Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice by Yoon-Young Sung, Seung-Hyung Kim, Dong-Seon Kim, Ji-eun Lee, Ho Kyoung Kim

“…We investigated the effects of treatment on airway hyperresponsiveness, IgE production, pulmonary eosinophilic infiltration, immune cell phenotypes, Th2 cytokine production in bronchoalveolar lavage, Th1/Th2 cytokine production in splenocytes, forkhead box protein 3 (Foxp3) expression, and lung histology. …”
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Changes in Corticospinal Tract Consistency after Dry Needling in a Stroke Patient by Masoome Ebrahimzadeh, Noureddin Nakhostin Ansari, Iraj Abdollahi, Behnam Akhbari, Jan Dommerholt

“…Additionally, secondary outcomes encompassed wrist extension range of motion (ROM) and performance in the box and block test (BBT). These measurements were taken both before and after the administration of DN treatment. …”
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ARTISTIC CREATIONS. ORIGINALITY, INSPIRATION, IMITATION AND ARTIFICIAL INTELLIGENCE by Carmen-Oana MIHĂILĂ

“…In these last few years, with the exponential development of artificial intelligence, Pandora's box of copyright issues has been opened. From a simple tool that helped the artist, it has led to original works created without human involvement. …”
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Consumer Preferences in Developing Derivative Product of Gluten Free Bread Cookly by Thania Usamah Balweel, Anny Ratnawati, Ani Nuraisyah

“…Conclusion: The most preferred attribute combination by respondents was a dominant savory taste with relatively low sugar content, a soft texture, bread with color, packaged in environmentally friendly boxes, and priced between IDR10,000-IDR25,000 Originality/value (State of the art): Cookly developed a convenient gluten-free bread product, the Gluten-Free Toasted Cassava Bread, with savory flavors offered as signature menu items and a "make your own" option. …”
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Transcranial Direct Current Stimulation (tDCS) in Unilateral Cerebral Palsy: A Pilot Study of Motor Effect by Emanuela Inguaggiato, Nadia Bolognini, Simona Fiori, Giovanni Cioni

“…Results showed, only following the active stimulation, an immediate improvement in unimanual gross motor dexterity of hemiplegic, but not of nonhemiplegic, hand in Box and Block test (BBT). Such improvement remained stable for at least 90 minutes. …”
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Energy-exergy and environ-economic (4E) analysis of heat storage-based single-slope solar stills integrated with solar air heater. by Sujit Kumar, Asim Ahmad, Kashif Irshad, Om Prakash, Rukaiya Kausher, S M Mozammil Hasnain, Prabhu Paramasivam, Abinet Gosaye Ayanie, Jayant Giri

“…The proposed solar still was modified by integrating a rectangular aluminium box filled with paraffin wax and black gravel as the TESS and coupled with a solar air heater. …”
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Improvement of the dissolution of the antineoplastic drug regorafenib through impregnation into pullulan polysaccharide using supercritical fluid technology: Optimization of the pr... by Ali Sheikhi, Sepideh Hamedi, Gholamhossein Sodeifian, Fariba Razmimanesh

“…Pullulan was first produced by Aureobasidium pullulans. A Box-Behnken design (BBD) was employed to optimize impregnation factors including temperature (308, 318 and 328 K), pressure (200, 240 and 280 bar) and time (5, 7 and 9 h) on drug loading. …”
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Optimization of extraction and enrichment process of cannabidiol from industrial hemp and evaluation of its bioactivity by Junkai Wu, Xiaomeng Zhang, Xiaoqing Liu, Zunlai Sheng, Zunlai Sheng, Jianping Hu, Feiyan Zhang

“…Cannabidiol (CBD), a non-psychotropic compound derived from industrial hemp, has garnered considerable interest due to its promising therapeutic potential.MethodsThe extraction parameters for CBD from industrial hemp were optimized using the Box-Behnken design and response surface methodology (RSM). …”
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The hidden drivers: Unraveling the impact of density, moisture, and scale on Hermetia illucens rearing. by Anjani Nayak, Patrick Klüber

“…In the second experiment, 300 and 350 larvae/box were tested at 70% and 75% moisture. The highest average individual larval fresh weight (158.6 mg) was observed at 70% moisture with 250 larvae, while the highest biomass was achieved at 75% moisture with 300 larvae. …”
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Knockout of <i>dhx38</i> Causes Inner Ear Developmental Defects in Zebrafish by Mengmeng Ren, Xiang Chen, Liyan Dai, Jiayi Tu, Hualei Hu, Xiaohan Sun, Jiong Luo, Pei Li, Yiyang Fu, Yuejie Zhu, Weiqiang Sun, Zhaohui Tang, Mugen Liu, Xiang Ren, Qunwei Lu

“…Disruptions in this process can result in both syndromic and non-syndromic forms of hearing loss. DHX38, a DEAH box RNA helicase, is integral to pre-mRNA splicing regulation and plays critical roles in development, cell differentiation, and stem cell maintenance. …”
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Central Corneal Subepithelial Haze Following Keratoplasty With Interrupted Sutures: A Novel Clinical Finding by Kirat O, Hawsawi R, AlHilali S

“…Omar Kirat, Rawan Hawsawi, Sara AlHilali Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi ArabiaCorrespondence: Sara AlHilali, Anterior segment division King Khaled Eye Specialist Hospital, P.O.Box 7191, Riyadh, 11462, Saudi Arabia, Tel +966544017155, Email SaraAlHilali@gmail.comPurpose: This study aims to describe a newly identified clinical finding of central corneal subepithelial haze following keratoplasty (both penetrating and lamellar) with interrupted sutures, and to explore its causes and management strategies.Methods: Case series.Results: The study included 7 males and 3 females, with an average age of 24.89 ± 6.57 years. …”
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Symbolic regression for strength prediction of eccentrically loaded concrete-filled steel tubular columns by Khaled Megahed

“…Previous studies have used two distinct approaches for estimating eccentric strength: explainable models based on theoretical derivations and black-box models derived from machine learning (ML) methods. …”
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Looking at Abortion Jurisprudence of the European Court of Human Rights as an Equality Issue by Kaisla Yli-Juuti

“…The aim is to change the underlying structures that cause inequalities in the first place and to celebrate differences instead of fitting everyone into the same box. A finding of a violation of Article 14 ECHR by the Court would provide additional benefits for those seeking justice under the ECHR framework for being denied legal abortions in their home States and would have a substantial impact as it would lead to acknowledging the disadvantages of belonging to certain groups, elimination of harmful gender stereotypes and to possible changes in domestic laws of the Contracting Parties due to the Court’s influence.…”
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Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis by Xiaoli Qin, Wenjing Niu, Kai Zhao, Yawen Luo, Wenfang Wang, Yang He, Fuyu Yang, Binghai Cao, Min Du, Huawei Su

“…Notably, gene expression analyses demonstrated that RES-treated mice exhibited elevated levels of myogenic markers, such as paired box 7 (Pax7), myogenic factor 5 (Myf5), myoblast determination protein (MyoD), and Myogenin (MyoG). …”
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A mini-review of sub-populations missing in the malaria control loop by Celina Onyawoibi Aju-Ameh

“…It is time to think outside the box. It is time for Africa to own her diseases, identify her research gaps and address them. …”
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HMGB1 released from pyroptotic vascular endothelial cells promotes immune disorders in exertional heatstroke by Chaoping Yu, Yang Huang, Jiangang Xie, Chujun Duan, Shanshou Liu, Wei Zhao, Yutong Wang, Ran Zhuang, Junjie Li, Wen Yin

“…As high mobility group box 1 (HMGB1) is a prototypical alarmin that activates inflammatory and immune responses, this study aimed to investigate the effect and mechanism of HMGB1 in the pathogenesis of EHS.Methods Peripheral blood mononuclear cell (PBMC) transcriptome sequencing of healthy volunteers, classical heatstroke patients, and EHS patients was performed. …”
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Photocatalytic improvement mechanism of SnO2/Sn-doped g-C3N4 Z-type heterojunctions for visible-irradiation-based destruction of organic pollutants: Experimental and RSM approaches by Yossor R. Abdulmajeed, Saad H. Ammar, Zaid H. Jabbar, Hind J. Hadi, Mohammed D. Salman, Alaa Jasim Awadh

“…Then, the process variables (IBP concentration, pH, and photocatalyst dose) were adjusted based on the Box-Behnken Design (BBD). The experimental IBP photodegradation was exceedingly correlated with that value predicted by the obtained quadratic model (R2 = 0.993, F-value = 79.19, and P-value <0.0001). …”
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IKEChecker: grammar-guided stateful fuzzer for IKE protocol implementions by ZHENG Yonghui, ZHAO Dongliang, GU Chunxiang, ZHANG Xieli

“…A message handler was designed to maintain protocol interaction context information and perform cryptographic operations, thereby supporting testing of the IKE protocol under black-box conditions. This enabled the exploration of deep protocol interaction behavior and state space. …”
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Study on Optimization of Grouting Curtain Design of Damsin Karst Areas Based on Response Surface Methodology by XIE Mengshan, CAO Lei, GUO Xiaojing, LIU Xu, ZHANG Cong, JIANG Maiyong, LI Jinyou

“…Curtain grouting is an effective measure to solve the seepage problem of dams in karst areas.In order to optimize the grouting curtain design of dams in karst areas and effectively control the seepage flow and pressure of the dam foundation,a curtain service model of dams in karst areas is firstly built by using multi-field coupling software,and the evaluation standard of curtain service performance of dams in karst areas is put forward.Secondly,based on experimental design of Box-Behnken response surface,a regression model among curtain permeability coefficient,curtain height,curtain width,and Ca(OH)₂ dissolution rate in the curtain body in karst areas is established.Finally,according to the fmincon function in Matlab,a model for optimizing design parameters of grouting curtain in karst areas is established,and the optimal combination of design parameters of curtain of a dangerous dam in the karst area is solved by taking the minimum curtain grouting amount as the optimization principle under the condition of satisfying the curtain service performance.The results show that the curtain permeability coefficient is the most important factor affecting the Ca(OH)₂ dissolution rate in the dam curtain in karst areas,followed by the curtain height and width.In view of the safety and economic requirements of the project,it is suggested that the curtain height of 15.80 m and the curtain width of 4.51 m should be adopted in the curtain design of the dam in the karst area.The research results can provide a reference for evaluating the service performance of dam curtain in karst areas and offer a new idea for optimizing the design of grouting curtain of dams in karst areas.…”
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Analysis of Rainfall Erosion and Protective Measures for the Aeolian Sand Subgrade Slope of the Wuma Expressway by Wenhua Yin, Fang Wang, Weizheng Liu, Yongxiang Wu, Xu Wang

“…The research found the stability of the subgrade slope given potential for rainfall erosion due to concentrated-rainfall periods in an aeolian sand region is promoted through measures including slope drainage on the highway combined with side ditch drainage, strengthening of the box culvert under embankment ditches, and local protection by laying geogrid in the embankment to produce a significant lateral diffusion effect.…”
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