Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat by Caroline E. Rasmussen, Jette Nowak, Julie M. Larsen, Emma Moore, David Bell, Kai Chiu Liu, Nanna Skall Sorensen, Wendela A. Kappers, Thomas Krogh-Meibom, Hanne Offenberg

“…Immunohistochemical staining examined the distribution of PEG in the brain. No adverse test item-related findings were seen and PEG was not detected in the brain. …”
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Simultaneous and Consecutive Drainage of Bilateral Chronic Subdural Hematoma: A Randomized Controlled Trial by Omer AKAR, Hasan Kamil SUCU, Selin BOZDAG

“…Furthermore, bilateral CSDHs are associated with rapid deterioration and poorer outcomes because of a higher risk of brain herniation than unilateral hematomas. The most contentious issue is the potential herniation of the medial temporal lobe, which remains on the unevacuated side during the brief interval between right and left procedures. …”
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Impaired Hippocampal Glutamate and Glutamine Metabolism in the db/db Mouse Model of Type 2 Diabetes Mellitus by Jens Velde Andersen, Jakob Dahl Nissen, Sofie Kjellerup Christensen, Kia Hjulmand Markussen, Helle Sønderby Waagepetersen

“…Type 2 diabetes mellitus (T2DM) is a risk factor for the development of Alzheimer’s disease, and changes in brain energy metabolism have been suggested as a causative mechanism. …”
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An Adaptive EEG Feature Extraction Method Based on Stacked Denoising Autoencoder for Mental Fatigue Connectivity by Zhongliang Yu, Lili Li, Wenwei Zhang, Hangyuan Lv, Yun Liu, Umair Khalique

“…These results imply that there are different brain patterns on the three conditions. This study provides an effective method for EEG analysis. …”
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Motor Control System for Adaptation of Healthy Individuals and Recovery of Poststroke Patients: A Case Study on Muscle Synergies by Fady S. Alnajjar, Juan C. Moreno, Ken-ichi Ozaki, Izumi Kondo, Shingo Shimoda

“…Understanding the complex neuromuscular strategies underlying behavioral adaptation in healthy individuals and motor recovery after brain damage is essential for gaining fundamental knowledge on the motor control system. …”
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Isolation and Identification of Toxoplasma gondii from Aborted Fetuses of Goats by PCR in Lorestan Province by Morad Beiranvand, Hossein Hamidinejat, Somayeh Bahrami, Mohammad Reza Tabandeh, Meysam Makki

“…Methods: From autumn 2023 to summer 2024, the brain and liver of 100 goat fetuses were examined for T. gondii by PCR based on the amplification of 529 base pair fragments from repetitive regions of the parasite genome. …”
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Nouvelles données sur les caractéristiques morphologiques immatures du crâne chez les Homo erectus asiatiques by Antoine Balzeau

“…Finally, the globularity of the brain and of the skull would persist late during the ontogenetic history in Homo erectus. …”
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Taurine Prevented Biochemical Alterations in Chronic Restraint-Stressed Wistar Rats by Iliya, Ezekiel, Agnes Igimi, Odey, Stephen Olawale, Ajayi, Ejike, Daniel Eze, Obioha, Mary

“…The result revealed significant (p < 0.05) increase in the brain AChE activity in taurine 100 mg/kg when compared to the control group. …”
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Circular RNA circ-Olfm1 induces progression of Alzheimer’s disease by regulating FOXO3a by YANG Hongyan, LIAO Qirong, HOU Mingliang

“…Conclusion‍　‍circ-Olfm1 is up-regulated in the brain tissue and neurons+Aβ42 of AD rats, and the mechanism of cognitive impairment in AD rats may be through its regulating FOXO3a protein. …”
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Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control by Mariah DeSerisy, Jacob W. Cohen, Huiyu Yang, Bruce Ramphal, Paige Greenwood, Kahini Mehta, Michael P. Milham, Theodore D. Satterthwaite, David Pagliaccio, Amy E. Margolis

“…Associations between irritability and brain connectivity between cognitive control and reward- or threat-processing circuits remain understudied. …”
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Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…Understanding the phenotype acquisition of microglia, the sentinel immune cells of the brain, is crucial for understanding the nature of age-related neurological diseases. …”
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Investigation of the Protective Effects of Dexmedetomidine, Midazolam, Propofol, and Intralipid on Oxidative Stress and Inflammation in Rats with Lidocaine-Induced Toxicity by Kucun MK, Guler EM, Saracoglu A, Yildirim M, Demirtas C, Serdogan F, Beyaztas H, Aktas S, Kacan M, Gaszynski T, Ratajczyk P, Saracoglu KT

“…Despite an increase in oxidative stress in brain tissue samples across all groups, it was found that all groups exhibited antioxidant protective effects (p < 0.05). …”
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Utilisation of the Innovative [18F]-Labelled Radiotracer [18F]-BIBD-071 Within HR+ Breast Cancer Xenograft Mouse Models by Di Fan, Xin Wang, Xueyuan Ling, Hongbin Li, Lu Zhang, Wei Zheng, Zehui Wu, Lin Ai

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Inducing aggresome and stable tau aggregation in Neuro2a cells with an optogenetic tool by Shigeo Sakuragi, Tomoya Uchida, Naoki Kato, Boxiao Zhao, Toshiki Takahashi, Akito Hattori, Yoshihiro Sakata, Yoshiyuki Soeda, Akihiko Takashima, Hideaki Yoshimura, Gen Matsumoto, Hiroko Bannai

“…Tauopathy is a spectrum of diseases characterized by fibrillary tau aggregate formation in neurons and glial cells in the brain. Tau aggregation originates in the brainstem and entorhinal cortex and then spreads throughout the brain in Alzheimer’s disease (AD), which is the most prevalent type of tauopathy. …”
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Clinical Utility of an Alzheimer’s Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study by Mark Monane, Demetrius M. Maraganore, Robert M. Carlile, Kim G. Johnson, David A. Merrill, Darren R. Gitelman, Kenneth S. Sharlin, Lawren A. VandeVrede, Kristi K. George, Jimin Wang, Tim West, Leslie Jacobs, Philip B. Verghese, Joel B. Braunstein

“…Anti-AD medication orders decreased among negative APS2 patients and increased among positive APS2 patients (<i>p</i> < 0.0001). Additional brain amyloid testing decreased among negative APS2 patients (<i>p</i> < 0.0001). …”
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CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer’s disease mice by Yuanyu Shen, Xiaolei Zhang, Siqi Liu, Lijing Xin, Wentao Xuan, Caiyu Zhuang, Yue Chen, Beibei Chen, Xinhui Zheng, Renhua Wu, Yan Lin

“…However, whether riluzole can improve Glu and GABA homeostasis in AD brain and its related mechanism of action remain unknown. …”
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Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo by Taro Ichimura, Taishi Kakizuka, Yoshitsugu Taniguchi, Satoshi Ejima, Yuki Sato, Keiko Itano, Kaoru Seiriki, Hitoshi Hashimoto, Ko Sugawara, Hiroya Itoga, Shuichi Onami, Takeharu Nagai

“…We applied the imaging technique to 1.2 cm-wide section of mouse brain, and successfully observed various regions of the brain with sub-cellular resolution in a single FOV. …”
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Research Progress on Animal Models of Sepsis-Related Organ Injury by YANG Jiahao, DING Chunlei, QIAN Fenghua, SUN Qi, JIANG Xusheng, CHEN Wen, SHEN Mengwen

“…It affects multiple important organs such as the heart, lungs, kidneys, liver, and brain. Establishing corresponding animal models of organ dysfunction syndrome is an essential step in clarifying its pathogenesis, researching potential effective drugs, and evaluating the effectiveness and safety of treatment plans. …”
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Effects of innovative modular prone positioning tools in patients with acute respiratory distress syndrome due to COVID-19 during awake prone position: a prospective randomized con... by Dunbing Huang, Huan Tian, Wei Song, Jiaqi Wang, Zizhe Yao, Lize Xiong, Cai Jiang, Anren Zhang, Xiaohua Ke

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Late-Onset Startle Syndrome and Obsessive Compulsive Disorder by Alejandro Gonzalez, Michael P. Philpot

“…A case of late onset sporadic startle syndrome in a patient with a right posterior fossa brain tumour is reported. The exaggerated startle response did not respond to treatment with clonazepam. …”
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