Application of psychological intervention combined with wet compress of Traditional Chinese Medicine in nursing of patients with diabetic foot ulcer (心理干预联合中药塌渍技术在糖尿病足溃疡护理中的应用)... by WANG Xiuyan (王秀燕), CAO Hongjing (曹红京), LI Ning (李宁), LI Yueru (李月茹), LI Jing (李静), YANG Kun (杨坤), LI Lin (李林), TANG Hong (汤虹)

“…All patients received local dressing change in addition to the comprehensive treatment such as blood glucose control and infection prevention. Patients in the observation group were given psychological intervention combined with wet compress of Traditional Chinese Medicine. …”
Get full text

Efficacy of bivalent vaccine against black body syndrome (BBS) of barramundi Lates calcalifer B. by Anis Nugrahawati, Sri Nuryati, Sukenda Sukenda, Rahman Rahman, Margie Brite, Tiya Widi Aditya

“…We observed relative percent survival (RPS), mortality, blood profile, antibody level, lysozyme activity, and histopathology of vaccinated fish. …”
Get full text

Expression of the NUP153 and YWHAB genes from their canonical promoters and alternative promoters of the LINE-1 retrotransposon in the placenta of the first trimester of pregnancy by V. V. Demeneva, E. N. Tolmacheva, T. V. Nikitina, E. A. Sazhenova, S. Yu. Yuriev, A. Sh. Makhmutkhodzhaev, A. S. Zuev, S. A. Filatova, A. E. Dmitriev, Ya. A. Darkova, L. P. Nazarenko, I. N. Lebedev, S. A. Vasilyev

“…The level of expression of both genes from canonical promoters was higher in blood lymphocytes than in placental tissues (p < 0.05). …”
Get full text

Elevated D-dimer on admission may predict poor prognosis in childhood influenza associated encephalopathy by Huizhen Wang, Lingkong Zeng, Xingfeng Cheng, Hui Li, Hong Zhang, Yuanmei Shi, Yong Zhang, Changjian Li

“…In the univariate analysis, the poor prognosis group compared with the clinically cured group showed a significant increase in the number of days of hospitalization (3.0 vs. 9.5 days, P < 0.001), high-sensitivity C-reactive protein (6.80 vs. 1.88 mg/L, P = 0.003), interleukin-6 (20.26 vs. 8.24 pg/mL, P = 0.001), interleukin-10 (11.75 vs. 4.72 pg/mL, P = 0.003), alanine aminotransferase (104.0 vs. 20.0 U/L, P = 0.011), aspartate azelotransferase (186.5 vs. 37.0 U/L, P = 0.003), serum albumin (37.99 vs. 40.76 g/L, P = 0.042), prothrombin time (13.2 vs. 11.4 s, P = 0.017), D-dimer (4.34 vs. 0.44 mg/L FEU, P < 0.001), peripheral blood CD19 B-cell count (35.11 vs. 32.75 cells/µL, P = 0.018), and cerebrospinal fluid chloride (126.82 vs. 125.50 mmol/L, P = 0.027) were statistically different in the above 11 indicators. …”
Get full text

T-cell receptor beta variable gene polymorphism predicts immune-related adverse events during checkpoint blockade immunotherapy by Linghua Wang, Siqing Fu, Aung Naing, Funda Meric-Bernstam, Carl Morrison, Joud Hajjar, Mingxuan Xu, Anas Alshawa, Bettzy Stephen, Ying Yuan, Jordi Rodon Ahnert, Abdulrazzak Zarifa, Shrutii Sarda, Timothy Looney, Sapna P Patel, Geoffrey M Lowman, Dzifa Yawa Duose, Jeffrey M Conroy, Evan Kwiatkowski

“…However, the repetitive nature of the TCRB locus and incomplete genome assembly has hampered the evaluation of TRBV polymorphisms in the past.Patients and methods We used a novel method for long-amplicon next generation sequencing of rearranged TCRB chains from peripheral blood total RNA to evaluate the link between TRBV polymorphisms and irAEs in patients treated with immunotherapy for cancer. …”
Get full text

Evaluating the effectiveness of immediate vs. elective thoracic endovascular aortic repair for blunt thoracic aortic injury by Zhaohui Hua, Baoning Zhou, Wenhao Xue, Zhibin Zhou, Jintao Shan, Lei Xia, Yunpeng Luo, Yiming Chai, Zhen Li

“…These factors included demographics, comorbidities, concomitant injuries, cause and location of aortic injury, Glasgow coma scale score, society for vascular surgery grading, hemoglobin concentration, creatinine concentration, shock, systolic blood pressure, and heart rate at admission. The comparison was conducted using SPSS 26 software. …”
Get full text

Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma by Yuan Yao, Yiyi Yan, Vera J. Suman, Allan B. Dietz, Courtney L. Erskine, Anastasios Dimou, Svetomir N. Markovic, Svetomir N. Markovic, Robert R. McWilliams, Heather N. Montane, Matthew S. Block, Matthew S. Block

“…Patients were treated until disease progression, intolerability, or patient decision to discontinue. Blood samples were collected after each cycle of treatment for immunophenotyping and Th1/Th2 polarity assessment based on immune response markers.ResultsBetween January 31, 2017 and January 9, 2023, 17 patients were enrolled. …”
Get full text

Enhancement of colour quality, growth, and health status of rainbow Kurumoi fish Melanotaenia parva through dietary synthetic carotenoids supplementation by Nina Meilisza, Muhammad Agus Suprayudi, Dedi Jusadi, Muhammad Zairin Junior, I Made Artika, Nur Bambang Priyo Utomo

“…This study was conducted to determine the effect of different carotenoids at two different doses in the feed on growth, pigmentation, vitamin A conversion, blood profile, antioxidant activity, and calcium bone of the rainbow fish. …”
Get full text

Seroprevalence of Malaria and Hepatitis B Coinfection among Pregnant Women in Tamale Metropolis of Ghana: A Cross-Sectional Study by Gideon Kofi Helegbe, Paul Armah Aryee, Baba Sulemana Mohammed, Anthony Wemakor, David Kolbila, Abdul-Wahid Abubakari, Salam Askanda, Rashid Alhassan, Collins Barnie, Afua Aboagyewaa Donkoh, Ernest Ofosu

“…Haemoglobin (Hb) values, sickling, and glucose-6-phosphate dehydrogenase deficiency (G6PDd) statuses were also assessed using full blood count (FBC), sodium metabisulphite, and methaemoglobin reduction tests, respectively. …”
Get full text

Utilization of hydrolyzed corncob as a carbohydrate source in diets for red Nile tilapia Oreochromis niloticus by Fauzan, Muhammad Agus Suprayudi, Ichsan Achmad Fauzi, Julie Ekasari

“…The digestibility test results showed that the hydrolyzed corn cob diet obtained a higher digestibility level, digestive enzyme activity, and blood plasma protein than the unhydrolyzed corncob diet (P<0.05). …”
Get full text

Olutasidenib in combination with azacitidine induces durable complete remissions in patients with relapsed or refractory mIDH1 acute myeloid leukemia: a multicohort open-label phas... by Jorge E. Cortes, Gail J. Roboz, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, P. Brent Ferrell, Jay Yang, Eunice S. Wang, William G. Blum, Alice Mims, Hua Tian, Aaron Sheppard, Stéphane de Botton, Pau Montesinos, Antonio Curti, Justin M. Watts, the Olutasidenib Combination Therapy Study Group

“…The most common Grade 3 or 4 adverse events (> 20% patients) were decreased platelet count (37%), red blood cell count (25%), and neutrophil count (24%). …”
Get full text

Digital Home-Based Self-Monitoring System for People with Heart Failure: Protocol for Development of SmartHeart and Evaluation of Feasibility and Acceptability by Ralph Maddison, Rebecca Nourse, Reza Daryabeygikhotbehsara, Teketo Kassaw Tegegne, Paul Jansons, Jonathan Charles Rawstorn, John Atherton, Andrea Driscoll, Brian Oldenburg, Rajesh Vasa, Vassilis Kostakos, Tilman Dingler, Gavin Abbott, Paul Scuffham, Jo-Anne Elizabeth Manski-Nankervis, Dominika Kwasnicka, Finn Kensing, Sheikh Mohammed Shariful Islam, Anthony Maeder, Yuxin Zhang

“… BackgroundHeart failure (HF) is a chronic, progressive condition where the heart cannot pump enough blood to meet the body’s needs. In addition to the daily challenges that HF poses, acute exacerbations can lead to costly hospitalizations and increased mortality. …”
Get full text

Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion by Risheng Xu, Max Wintermark, Gregory W Albers, Jeremy J Heit, Adam A Dmytriw, Adrien Guenego, Yasmin Aziz, Kambiz Nael, Benjamin Pulli, Victor Urrutia, Dhairya A Lakhani, Tobias D Faizy, Argye Hillis, Vivek Yedavalli, Dylan Wolman, Licia P Luna, Elisabeth B Marsh, Hamza Adel Salim, Janet Mei, Vaibhav Vagal, Aakanksha Sriwastwa, Raf Llinas, Hanzhang Lu, Mona N Bahouth

“…Background Acute ischaemic stroke (AIS) is a leading cause of mortality and disability globally, with volume contracted state (VCS), as indicated by an elevated blood urea nitrogen to creatinine (BUN/Cr) ratio, potentially influencing outcomes. …”
Get full text

Development of a Predictive Model of Occult Cancer After a Venous Thromboembolism Event Using Machine Learning: The CLOVER Study by Anabel Franco-Moreno, Elena Madroñal-Cerezo, Cristina Lucía de Ancos-Aracil, Ana Isabel Farfán-Sedano, Nuria Muñoz-Rivas, José Bascuñana Morejón-Girón, José Manuel Ruiz-Giardín, Federico Álvarez-Rodríguez, Jesús Prada-Alonso, Yvonne Gala-García, Miguel Ángel Casado-Suela, Ana Bustamante-Fermosel, Nuria Alfaro-Fernández, Juan Torres-Macho

“…The final CatBoost model included, among the top 15 variables to predict hidden malignancy, age, gender, systolic blood pressure, heart rate, weight, chronic lung disease, D-dimer, alanine aminotransferase, hemoglobin, serum creatinine, cholesterol, platelets, triglycerides, leukocyte count and previous VTE. …”
Get full text

Nymphaea pubescens Willd. extract and its flavonoid constituents vasodilate rat isolated pulmonary artery via NO-sGC-cGMP pathway by Teerapap Panklai, Prapapan Temkitthawon, Nungruthai Suphrom, Corine Girard, Perle Totoson, Kowit Hengphasatporn, Yasuteru Shigeta, Krongkarn Chootip, Kornkanok Ingkaninan

“…Background: Pulmonary arterial hypertension (PAH) is a progressive disorder indicated by elevated blood pressure in pulmonary artery (PA). PAH treatment focuses on inducing PA vasodilation by inhibiting phosphodiesterase 5 (PDE5), the enzyme prominently expressed in pulmonary vasculature. …”
Get full text

The Effects of Artificial vs. Natural Rearing on Growth Performance, Thyroid Hormone Levels, Locomotor Activity, Carcass Traits and Meat Quality Characteristics in Chios Lambs by Panagiotis Simitzis, Georgia Alexopoulou, Eftychis Karampekos, Konstantina Linardopoulou, Anargyros Rigakis, Niki Stamelou, Michael Goliomytis, Iosif Bizelis, Ioannis Bossis

“…The lambs’ behavior was continuously videotaped until weaning, and their standing percentage was recorded as an activity index. Blood samples were collected from the jugular vein of lambs on days 3, 10, 17 and 40 after birth to assess thyroid hormone levels. …”
Get full text

Effect of L-Citrulline on Creatine Kinase MM (CK-MM) Isoenzymes in Mice: An In Vivo Study Focusing on Immunohistochemistry Analysis by Dhoni Akbar Ghozali, Annisa Aghnia Rahma, Shafira Nur Hanifa, Muhana Fawwazy Ilyas

“…This study contributes valuable insights into the multifaceted benefits of L-citrulline supplementation for supporting overall muscle health and performance by identifying its protective effects under different mechanisms, including improved blood flow, antioxidant activity, enhanced mitochondrial function, and promotion of muscle protein synthesis.   …”
Get full text

Atezolizumab, bevacizumab, pemetrexed and platinum for EGFR‐mutant NSCLC patients after EGFR TKI failure: A phase II study with immune cell profile analysis by Shang‐Gin Wu, Chao‐Chi Ho, James Chih‐Hsin Yang, Shu‐Han Yu, Yen‐Feng Lin, Shu‐Chin Lin, Bin‐Chi Liao, Ching‐Yao Yang, Yen‐Ting Lin, Chong‐Jen Yu, Ya‐Ting Chuang, Wei‐Yu Liao, Kah Yi Yap, Weng Si Kou, Jin‐Yuan Shih

“…The re‐biopsy tissue specimens and serial peripheral blood samples were collected to analyse the immune cell profile and tumour microenvironments. …”
Get full text

Characteristics of the Small Bowel Lesions Detected by Capsule Endoscopy in Patients with Chronic Kidney Disease by Harunobu Kawamura, Eiji Sakai, Hiroki Endo, Leo Taniguchi, Yasuo Hata, Akiko Ezuka, Hajime Nagase, Takaomi Kessoku, Eiji Yamada, Hidenori Ohkubo, Takuma Higrashi, Yusuke Sekino, Tomoko Koide, Hiroshi Iida, Takashi Nonaka, Hirokazu Takahashi, Masahiko Inamori, Shin Maeda, Atsushi Nakajima

“…In CKD patients, past history of blood transfusion (OR 5.66; 95% CI 1.10–29.1, P=0.04) was identified as an independent predictor of the presence of vascular lesions, and history of low-dose aspirin use (OR 6.00; 95% CI 1.13–31.9, P=0.04) was identified as that of erosive/ulcerated lesions. …”
Get full text

Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma by Thomas Kapapa, Vanida Wernheimer, Andrea Hoffmann, Tamara Merz, Fabia Zink, Eva-Maria Wolfschmitt, Oscar McCook, Josef Vogt, Martin Wepler, David Alexander Christian Messerer, Claire Hartmann, Angelika Scheuerle, René Mathieu, Simon Mayer, Michael Gröger, Nicole Denoix, Enrico Clazia, Peter Radermacher, Stefan Röhrer, Thomas Datzmann

“…Extracerebral, intraparenchymal–extraventricular and intraventricular blood, combined with brainstem and basal ganglia injury, influenced the experiment and its outcome. …”
Get full text