NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model by Ismail M Meraz, Mourad Majidi, Renduo Song, Feng Meng, Lihui Gao, Qi Wang, Jing Wang, Elizabeth J Shpall, Jack A Roth

“…Humanized-mice were generated by transplanting fresh human cord blood-derived CD34 stem cells into sub-lethally irradiated NSG mice. …”
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Diagnosis, treatment, surgical practices and review of the literature in rare coagulation factor deficiencies by Hüseyin Avni Solgun

“…The normal range laboratory reference values for rare blood factor levels in our institute (factor V, VII and X deficencies) is 70–120%. …”
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Positron emission tomography for phenotyping inflammation of cardiovascular diseases by Xiaoyun Luo, Chentao Jin, Hetian Chen, Xiaohui Zhang, Yan Zhong, Peili Cen, Hong Zhang, Mei Tian

“…However, the current tools used to measure inflammation have some limitations. Blood biomarkers cannot pinpoint the location of inflammation and are vulnerable to various factors. …”
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Gender differences in efficiency of the telemedicine care of heart failure patients. The results from the TeleEduCare-HF study by Agata Bielecka-Dąbrowa, Dariusz Trzmielak, Agata Sakowicz, Kamil Janikowski, Maciej Banach

“…Based on regular measurements of weight and blood pressure HF patients were telemonitored by nurses, primary care physicians and referred to cardiologists when necessary. …”
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Effect of Rifaximin and a Multi-Strain Probiotic on the Intestinal Microbiome and Cardiovascular Risk Indicators in Patients with Coronary Heart Disease by E. A. Kashukh, E. A. Poluektova, A. V. Kudryavtseva, G. S. Krasnov, V. I. Kazey, P. D. Sobolev, P. V. Gremyakova, V. T. Ivashkin

“…Group 4 consisted of healthy individuals, comparable in age and sex with the examined CHD patients. In group 4, blood and stool tests were performed once to provide a comparison with group 1. …”
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Hyperglycemia and Correlated High Levels of Inflammation Have a Positive Relationship with the Severity of Coronavirus Disease 2019 by Wen Zhang, Chuanwei Li, Yu Xu, Binfeng He, Mingdong Hu, Guoqiang Cao, Li Li, Shuang Wu, Xia Wang, Chun Zhang, Jianping Zhao, Jungang Xie, Zihui Xu, Qi Li, Guansong Wang

“…This study sought to investigate whether blood glucose (BG) levels or comorbid diabetes are associated with inflammatory status and disease severity in patients with COVID-19. …”
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NALCN expression is down-regulated and associated with immune infiltration in gastric cancer by Xuewei Li, Xuewei Li, Na Wu, Chen Wang, Beibei Pei, Xiaoyan Ma, Jun Xie, Jun Xie, Wenhui Yang

“…However, there is a paucity of experimental studies specifically addressing the relationship between NALCN and immune cell infiltration in gastric cancer (GC).MethodsThe expression levels of NALCN in tumor tissues, peripheral blood and gastric cancer cells lines from patients with GC were assessed using RNA sequencing, immunohistochemistry (IHC) staining and RT-qPCR. …”
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Risk factors associated with mortality and pathogen characteristics of bloodstream infection-induced severe sepsis in the pediatric intensive care unit: a retrospective cohort stud... by Jian Chen, Jian Chen, Haixin Huang, Ruichen Zhang, Yueqiang Fu, Chunmei Jing

“…Double organism growth was detected in 8 cultures, and a total of 200 pathogenic bacteria were isolated from all blood cultures. Of these, 110 strains (55.0%) were Gram-negative bacteria, 88 strains (44.0%) were gram-positive bacteria, and 2 strains (1.0%) were Candida albicans. …”
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A concept of natural genome reconstruction. Part 2. Effect of extracellular double-stranded DNA fragments on hematopoietic stem cells by V. S. Ruzanova, S. G. Oshikhmina, A. S. Proskurina, G. S. Ritter, S. S. Kirikovich, E. V. Levites, Y. R. Efremov, T. V. Karamysheva, M. I. Meschaninova, A. L. Mamaev, O. S. Taranov, A. S. Bogachev, S. V. Sidorov, S. D. Nikonov, O. Y. Leplina, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, E. V. Dolgova, S. S. Bogachev

“…At the same time, treatment with hDNAgr induces proliferation of blood stem cells and their immediate descendants and stimulates colony formation (mouse, rat and humans as the model organisms). …”
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Prevalence of vitamin D deficiency and its association with adverse obstetric outcomes among pregnant women in Uganda: a cross-sectional study by Cristina Reverzani, Daniel Zaake, Faridah Nansubuga, Herman Ssempewo, Leonard Manirakiza, Anthony Kayiira, Gilbert Tumwine

“…We excluded pregnant women admitted to the hospital longer than 1 week before delivery; pregnant women with self-reported pre-existing kidney diseases, liver diseases, or gut or malabsorption disorders and pregnant women with severe pregnancy-unrelated comorbidities requiring intensive care unit admission before delivery.Interventions Maternal venous blood was collected at admission, and serum 25-hydroxy-vitamin D (25(OH)D) was measured by an electrochemiluminescence binding assay.Primary and secondary outcome measures Maternal sociodemographic characteristics and obstetric-medical factors, and adverse maternal and foetal outcomes were captured by using a data collection form. …”
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Th1/Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure by Jian Wu, Yurong Guo, Xuan Lu, Fen Huang, Feifei Lv, Daqiao Wei, Anquan Shang, Jinfeng Yang, Qiaoling Pan, Bin Jiang, Jiong Yu, Hongcui Cao, Lanjuan Li

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Serum proteomic and metabolomic profiling of hepatocellular carcinoma patients co-infected with Clonorchis sinensis by Zeli Tang, Zeli Tang, Zeli Tang, Caibiao Wei, Xueling Deng, Qiumei Lin, Qiping Hu, Qiping Hu, Qiping Hu, Shitao Li, Jilong Wang, Yuhong Wu, Dengyu Liu, Dengyu Liu, Dengyu Liu, Min Fang, Min Fang, Tingzheng Zhan, Tingzheng Zhan, Tingzheng Zhan

“…It also associated with shorter overall survival (OS) and recurrence-free survival (RFS). The levels of blood lipids (e.g., APO-A, HDL-C, and TG) were significantly altered after C. sinensis infection. …”
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Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. by Andrés F. Zea-Vera, Carlos Andrés Rodríguez, Sebastián Giraldo, Mario Alejandro Chacón, Luis Fernando Guerrero, Ricardo Mosquera, Raúl Andrés Vallejo, Fabio Samir Vargas, María Andrea García, María A. Rengifo, Anilza Bonelo, Maximiliano Parra

“…Participants underwent laboratory tests, including complete blood count, serum immunoglobulin levels, and, in some cases, additional tests. …”
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Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway by Li Wang, Chaofan Zhang, Muhammad Azhar Memon, Qianting Shi, Le Lu, Xishuai Tong, Yonggang Ma, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan

“…In addition, CGA can penetrate the blood-brain barrier and exert neuroprotective effects. …”
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Differences in the Cardiovascular Risk Assessment in Cardiology Outpatients in Mali: Comparison between Framingham Body Mass Index-Based Tool and Low-Information World Health Organ... by Bâ Hamidou Oumar, Sangaré Ibrahima, Camara Youssouf, Sidibé Noumou, Coulibaly Souleymane, Cissoko Yacouba, Sidibé Samba, Konaté Massama, Maiga Asmaou Kéita, Doumbia Coumba Thiam, Touré Mamadou, Diakité Mamadou, Menta Ichaka, Diall Ilo Bella

“…Means for age, body mass index (BMI), and systolic blood pressure (SBP) were, respectively, 53.81 ± 16.729 years, 25.29 ± 06.151 kg/m2, and 139.49 ± 27.110 mm Hg. …”
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Cardiovascular function shows early impairment in asymptomatic adolescents diagnosed with type 1 diabetes mellitus: an ultrasound-derived myocardial work study by Martina Ghirardo, Martina Ghirardo, Irene Cattapan, Irene Cattapan, Jolanda Sabatino, Jolanda Sabatino, Alice Pozza, Alice Pozza, Jennifer Fumanelli, Jennifer Fumanelli, Martina Avesani, Joaquin Gutierrez De Rubalcava Doblas, Carlo Moretti, Biagio Castaldi, Giovanni Di Salvo

“…We collected data relating to anthropometry, lifestyle, blood tests, glycemic control parameters, and conventional and advanced echocardiographic measurements. …”
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Association between Loa loa microfilaremia and anatomical hyposplenia in a rural area of the Republic of Congo: a population-based cross-sectional study by Charlotte Boullé, Elodie Lebredonchel, Jérémy T. Campillo, Valentin Dupasquier, Marlhand C. Hemilembolo, Sébastien D. S. Pion, Jean Claude Djontu, Ludovic Rancé, Philippe Souteyrand, François Missamou, Michel Boussinesq, Francine Ntoumi, Cédric B. Chesnais

“…The primary outcomes included SV, splenomegaly (cranio-caudal-distance ≥ 13 cm), and anatomical hyposplenia (AH) (SV ≤ 80, ≤ 110 or ≤ 150 cm3). Blood samples were analyzed for L. loa MFD, Plasmodium-PCR, Anti-Plasmodium falciparum-IgG, total IgM, sickle-cell disease status, and hematological abnormalities. …”
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Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail by Lorena V. Cortés-Medina, Herminia Pasantes-Morales, Alejandro Aguilera-Castrejon, Arturo Picones, Cesar O. Lara-Figueroa, Enoch Luis, Juan Jose Montesinos, Victor A. Cortés-Morales, M. P. De la Rosa Ruiz, Erika Hernández-Estévez, Laura C. Bonifaz, Marco Antonio Alvarez-Perez, Gerardo Ramos-Mandujano

“…MSCs can be obtained from many different sources, and the present study compares the potential of neuronal transdifferentiation in MSCs from adult and neonatal sources (Wharton’s jelly (WhJ), dental pulp (DP), periodontal ligament (PDL), gingival tissue (GT), dermis (SK), placenta (PLAC), and umbilical cord blood (UCB)) with a protocol previously tested in bone marrow- (BM-) MSCs consisting of a cocktail of six small molecules: I-BET151, CHIR99021, forskolin, RepSox, Y-27632, and dbcAMP (ICFRYA). …”
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Aluminum-Induced Alterations in Purinergic System Parameters of BV-2 Brain Microglial Cells by Charles Elias Assmann, Vitor Bastianello Mostardeiro, Grazielle Castagna Cezimbra Weis, Karine Paula Reichert, Audrei de Oliveira Alves, Vanessa Valéria Miron, Margarete Dulce Bagatini, Taís Vidal Palma, Cinthia Melazzo de Andrade, Micheli Mainardi Pillat, Fabiano Barbosa Carvalho, Cristina Ruedell Reschke, Ivana Beatrice Mânica da Cruz, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch

“…The trivalent free Al anion (Al3+) can cross the blood-brain barrier (BBB), accumulate in the brain, and elicit harmful effects to the central nervous system (CNS) cells. …”
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Predictors of cytomegalovirus infection in patients with connective tissue disease treated by pulsed methylprednisolone therapy: a multicenter retrospective cohort study by Haruka Ito, Takahiko Yoshimoto, Akatsuki Kokaze, Kuninobu Wakabayashi, Kazuteru Noguchi, Kiyoshi Matsui, Bunki Natsumoto, Keishi Fujio, Yutaro Hayashi, Yuko Kaneko, Takahisa Gono, Koh Okamoto, Shu Okugawa, Kyoji Moriya, Hirohiko Sueki

“…We included patients who received p-MPSL therapy for connective tissue disease and had CMV antigenemia measured between April 2011 and December 2020. Peripheral blood cell data before the start of p-MPSL therapy and at the start of steroid tapering were collected in addition to baseline characteristics, including age, sex, and body mass index. …”
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