The Holy Grail of Orthopedic Surgery: Mesenchymal Stem Cells—Their Current Uses and Potential Applications by Roberto Berebichez-Fridman, Ricardo Gómez-García, Julio Granados-Montiel, Enrique Berebichez-Fastlicht, Anell Olivos-Meza, Julio Granados, Cristina Velasquillo, Clemente Ibarra

“…Here, we review the application of MSCs to various orthopedic conditions, namely, orthopedic trauma; muscle injury; articular cartilage defects and osteoarthritis; meniscal injuries; bone disease; nerve, tendon, and ligament injuries; spinal cord injuries; intervertebral disc problems; pediatrics; and rotator cuff repair. …”
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Dyslipidemia Impacts Cardiometabolic Health and CVD Risk in a Relatively Young Otherwise Healthy Population by Jillian M. Lang, Elena S. Shostak, William K. Quinn, Valerie D. Chervinskaya, Elisa Fioraso, Everett Smith, Christopher J. Kotarsky, Justin A. DeBlauw, Jennifer L. Lloyd, Stephen J. Ives

“…There were significant differences between groups for body weight and composition (total mass, muscle mass, visceral fat, bone mass, and body mass index, all, p < 0.027, Cohen's d > 0.605) with the dyslipidemia group being higher. …”
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Non-cancerous CT findings as predictors of survival outcome in advanced non-small cell lung cancer patients treated with first-generation EGFR-TKIs. by Pakorn Prakaikietikul, Pattraporn Tajarenmuang, Phumiphat Losuriya, Natee Ina, Thanika Ketpueak, Thanat Kanthawang

“…Baseline CT chest assessed visceral/subcutaneous fat (L1 level), sarcopenia, and myosteatosis (multiple levels), main pulmonary artery (MPA) size, MPA to aorta ratio, emphysema, and bone mineral density. Cox regression analyzed prognostic factors at 18-month outcome.…”
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CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review by M. Guerreiro, F. Príncipe, M. J. Teles, S. Fonseca, A. H. Santos, E. Fonseca, P. Gomes, C. Marques, M. Lima

“…He had hepatosplenomegaly, severe pancytopenia, hepatic cytolysis, and very high serum lactic dehydrogenase levels. The bone marrow studies resulted in the diagnosis of an EBV-positive, CD56-negative ANKL. …”
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Th9 Cells in Peripheral Blood Increased in Patients with Immune-Related Pancytopenia by Qing Shao, Yangyang Wang, Zhaoyun Liu, Hui Liu, Yihao Wang, Yang Zhao, Lijuan Li, Rong Fu

“…Immune-related pancytopenia (IRP) is a kind of autoimmune disease mediated by autoantibodies in bone marrow. T helper 9 (Th9) cell is a new subset of T cell discovered recently, which mainly expresses cytokine interleukin-9 (IL-9) to exert immune function. …”
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Сandidate SNP-markers of rheumatoid arthritis that can significantly alter the affinity of the TATA-binding protein for human gene promoters by I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, I. A. Drachkova, E. A. Oshchepkova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, V. A. Kozlov

“…Rheumatoid polyarthritis (RA) is an autoimmune disease with autoantibodies, including antibodies to citrullant antigens and proinflammatory cytokines, such as TNF-α and IL-6, which are involved in the induction of chronic synovitis, bone erosion, followed by deformity. Immunopathogenesis is based on the mechanisms of the breakdown of immune tolerance to its own antigens, which is characterized by an increase in the activity of T-effector cells, causing RA symptomatology. …”
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The Safety and Efficacy of the Repeated PRRT with [90Y]Y/[177Lu]Lu-DOTATATE in Patients with NET by Anna Zemczak, Paweł Gut, Dariusz Pawlak, Maciej Kołodziej, Leszek Królicki, Beata Kos-Kudła, Marek Ruchała, Grzegorz Kamiński, Jolanta Kunikowska

“…No other cases of grade 3 or 4 bone marrow and renal toxicity were observed. The median PFS rate was 31 months after the PRRT and 23 months following the R-PRRT. …”
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New prognostic model in patients with advanced urothelial carcinoma treated with second-line immune checkpoint inhibitors by Ernest Choy, Yohann Loriot, Fabio Calabrò, Cora N Sternberg, Guillermo De Velasco, Daniel Castellano, Roubini Zakopoulou, Aristotelis Bamias, Nicholas James, Axel Merseburger, F Lopez-Rios, Mario Kramer, Kimon Tzannis

“…The development and internal validation of a prognostic model for overall survival (OS) was performed using Cox regression analyses, bootstrapping methods and calibration.Results In 936 patients, ECOG PS, alkaline phosphatase, hemoglobin, neutrophil-to-lymphocyte ratio, liver metastases, bone metastases and time from last chemotherapy were identified as independent prognostic factors. …”
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Femoral Head Pathology in Subcapital Hip Fractures: Clinical Value and Cost-Effectiveness in a 230-Patient Case Series by Nissim Ohana, Omer Marom, David Segal, Refael Behrbalk, Yuval Ben-Sira, Alex Tavdi, Ezequiel Palmanovich, Eyal Yaacobi

“…The routine pathological examination of resected femoral heads in such cases is common practice, aimed at identifying malignancies that may have contributed to bone fragility. This study evaluated the cost-effectiveness and clinical utility of routine femoral head pathology in patients undergoing surgical treatment for SCF. …”
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Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein by Paula Andréa Malveira Cavalcante, Natalia Alenina, Alexandre Budu, Leandro Ceotto Freitas-Lima, Thaís Alves-Silva, Juan Sebastian Henao Agudelo, Fatimunnisa Qadri, Niels Olsen Saraiva Camara, Michael Bader, Ronaldo Carvalho Araújo

“…This study revealed an important role for M2 macrophages and the YM1/Chi3l3 protein in hypertensive nephropathy in a mouse model of hypertension. Bone marrow cells were isolated from the femurs and tibia of male FVB/N (control) and transgenic hypertensive animals that overexpressed the rat form of angiotensinogen (TGM(rAOGEN)123, TGM123-FVB/N). …”
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Stress distribution in endodontically treated external cervical resorption lesions restored with MTA and biodentine – A finite element analysis by Mudita Manaktala, Sonali Taneja, Vidhi Kiran Bhalla

“…Three-dimensional models of maxillary central incisors were generated based on CBCT scans, incorporating periodontal ligament and surrounding bone structures. Eight experimental models representing different ECR configurations were created and subjected to FEA using Optistruct software based on dimensional classification given by Patel et al., in 2018, A70 M &amp; A70B: 1Ap, A130 M &amp; A130B: 1Bp, B70 M &amp; B70B: 2Ap, B130 M &amp; B130B: 2Bp. …”
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A novel LC-MS/MS analysis of vitamin D metabolites in mice serum and hair: impact of diet and light exposure by Muhammad K. Hakeem, Asma Al-Menhali, Sampath K. Elangovan, Iltaf Shah

“…IntroductionNumerous physiological systems, such as the functioning of the immune system, bone health, and the regulation of expression of genes, depend critically on vitamin D. …”
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Pharmacological Preconditioning Improves the Viability and Proangiogenic Paracrine Function of Hydrogel-Encapsulated Mesenchymal Stromal Cells by Francesco K. Touani, Melanie Borie, Feryel Azzi, Dominique Trudel, Nicolas Noiseux, Shant Der Sarkissian, Sophie Lerouge

“…In this work, we hypothesize that pharmacological preconditioning with celastrol, a natural potent antioxidant, could improve the viability and functions of mesenchymal stromal cells (MSC) encapsulated within an injectable scaffold. Bone marrow MSCs from rat (rMSC) and human (hMSC) origin were preconditioned for 1 hour with celastrol 1 μM or vehicle (DMSO 0.1% v/v), then encapsulated within a chitosan-based thermosensitive hydrogel. …”
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Considérations ontogénétiques et phylogénétiques concernant l’origine de la parole by Louis-Jean Boë, Jean Granat, Jean-Louis Heim, Jean-Luc Schwartz, Pierre Badin, Guillaume Barbier, Guillaume Captier, Antoine Serrurier, Nicolas Kielwasser

“…We attempt to: (1) Localize hyoid bone and then glottis position; (2) Reconstitute a vocal tract model in a plausible way using an articulatory model; (3) Quantify the acoustic capabilities of this reconstituted vocal tract. …”
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HGF-Modified Dental Pulp Stem Cells Mitigate the Inflammatory and Fibrotic Responses in Paraquat-Induced Acute Respiratory Distress Syndrome by Panpan Geng, Yuning Zhang, Huan Zhang, Xiwen Dong, Yuefeng Yang, XiaoNa Zhu, Chu-Tse Wu, Hua Wang

“…MSCs can be derived from bone marrow (BM-MSCs), adipose tissue (AD-MSCs), umbilical cord (UC-MSCs), dental pulp (DPSCs), and other sources. …”
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Dendriform pulmonary ossification in military combat veterans: A case series by Jeremy T. Hua, Carlyne D. Cool, Tami J. Bang, Silpa D. Krefft, Richard C. Kraus, Cecile S. Rose

“…Dendriform pulmonary ossification (DPO) is a rare condition characterized by mature bone formation in the lung. DPO has been linked to various conditions, but little is known about the link between DPO and hazardous airborne exposures. …”
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Outcomes of oncologic arthroplasty in children and adolescents with malignant limb tumors: a systematic review by Vyacheslav I. Zorin, Sergei V. Vissarionov, Alexandr Y. Makarov, Timofey S. Rybinskikh, Kristina N. Rodionova

“…Amputation was historically the primary surgical intervention for children with limb bone sarcomas. However, the development and refinement of chemotherapy and radiotherapy protocols, along with advances in surgical techniques and implants, have significantly altered the treatment landscape for these patients. …”
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Universal conditional networks (UniCoN) for multi-age embryonic cartilage segmentation with Sparsely annotated data by Nishchal Sapkota, Yejia Zhang, Zihao Zhao, Maria Jose Gomez, Yuhan Hsi, Jordan A. Wilson, Kazuhiko Kawasaki, Greg Holmes, Meng Wu, Ethylin Wang Jabs, Joan T. Richtsmeier, Susan M. Motch Perrine, Danny Z. Chen

“…Abstract Osteochondrodysplasia, affecting 2–3% of newborns globally, is a group of bone and cartilage disorders that often result in head malformations, contributing to childhood morbidity and reduced quality of life. …”
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Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome with Purely Osteolytic, Not Osteosclerotic, Lesions Mimicking a Malignant Tumor by Hideyuki Kinoshita, Takeshi Ishii, Hiroto Kamoda, Yoko Hagiwara, Toshinori Tsukanishi, Sumihisa Orita, Kazuhide Inage, Naoya Hirosawa, Seiji Ohtori, Tsukasa Yonemoto

“…Although SAPHO syndrome was suspected because of palmoplantar pustulosis, based on radiologic findings, bone metastasis of a malignant tumor or chronic bacterial osteomyelitis owing to a purely osteolytic lesion was suspected. …”
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Severe pregnancy-associated atypical hemolytic uremia syndrome in the context of the COVID-19 pandemic: a novel survival case report by Yan Yang, Xiao-jin Li, Hua-Yan Yuan, Jing-Jing Xiong, Peng-Fei Li, Zhen Wang

“…Renal function improved gradually, and a bone marrow biopsy revealed no fragmented red blood cells. …”
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