A rare case of malignant melanoma presenting as anterior-superior mediastinal mass by Dario Familiari, MD, Silvana Parisi, MD, Rossana Rizzo, MD, Elena Valenti, MD, Flavia Nunnari, MD, Michele Sibilio, MD, Rosario Marando, MD, Giancarlo Pino, MD, Francesco Monaco, MD

“…We present an extremely rare case of primary melanoma presenting as an anterior-superior mediastinal mass in a 65 years-old woman who went to the hospital for neurological symptoms due to unknown metastatic brain melanomas.…”
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Multiscale Modeling Indicates That Temperature Dependent [Ca2+]i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity by Niko Komin, Mahsa Moein, Mark H. Ellisman, Alexander Skupin

“…Here we revisit our previously published data on the strong temperature dependence of Ca2+ signals in both cultured primary astrocytes and astrocytes in acute brain slices of mice. We apply multiscale modeling to test the hypothesis that the temperature dependent [Ca2+]i spiking is mainly caused by the increased activity of the sarcoendoplasmic reticulum ATPases (SERCAs) that remove Ca2+ from the cytosol into the endoplasmic reticulum. …”
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3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering by Damla Aykora, Ayhan Oral, Cemre Aydeğer, Metehan Uzun

“…Melatonin is a well‐known antioxidant with many osteoinductive properties and is one of the key hormones in the brain–bone axis. 3D bioprinted melatonin‐loaded polymers with unique lipophilic, anti‐inflammatory, antioxidant, and osteoinductive properties for filling large bone gaps following fractures or congenital bone deformities may be developed in the future. …”
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Expressional Subpopulation of Cancers Determined by G64, a Co-regulated Module by Jae-Woong Min, Sun Shim Choi

“…In each of the 22 cancers, we examined whether patient survival was different among the three different subgroups and found that G64 could differentiate tumor subpopulations in six other cancers, including sarcoma, kidney, brain, liver, and esophageal cancers.…”
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STRUCTURE DESIGN AND EXPERIMENT OF MULTIPURPOSE LOWER LIMB REHABILITATION EXOSKELETON by LI Gang, WANG YuJuan, LI XueWei, DU ZhenJun, CHEN YuXi

“…In order to effectively solve the motor dysfunction of lower limbs caused by spinal injury,brain injury,cerebrovascular disease and orthopaedic surgery, a multi-purpose detachable exoskeleton design scheme for lower limb rehabilitation was proposed. …”
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The Influence of Pharmacological Preconditioning with Sevoflurane on Incidence of Early Allograft Dysfunction in Liver Transplant Recipients by Andrei F. Minou, Alexander M. Dzyadzko, Aliaksei E. Shcherba, Oleg O. Rummo

“…Consecutive 60 deceased brain donors were randomized into sevoflurane group or control group. …”
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Bone within bone as a calcified chronic extra-dural hematoma mimicking ossified chronic subdural hematomas: a rare case report in pediatric patients by Mohan Karki, Yam Bahadur Roka, Abhinash Jha

“…Computed tomography scan of head was done that revealed large extra-axial hypodense mass with thick hyperdense calcified layer between brain parenchyma and hypodense mass in right fronto-temporo-parietal convexity causing mass effect with midline shift: s/o calcified chronic subdural hematoma. …”
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Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia by Megumi Andoh, Natsuki Shinoda, Yusuke Taira, Tasuku Araki, Yuka Kasahara, Haruki Takeuchi, Masayuki Miura, Yuji Ikegaya, Ryuta Koyama

“…Abstract Caspases are known to mediate neuronal apoptosis during brain development. However, here we show that nonapoptotic activation of caspase-3 at presynapses drives microglial synaptic phagocytosis. …”
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Does mental exertion during incremental exercise change substrate oxidation and cardiorespiratory outcomes in individuals with overweight? by Samira Pourmirzaei Kouhbanani, Seyed Kamaledin Setarehdan, Rana Fayazmilani

“…Abstract Given the growing concern over the impact of brain health in individuals with overweight, understanding how mental exertion (ME) during exercise affects substrate oxidation and cardiorespiratory outcomes is crucial. …”
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Overexpression of SFPQ Improves Cognition and Memory in AD Mice by Jinshan Tie, Hongxiang Wu, Wei Liu, Yuying Li, Lu Li, Suju Zhao, Zhijiao Yuan, Khan Mahmood, Shaochun Chen, Huidong Wu

“…Splicing factor proline and glutamine rich (SFPQ) is known to play a crucial role in neurodegenerative diseases, including antioxidant-related functions and regulating gene expression within brain neurons. However, the specific role of SFPQ in AD pathology is not well understood. …”
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Postural correlates of pleasant landscapes visual perception by Mbarka Akounach, Thierry Lelard, Harold Mouras

“…IntroductionThe interplay between motor skills and emotions in the brain represents a significant and longstanding research question. …”
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Role of Opioid Ligands in the Irritable Bowel Syndrome by Enrico Corazziari

“…Endogenous opioid peptides – enkephalins, beta-endorphin and dynorphins – are located in specific sites of the brain, the spinal cord, the autonomic ganglia and the enteric nervous system. …”
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The pleasurable urge to move to music is unchanged in people with musical anhedonia. by Isaac D Romkey, Tomas Matthews, Nicholas Foster, Simone Dalla Bella, Virginia B Penhune

“…However, recent behavioural and brain imaging work has shown that these two components may be separable. …”
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Clinically Relevant Drug Interactions with Monoamine Oxidase Inhibitors by Amber N. Edinoff, Connor R. Swinford, Amira S. Odisho, Caroline R. Burroughs, Cain W. Stark, Walid A. Raslan, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye

“…When MAO-A is inhibited, the capacity to handle tyramine intake from the diet is significantly reduced causing the brain to be vulnerable to overstimulation of postsynaptic adrenergic receptors with as little as 8-10 mg of tyramine ingested and can result in life-threatening blood pressure elevations. …”
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Rapid and quantitative functional interrogation of human enhancer variant activity in live mice by Ethan W. Hollingsworth, Taryn A. Liu, Joshua A. Alcantara, Cindy X. Chen, Sandra H. Jacinto, Evgeny Z. Kvon

“…In doing so we identify variants that reproducibly alter the in vivo activity of OTX2 and MIR9-2 brain enhancers, implicating them in autism. Dual-enSERT thus allows researchers to go from identifying candidate enhancer variants to analysis of comparative enhancer activity in live embryos in under two weeks.…”
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Pilocarpine-Induced Status Epilepticus Is Associated with Changes in the Actin-Modulating Protein Synaptopodin and Alterations in Long-Term Potentiation in the Mouse Hippocampus by Maximilian Lenz, Marina Ben Shimon, Thomas Deller, Andreas Vlachos, Nicola Maggio

“…However, the molecular mechanisms by which status epilepticus influences brain function beyond seizure activity remain not well understood. …”
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A Case of Reverse Takotsubo Cardiomyopathy Incited by a Spinal Subdural Hematoma by Kyle Sanchez, Steven Glener, Nathan E. Esplin, Okorie N. Okorie, Amay Parikh

“…We report a case of r-TTC in an otherwise healthy 23-year-old man presenting with back pain, urinary retention, bradycardia, and hypertension. Troponin levels and brain natriuretic peptide (BNP) were elevated, and echocardiogram revealed an ejection fraction (EF) of less than 20%. …”
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Impact of Time Delay in Perceptual Decision-Making: Neuronal Population Modeling Approach by Urszula Foryś, Natalia Z. Bielczyk, Katarzyna Piskała, Martyna Płomecka, Jan Poleszczuk

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SPICE-Level Demonstration of Unsupervised Learning With Spintronic Synapses in Spiking Neural Networks by Salah Daddinounou, Anteneh Gebregiorgis, Said Hamdioui, Elena-Ioana Vatajelu

“…Spiking Neural Networks (SNNs) are Artificial Neural Networks which promise to mimic the biological brain processing with unsupervised online learning capability for various cognitive tasks. …”
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Neurally Derived Tissues in Xenopus laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry by Vaibhav P. Pai, Laura N. Vandenberg, Douglas Blackiston, Michael Levin

“…Although embryonic patterning of asymmetric viscera, heart, and brain is beginning to be understood, less is known about possible subtle asymmetries present in anatomically identical paired structures. …”
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