RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection by Ignacio Silva-Llanes, Ignacio Silva-Llanes, Ignacio Silva-Llanes, Enrique Madruga, Enrique Madruga, Ana Martínez, Ana Martínez, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker

“…We examined mouse models of frontotemporal dementia (FTD), as well as brain tissue samples from patients with progressive supranuclear palsy (PSP), a primary form of 4R tauopathy, and Alzheimer’s disease (AD), which is considered a secondary tauopathy. …”
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Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease by Tristan Gabriel-Segard, Margherita Boltri, Mathilde Barrau, Catherine Massoubre, Stéphane Paul, Xavier Roblin

“…<b>Conclusions:</b> To tackle the question of fatigue in IBD, research should consider investigating the biological mechanisms implicating intestinal physiopathology of IBD in the impairment of brain structure involved in motivation. This may open new fields for treatment in targeting structures of the brain reward system.…”
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Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review by Michael D Jenkinson, Ashwin Venkatesh, Colin Watts, Michael T C Poon, Victoria Wykes, Stephen John Price, Puneet Plaha, Georgios Solomou, Melissa Gough, Conor S Gillespie, Aref-Ali Gharooni, Waqqas Patel

“…Introduction 5-aminolevulinic acid (5-ALA) is a proagent developed for fluorescent-guided surgery for high-grade glioma patients associated with a significant increase in resection conferring survival. 5-ALA was shown to penetrate the blood–brain barrier accumulating in malignant glioma cells with high selectivity, sensitivity and positive predictive value. …”
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Determining the relationship between the speed of motion of large permanent magnets and the trajectory of implants in magnetic stereotaxic systems by Ц. Ханькунь, О. Г. Аврунін

“…This method allows the implant to be controlled non-contact by an external magnetic field, allowing it to move along an arbitrary trajectory to a lesion located in a deep structure of the brain tissue to deliver hyperthermia to the lesion site or deliver medication through a catheter. …”
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Role of neuroinflammation in the pathogenesis of glaucomatous optic neuropathy by E.A. Egorov, V.E. Korelina, D.V. Cherednichenko, I.R. Gazizova

“…Astrocytes produce neurotrophic brain factor which promote the survival of damaged neurons. …”
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Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and no... by Zhirui Zhang, Wenhuan Song, Wenyu Chen, Wenze Cui, Wenyi Chen, Qinheng Zhang, Wenwen Ji, Yinglin Wang, Jiayi Wang, Wenhao Yu, Mingkun Yu, Mingkun Yu, Tao Hao, Hong Jiang

“…Prostate cancer showed a shift toward clinical applications, while leukemia and brain tumor research, though less extensive, highlighted miRNA’s potential in early diagnosis and treatment. …”
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De novo assembly and analysis of the transcriptome of the Siberian wood frog Rana amurensis by D. N. Smirnov, S. V. Shekhovtsov, A. A. Shipova, G. R. Gazizova, E. I. Shagimardanova, N. A. Bulakhova, E. N. Meshcheryakova, T. V. Poluboyarova, E. E. Khrameeva, S. E. Peltek, D. I. Berman

“…To make the Siberian wood frog more amenable for genetic analysis, we performed transcriptome sequencing and de novo assembly for the R. amurensis brain under hypoxia and normoxia, as well as for the normoxic heart. …”
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Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails by Veronica Rivi, Anuradha Batabyal, Cristina Benatti, Fabio Tascedda, Johanna Maria Catharina Blom, Ken Lukowiak

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Phenolic Compounds and Pharmacological Potential of <em>Lavandula angustifolia</em> Extracts for the Treatment of Neurodegenerative Diseases by Olha Mykhailenko, Viktoriia Hurina, Nataliia Herbina, Yuliia Maslii, Liudas Ivanauskas, Inna Vladymyrova, Dmytro Lytkin, Zigmantas Gudžinskas, Hanna Severina, Olena Ruban, Victoriya Georgiyants

“…The search for neuroprotective compounds in lavender is driven by its traditional use for brain health, with antioxidant activity serving as a key mechanism in reducing oxidative stress and supporting cognitive function. …”
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Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade by Xiaolin Liu, Xiao Liu, Xiaonan Luo, Maorong Zhu, Nannan Liu, Juan Li, Qi Zhang, Cheng Zou, Yuxin Wu, Zhengcong Cao, Shuangxin Ma, Weizhong Wang, Guangzhao Yang, Jintao Gu, Wei Liu, Meng Li, Anan Yin, Yalong He, Wei Lin

“…Abstract Glioblastoma (GBM) is a primary brain tumor known for its high levels of aggressiveness and resistance to current treatments such as radiotherapy and chemotherapy. …”
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Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia by Haolin Zheng, Akiko Mizokami, Sergio Romera-Giner, Jaime Llera-Oyola, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Francisco García-García, Takashi Kanematsu

“…Notably, testosterone has been reported to regulate cognitive functions in the brain, with low serum testosterone levels correlating with increased AD risk. …”
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Investigating the antioxidant effects of Cucurbita maxima Duchesne extract on motor coordination and memory impairment induced by scopolamine in rats by Najmeh Asgharzadeh, Fatemeh Azizi, Mohammadreza Hojjati, Leila Roohi, Zahra Rabiei, Mehrdad Shahrani-Korani

“…Additionally, serum and brain levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured. …”
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A Neural Circuit For Bergamot Essential Oil‐Induced Anxiolytic Effects by Meng‐Yu Zhu, Wan‐Ying Dong, Jin‐Rong Guo, Ji‐Ye Huang, Ping‐Kai Cheng, Yumeng Yang, An Liu, Xin‐Lu Yang, Xia Zhu, Zhi Zhang, Yuanyin Wang, Wenjuan Tao

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Comparison of Nasopharyngeal Airway with Endoscopic Respiratory Mask for Hypoxemia in Painless Gastrointestinal Endoscopy in Obese Outpatients: Study Protocol for a Randomized Cont... by Xiang D, Deng L, Zhou R, Zhang X, Tian L, Jiang W, Zhou Y, Chen W, Peng Y

“…Dongmei Xiang,1,&ast; Lei Deng,2,&ast; Rui Zhou,3– 5 Xianjie Zhang,1 Lei Tian,1 Wencai Jiang,1 Yukai Zhou,1 Wenya Chen,1 Yanhua Peng1 1Department of Anesthesiology, the Deyang People’s Hospital, Deyang City, Sichuan Province, 618000, People’s Republic of China; 2Department of Gastroenterology, the Deyang People’s Hospital, Deyang City, Sichuan Province, 618000, People’s Republic of China; 3Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 4Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 5Clinical Research Center for Anesthesiology and Perioperative Medicine, Tongji University, Shanghai, 200434, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yanhua Peng, Department of Anesthesiology, the Deyang People’s Hospital, No. 173 section 1 Mount Taishan North Road Jingyang District, Deyang City, Sichuan Province, People’s Republic of China, Email pyhuaa@163.comIntroduction: Sedatives and anesthetics can modify airway tone and induce respiratory depression, exacerbating the gas exchange impairments associated with obesity. …”
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Graph analysis based on SCN reveals novel neuroanatomical targets related to tinnitus distress by Yawen Lu, Yifeng Yang, Meijing Yan, Lianxi Sun, Caixia Fu, Jianwei Zhang, Jianwei Zhang, Yuehong Liu, Kefeng Li, Zhao Han, Guangwu Lin, Shihong Li

“…This study aimed to investigate the structural brain covariance network in tinnitus patients and analyze its altered topological properties.MaterialsFifty three primary tinnitus patients and 67 age- and sex-matched healthy controls (HCs) were included. …”
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Lutein and inflammation: a comprehensive review of its mechanisms of action by Paradentavida Prathyusha, Geetha Viswanathan, Anjilikal Tomy Tomcy, Ponnamparambil P. Binitha, Smitha V. Bava, Edakkadath R. Sindhu

“…In the central nervous system (CNS), lutein supports brain homeostasis through its antioxidant and anti-inflammatory properties, increasing interleukin-10 (IL-10) and reducing tumor necrosis factor-α (TNF-α). …”
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Secondary Cancer after Androgen Deprivation Therapy in Prostate Cancer: A Nationwide Study by Jae Heon Kim, Gi Hwan Bae, Jaehun Jung, Tae Il Noh

“…The ADT group showed higher risk of overall brain and other central nervous system (CNS) cancer-specific incidence than the non- ADT group (adjusted HR: 1.648, 95% CI: 1.21–2.24). …”

Biopsy location and tumor-associated macrophages in predicting malignant glioma recurrence using an in-silico model by Pejman Shojaee, Edwin Weinholtz, Nadine S. Schaadt, Friedrich Feuerhake, Haralampos Hatzikirou

“…T1-weighted imaging highlights anatomical structures with high contrast, providing clear detail on brain morphology, whereas FLAIR suppresses fluid signals, improving the visualization of lesions near fluid-filled spaces, which is particularly helpful for identifying peritumoral edema. …”
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Echoes of Strain: A Two-Year Longitudinal Study on the Impact of China&rsquo;s Zero-COVID Policy on College Students&rsquo; Insomnia and Depressive Symptoms by Wang S, Zou X, Tang Q, Zhang L, Liu X, Liu G, Tao Y

“…Shujian Wang,1,2 Xinyuan Zou,1,2 Qihui Tang,1,2 Liang Zhang,3 Xiangping Liu,1,2 Gang Liu,4 Yanqiang Tao1,2 1Faculty of Psychology, Beijing Normal University, Beijing, 100875, People’s Republic of China; 2Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education, Beijing, 100875, People’s Republic of China; 3College Students’ Mental Health Education Center, Northeast Agricultural University, Harbin, 150030, People’s Republic of China; 4Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, 210029, People’s Republic of ChinaCorrespondence: Gang Liu, Nanjing Brain Hospital, 264 Guangzhou Road, Nanjing, Jiangsu, 210029, People’s Republic of China, Email dliugang@126.com Yanqiang Tao, Beijing Normal University, No. 19, Xinjiekouwai Street, Beijing, 100875, People’s Republic of China, Email psyxuele2020@163.comPurpose: In China, stringent and long-lasting infection control measures, which were called “dynamic zero-COVID policy”, have significantly affected the mental health of college students, particularly concerning depressive and insomnia symptoms. …”
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Synergistic Effect of Quercetin and α-Lipoic Acid on Aluminium Chloride Induced Neurotoxicity in Rats by Sooad Saud Al-Otaibi, Maha Mohamad Arafah, Bechan Sharma, Abdullah Salih Alhomida, Nikhat Jamal Siddiqi

“…Quercetin and α-lipoic acid complemented each other in protecting the rat brain against oxidative stress induced by aluminium chloride.…”
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