Effect of chemoradiotherapy on the dynamics of circulating lymphocyte subsets in patients with non-metastatic nasopharyngeal carcinoma by Lilan Yi, Lilan Yi, Yinfang Gu, Yinfang Gu, Longhua Guo, Longhua Guo, Xiaofang Zou, Xiaofang Zou, Guowu Wu, Guowu Wu

“…Flow cytometry was employed to detect the expression of CD3, CD4, CD8, CD56, and CD19 on peripheral blood cells. The composition of lymphocyte subsets before treatment, post-completion of CRT, and one month following CRT was retrospectively analyzed. …”
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Physiochemical and functional evaluation of the first-in-class anti-cancer IgE antibody drug, MOv18, through process development and good manufacturing practice production by Heather J Bax, Jitesh Chauhan, Alexandra J McCraw, Melanie Grandits, Chara Stavraka, Heike Lentfer, Tim Hillyer, Simon Carroll, Kim Vigor, Chris Selkirk, Mariangela Figini, Jack Cheeseman, Paulina A Urbanowicz, Richard A Gardner, Daniel I R Spencer, Nigel Westwood, Sarah Mellor, James Spicer, Debra H Josephs, Sophia N Karagiannis

“…Furthermore, we screened patient blood ex vivo for potential type I hypersensitivity reaction to MOv18 IgE, using the basophil activation test, to identify patients not predicted to be hypersensitive to MOv18 IgE administration. …”
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Clinical and analytical monitoring of patients with multiple sclerosis on anti-CD20 therapeutics: a real-world safety profile study by André Aires Fernandes, André Aires Fernandes, Ana Lídia Neves, Ana Lídia Neves, Daniela Ferro, Daniela Ferro, Mafalda Seabra, Mafalda Seabra, Teresa Mendonça, Ricardo Soares dos Reis, Ricardo Soares dos Reis, Maria José Sá, Joana Guimarães, Joana Guimarães, Pedro Abreu, Pedro Abreu

“…Clinical and paraclinical parameters were evaluated, including complete blood count and immunoglobulins measurements.ResultsA total of 160 with multiple sclerosis (pwMS) were included in our study, of whom 110 (68.8%) were female and 147 are currently receiving anti-CD20 therapies. …”
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Differential expression of circulating microRNAs in lactating Holstein and Jersey cows exposed to heat stress by Jihwan Lee, Doosan Kim, Byeonghwi Lim, Gyeonglim Ryu, Hyeonguk Baek, Joohwan Kim, Seungmin Ha, Sangbum Kim, Seunghwan Lee, Taejeong Choi, Inchul Choi

“…To explore molecular mechanisms, we analyzed circulating microRNA profiles from whole blood samples collected under heat stress and normal conditions using microRNA-sequencing. …”
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Risk Factors for Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction: Multicenter Retrospective Cohort Study by Yanqi Kou, Shicai Ye, Yuan Tian, Ke Yang, Ling Qin, Zhe Huang, Botao Luo, Yanping Ha, Liping Zhan, Ruyin Ye, Yujie Huang, Qing Zhang, Kun He, Mouji Liang, Jieming Zheng, Haoyuan Huang, Chunyi Wu, Lei Ge, Yuping Yang

“…Key predictors included red blood cell count, hemoglobin, maximal myoglobin, hematocrit, CHD, and other variables, all of which were strongly associated with GIB risk. …”
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Dietary and lifestyle patterns identified through reduced rank regression and their association with insulin-related disorders: a prospective analysis from the Tehran Lipid and Glu... by Ebrahim Mokhtari, Hossein Farhadnejad, Farshad Teymoori, Mitra Kazemi Jahromi, Mehrnaz Nikkhah, Parvin Mirmiran, Fereidoun Azizi

“…Methods The current study was conducted on 1063 individuals aged ≥ 25 years old of the Tehran Lipid and Glucose Study who have complete data on fasting blood sugar, plasma insulin, anthropometric variables, and nutritional intakes. …”
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Validation of the efficacy of the porous medium model in hemodynamic analysis of iliac vein compression syndrome by Lingling Wei, Ke Hu, Jiaqiu Wang, Shuang Zhang, Xiaoxiao Yang, Yuanli Chen, Chenshu Li, Xinwu Lu, Kaichuang Ye, Peng Qiu, Yanqing Zhan, Yanqing Zhan

“…In comparison to CFD analysis conducted without the porous medium model, the incorporation of the porous medium model resulted in a substantial decrease in blood flow velocity by 87.5% within the compressed region, a significant increase in pressure gradient of 141 Pa between the inferior vena cava and left iliac vein, and a wider distribution of wall shear stress exceeding 2.0 Pa in collateral vessels rather than in the compressed region. …”
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Comparative quantitative assessment of the placement and intensity of laser spots for treating diabetic macular edema by E.A. Zamytskiy, A.V. Zolotarev, E.V. Karlova, N.Yu. Il’yasova, A.S. Shirokanev

“…The number of non-optimal laser burns placed on retinal hemorrhages, blood vessels, hard exudates or healthy retina was calculated. …”
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Obtaining patient phenotypes in SARS-CoV-2 pneumonia, and their association with clinical severity and mortality by Fernando García-García, Dae-Jin Lee, Mónica Nieves-Ermecheo, Olaia Bronte, Pedro Pablo España, José María Quintana, Rosario Menéndez, Antoni Torres, Luis Alberto Ruiz Iturriaga, Isabel Urrutia, COVID-19 & Air Pollution Working Group

“…We collected a broad spectrum of variables to describe exhaustively each case: patient demographics, comorbidities, symptoms, physiological status, baseline examinations (blood analytics, arterial gas test), etc. For the development and internal validation of the clustering/phenotype models, the dataset was split into training and test sets (50% each). …”
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The absolute number of circulating Treg cells is reduced in difficult-to-treat RA patients and is ameliorated by low-dose IL-2 by Huanhuan Yan, Huanhuan Yan, Huanhuan Yan, Xiaoyu Zi, Xiaoyu Zi, Xiaoyu Zi, Huer Yan, Xiaoying Zhang, Xiaoying Zhang, Xiaoying Zhang, Jie Bai, Jie Bai, Jie Bai, Chong Gao, Xiaofeng Li, Xiaofeng Li, Xiaofeng Li, Caihong Wang, Caihong Wang, Caihong Wang

“…The absolute numbers of peripheral blood lymphocyte subsets were detected by flow cytometry (FCM) and serum cytokine levels were detected by flow cytometry bead array (CBA).ResultsThe absolute number of T, CD4+ T, and Treg cells in the D2T RA group was lower than that in the HC, new, and treated RA groups. …”
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Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01E vaccine, seasonal malaria chemoprevention and the combination of vaccination... by Ismaila Thera, Irene Kuepfer, Daniel Chandramohan, Alassane Dicko, Issaka Zongo, Issaka Sagara, Matthew Cairns, Modibo Diarra, Amadou Tapily, Djibrilla Issiaka, Koualy Sanogo, Almahamoudou Mahamar, Frederic Sompougdou, Serge Yerbanga, Paul Milligan, Halidou Tinto, Opokua Ofori-Anyinam, Jean-Bosco Ouedraogo, B Greenwood

“…The primary endpoint is the incidence of clinical malaria confirmed by a positive blood film with a minimum parasite density of 5000 /µL. …”
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Predictive biomarkers of performance under stress: a two-phase study protocol to develop a wearable monitoring system by Cassandra Pattinson, Graham Kerr, Simon S Smith, Chamindie Punyadeera, Ian Stewart, Kerrie Mengersen, Karen A Sullivan, Jonathan M Flintoff, Sarah Ahamed, Shahnewaz Ali, Angus Bagley, Daniel Broszczak, Blair Crewther, Louis de Waal, Shannon L Edmed, Tharindu Fernando, Clinton Fookes, Francesca D Frentiu, Andrew P Hunt, Ottmar V Lipp, Ben McMaster, Luke Ney, Senn L Oon, Ajay Pandey, Parth Pandit, Jonathan M Peake, Muthukuttige Madusha Nuwanthi Perera, Virginie Perlo, Luke Schmidt, Kirsten Spann, Danielle Young, Tony J Parker

“…Biomarkers will be identified from molecular markers in biological samples (eg, blood, saliva, sweat and stool), physiological measures and psychological assessments to predict cognitive and physical performance under stress. …”
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Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing’s syndrome by Peter Wolf, Simon Travers, Oliver Domenig, Stephanie Baron, Anne Blanchard, Khaoula Bouazizi, Nadjia Kachenoura, Sylvie Salenave, Marko Poglitsch, Alban Redheuil, Severine Trabado, Jacques Young, Philippe Chanson, Peter Kamenický

“…Angiotensin metabolites and adrenal steroids were measured by liquid chromatography tandem mass spectrometry, and their relation to blood pressure and cardiac structure was evaluated. …”
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Hepatoprotection and Phytochemistry of the Vietnamese Herbs Cleome chelidonii and Cleome viscosa Stems by Nhat Minh Phan, Thi Hong Tuoi Do, Le Thanh Tuyen Nguyen, Trong Tuan Nguyen, Quoc Luan Ngo, Trong Duc Tran, Quan Hien Nguyen, Bui Linh Chi Huynh, Diep Xuan Ky Nguyen, Trong Dat Bui, Dinh Tri Mai, Tan Phat Nguyen

“…Levels of aspartate aminotransferase (ALT) and alanine aminotransferase (AST) in the blood were measured and compared to the silymarin control. …”
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Nitrate–Nitrite–Nitric Oxide Pathway, Oxidative Stress, and Fertility Outcomes in Morbidly Obese Women Following Bariatric Surgery: A Systematic Review by Charalampos Voros, Despoina Mavrogianni, Aspasia Minaoglou, Alexios Karakasis, Anthi-Maria Papahliou, Vasileios Topalis, Antonia Varthaliti, Raphail Mantzioros, Panagiota Kondili, Menelaos Darlas, Regina Sotiropoulou, Diamantis Athanasiou, Dimitrios Loutradis, Georgios Daskalakis

“…The NO₃-NO₂-NO route is critical in compensating for lower NO generation under oxidative stress and hypoxia, and bariatric surgery significantly improves this pathway to optimize blood flow, mitochondrial function, and reproductive results.…”
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The hematopoietic function, histological characteristics, and transcriptome profiling of Wanxi white geese ovary during nesting and late-laying stages by Chunfang Zhao, Tao Jin, Kefeng Yang, Xinyu Liu, Man Ren, Deyong She, Qianqian Hu, Shenghe Li

“…Triglyceride (TG) and alkaline phosphatase (ALP) levels were higher in late-laying geese, while white blood cell (WBC), neutrophil (NEU), hemoglobin (HGB), and hematocrit (HCT) levels were significantly lower in late-laying geese. …”
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Isolation of a tumor neoantigen specific CD8+ TCR from a skin biopsy of a vaccination site by Maria Paula Roberti, Pornpimol Charoentong, Yanhong Lyu, Marten Meyer, Stefan B. Eichmüller, Patrick Schmidt, Frank Momburg, Miray Cetin, Felix Hartmann, Nektarios A. Valous, Albrecht Stenzinger, Laura Michel, Peter Lichter, Andreas Schneeweiss, Verena Thewes, Carlo Fremd, Inka Zörnig, Dirk Jäger

“…Reactive T cells from VILs were non-overlapping with those detected in the blood and the tumor-microenvironment. ScTCR Seq analysis revealed the presence of a clonotype in VILs that further expanded after a round of in vitro stimulation and validated to be specific against a private mutation, namely NCOR1L1475R, presented in the context of HLA-B * 07:02, with no reactivity to the wild-type peptide. …”
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High-resolution awake mouse fMRI at 14 tesla by David Hike, Xiaochen Liu, Zeping Xie, Bei Zhang, Sangcheon Choi, Xiaoqing Alice Zhou, Andy Liu, Alyssa Murstein, Yuanyuan Jiang, Anna Devor, Xin Yu

“…Besides activated ascending visual and vibrissa pathways, robust blood oxygen level-dependent (BOLD) responses were detected in the anterior cingulate cortex upon visual stimulation and spread through the ventral retrosplenial area (VRA) with vibrissa air-puff stimulation, demonstrating higher-order sensory processing in association cortices of awake mice. …”
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Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics by Grant McGee Talkington, Grant McGee Talkington, Paresh Kolluru, Timothy E. Gressett, Timothy E. Gressett, Saifudeen Ismael, Umar Meenakshi, Mariana Acquarone, Rebecca J. Solch-Ottaiano, Amanda White, Blake Ouvrier, Blake Ouvrier, Kristina Paré, Nicholas Parker, Amanda Watters, Nabeela Siddeeque, Brooke Sullivan, Nilesh Ganguli, Victor Calero-Hernandez, Gregory Hall, Michele Longo, Gregory J. Bix, Gregory J. Bix, Gregory J. Bix, Gregory J. Bix

“…In this review, we explore the mechanistic hypotheses of these neurological changes, which describe CNS invasion, neuroinflammation, blood-brain barrier disruption, and gut-brain axis dysregulation, along with the novel vascular disruption hypothesis that highlights endothelial dysfunction and hypoperfusion as a core underlying mechanism. …”
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First report of serological, molecular detection, and characterization of human parvovirus B19 infections among sickle cell anaemia patients in Khartoum State, Sudan by Khalid Salman, Sittna Hayder El Nagar, Abdel Rahim M. El Hussein, Mohammed A. El Hussein, Hadi M. Yassine, Hebah A. Al Khatib, Mashael Ali Al- Badr, Ibrahim Farah, Khalid A. Enan

“…Screening for parvovirus B19 is critical for patients requiring blood transfusions, particularly those with haematological disorders. …”
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