Tissue Anisotropy Modeling Using Soft Composite Materials by Arnab Chanda, Christian Callaway

“…The mechanical behavior of the soft composites was characterized using hyperelastic material models such as Mooney-Rivlin’s, Humphrey’s, and Veronda-Westmann’s model and also compared with the anisotropic mechanical behavior of the human skin, pelvic tissues, and brain tissues. This work lays the foundation for the experimental modelling of tissue anisotropy, which combined with microscopic studies on tissues can lead to refinements in the simulation of localized fiber distribution and orientations, and enable the development of biofidelic anisotropic tissue phantom materials for various tissue engineering and testing applications.…”
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Fatal Overdose due to Confusion of an Transdermal Fentanyl Delivery System by Ingo Voigt

“…CCT scan presented a global hypoxic brain disease. Treatment and Outcome. The patient was discharged 30 days after admittance in a hemodynamic stable condition but a vegetative state and transferred to a rehabilitation center. …”
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Phospho-seq: integrated, multi-modal profiling of intracellular protein dynamics in single cells by John D. Blair, Austin Hartman, Fides Zenk, Philipp Wahle, Giovanna Brancati, Carol Dalgarno, Barbara Treutlein, Rahul Satija

“…We apply our workflow to cell lines, induced pluripotent stem cells, and months-old retinal and brain organoids to demonstrate its broad applicability. …”
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Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease by Susmita Sil, Tusharkanti Ghosh

“…The present study showed that anxiolytic behavior in cADr is predominantly due to cox-2 mediated neuroinflammation induced neurodegeneration in the brain.…”
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Electromagnetic Fields, Oxidative Stress, and Neurodegeneration by Claudia Consales, Caterina Merla, Carmela Marino, Barbara Benassi

“…Since free radicals are essential for brain physiological processes and pathological degeneration, research focusing on the possible influence of the EMFs-driven oxidative stress is still in progress, especially in the light of recent studies suggesting that EMFs may contribute to the etiology of neurodegenerative disorders. …”
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Aduhelm, a novel anti-amyloid monoclonal antibody, for the treatment of Alzheimer’s Disease: A comprehensive review by Hannah W. Haddad, Garett W. Malone, Nicholas J. Comardelle, Arielle E. Degueure, Salomon Poliwoda, Rachel J. Kaye, Kevin S. Murnane, Adam M Kaye, Alan D. Kaye

“…Despite skepticism, Adulhelm has proven to significantly decrease amyloid in all cortical brain regions examined. With such high stakes and potential, further research into Adulhelm's clinical efficacy is warranted in the treatment of AD.…”
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Current Trends in Targeted Therapies for Glioblastoma Multiforme by Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

“…To date, many studies report several determinants of resistance to this aggressive therapy: (1) O6-methylguanine-DNA methyltransferase (MGMT), (2) the complexity of several altered signaling pathways in GBM, (3) the existence of glioma stem-like cells (GSCs), and (4) the blood-brain barrier. Many studies aim to overcome these determinants of resistance to conventional therapy by using various approaches to improve the dismal prognosis of GBM such as modifying TMZ administration and combining TMZ with other agents, developing novel molecular-targeting agents, and novel strategies targeting GSCs. …”
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Germinoma in the Internal Auditory Canal Mimicking a Vestibular Schwannoma by Rubén Martín-Hernández, Diego Hernando Macías-Rodríguez, Ángel Muñoz-Herrera, Juan Carlos Del Pozo-de Dios, Santiago Santa Cruz-Ruiz, Ángel Batuecas-Caletrío

“…The appearance of a primary germinoma in the central nervous system but not on or near the midline or within the brain is exceptional. It may occur at any age; however, it is rare in patients over 50 years old. …”
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How Accurately Can Prostate Gland Imaging Measure the Prostate Gland Volume? Results of a Systematic Review by David R. H. Christie, Christopher F. Sharpley

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Radiation-Induced Peripheral Malignant Nerve Sheath Tumor Arising from Vestibular Schwannoma after Linac-Based Stereotactic Radiation Therapy: A Case Report and Review of Literatur... by Putipun Puataweepong, Taweesak Janwityanujit, Noppadol Larbcharoensub, Mantana Dhanachai

“…At 6 years after SRT, the patient came with left facial palsy and severe headache. CT brain revealed progression in size with cystic and hemorrhagic changes of the preexisting tumor at left CPA with new obstructive hydrocephalus. …”
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Protocol for generating protein profiles and distance-based network analysis of murine tissue slices by Luisa Schmidt, Philipp Antczak, Marcus Krüger

“…This protocol has potential for applications in spatial proteomics to other tissues with asymmetric patterns such as the brain and heart tissue.For complete details on the use and execution of this protocol, please refer to Schmidt et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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A Novel Heterozygous De Novo MORC2 Missense Variant Causes an Early Onset and Severe Neurodevelopmental Disorder by Daniel Arbide, Nour Elkhateeb, Ewa Goljan, Carolina Perez Gonzalez, Anna Maw, Soo-Mi Park

“…MORC2 may have a role in the development of neurones, and dominant variants in this gene have recently been linked with disorders including Charcot-Marie-Tooth type 2Z disease, spinal muscular atrophy and, more recently, a neurodevelopmental syndrome consisting of developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy (DIGFAN), presenting with hypotonia, microcephaly, brain atrophy, intellectual disability, hearing loss, faltering growth, and craniofacial dysmorphism. …”
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Lower Limb Ischemia: Aortoiliac Thrombosis Related to Antiphospholipid Syndrome (APS)—Case Report and Review of the Literature by Arnaldo Toffon, Raffaella Piovesan, Consolato Francesco Minniti, Omar Caruso, Paolo Criscenti, Sabina Villalta, Maurizio Cavallo

“…In this disease, arterial thrombosis occurs mainly in the brain. Peripheral arteries are affected less frequently. …”
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Amebic Encephalitis in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib Therapy by Ensi Voshtina, Huiya Huang, Renju Raj, Ehab Atallah

“…The patient ultimately expired, and autopsy of the brain revealed granulomatous amebic encephalitis due to opportunistic infection by Acanthamoeba species. …”
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Campbell S. Rapid psychological change / trans. from Engl. O. M. Kadochnikova by O. M. Kadochnikova

“…In case of rapid psychological change, the former personality is completely erased by brain-zap to install bit-by-bit a new person at 100 seconds. …”
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Targeting glycolysis: exploring a new frontier in glioblastoma therapy by Lu Yang, Sijia Li, Lei Yu, Jiao Leng, Na Li

“…Despite progress made in existing research, challenges remain, including drug penetration across the blood-brain barrier, side effects, and resistance. Future research will aim to address these challenges by improving drug delivery, minimizing side effects, and exploring combination therapies with radiotherapy, chemotherapy, and immunotherapy to develop more precise and effective personalized treatment strategies for GBM.…”
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Attenuating Photostress and Glare Disability in Pseudophakic Patients through the Addition of a Short-Wave Absorbing Filter by Billy R. Hammond

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Paroxysmal sympathetic hyperactivity and refractory hypotension in Guillain-Barré syndrome with autoimmune encephalitis: a case report and literature review by Jun-Ping Wang, Yan-Bo He

“…Cerebrospinal fluid (CSF) analysis revealed protein-cell dissociation, indicative of GBS. Brain magnetic resonance imaging (MRI) showed abnormal signals in the splenium of the corpus callosum. …”
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Early Head Specification in Xenopus laevis by Blue B. Lake, Kenneth R. Kao

“…Similarly, Wnt signaling is required along the length of the neural tube, but must be suppressed at its rostral end for normal brain development. Nodal signaling is also necessary for induction of the mesendoderm, but is subsequently suppressed in its dorsal-anterior extreme to specify head organizer. …”
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The Neuroplastic Adaptation Trident Model: A Suggested Novel Framework for ACL Rehabilitation by Timothy Machan, Kody Krupps

“…Following injury, the brain enters a neuroplastic state and can adapt and change positively or negatively based on the rehabilitation or lack thereof. …”
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