Unravelling a mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in Mucopolysaccharidosis VII by Nishan Mandal, Apurba Das, Rupak Datta

“…This, in turn, compromised mitochondrial function, as reflected by drastically reduced brain ATP levels. Energy depletion triggered apoptosis in neuronal as well as non-neuronal cells of the CG2135−/− fly brain, where apoptotic dopaminergic neurons were also detected. …”
Get full text

Interactions between Neutrophils, Th17 Cells, and Chemokines during the Initiation of Experimental Model of Multiple Sclerosis by Dagmara Weronika Wojkowska, Piotr Szpakowski, Dominika Ksiazek-Winiarek, Marcin Leszczynski, Andrzej Glabinski

“…In this study the expression of CCR6, CXCR2, and CXCR6 in Th17 cells and neutrophils migrating to the brain during EAE was measured, alongside an evaluation of the production of IL-17, IL-23, CCL-20, and CXCL16 in the brain. …”
Get full text

Challenges and insights of transferring animal maze studies principles to human spatial learning research by Piruza Manukyan, Elizaveta Romanova, Alexander Latanov, Pavel Shlepnev, Anastasia Sharapkova, Naida Garabova, Vladimir Kasatkin, Vera Tolchennikova

Get full text

Integrating fMRI spatial network dynamics and EEG spectral power: insights into resting state connectivity by Souvik Phadikar, Krishna Pusuluri, Armin Iraji, Vince D. Calhoun

“…IntroductionThe Integration of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) has allowed for a novel exploration of the brain’s spatial–temporal resolution. While functional brain networks show variations in both spatial and temporal dimensions, most studies focus on fixed spatial networks that change together over time.MethodsIn this study, for the first time, we link spatially dynamic brain networks with EEG spectral properties recorded simultaneously, which allows us to concurrently capture high spatial and temporal resolutions offered by these complementary imaging modalities. …”
Get full text

Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment by Liriopé Toupenet Marchesi, Daniel Stockholm, Typhaine Esteves, Marion Leblanc, Nicolas Auger, Julien Branchu, Khalid Hamid El Hachimi, Giovanni Stevanin

Get full text

Shared rare genetic variants in multiplex autism families suggest a social memory gene under selection by Kang Seon Lee, Taeyeop Lee, Mujun Kim, Elizaveta Ignatova, Hyo-Jeong Ban, Min Kyung Sung, Younghoon Kim, Youn-Jae Kim, Jin-Hee Han, Jung Kyoon Choi

Get full text

Calcium/calmodulin-dependent protein kinase II α and β differentially regulate mammalian sleep by Weiwen Yang, Jingyi Shi, Chenggang Li, Jingqun Yang, Jianjun Yu, Juan Huang, Yi Rao

Get full text

Metformin for neurocognitive dysfunction in schizophrenia: a systematic review by Zhen-Juan Qin, Zhan-Ming Shi, Li-Juan Li, Xin Wei, Hui-Lin Hu, Wei Wei, Zhi-Yuan Xie, Hang-Xi Ji, Yu-Hua Wei, Wei Zheng, Wei Zheng

Get full text

The left amygdala is genetically sexually-dimorphic: multi-omics analysis of structural MRI volumes by Yuanyuan Gui, Geyu Zhou, Shuya Cui, Hongyu Li, Hui Lu, Hongyu Zhao

“…Abstract Brain anatomy plays a key role in complex behaviors and mental disorders that are sexually divergent. …”
Get full text

Enjoy it! Cosmetic try-on apps and augmented reality, the impact of enjoyment, informativeness and ease of use by V. Micheletto, S. Accardi, A. Fici, A. Fici, F. Piccoli, C. Rossi, M. Bilucaglia, V. Russo, V. Russo, M. Zito, M. Zito

Get full text

Metabolomic characterisation of the glioblastoma invasive margin reveals a region-specific signature by James Wood, Stuart J. Smith, Marcos Castellanos-Uribe, Anbarasu Lourdusamy, Sean T. May, David A. Barrett, Richard G. Grundy, Dong-Hyun Kim, Ruman Rahman

“…Multi-region surgical sampling was performed on five adult GBM patients based on pre-operative brain imaging and fluorescence-guided surgery. Polar and hydrophobic metabolites extracted from tumour fragments were assessed, followed by putative assignment of metabolite identifications based on retention times and molecular mass. …”
Get full text

Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer’s disease progression by Daniele Lana, Filippo Ugolini, Ludovica Iovino, Selene Attorre, Maria Grazia Giovannini

“…For over a century after their discovery astrocytes were regarded merely as cells located among other brain cells to hold and give support to neurons. …”
Get full text

Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina by Ling-Dan Dong, Jie Chen, Fang Li, Feng Gao, Jihong Wu, Yanying Miao, Zhongfeng Wang

Get full text

Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on Chronic Mouse Model of Lear... by Zhilu Zou, Yin Chen, Qinqin Shen, Xiaoyan Guo, Yuxuan Zhang, Gang Chen

“…In the hippocampus, Yueju and fluoxetine both normalized brain-derived neurotrophic factor (BDNF) and PKA level. …”
Get full text

Pisa Syndrome in Parkinson’s Disease: Electromyographic Aspects and Implications for Rehabilitation by Giuseppe Frazzitta, Pietro Balbi, Francesco Gotti, Roberto Maestri, Annarita Sabetta, Luca Caremani, Laura Gobbi, Marina Capobianco, Rossana Bera, Nir Giladi, Davide Ferrazzoli

Get full text

Best1 mitigates ER stress induced by the increased cellular microenvironment stiffness in epilepsy by Hao Wu, Yicong Dong, Qiang Meng, Jingyi Jiang, Bojian Gao, Yutao Ren, Yong Liu, Huanfa Li, Changhe Wang, Hua Zhang

“…Changes in brain tissue stiffness are closely linked to the development and diseases of the nervous system. …”
Get full text

Altered Coactive Micropattern Connectivity in the Default-Mode Network during the Sleep-Wake Cycle by Yan Cui, Qiao Chen, Yang Xia, Zeru Wang, Yujia Guo, Ge Zhang, Dezhong Yao, Daqing Guo

Get full text

Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease by Judy Cheng, Ellen T. Koch, Daniel Ramandi, James P. Mackay, Timothy P. O’Leary, William Rees-Jones, Lynn A. Raymond

“…Thus, we used corticostriatal brain slices and optogenetic probes to directly investigate neuromodulatory signaling in the transgenic YAC128 HD mouse model. …”
Get full text

Age of Insomnia Onset Correlates with a Reversal of Default Mode Network and Supplementary Motor Cortex Connectivity by Emiliano Santarnecchi, Chiara Del Bianco, Isabella Sicilia, Davide Momi, Giorgio Di Lorenzo, Salvatore Ferrone, Giulia Sprugnoli, Simone Rossi, Alessandro Rossi

“…This might lead to alterations in brain connectivity patterns as those captured by functional connectivity fMRI analysis, leading to potential insight about primary insomnia (PI) pathophysiology as well as the impact of long-term exposure to sleep deprivation. …”
Get full text

Positron Emission Tomography—Computer Tomography Scan Used as a Monitoring Tool Following Cellular Therapy in Cerebral Palsy and Mental Retardation—A Case Report by Alok Sharma, Hemangi Sane, Amruta Paranjape, Nandini Gokulchandran, Pooja Kulkarni, Anjana Nagrajan, Prerna Badhe

“…Cerebral palsy (CP) is one of the non-progressive neurological diseases caused by damage to the brain tissue at birth, which leads to physical, cognitive and perceptive symptoms. …”
Get full text