used to evaluate the neurological deficits; triphenyltetrazolium chloride (TTC) staining method was used to evaluate cerebral infarction rate, and dry-wet method was used to evaluate brain water content; hematoxylin-eosin staining (HE) staining and TUNEL staining were used to observe pathological changes and apoptosis of cortical neurons; ELISA method was used to detect the level of inflammatory factors in brain tissue (TNF-α, IL-1β, IL-6, etc.); western blot was used to detect the expression of toll-like receptor 4 (TLR4), nuclear factor-κB p65 (NF-κB p65), p-NF-κB p65, IκBα, p-IκBα, Cleved Caspase-3, B-lymphoma-2 gene (Bcl-2), Bcl-2-related X protein (Bax).Results(1) Neurological function, cerebral infarction rate and cerebral water content: compared with the sham operation group, the mNSS score, cerebral infarction rate, cerebral water content in the model group increased significantly (<italic>P</italic>&lt;0.05); compared with the model group, the mNSS score, cerebral infarction rate, cerebral water content in the crocin group and the crocin + lipopolysaccharide group decreased significantly (<italic>P</italic>&lt;0.05); compared with the crocin group, the mNSS score, cerebral infarction rate, cerebral water content in the crocin + lipopolysaccharide group increased significantly (<italic>P</italic>&lt;0.05). (2) Pathological changes and apoptosis of cortical neurons: the cortical neurons in the sham operation group showed normal morphology and complete structure; the pathological changes of cortical neurons such as disordered arrangement, decreased number, vacuolar degeneration, hyperchromatic cytoplasmic pyknosis, unclear nuclear membrane boundary, inflammatory cell infiltration were observed in the model group; the pathological changes of cortical neurons in the crocin group were significantly improved. …”
Get full text

Aspirin-triggered resolvin D1 modulates pulmonary and neurological inflammation in an IL-22 knock-out organic dust exposure mouse model by Alissa N. Threatt, Jade White, Jade White, Nathan Klepper, Nathan Klepper, Zachary Brier, Zachary Brier, Logan S. Dean, Logan S. Dean, Ash Ibarra, Macallister Harris, Kaylee Jones, Maëlis J. L. Wahl, Melea Barahona, Melea Barahona, Emmanuel O. Oyewole, Morgan Pauly, Julie A. Moreno, Julie A. Moreno, Tara M. Nordgren

“…We observed a significant pulmonary and neurological immune response to DE characterized by the development of inducible bronchus associated lymphoid tissue in the lung and gliosis in the frontal areas of the brain. We also observed that IL-22 knock-out increased pulmonary and neurological inflammation severity. …”
Get full text

Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma by Ting Li, Zhanyi Zhao, Meichang Peng, Lu Zhang, Cheng Wang, Feiyang Luo, Meiqin Zeng, Kaijian Sun, Zhencheng Fang, Yunhao Luo, Yugu Xie, Cui Lv, Jiaxuan Wang, Jian-Dong Huang, Hongwei Zhou, Haitao Sun

“…Six genera were found to be significantly enriched in glioma tissues compared to adjacent normal brain tissues, including Fusobacterium, Longibaculum, Intestinimonas, Pasteurella, Limosilactobacillus, and Arthrobacter. …”
Get full text

2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment by Minzhen Xie, Siqi Gu, Yan Liu, Haolin Yang, Yuqi Wang, Wei Yin, Yang Hong, Wanying Lu, Chengbing He, Lin Li, Limin Zhao, Jianjia Zhang, Heng Liu, Tian Lan, Shuijie Li, Qi Wang

“…The nanoLC-Obitrap-MS technology was utilized to detect the content of selected small molecules with differential metabolic activity in the hippocampus and mitochondria of mice to evaluate their permeability through the blood-brain barrier (BBB) and outer mitochondrial membrane. …”
Get full text

Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics by Nils A. Koch, Benjamin W. Corrigan, Michael Feyerabend, Roberto A. Gulli, Michelle S. Jimenez-Sosa, Mohamad Abbass, Julia K. Sunstrum, Sara Matovic, Megan Roussy, Rogelio Luna, Samuel A. Mestern, Borna Mahmoudian, Susheel Vijayraghavan, Hiroyuki Igarashi, Kartik S. Pradeepan, William J. Assis, J. Andrew Pruszynski, Shreejoy Tripathy, Jochen F. Staiger, Guillermo Gonzalez-Burgos, Andreas Neef, Stefan Treue, Stefan Everling, Wataru Inoue, Anmar Khadra, Julio C. Martinez-Trujillo

“…Summary: Cortical neurons in brain slices display intrinsic spike frequency adaptation (I-SFA) to constant current inputs, while extracellular recordings show extrinsic SFA (E-SFA) during sustained visual stimulation. …”
Get full text

Navigating Ethical Dilemmas Of Generative AI In Medical Writing by Qurrat Ulain Hamdan, Waleed Umar, Mahnoor Hasan

“…AI is a field of computer science which deals with the development of programs or computational models that are inspired by the human brain’s ability to learn and adapt.1 Perhaps the most prominent advancement AI contributes is generative AI, which has led to the development of robotic “human-like” tools that can generate text, audio, images, and even video with a simple prompt. …”
Get full text

Olanzapine for young PEople with aNorexia nervosa (OPEN): results of a feasibility study by Olena Said, Dominic Stringer, Ece Sengun Filiz, Hiba Mutwalli, Sevgi Bektas, Melahat Nur Akkese, Vanessa Kellermann, Katie Ireland, Elizabeth Tyrrell-Bunge, Demelza Beishon-Murley, Joel W. T. Khor, Lee Allman, Joanna Barker, Nicus Kotze, Ben Carter, Mima Simic, Dilveer Singh Sually, Jessica Bentley, Allan H. Young, Sloane Madden, Sarah Byford, Sabine Landau, Vanessa Lawrence, Janet Treasure, Ulrike Schmidt, Dasha Nicholls, Hubertus Himmerich

Get full text

Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury by Ali Khadim, Georgios Kiliaris, Ana Ivonne Vazquez-Armendariz, Tara Procida-Kowalski, David Glaser, Marek Bartkuhn, Tanya Malik, Xuran Chu, Alena Moiseenko, Irina Kuznetsova, Negah Ahmadvand, Arun Lingampally, Stefan Hadzic, Ioannis Alexopoulos, Yuexin Chen, Andreas Günther, Jürgen Behr, Jens Neumann, Herbert B. Schiller, Xiaokun Li, Norbert Weissmann, Thomas Braun, Werner Seeger, Malgorzata Wygrecka, Rory E. Morty, Susanne Herold, Elie El Agha

Get full text

Leptomeningeal Cells Transduce Peripheral Macrophages Inflammatory Signal to Microglia in Reponse to Porphyromonas gingivalis LPS by Yicong Liu, Zhou Wu, Xinwen Zhang, Junjun Ni, Weixian Yu, Yanmin Zhou, Hiroshi Nakanishi

“…We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) …”
Get full text

Fatal Postpartum Hemorrhage in Diffuse Midline Glioma with H3-K27M Mutation by Takeshi Miyazaki, Masahiro Tsuji, Shinya Hagiwara, Toshiko Minamoto, Noriyoshi Ishikawa, Junko Hirato, Sumihito Nobusawa, Yasuhiko Akiyama

“…Management of pregnant women with brain tumors necessitates difficult decision-making especially for estimating or preventing its intratumoral hemorrhage. …”
Get full text

Distinctive Gut Microbiota Alteration Is Associated with Poststroke Functional Recovery: Results from a Prospective Cohort Study by Yini Dang, Xintong Zhang, Yu Zheng, Binbin Yu, Dijia Pan, Xiaomin Jiang, Chengjie Yan, Qiuyu Yu, Xiao Lu

“…Functional prognosis is potentially correlated with gut microbiota alterations following the dysregulation of the gut-microbiota-brain axis after stroke. This study was designed to explore the poststroke alterations of gut microbiota and potential correlations between gut microbiota and global functions. …”
Get full text

A Single‐Center Retrospective Cohort Study of Biopterin Metabolism Disorders in the United Arab Emirates by Omar Jarrah, Mahmood Nouri, Aisha Al Shamsi

“…Seizure and movement disorders were reported in five and three patients, respectively. Brain MRI showed cortical atrophic changes, corpus callosum hypoplasia, hyperintensities in the parieto‐occipital region, and periventricular white matter. …”
Get full text

Inaudible airborne ultrasound affects emotional states in the olfactory bulbectomized rat depression model by Tsugumi Yamauchi, Kou Takahashi, Toshinori Yoshioka, Daisuke Yamada, Yoshio Nakano, Satoka Kasai, Satoshi Iriyama, Kazumi Yoshizawa, Shoichi Nishino, Satoru Miyazaki, Akiyoshi Saitoh

“…Abstract Recently, exposure to sounds with ultrasound (US) components has been shown to modulate brain activity. However, the effects of US on emotional states remain poorly understood. …”
Get full text

Efficacy of in-person and telepractice-based extended Lee Silverman Voice Treatment LOUD on dysarthria and dysphagia in adults with cerebral palsy by Kyung Min Kim, Sang Ah Park, Seong Hye Hwang, Alyssia Park, Hyang Hee Kim, Jihye Hwang, Sung-Rae Cho

Get full text