Proof of concept of fully automated adaptive workflow for head and neck radiotherapy treatments with a conventional linear accelerator by Gaia Muti, Marco M. J. Felisi, Angelo F. Monti, Chiara Carsana, Roberto Pellegrini, Edoardo Salmeri, Mauro Palazzi, Paola E. Colombo

“…The organs at risk (OARs) of the H&N district and five additional structures (air, fat, tissue, bone and patient’s exterior) subsequently used for the creation of the synthetic CT are auto-contoured with the Elekta ADMIRE® software. …”
Get full text

Role of SOCS2 in the Regulation of Immune Response and Development of the Experimental Autoimmune Encephalomyelitis by Allysson Cramer, Bruno Cabral de Lima Oliveira, Paulo Gaio Leite, David Henrique Rodrigues, Fatima Brant, Lisia Esper, Pollyana Maria Oliveira Pimentel, Rafael Machado Rezende, Milene Alvarenga Rachid, Antonio Lucio Teixeira, Ana Maria Caetano Faria, Mauro Martins Teixeira, Fabiana Simão Machado

“…There was a prolonged inflammatory response (increased Th1 and decreased Th2 and T regulatory cells) in the late phase of EAE in the CNS of SOCS2-/- mice. Transplantation of bone marrow cells from SOCS2-/- into irradiated WT mice resulted in higher lethality at the early phase of EAE. …”
Get full text

Assessment of Vitamin D3 Level Among a Sample of Type 2 Diabetic Patients Attending Diabetes and Endocrinology Center in Al-Hilla City by Ahmed Mahdi Habeeb, Atta Ah Mousa Al-Sarray, Ali Hussein Al Hafidh, Rafah Sabah Barrak, Afraa Brahim

“…Aside from its well-known effects on bone health, vitamin D has been hypothesized to play a role in various disease states and health situations, such as cardiovascular disease and type 2 diabetes. …”
Get full text

Alterations of the Temporomandibular Joint on Magnetic Resonance Imaging according to Growth and Development in Schoolchildren by Tatsurou Tanaka, Tetsuro Konoo, Manabu Habu, Masafumi Oda, Shinji Kito, Masaaki Kodama, Shinya Kokuryo, Nao Wakasugi-Sato, Shinobu Matsumoto-Takeda, Ikuko Nishida, Kazumasa Morikawa, Katsura Saeki, Kenshi Maki, Kazuhiro Tominaga, Shin-ichi Masumi, Masamichi Terashita, Yasuhiro Morimoto

“…The relationship between red marrow and yellow marrow in the articular eminence of temporal bone, the disappearance of DCLS, and alterations of the mandibular condyle have been elucidated.…”
Get full text

Three-dimensional evaluation of tongue position and volume in adult patients with different skeletal malocclusions by CHIOU Wei-Cho, MEN Xinrui, ZHANG Kaiwen, JIANG Xiaoge, CHEN Song

“…Additionally, tongue volume showed a significant positive correlation with Go-Gn and Pg-Np (<i>P </i>&lt; 0.01), as well as with maxillary and mandibular dental arch width and basal bone arch width (<i>P </i>&lt; 0.01). Upper airway volume was positively correlated with TT-VRL and TP-VRL (<i>P </i>&lt; 0.05). …”
Get full text

Comparative Numerical Analysis between Two Types of Orthodontic Wire for the Lingual Technique, Using the Finite Element Method by Rosa Alicia Hernández-Vázquez, Rodrigo Arturo Marquet-Rivera, Octavio Alejandro Mastache-Miranda, Angel Javier Vázquez-López, Salvador Cruz-López, Juan Alejandro Vázquez-Feijoo

“…Using 3D imaging, a high-biofidelity biomodel of the patient’s mandible was generated, with which the FEM analysis was performed, which allowed comparing the reactions of the mandibular bone and appliances with the different arches. It was found that, on the side with the straight arch, there were greater deformations, and in the mushroom arch, there were greater stresses. …”
Get full text

Warifteine, an Alkaloid Purified from Cissampelos sympodialis, Inhibits Neutrophil Migration In Vitro and In Vivo by Thaline F. A. Lima, Juliana D. B. Rocha, Anderson B. Guimarães-Costa, José M. Barbosa-Filho, Débora Decoté-Ricardo, Elvira M. Saraiva, Luciana B. Arruda, Marcia R. Piuvezam, Ligia M. T. Peçanha

“…In vivo warifteine treatment inhibited casein-induced neutrophil migration to the peritoneal cavity but did not inhibit neutrophil mobilization from the bone marrow. Analysis of the direct effect of warifteine upon neutrophil adherence and migration in vitro demonstrated that the alkaloid decreased cell adhesion to P and E-selectin-transfected cells. …”
Get full text

Inferior outcome of stand-alone short versus long tibial stem in revision total knee arthroplasty. A retrospective comparative study with minimum 2 year follow-up by Abdelatif Elsayed Ahmed, Abu Mukh Assala, Elsaid Ahmed Nady Saleh, Youssef Ahmed Omar, Foissey Constant, Servien Elvire, Lustig Sebastien

“…Introduction: Revision Total Knee Arthroplasty (RTKA) is complex, and induced bone loss might endanger implant fixation and joint stability. …”
Get full text

Autologous precision-cut lung slice co-culture models for studying macrophage-driven fibrosis by So-Yi Chang, So-Yi Chang, Wen-Hsin Chang, Wen-Hsin Chang, David C. Yang, Qi-Sheng Hong, Qi-Sheng Hong, Ssu-Wei Hsu, Ssu-Wei Hsu, Reen Wu, Ching-Hsien Chen, Ching-Hsien Chen

“…Chemotactic studies revealed increased migration of autologous bone marrow-derived macrophages (BMDMs) toward and infiltration into CSE-injured PCLS. …”
Get full text

An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review by Reina Takeda, Kazuaki Yokoyama, Seiichiro Kobayashi, Toyotaka Kawamata, Sousuke Nakamura, Tomofusa Fukuyama, Mika Ito, Nozomi Yusa, Eigo Shimizu, Nobuhiro Ohno, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Kaoru Uchimaru, Arinobu Tojo

“…The patient presented with persistent fever and monocytosis without any evidence of infectious diseases. Bone marrow examinations revealed chronic myelomonocytic leukemia-like disease with a chromosomal translocation of t(11;22)(q23;q13) as a solo cytogenetic abnormality, resulting in the diagnosis of t-MN. …”
Get full text

Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome by Manjula Nandakumar, Priya Das, Thozhukat Sathyapalan, Alexandra E. Butler, Stephen L. Atkin

“…Results: Eleven CVRPs were dysregulated in PCOS (whole set, without matching for body mass index (BMI) or insulin resistance (IR)): leptin, Interleukin-1 receptor antagonist protein (IL-1Ra), polymeric immunoglobulin receptor (PIGR), interleukin-18 receptor (IL-18Ra), C-C motif chemokine 3 (MIP-1a), and angiopoietin-1 (ANGPT1) were upregulated whilst advanced glycosylation end product-specific receptor, soluble (sRAGE), bone morphogenetic protein 6 (BMP6); growth/differentiation factor 2 (GDF2), superoxide dismutase [Mn] mitochondrial (MnSOD), and SLAM family member 5 (SLAF5) were downregulated versus the controls. …”
Get full text

Anti-NMDAR-Positive Small-Cell Lung Cancer Paraneoplastic Limbic Encephalitis: A Case Report and Literature Review by Raman Sohal, Steven H. Adams, Vishal Phogat, Abha Harish, Carlos Ynigo D. Lopez, Michael P. A. Williams, Kamal K. Khurana, Basel Abuzuaiter, Nia Jagroop, Bhavya Narapureddy

“…FNA of the R4 lymph node revealed SCLC. The NM bone scan showed no osteoblastic lesions. While the serum autoantibody panel was positive for anti-NMDAR, the CSF autoantibody panel returned entirely negative. …”
Get full text

The Role of 3D Virtual Anatomy and Scanning Environmental Electron Microscopy in Understanding Morphology and Pathology of Ancient Bodies by Sara Salucci, Mirko Traversari, Laura Valentini, Ilaria Versari, Luca Ventura, Emanuela Giampalma, Elena Righi, Enrico Petrella, Pietro Gobbi, Gianandrea Pasquinelli, Irene Faenza

“…However, the radiological approach shows some limitations. Although bone structures are easy to differentiate, soft tissue components are much more challenging, especially when they overlap. …”
Get full text

Management and outcomes of thoracic sarcomas - a collaboration between Orthopaedic Oncology and cardiothoracic surgery: seven-year clinical data from a tertiary referral centre by Zaid Ahmed Shamsi, Vlad Paraoan, Chang Kim, Sarah Raihanah Saifuddin, Thomas D A Cosker, Duncan Whitwell, Christopher L M H Gibbons, Dionisios Stavroulias, Francesco DiChiara

“…This approach necessitates a multidisciplinary team, ideally in specialised cancer centres. The Oxford Bone and Soft Tissue Tumour Service is one such centre, and routinely treats such cancers through collaboration between orthopaedic oncology and cardiothoracic surgeons, as well as members of the wider MDT. …”
Get full text

Insulin-Attenuated Inflammatory Response of Dendritic Cells in Diabetes by Regulating RAGE-PKCβ1-IRS1-NF-κB Signal Pathway: A Study on the Anti-Inflammatory Mechanism of Insulin in... by Liding Zhao, Ya Li, Qingbo Lv, Min Wang, Yi Luan, Jiale Song, Guosheng Fu, Junbo Ge, Yunzeng Zou, Wenbin Zhang

“…Streptozotocin was injected into the diabetic mice model. The bone marrow-derived DCs (BMDCs) were obtained from C57BL/6 mice. …”
Get full text

Post-craniotomy infections: A point-by-point approach by Giovanni Carone, Marta Bonada, Evelyn Gisell Belotti, Eugenia D'Angeli, Annica Piccardi, Fabio Martino Doniselli, Guido Gubertini, Cecilia Casali, Francesco DiMeco, Massimiliano Del Bene

“…Surgical intervention is often indispensable for managing organ-space infections, with a trend towards bone flap preservation and one-step cranioplasty procedures in certain cases. …”
Get full text

Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a p... by Ziyu Weng, Chenzhong Wang, Bo Liu, Yi Yang, Yueqi Zhang, Chi Zhang

“…Abstract Background Osteoarthritis (OA), characterized by progressive degeneration of cartilage and reactive proliferation of subchondral bone, stands as a prevalent condition in orthopedic clinics. …”
Get full text

Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain by Christian Kirschneck, Erika Calvano Küchler, Michael Wolf, Gerrit Spanier, Peter Proff, Agnes Schröder

“…Extracellular matrix remodeling (COL1A2, FN1) and bone anabolism (ALPL), by contrast, were significantly stimulated particularly at 5.49 μM. …”
Get full text

A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression by Qiuyang Wang, Kai Feng, Guangsheng Wan, Wei Liao, Jing Jin, Peng Wang, Xiaolian Sun, Weijun Wang, Qing Jiang

“…The si-Fe-HPP treatment not only notably alleviated synovitis, osteophyte formation and subchondral bone sclerosis, but also markedly improved physical activity and reduced pain in DMM-induced OA mice. …”
Get full text

The Cognitive Differences between the Teachers and Students in the Emergency Professional Skills Training Program of Standardized Residency Training by LYU Baopu, LIU Liang, XIAO Hao, GONG Yu, MENG Qingbing, GAO Hengbo, TIAN Yingping, YAO Dongqi

“…There are no differences were observed between teachers and students in terms of &quot;difficulty&quot; and &quot;omissions during operation&quot; for the remaining three: pericardium puncture, cardioversion, and bone marrow puncture (P&gt;0.05) . Conclusion This study confirmed that there are differences between teachers and trainees in the &quot;difficulty&quot; and &quot;omissions in operation&quot; of core skills training in emergency department. …”
Get full text