Cytokine and Chemokine Profile in Patients with Multiple Myeloma Treated with Bortezomib by Paweł Robak, Edyta Węgłowska, Izabela Dróżdż, Damian Mikulski, Dariusz Jarych, Magdalena Ferlińska, Ewa Wawrzyniak, Małgorzata Misiewicz, Piotr Smolewski, Wojciech Fendler, Janusz Szemraj, Tadeusz Robak

“…Higher levels of MIP-1α and lower levels of MIP-1β and IL-9 were associated with better responses to bortezomib-based treatment, and higher levels of IL-1ra and IL-8 were associated with bone involvement. MCP-1 was elevated in patients with hemoglobin<10 g/dl compared to those without anemia. …”
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Isolated Liver Metastasis of Sacrococcygeal Chordoma: Case Report and Review of the Literature by Murat Akyol, Umut Varol, Ibrahim Yildiz, Ibrahim Vedat Bayoglu, Yasar Yildiz, Lutfiye Demir, Ahmet Dirican, Alper Can, Suna Cokmert, Mine Tunakan Oztop, Ahmet Alacacioglu, Yuksel Kucukzeybek, Mustafa Oktay Tarhan

“…Chordomas rarely metastasize to lung, bone, soft tissue, liver, lymph nodes, and skin. …”
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Human Suprapatellar Fat Pad-Derived Mesenchymal Stem Cells Induce Chondrogenesis and Cartilage Repair in a Model of Severe Osteoarthritis by Ignacio Muñoz-Criado, Jose Meseguer-Ripolles, Maravillas Mellado-López, Ana Alastrue-Agudo, Richard J Griffeth, Jerónimo Forteza-Vila, Ramón Cugat, Montserrat García, Victoria Moreno-Manzano

“…Cartilage degeneration is associated with degenerative bone and joint processes in severe osteoarthritis (OA). …”
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TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility by Elijah Edmondson, Takahito Kimura, Eunmi Hwang, Minjun Kim, Andrew Warner, Yuelin Zhu, Li Zhao, Yanlin Yu, Xuguang Zhu, Maria Hernandez, Noemi Kedei, Sheue-yann Cheng

“…We created a mouse model expressing a dominant negative mutated TRα1 (Thra1PV/+ mice) that exhibits growth retardation, bone abnormalities, constipation, and anemia, as found in RTHα patients. …”
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A two-scale computational homogenization approach for elastoplastic truss-based lattice structures by Hooman Danesh, Lisamarie Heußen, Francisco J. Montáns, Stefanie Reese, Tim Brepols

“…The framework is validated through numerical examples, including a double-clamped beam, a square plate under tension, and a dog-bone specimen under cyclic loading. It is demonstrated that the homogenization framework accurately captures force-displacement responses as well as full-field local solutions during loading, unloading, and reverse loading. …”
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Sex Difference in the Association of Osteoporosis and Osteopenia Prevalence in Patients with Adrenal Adenoma and Different Degrees of Cortisol Excess by Shoichiro Izawa, Kazuhisa Matsumoto, Kazuhiko Matsuzawa, Takuyuki Katabami, Takanobu Yoshimoto, Michio Otsuki, Masakatsu Sone, Yoshiyu Takeda, Shintaro Okamura, Takamasa Ichijo, Mika Tsuiki, Tomoko Suzuki, Mitsuhide Naruse, Akiyo Tanabe

“…Prevalence of fragility fractures, medication for osteoporosis, and bone mineral density. Results. In total, 112 of 237 patients, who were predominantly female (P<0.001) and had lower BMI (P=0.013), had OS/OP. …”
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Stem Cell Transplantation for Ovarian Cancer Patient with Associated Myelodysplasia After Maintenance Therapy with Olaparib: A Case Report by Linn Z, Gu Z, Wang L, Cai S

“…After two years, she experienced abnormal blood test results, which ultimately led to a diagnosis of myelodysplastic syndrome (MDS), confirmed through a bone marrow biopsy. Despite initial obstacles, the patient underwent stem cell transplantation as a treatment for MDS. …”
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Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Induce T Lymphocyte Apoptosis and Cell Cycle Arrest by Expression of Indoleamine 2, 3-Dioxygenase by Xiuying Li, Zhuo Xu, Jinping Bai, Shuyuan Yang, Shuli Zhao, Yingjie Zhang, Xiaodong Chen, Yimin Wang

“…In this study, we have compared the MSCs from bone marrow (BM), adipose tissue (AT), placenta (PL), and umbilical cord (UC) to determine which one displayed the most efficient immunosuppressive effects on phytohemagglutinin-induced T cell proliferation. …”
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Mechanical Strain-Mediated Tenogenic Differentiation of Mesenchymal Stromal Cells Is Regulated through Epithelial Sodium Channels by Hui Yin Nam, Malliga Raman Murali, Raja Elina Ahmad, Belinda Pingguan-Murphy, Hanumantha Rao Balaji Raghavendran, Tunku Kamarul

“…The present study was thus conducted to investigate the role of ENaC in human bone marrow-derived MSCs (hMSCs) tenogenic differentiation during uniaxial tensile loading. …”
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Effects of Muse Cell on a Mouse Model With Acute Encephalopathy by Tatsuya Kawaguchi, Tetsuji Mori, Kaori Adachi, Jun Fujii, Yoshihiro Maegaki, Fumiko Obata

“…Although non‐Muse cells, a residual cell population in the bone marrow after isolating Muse cells, also improved some symptoms, their effects were weaker than those of Muse cells. …”
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Differences and Correlations of Anxiety, Sleep Quality, and Pressure-Pain Threshold between Patients with Chronic Low Back Pain and Asymptomatic People by Changming Xu, Zhiwei Fu, Juan Wang, Bao Wu, Xue-Qiang Wang

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The Fibularis Quartus Muscle: A Cadaveric Case Report with Historical, Embryological, Molecular and Clinical Considerations by Dibakar Borthakur, Rajesh Kumar, Namaschivayam G R, Mohammed Ahmed Ansari, Seema Singh

“…FQ arises from the fibularis brevis (FB) in most instances and distally gets attached to the lateral aspect of the base of the fifth metatarsal or the cuboid or the calcaneus bone. The muscle has been implicated in a variety of clinical problems ranging from ankle pain to subluxation and tear of peroneal tendons. …”
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Correlation of serum C - reactive protein with clinical parameters in diabetic patients having chronic periodontitis before and after treatment by Arkhawan Ali Abdulhaq, Ziwar Ahmed Salih, Solaf Abdulqadir Mustafa

“… Background and Objectives: Chronic periodontitis is an infectious disease characterized by inflammation within the supporting tissues of the teeth, progressive attachment loss, and bone loss. C-reactive protein, are acute phase proteins monitored as a marker of inflammatory status. …”
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The Value of Immune-Related Genes Signature in Osteosarcoma Based on Weighted Gene Co-expression Network Analysis by Xin Wang, Li Gan, Ju Ye, Mengjie Tang, Wei Liu

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Impact of delayed pelvic imaging on the staging of biochemical recurrence in prostate cancer patients using [18F]DCFPYL PET/CT: a retrospective evaluation by Ana Rodríguez-Pajuelo, Miriam Guerra-Gómez, Juan Ignacio Cuenca Cuenca, José María Freire-Macías, José Manuel Jiménez-Hoyuela García, Rosa María Álvarez-Pérez

“…We analyzed the number and maximum SUV (SUVmax) of lesions only in the pelvic region (prostate, locoregional lymph nodes and bone), based on PSMA-RADS version 2.0 and miTNM criteria. …”
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Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimenta... by Ren J, Liu Z, Qi X, Meng X, Guo L, Yu Y, Dong T, Li Q

“…Jinhong Ren, Ze Liu, Xiaoming Qi, Xiangda Meng, Linglin Guo, Yating Yu, Tao Dong, Qingshan Li Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, People’s Republic of ChinaCorrespondence: Qingshan Li, Email sxlqs0501@sxtcm.edu.cnBackground: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease in which macrophages produce cytokines that enhance inflammation and contribute to the destruction of cartilage and bone. Additive Sishen decoction (ASSD) is a widely used traditional Chinese medicine for the treatment of RA; however, its active ingredients and the mechanism of its therapeutic effects remain unclear.Methods: To predict the ingredients and key targets of ASSD, we constructed “drug-ingredient-target-disease” and protein–protein interaction networks. …”
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Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques by Yaning Li, Yan Wang, Yang Yao, Brian B. Griffiths, Liangshu Feng, Tao Tao, Feng Wang, Baohui Xu, Creed M. Stary, Heng Zhao

“…We detected these immune cells from the ischemic brain, peripheral blood, spleen, and bone marrow at different time courses after stroke. …”
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The production process of chepa shutki: A traditional Bangladeshi fermented fish product by Jasmin Ara Farhana, Sijmen E. Schoustra, Ferdous Ahamed, Bas Zwaan, Oscar van Mastrigt

“…Although chepa shutki is an important part of the human diet in Bangladesh, providing flavour as well as essential nutrients (especially protein and bone minerals), research on variations in production of chepa shutki has been limited. …”
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Sulforaphane attenuates dextran sodium sulphate induced intestinal inflammation via IL-10/STAT3 signaling mediated macrophage phenotype switching by Yuyang Sun, Jiqing Tang, Cui Li, Jun Liu, Haijie Liu

“…Of note, sulforaphane skewed the switching from classically (M1) to alternatively (M2) activated phenotype both in intestinal and bone marrow-derived macrophages (BMDMs). The expression levels of M1 associated maker genes induced by DSS or lipopolysaccharide (LPS) plus interferon gamma-γ (IFN-γ) were suppressed by sulforaphane while M2 marker gene expression levels were improved. …”
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Case report: A rare case of delayed drug-induced hyponatremia in recurrent upper tract urothelial carcinoma following GC and Tislelizumab treatment by Zhi-Jie Wang, Zhi-Jie Wang, Ying-Fang Nie, Shi-Bing Liang, Shi-Bing Liang, Shi-Bing Liang, Jing Zhou, Shu-Lan Hao, Li-Kun Liu

“…From the third cycle, due to grade IV bone marrow suppression, she had Tislelizumab alone. …”
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