Capecitabine enhances sensitivity to oxaliplatin in advanced gastric cancer and the effects on patients’ FOXP1 and GGT levels by Xinyu Guo, Yi Liu

“…Abstract Objective To investigate the effect of capecitabine on the sensitivity of oxaliplatin and on the level of transcription factor forkhead box P1 (FOXP1) and gamma-glutamyl transpeptidase (GGT) in patients with intermediate and advanced gastric cancer. …”
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Idiopathic pulmonary fibrosis is a risk factor for cardiovascular disease: potential role of KL-6 and systemic inflammation by Mohamed F. AbdelGhany, Waleed GamalEldin Khaleel, Asmaa Omar Ahmed, Ahmad BaheyElden Ahmed, Lamees M. Bakkar

“…As regards laboratory serum biomarkers, the group with comorbidities showed significantly higher CRP, KL-6, cholesterol level, triglyceride level, and LDL-cholesterol level (P value < 0.001). Box plot analysis demonstrated significantly higher KL-6 serum level among IPF patients with cardiovascular comorbidities. …”
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Simulation and Test of Key Decorticating Components of Spiral Ramie Decorticator by Wenlong Zheng, Lan Ma, Jiajie Liu, Bo Yan, Yiping Duan, Sixun Chen, Jiangnan Lyu, Wei Xiang

“…The three-dimensional model of the ramie stripping component was crafted with SolidWorks software, and subsequent modal analysis and dynamic simulation studies were conducted using Abaqus software. The Box–Behnken experimental design method was used to construct a mathematical model describing the effects of the decorticating drum rotation speed and the decorticating gap on the fiber percentage of fresh stalk, and the optimal operating parameters were determined accordingly. …”
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Development of Chitosan-Polyacrylic Acid Complex Systems for Enhanced Oral Delivery of Lactobacillus Gasseri and Bifidobacterium Bifidum Probiotics by AL-Fawares O, Alshweiat A, Abuawad A

“…O’la AL-Fawares,1 Areen Alshweiat,2 Alaa Abuawad3 1Department of Applied Biological Sciences, Faculty of Science, Al-Balqa Applied University, Al-salt, 19117, Jordan; 2Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, 13133, Jordan; 3Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, ‎Applied ‎Science Private University, Amman, 11937, JordanCorrespondence: O’la AL-Fawares, Department of Applied Biological Sciences, Faculty of Science, Al-Balqa Applied University, P.O. Box 206, Al-salt, 19117, Jordan, Tel +9627997622457, Email ola.alfawares@bau.edu.joIntroduction: The beneficial effects of probiotics are encountered by their low viability in gastrointestinal conditions and their insufficient stability during manufacturing, throughut the gastrointestinal transit, and storage. …”
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Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice by Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi

“…Pirfenidone significantly reduced pro-inflammatory cytokines including interleukin-6, interleukin-1β, transforming growth factor-β, tumor necrosis factor- α, high-mobility group box-1, and toll-like receptor-4, elevated gamma-aminobutyric acid, decreased glutamate levels, modulated aspartate aminotransferase and alanine aminotransferase levels. …”
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Exosomal miR-222-3p derived from dermal papilla cells inhibits melanogenesis in melanocytes by targeting SOX10 in rabbits by Yang Chen, Tingting Lu, Yingying Dai, Yu Xue, Bohao Zhao, Xinsheng Wu

“…Sex determining region Y-box 10 (SOX10), a potential target gene regulated by miR-222-3p, was validated using a dual-luciferase reporter assay, site-specific mutation, and WB. …”
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Predicting egg production rate and egg weight of broiler breeders based on machine learning and Shapley additive explanations by Hengyi Ji, Yidan Xu, Ganghui Teng

“…Given the inherent black-box nature of ML models, we used the Shapley additive explanations (SHAP) method to interpret the key features influencing the XGBoost model's predictions and the interactions between these features. …”
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Comparative analysis of deep learning and radiomic signatures for overall survival prediction in recurrent high-grade glioma treated with immunotherapy by Qi Wan, Clifford Lindsay, Chenxi Zhang, Jisoo Kim, Xin Chen, Jing Li, Raymond Y. Huang, David A. Reardon, Geoffrey S. Young, Lei Qin

“…The potential time-saving must be weighed against the lower interpretability of end-to-end black box modeling.…”
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evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomat... by Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

“…The primary endpoint is the semaglutide–placebo difference on change from baseline to week 104 in the Clinical Dementia Rating – Sum of Boxes score. Analyses of plasma biomarkers, collected from all participants, and a CSF sub-study (planned n = 210) will explore semaglutide effects on AD biomarkers and neuroinflammation. …”
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LightweightUNet: Multimodal Deep Learning with GAN-Augmented Imaging Data for Efficient Breast Cancer Detection by Hari Mohan Rai, Joon Yoo, Saurabh Agarwal, Neha Agarwal

“…Since the datasets are from various sources, we have resized them to the uniform size of 256 × 256 pixels and normalized them using the Box-Cox transformation technique. Since the USI dataset is smaller, we have applied the StyleGAN3 model to generate 10,000 synthetic ultrasound images. …”
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Optimised extraction of antioxidant components from Calophyllum inophyllum L. seeds using response surface methodology by L. Fitriyana, M.D. Supardan, Y. Aisyah, Irfan .

“…The study optimised extracting the antioxidant components from C. inophyllum seeds using response surface methodology.METHODS: The experimental design used in this study was response surface methodology with a Box–Behnken design to model the influence of variables on the response of the yield and antioxidant activity of extracts obtained through maceration and ultrasonic extraction and to model lotion formulation. …”
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Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy by Coraline Radermecker, Pascale Hubert, Patrick Roncarati, Stephanie Demoulin, Charlotte Pilard, Marie Ancion, Celia Reynders, Thomas Lerho, Diane Bruyere, Alizee Lebeau, Margot Meunier, Marie-Julie Nokin, Elodie Hendrick, Olivier Peulen, Philippe Delvenne, Michael Herfs

“…Background High-mobility group box 1 (HMGB1) is a multifunctional redox-sensitive protein involved in various intracellular (eg, chromatin remodeling, transcription, autophagy) and extracellular (inflammation, autoimmunity) processes. …”
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Credit Risk Modeling Using Interpreted XGBoost by Marcin Hernes, Jędrzej Adaszyński, Piotr Tutak

“…The models often perform as the “black box”. However, the interpretation of the results of risk assessment models is very important due to the need to explain to the client the reasons for assessing their credit risk.…”
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Enteral Nutrition Practices and Complications in ICU Settings: A Cross-Sectional Study of Healthcare Professionals&rsquo; Perspectives in Saudi Arabia by Zaher S, Alhindi R, Alturki L, Alsobhi E, Alahmadi L, Aldhowayan HA

“…Sara Zaher, Reham Alhindi, Layan Alturki, Elaf Alsobhi, Lora Alahmadi, Hadeel Abdulla Aldhowayan Clinical Nutrition Department, College of Applied Medical Sciences, Taibah University, Madinah, Kingdom of Saudi ArabiaCorrespondence: Sara Zaher, Clinical Nutrition Department, College of Applied Medical Sciences, Taibah University, P.O. Box 344, Madinah, 42353, Kingdom of Saudi Arabia, Email Sz332@cam.ac.uk; szaher@taibahu.edu.saBackground: Enteral Nutrition (EN) is the preferred method for providing nutritional support in intensive care units (ICUs) compared to parenteral nutrition (PN) due to its physiological advantages, safety profile, and cost-effectiveness compared to parenteral nutrition (PN). …”
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Emission Factors of PAHs Components and Bioreactivity in PM2.5 from Biomass Burning by Xinye Zhu, Kin-Fai Ho, Tzu-Ting Yang, Vincent Laiman, Jian Sun, Zhenxing Shen, Hsiao-Chi Chuang

“…A549 cells were exposed to biomass PM2.5 at 0 and 50 µg mL–1 for 24 h, and the expression of Yes-associated protein (YAP), phosphorylated (p)-YAP, transcription coactivator with a PDZ-binding motif (TAZ), p-TAZ, E-cadherin, and high mobility group box 1 (HMGB1) proteins were assessed by Western blotting. …”
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Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma by Huai-Yu Wu, Shu-Ya Cao, Zheng-Gang Xu, Tian- Wang, Gu-Wei Ji, Ke Wang

“…Results A total of four gene signatures related to ERS, including Stanniocalcin-2 (STC2), Melanoma-Associated Antigen 3 (MAGEA3), BR Serine/Threonine-Protein Kinase 2 (BRSK2), DEAD/H-Box Helicase 11 (DDX11) were identified. Macrophages were significantly different between high-risk and low-risk groups. …”
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Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4 by Arushi Vats, Luca Braga, Nezka Kavcic, Paola Massimi, Edoardo Schneider, Mauro Giacca, Laimonis A. Laimins, Lawrence Banks

“…Upon validation of the interaction of 18E6 with these ubiquitin ligases in cervical cancer-derived cell lines, we found that the knockdown of ubiquitin ligase F-box protein 4 (FBXO4), together with E6AP knockdown, leads to a dramatic increase in the levels of endogenous HPV-18E6 oncoprotein. …”
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A deep learning-based method for the intelligent identification of the quantity of coals flushed out during borehole hydraulic flushing by Xiaojun LI, Mingyang ZHAO, Miao LI

“…The CIoU loss function was replaced with the SIoU loss function to accelerate the matching between prediction and ground truth boxes. Finally, the improved YOLOv8n algorithm was validated using a self-built dataset. …”
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The Creation of the Arabic Version of the Hyperhidrosis Quality of Life Index (HidroQoL&copy;) with Validation and Cross-Cultural Adaptation by Almuhaideb QA, AbuDujain NM, Alghamdi KM

“…Qais A Almuhaideb,1 Nasser M AbuDujain,2 Khalid M Alghamdi3,4 1Department of Dermatology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia; 2Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 3Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 4Vitiligo Research Chair, College of Medicine, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Khalid M Alghamdi, Department of Dermatology, Vitiligo Research Chair, College of Medicine, King Saud University, P.O. Box 240997, Riyadh, 11322, Saudi Arabia, Email kmgderm@gmail.comPurpose: Hyperhidrosis (HH) is characterized by excessive sweating, which can significantly affect quality of life. …”
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Do Activity Sensors Identify Physiological, Clinical and Behavioural Changes in Laying Hens Exposed to a Vaccine Challenge? by Hyungwook Kang, Sarah Brocklehurst, Marie Haskell, Susan Jarvis, Victoria Sandilands

“…., litter, perches, nest box), where they wore two sensors (FitBark, TrackLab). …”
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